Retinol, acetate

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  • Identifiers

    CAS number
    127-47-9

    Molecular formula
    C22H32O2

    SMILES
    CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/COC(=O)C)/C)/C

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Woody 70.52%
    Floral 69.01%
    Sweet 68.0%
    Fruity 58.36%
    Berry 48.67%
    Balsamic 48.48%
    Tropical 48.1%
    Powdery 44.93%
    Violet 40.75%
    Waxy 34.93%

     

    Flavor
    Balsam 31.67%
    Sweet 28.15%
    Woody 26.84%
    Balsamic 25.37%
    Floral 24.85%
    Spicy 23.68%
    Oriental 22.8%
    Wood 22.44%
    Bergamot 20.55%
    Diterpene 20.41%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    6.3

    pKa est.
    7.47 (neutral)

    Molecular weight
    328.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    377°C

    Flash point

    • 183.01 ˚C est.

  • Synonyms

    • RETINYL ACETATE
    • Vitamin A acetate
    • 127-47-9
    • Retinol acetate
    • Retinol, acetate
    • Vitamin A1 acetate
    • all-trans-Retinol acetate
    • Crystalets
    • Vitamin A alcohol acetate
    • Davitan A 650
    • all-trans-Vitamin A acetate
    • Retinol, acetate, all-trans-
    • (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl acetate
    • all-trans-Retinylacetate
    • Acetic acid, retinyl ester
    • [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] acetate
    • 3LE3D9D6OY
    • Vitamin A, acetate
    • Vitamin A acetate (tritiated)
    • DTXSID6021240
    • O(15)-acetylretinol
    • ORISTAR RA
    • NSC-122045
    • NSC-122760
    • RO-1-5275
    • DTXCID701240
    • CHEBI:32095
    • NSC122045
    • NSC122760
    • VITAMIN A ACETATE 1.5 M.I.U./G
    • ((2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl) acetate
    • PureVita Vitamin A
    • RefChem:879482
    • (2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl acetate
    • 204-844-2
    • Myvak
    • Myvax
    • all-trans-Retinyl acetate
    • Vitamin A ester
    • O~15~-acetylretinol
    • MFCD00019413
    • NSC 122045
    • trans-Retinyl acetate
    • RO 1-5275
    • Retinol acetate [JAN]
    • trans-Vitamin A acetate
    • Myvak (VAN)
    • Myvax (VAN)
    • Vitamin A acetate (VAN)
    • NCGC00090756-09
    • Retinol Acetate/All-trans-retinyl Acetate
    • VitaminAacetate
    • 64536-04-5
    • Retinol, acetate, labeled with tritium
    • 9-cis Retinol Acetate
    • Retinyl acetate, all-trans-
    • CAS-127-47-9
    • CCRIS 1907
    • trans-Retinol Acetate
    • SR-05000001431
    • EINECS 204-844-2
    • UNII-3LE3D9D6OY
    • BRN 1915439
    • Retinol acetate;Vitamin A acetate
    • retinyl-acetate
    • WLN: L6UTJ A1 B1U1Y1 & U2U1Y1 & U2OV1 C1 C1
    • 9-cis,13-cis-Retinol15-Acetate
    • Retinol Acetate RS
    • Retinol acetate CRS
    • 9-cis-Retinol acetate;9-cis-Vitamin A acetate
    • Spectrum5_001195
    • Spectrum5_002001
    • Retinol acetate (JP17)
    • EC 204-844-2
    • retinol, O~15~-acetyl-
    • Retinyl acetate (Standard)
    • SCHEMBL21589
    • BSPBio_002833
    • SPECTRUM1503051
    • C22H32O2 (retinol acetate)
    • CHEMBL486193
    • orb1310387
    • orb3025126
    • VITAMIN A ACETATE [MI]
    • CHEBI:94695
    • HMS501K04
    • HY-N0679R
    • MSK1503
    • RETINOL ACETATE [WHO-DD]
    • RETINYL ACETATE [USP-RS]
    • VITAMIN A ACETATE [VANDF]
    • HMS1922A19
    • HMS2089G20
    • HMS5082G10
    • Pharmakon1600-01503051
    • HY-N0679
    • Retinyl acetate, analytical standard
    • Tox21_113549
    • Tox21_201423
    • Tox21_302737
    • BDBM50442911
    • CCG-39564
    • EBC-07773
    • EBC-58029
    • LMPR01090012
    • NSC758220
    • s4083
    • AKOS015914999
    • Tox21_113549_1
    • CS-8187
    • FV28713
    • NSC-758220
    • 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl acetate
    • IDI1_000522
    • NCGC00090756-01
    • NCGC00090756-02
    • NCGC00090756-03
    • NCGC00090756-05
    • NCGC00090756-06
    • NCGC00090756-07
    • NCGC00090756-08
    • NCGC00090756-10
    • NCGC00090756-11
    • NCGC00090756-12
    • NCGC00256509-01
    • NCGC00258974-01
    • VITAMIN A (AS ACETATE) [VANDF]
    • Retinyl Acetate

  • Applications

    Retinyl acetate is primarily used as a vitamin A ester in consumer and industrial formulations. In cosmetics and personal care, it provides a stable vitamin A source for creams, serums, and anti-aging formulations. In food processing and fortification, it is employed as a vitamin A fortificant in fortified foods and dietary supplements. In pharmaceuticals, it functions as an intermediate in the synthesis of retinoid compounds and is used in certain vitamin A related drug products. In agriculture and animal nutrition, retinyl acetate is added to animal feeds as a vitamin A supplement to support growth and physiological functions.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 80.09
    methanol 70.78
    isopropanol 30.9
    water 0.02
    ethyl acetate 89.64
    n-propanol 69.05
    acetone 36.45
    n-butanol 73.58
    acetonitrile 16.03
    DMF 54.58
    toluene 90.9
    isobutanol 36.75
    1,4-dioxane 225.94
    methyl acetate 43.69
    THF 358.1
    2-butanone 73.67
    n-pentanol 68.61
    sec-butanol 51.56
    n-hexane 8.34
    ethylene glycol 1.26
    NMP 77.47
    cyclohexane 14.6
    DMSO 30.43
    n-butyl acetate 83.58
    n-octanol 25.5
    chloroform 296.58
    n-propyl acetate 66.38
    acetic acid 22.12
    dichloromethane 238.35
    cyclohexanone 122.12
    propylene glycol 6.24
    isopropyl acetate 64.37
    DMAc 129.41
    2-ethoxyethanol 94.03
    isopentanol 55.43
    n-heptane 5.5
    ethyl formate 26.74
    1,2-dichloroethane 104.85
    n-hexanol 68.8
    2-methoxyethanol 88.52
    isobutyl acetate 56.89
    tetrachloromethane 20.57
    n-pentyl acetate 55.77
    transcutol 486.48
    n-heptanol 32.29
    ethylbenzene 51.22
    MIBK 56.0
    2-propoxyethanol 136.65
    tert-butanol 41.04
    MTBE 91.57
    2-butoxyethanol 76.71
    propionic acid 17.93
    o-xylene 41.94
    formic acid 7.36
    diethyl ether 131.29
    m-xylene 56.78
    p-xylene 52.91
    chlorobenzene 81.78
    dimethyl carbonate 16.21
    n-octane 2.18
    formamide 11.96
    cyclopentanone 97.92
    2-pentanone 70.39
    anisole 125.21
    cyclopentyl methyl ether 125.2
    gamma-butyrolactone 73.84
    1-methoxy-2-propanol 79.75
    pyridine 137.46
    3-pentanone 59.02
    furfural 80.19
    n-dodecane 1.73
    diethylene glycol 38.17
    diisopropyl ether 28.19
    tert-amyl alcohol 52.76
    acetylacetone 63.18
    n-hexadecane 2.06
    acetophenone 88.99
    methyl propionate 55.82
    isopentyl acetate 91.42
    trichloroethylene 198.61
    n-nonanol 29.21
    cyclohexanol 47.64
    benzyl alcohol 61.45
    2-ethylhexanol 46.73
    isooctanol 28.99
    dipropyl ether 74.94
    1,2-dichlorobenzene 77.25
    ethyl lactate 24.39
    propylene carbonate 48.16
    n-methylformamide 19.48
    2-pentanol 37.99
    n-pentane 6.16
    1-propoxy-2-propanol 93.44
    1-methoxy-2-propyl acetate 120.91
    2-(2-methoxypropoxy) propanol 110.45
    mesitylene 30.88
    ε-caprolactone 117.32
    p-cymene 27.33
    epichlorohydrin 170.69
    1,1,1-trichloroethane 80.07
    2-aminoethanol 10.26
    morpholine-4-carbaldehyde 130.43
    sulfolane 74.84
    2,2,4-trimethylpentane 4.98
    2-methyltetrahydrofuran 202.85
    n-hexyl acetate 76.06
    isooctane 3.35
    2-(2-butoxyethoxy)ethanol 141.36
    sec-butyl acetate 67.55
    tert-butyl acetate 82.46
    decalin 10.04
    glycerin 8.9
    diglyme 248.46
    acrylic acid 10.12
    isopropyl myristate 32.47
    n-butyric acid 51.94
    acetyl acetate 42.59
    di(2-ethylhexyl) phthalate 38.63
    ethyl propionate 61.68
    nitromethane 31.69
    1,2-diethoxyethane 168.85
    benzonitrile 48.2
    trioctyl phosphate 19.78
    1-bromopropane 92.19
    gamma-valerolactone 165.75
    n-decanol 20.18
    triethyl phosphate 39.21
    4-methyl-2-pentanol 25.57
    propionitrile 29.04
    vinylene carbonate 43.72
    1,1,2-trichlorotrifluoroethane 66.71
    DMS 45.19
    cumene 35.5
    2-octanol 19.28
    2-hexanone 76.94
    octyl acetate 40.52
    limonene 37.88
    1,2-dimethoxyethane 195.83
    ethyl orthosilicate 46.37
    tributyl phosphate 25.44
    diacetone alcohol 64.96
    N,N-dimethylaniline 85.23
    acrylonitrile 23.58
    aniline 62.19
    1,3-propanediol 27.7
    bromobenzene 88.96
    dibromomethane 145.57
    1,1,2,2-tetrachloroethane 177.94
    2-methyl-cyclohexyl acetate 90.17
    tetrabutyl urea 38.2
    diisobutyl methanol 23.23
    2-phenylethanol 82.47
    styrene 56.73
    dioctyl adipate 58.11
    dimethyl sulfate 20.51
    ethyl butyrate 76.1
    methyl lactate 16.66
    butyl lactate 39.75
    diethyl carbonate 44.23
    propanediol butyl ether 45.13
    triethyl orthoformate 71.79
    p-tert-butyltoluene 26.47
    methyl 4-tert-butylbenzoate 79.49
    morpholine 275.27
    tert-butylamine 27.83
    n-dodecanol 14.19
    dimethoxymethane 97.7
    ethylene carbonate 37.46
    cyrene 79.91
    2-ethoxyethyl acetate 96.52
    2-ethylhexyl acetate 82.47
    1,2,4-trichlorobenzene 92.19
    4-methylpyridine 133.93
    dibutyl ether 51.49
    2,6-dimethyl-4-heptanol 23.23
    DEF 87.48
    dimethyl isosorbide 198.41
    tetrachloroethylene 93.34
    eugenol 79.82
    triacetin 78.97
    span 80 85.45
    1,4-butanediol 10.63
    1,1-dichloroethane 80.07
    2-methyl-1-pentanol 70.07
    methyl formate 11.79
    2-methyl-1-butanol 58.12
    n-decane 3.78
    butyronitrile 45.59
    3,7-dimethyl-1-octanol 33.49
    1-chlorooctane 20.39
    1-chlorotetradecane 7.16
    n-nonane 3.14
    undecane 2.43
    tert-butylcyclohexane 9.18
    cyclooctane 4.45
    cyclopentanol 31.05
    tetrahydropyran 254.83
    tert-amyl methyl ether 77.91
    2,5,8-trioxanonane 178.64
    1-hexene 39.16
    2-isopropoxyethanol 72.56
    2,2,2-trifluoroethanol 4.79
    methyl butyrate 73.54

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction