Retinyl propionate

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  • Identifiers

    CAS number
    7069-42-3

    Molecular formula
    C23H34O2

    SMILES
    CCC(=O)OC/C=C(\C)/C=C/C=C(\C)/C=C/C1=C(CCCC1(C)C)C

    Safety labels

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Sweet 66.46%
    Woody 65.55%
    Floral 64.18%
    Fruity 59.23%
    Berry 46.72%
    Tropical 45.41%
    Balsamic 44.59%
    Powdery 44.34%
    Violet 39.58%
    Waxy 35.25%

     

    Flavor
    Balsam 28.61%
    Spicy 24.05%
    Sweet 23.82%
    Woody 23.53%
    Herbal 23.48%
    Balsamic 22.84%
    Oriental 22.59%
    Heather 20.41%
    Diterpene 20.33%
    Genet 20.25%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    6.7

    pKa est.
    7.4 (neutral)

    Molecular weight
    342.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    387°C

    Flash point

    • 186.82 ˚C est.

  • Synonyms

    • Retinyl propionate
    • 7069-42-3
    • Retinol propionate
    • Retinol, propanoate
    • 32JK994WMC
    • DTXSID701019851
    • VITAMIN A PROPIONATE 2.5 MIO IU/G
    • RefChem:879488
    • DTXCID60909505
    • 230-363-2
    • Vitamin A propionate
    • [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] propanoate
    • (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl propionate
    • Retinyl Propionate (Stabilized with BHT) 90%
    • UNII-32JK994WMC
    • Propionic acid, retinol ester
    • EC 230-363-2
    • Retinol, 15-propanoate; Retinol propionate (7CI); Retinol, propanoate (9CI); Retinol, propionate, all-trans- (8CI); Retinyl propionate; Vitamin A propionate
    • EINECS 230-363-2
    • 1795139-60-4
    • O~15~-Propanoylretinol
    • SCHEMBL80075
    • orb2664883
    • RETINOL, 15-PROPANOATE
    • SFRPDSKECHTFQA-ONOWFSFQSA-N
    • Microvit a dlc [veterinary] (TN)
    • MSK15035
    • RETINOL PROPIONATE [WHO-DD]
    • MFCD00129785
    • AKOS024386409
    • CS-W011896
    • RETINOL, PROPIONATE, ALL-TRANS-
    • AC-34856
    • LS-15018
    • ALL-(E)-RETINOL PROPIONATE [WHO-IP]
    • NS00007709
    • ST51037678
    • D08477
    • F87590
    • Q27256177
    • Retinyl Propionate (Stabilized with BHT) 90per cent
    • Retinyl propionate, >=98.0% (sum of isomers, HPLC), ~2500 U/mg
    • Retinyl Propionate, Pharmaceutical Secondary Standard; Certified Reference Material
    • (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ylpropionate
    • (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetr aenyl propanoate
    • 7069-42-3

  • Applications

    Retinyl propionate (CAS 7069-42-3) is an ester of retinol commonly used in cosmetics and personal care as a milder retinoid active, functioning as a prodrug that delivers retinol to the skin and supporting anti-aging and skin conditioning with typically lower irritation than retinol. In pharmaceutical research and development, it is considered an intermediate in the synthesis of retinoid compounds and is evaluated as a potential prodrug for topical delivery. In topical formulation science, it is valued for its improved stability relative to retinol, enabling more stable serums and moisturizers with retinoid activity. It can also serve as a reference material or standard for vitamin A esters in analytical methods and quality control in research settings.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 83.9
    methanol 64.68
    isopropanol 36.97
    water 0.02
    ethyl acetate 127.87
    n-propanol 79.19
    acetone 38.81
    n-butanol 95.5
    acetonitrile 15.93
    DMF 48.99
    toluene 144.77
    isobutanol 45.17
    1,4-dioxane 225.85
    methyl acetate 53.41
    THF 372.74
    2-butanone 97.0
    n-pentanol 90.15
    sec-butanol 69.41
    n-hexane 16.07
    ethylene glycol 0.82
    NMP 86.34
    cyclohexane 27.3
    DMSO 28.11
    n-butyl acetate 125.18
    n-octanol 30.44
    chloroform 402.06
    n-propyl acetate 95.4
    acetic acid 26.16
    dichloromethane 362.02
    cyclohexanone 174.35
    propylene glycol 4.04
    isopropyl acetate 97.21
    DMAc 141.79
    2-ethoxyethanol 93.76
    isopentanol 82.12
    n-heptane 9.47
    ethyl formate 31.02
    1,2-dichloroethane 162.76
    n-hexanol 88.52
    2-methoxyethanol 76.44
    isobutyl acetate 81.16
    tetrachloromethane 35.67
    n-pentyl acetate 90.54
    transcutol 510.07
    n-heptanol 43.56
    ethylbenzene 87.09
    MIBK 83.11
    2-propoxyethanol 136.21
    tert-butanol 48.64
    MTBE 145.47
    2-butoxyethanol 90.36
    propionic acid 21.04
    o-xylene 71.41
    formic acid 6.47
    diethyl ether 201.01
    m-xylene 90.84
    p-xylene 84.43
    chlorobenzene 120.82
    dimethyl carbonate 17.45
    n-octane 3.57
    formamide 10.57
    cyclopentanone 114.19
    2-pentanone 101.86
    anisole 156.49
    cyclopentyl methyl ether 163.25
    gamma-butyrolactone 87.99
    1-methoxy-2-propanol 72.96
    pyridine 171.92
    3-pentanone 83.95
    furfural 88.65
    n-dodecane 2.48
    diethylene glycol 30.71
    diisopropyl ether 44.13
    tert-amyl alcohol 76.45
    acetylacetone 80.73
    n-hexadecane 2.94
    acetophenone 116.38
    methyl propionate 67.44
    isopentyl acetate 139.97
    trichloroethylene 291.02
    n-nonanol 35.77
    cyclohexanol 70.11
    benzyl alcohol 73.66
    2-ethylhexanol 64.56
    isooctanol 42.2
    dipropyl ether 101.08
    1,2-dichlorobenzene 121.64
    ethyl lactate 26.72
    propylene carbonate 60.9
    n-methylformamide 18.26
    2-pentanol 55.29
    n-pentane 11.57
    1-propoxy-2-propanol 97.16
    1-methoxy-2-propyl acetate 148.28
    2-(2-methoxypropoxy) propanol 118.82
    mesitylene 49.46
    ε-caprolactone 163.87
    p-cymene 42.41
    epichlorohydrin 202.73
    1,1,1-trichloroethane 131.16
    2-aminoethanol 7.41
    morpholine-4-carbaldehyde 127.56
    sulfolane 86.95
    2,2,4-trimethylpentane 10.01
    2-methyltetrahydrofuran 260.84
    n-hexyl acetate 110.95
    isooctane 6.16
    2-(2-butoxyethoxy)ethanol 152.53
    sec-butyl acetate 103.25
    tert-butyl acetate 120.73
    decalin 17.67
    glycerin 6.46
    diglyme 285.32
    acrylic acid 11.66
    isopropyl myristate 44.4
    n-butyric acid 68.82
    acetyl acetate 61.46
    di(2-ethylhexyl) phthalate 49.86
    ethyl propionate 86.27
    nitromethane 34.42
    1,2-diethoxyethane 218.64
    benzonitrile 63.3
    trioctyl phosphate 26.33
    1-bromopropane 157.64
    gamma-valerolactone 189.82
    n-decanol 24.2
    triethyl phosphate 52.52
    4-methyl-2-pentanol 37.9
    propionitrile 33.6
    vinylene carbonate 53.47
    1,1,2-trichlorotrifluoroethane 72.08
    DMS 53.65
    cumene 54.42
    2-octanol 26.41
    2-hexanone 109.43
    octyl acetate 53.31
    limonene 60.64
    1,2-dimethoxyethane 206.24
    ethyl orthosilicate 65.31
    tributyl phosphate 32.85
    diacetone alcohol 80.85
    N,N-dimethylaniline 111.95
    acrylonitrile 26.28
    aniline 79.15
    1,3-propanediol 23.82
    bromobenzene 143.84
    dibromomethane 228.63
    1,1,2,2-tetrachloroethane 247.84
    2-methyl-cyclohexyl acetate 125.15
    tetrabutyl urea 49.41
    diisobutyl methanol 33.81
    2-phenylethanol 98.66
    styrene 94.44
    dioctyl adipate 77.82
    dimethyl sulfate 22.05
    ethyl butyrate 115.49
    methyl lactate 15.67
    butyl lactate 50.55
    diethyl carbonate 61.35
    propanediol butyl ether 44.15
    triethyl orthoformate 97.84
    p-tert-butyltoluene 40.76
    methyl 4-tert-butylbenzoate 107.37
    morpholine 280.48
    tert-butylamine 37.28
    n-dodecanol 16.95
    dimethoxymethane 90.43
    ethylene carbonate 45.02
    cyrene 91.25
    2-ethoxyethyl acetate 139.99
    2-ethylhexyl acetate 130.77
    1,2,4-trichlorobenzene 136.33
    4-methylpyridine 174.99
    dibutyl ether 69.8
    2,6-dimethyl-4-heptanol 33.81
    DEF 122.04
    dimethyl isosorbide 224.52
    tetrachloroethylene 136.38
    eugenol 98.6
    triacetin 100.84
    span 80 94.42
    1,4-butanediol 9.97
    1,1-dichloroethane 124.6
    2-methyl-1-pentanol 104.93
    methyl formate 10.54
    2-methyl-1-butanol 84.9
    n-decane 5.51
    butyronitrile 59.33
    3,7-dimethyl-1-octanol 42.83
    1-chlorooctane 30.12
    1-chlorotetradecane 10.22
    n-nonane 4.71
    undecane 3.48
    tert-butylcyclohexane 15.87
    cyclooctane 8.32
    cyclopentanol 37.13
    tetrahydropyran 313.14
    tert-amyl methyl ether 128.85
    2,5,8-trioxanonane 192.23
    1-hexene 68.8
    2-isopropoxyethanol 81.45
    2,2,2-trifluoroethanol 5.62
    methyl butyrate 104.62

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction