Retinol Palmitate

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  • Identifiers

    CAS number
    79-81-2

    Molecular formula
    C36H60O2

    SMILES
    CCCCCCCCCCCCCCCC(=O)OC/C=C(\C)/C=C/C=C(\C)/C=C/C1=C(CCCC1(C)C)C

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Floral 56.48%
    Woody 51.6%
    Waxy 49.95%
    Balsamic 44.6%
    Oily 43.34%
    Sweet 40.4%
    Green 37.23%
    Fruity 36.76%
    Rose 32.58%
    Fatty 30.17%

     

    Flavor
    Herbal 35.1%
    Balsam 31.31%
    Woody 29.25%
    Wood 23.15%
    Balsamic 23.13%
    Floral 23.05%
    Waxy 22.72%
    Diterpene 21.69%
    Low 21.67%
    Oriental 21.07%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    13.6

    pKa est.
    -43.59 (strong acid)

    Molecular weight
    524.9 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    551°C

    Melting point expt.

    • 28.5 °C

    Flash point

    • -24.85 ˚C est.

  • Synonyms

    • retinyl palmitate
    • VITAMIN A PALMITATE
    • 79-81-2
    • Retinol palmitate
    • Retinol, hexadecanoate
    • all-trans-Retinyl palmitate
    • Arovit
    • Optovit-A
    • Retinyl hexadecanoate
    • Vitamin A Solubilized
    • DTXSID1021241
    • [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] hexadecanoate
    • 1D1K0N0VVC
    • NSC-758478
    • Retinol, palmitate, all-trans
    • All-(e)-retinol palmitate
    • DTXCID101241
    • CHEBI:17616
    • Vitamin a palmitate (solubilized)
    • Retinol Hexadecanoate
    • ((2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl) hexadecanoate
    • (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl palmitate
    • palmitate-1-14c
    • Retinol-15-3H
    • RefChem:56213
    • Retinyl-10,11-14C2
    • CHEBI:15040
    • 201-228-5
    • Afaxin
    • Del-Vi-A
    • Vi-Dom-A
    • Aquapalm
    • Dispatabs Tabs
    • Vitazyme A
    • Optovit A
    • Axerophthol palmitate
    • trans-Retinol palmitate
    • trans-Retinyl palmitate
    • Lutavit A 500 Plus
    • all-trans-Retinol palmitate
    • Arovit (Roche)
    • MFCD00019414
    • all-trans-Vitamin A palmitate
    • Aquasol A (TN)
    • Retinol palmitate [JAN]
    • C36H60O2
    • Retinol palmitate (6CI,7CI)
    • Palmitic acid, ester with retinol
    • Retinyl (Vitamin A) Palmitate
    • Retinol, palmitate, all-trans- (8CI)
    • NCGC00095056-03
    • (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl hexadecanoate
    • (2E,4E,6E,8E)-Hexadecanoic acid 3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2, 4,6,8,tetraenyl ester
    • Retinyl (palmitate)
    • CAS-79-81-2
    • SMR000112463
    • CCRIS 3280
    • Retinol, palmitate, all-trans-
    • EINECS 201-228-5
    • UNII-1D1K0N0VVC
    • BRN 1917366
    • retinylpalmitate
    • retinol-palmitate
    • retinyl-palmitate
    • all-trans-RetinylPalmitate-d5(Major)
    • Retinol, all-trans-, palmitate
    • Vitamin A palmitate;Retinol palmitate
    • Retinyl palmitic acid
    • Retinol Palmitate RS
    • Vitamin- A palmitate
    • Retinyl hexadecanoic acid
    • Spectrum5_001201
    • bmse000501
    • EC 201-228-5
    • Retinol palmitate (JP18)
    • CHEMBL1675
    • SCHEMBL41649
    • MLS001332437
    • MLS001332438
    • SPECTRUM1503604
    • all-trans-retinyl hexadecanoate
    • orb1309911
    • orb3025125
    • Retinol, O-(1-oxohexadecyl)-
    • HMS500M11
    • MSK1568
    • RETINYL PALMITATE [VANDF]
    • VITAMIN A PALMITATE [MI]
    • HMS1922E10
    • HMS2093G13
    • HMS2268C06
    • HMS5087A18
    • Pharmakon1600-01503604
    • RETINOL PALMITATE [WHO-DD]
    • RETINYL PALMITATE [USP-RS]
    • HY-B1384
    • VAE 16:0
    • VITAMIN A PALMITATE [VANDF]
    • Tox21_113452
    • Tox21_303008
    • CCG-39342
    • EBC-74036
    • LMPR01090013
    • NSC758478
    • s4126
    • retinol, O~15~-(1-oxohexadecyl)-
    • AKOS015918435
    • FV29799
    • NSC 758478
    • Vitamin A palmitate, 1.7 M.I.U./g
    • Vitamin A Palmitate; Retinol Palmitate
    • IDI1_000249
    • NCGC00095056-01
    • NCGC00095056-02
    • NCGC00256427-01
    • AC-20001
    • MS-29721
    • VITAMIN A PALMITATE [ORANGE BOOK]
    • SBI-0051830.P002
    • ALL-(E)-RETINOL PALMITATE [WHO-IP]
    • CS-0013116
    • NS00005806
    • C02588
    • C76552
    • D00164
    • AB00052360_04
    • VITAMINAPALMITATE,LIQUIDINOIL,1MILLIONIU/G
    • 79-81-2

  • Applications

    Retinol Palmitate (CAS 79-81-2) is used primarily as a vitamin A ester in cosmetics and personal care, where it acts as a skin-conditioning agent and contributes to anti-aging formulations. It is also used in food processing as a source of vitamin A for dietary supplementation and to increase the vitamin A content of various fortified products. In animal nutrition, it serves as a vitamin A additive for feed formulations. These applications illustrate its role as a relatively stable vitamin A source across cosmetic, nutrition, and agricultural sectors.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 10.21
    methanol 9.36
    isopropanol 5.21
    water 0.02
    ethyl acetate 73.58
    n-propanol 17.05
    acetone 26.11
    n-butanol 19.89
    acetonitrile 5.71
    DMF 36.28
    toluene 64.18
    isobutanol 12.94
    1,4-dioxane 70.11
    methyl acetate 31.77
    THF 197.1
    2-butanone 64.59
    n-pentanol 23.16
    sec-butanol 16.62
    n-hexane 16.63
    ethylene glycol 0.21
    NMP 163.99
    cyclohexane 25.98
    DMSO 24.51
    n-butyl acetate 75.67
    n-octanol 19.05
    chloroform 257.88
    n-propyl acetate 75.89
    acetic acid 15.13
    dichloromethane 266.58
    cyclohexanone 183.38
    propylene glycol 0.86
    isopropyl acetate 62.41
    DMAc 142.64
    2-ethoxyethanol 30.31
    isopentanol 22.25
    n-heptane 10.64
    ethyl formate 22.1
    1,2-dichloroethane 134.02
    n-hexanol 20.5
    2-methoxyethanol 18.86
    isobutyl acetate 60.61
    tetrachloromethane 44.48
    n-pentyl acetate 116.03
    transcutol 181.65
    n-heptanol 24.22
    ethylbenzene 49.82
    MIBK 59.96
    2-propoxyethanol 40.92
    tert-butanol 9.01
    MTBE 49.45
    2-butoxyethanol 58.24
    propionic acid 15.11
    o-xylene 45.14
    formic acid 3.02
    diethyl ether 60.6
    m-xylene 44.1
    p-xylene 55.22
    chlorobenzene 89.39
    dimethyl carbonate 16.48
    n-octane 4.42
    formamide 5.07
    cyclopentanone 143.5
    2-pentanone 71.09
    anisole 82.6
    cyclopentyl methyl ether 125.99
    gamma-butyrolactone 125.68
    1-methoxy-2-propanol 22.78
    pyridine 99.48
    3-pentanone 76.66
    furfural 79.23
    n-dodecane 2.07
    diethylene glycol 7.16
    diisopropyl ether 23.28
    tert-amyl alcohol 26.26
    acetylacetone 70.02
    n-hexadecane 2.53
    acetophenone 88.73
    methyl propionate 53.01
    isopentyl acetate 85.5
    trichloroethylene 247.7
    n-nonanol 23.77
    cyclohexanol 34.15
    benzyl alcohol 32.23
    2-ethylhexanol 29.77
    isooctanol 27.85
    dipropyl ether 67.53
    1,2-dichlorobenzene 105.94
    ethyl lactate 20.24
    propylene carbonate 71.45
    n-methylformamide 11.78
    2-pentanol 14.63
    n-pentane 8.66
    1-propoxy-2-propanol 43.98
    1-methoxy-2-propyl acetate 80.93
    2-(2-methoxypropoxy) propanol 61.88
    mesitylene 28.17
    ε-caprolactone 196.29
    p-cymene 29.73
    epichlorohydrin 176.34
    1,1,1-trichloroethane 131.5
    2-aminoethanol 1.76
    morpholine-4-carbaldehyde 93.13
    sulfolane 160.26
    2,2,4-trimethylpentane 10.17
    2-methyltetrahydrofuran 169.04
    n-hexyl acetate 101.95
    isooctane 4.17
    2-(2-butoxyethoxy)ethanol 72.55
    sec-butyl acetate 80.19
    tert-butyl acetate 86.78
    decalin 17.18
    glycerin 1.66
    diglyme 177.31
    acrylic acid 9.36
    isopropyl myristate 34.82
    n-butyric acid 46.37
    acetyl acetate 40.05
    di(2-ethylhexyl) phthalate 33.21
    ethyl propionate 78.82
    nitromethane 27.64
    1,2-diethoxyethane 107.06
    benzonitrile 29.55
    trioctyl phosphate 20.47
    1-bromopropane 106.86
    gamma-valerolactone 191.36
    n-decanol 14.24
    triethyl phosphate 48.84
    4-methyl-2-pentanol 13.85
    propionitrile 13.64
    vinylene carbonate 58.03
    1,1,2-trichlorotrifluoroethane 68.51
    DMS 39.55
    cumene 35.26
    2-octanol 17.86
    2-hexanone 84.82
    octyl acetate 42.95
    limonene 47.22
    1,2-dimethoxyethane 90.07
    ethyl orthosilicate 60.37
    tributyl phosphate 26.06
    diacetone alcohol 51.05
    N,N-dimethylaniline 65.9
    acrylonitrile 11.64
    aniline 37.03
    1,3-propanediol 5.17
    bromobenzene 117.26
    dibromomethane 160.8
    1,1,2,2-tetrachloroethane 224.94
    2-methyl-cyclohexyl acetate 98.17
    tetrabutyl urea 41.67
    diisobutyl methanol 20.24
    2-phenylethanol 36.4
    styrene 51.5
    dioctyl adipate 62.59
    dimethyl sulfate 33.69
    ethyl butyrate 92.53
    methyl lactate 12.1
    butyl lactate 50.9
    diethyl carbonate 47.09
    propanediol butyl ether 22.55
    triethyl orthoformate 85.31
    p-tert-butyltoluene 27.54
    methyl 4-tert-butylbenzoate 99.59
    morpholine 90.5
    tert-butylamine 8.44
    n-dodecanol 9.32
    dimethoxymethane 46.99
    ethylene carbonate 52.98
    cyrene 67.49
    2-ethoxyethyl acetate 129.15
    2-ethylhexyl acetate 86.86
    1,2,4-trichlorobenzene 124.1
    4-methylpyridine 98.12
    dibutyl ether 57.84
    2,6-dimethyl-4-heptanol 20.24
    DEF 95.35
    dimethyl isosorbide 154.83
    tetrachloroethylene 132.77
    eugenol 63.52
    triacetin 93.27
    span 80 57.14
    1,4-butanediol 2.5
    1,1-dichloroethane 92.45
    2-methyl-1-pentanol 37.06
    methyl formate 9.37
    2-methyl-1-butanol 26.79
    n-decane 5.73
    butyronitrile 19.22
    3,7-dimethyl-1-octanol 24.6
    1-chlorooctane 28.46
    1-chlorotetradecane 7.87
    n-nonane 5.04
    undecane 3.15
    tert-butylcyclohexane 14.06
    cyclooctane 9.58
    cyclopentanol 23.39
    tetrahydropyran 150.61
    tert-amyl methyl ether 70.92
    2,5,8-trioxanonane 97.36
    1-hexene 42.65
    2-isopropoxyethanol 31.16
    2,2,2-trifluoroethanol 5.6
    methyl butyrate 99.87

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction