Retinol

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  • Identifiers

    CAS number
    68-26-8

    Molecular formula
    C20H30O

    SMILES
    CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/CO)/C)/C

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Properties

    XLogP3-AA
    5.7

    Molecular weight
    286.5 g/mol

    Melting point expt.

    • 144 to 147 °F (NTP, 1992)
    • 63.5 °C
    • 62-64 °C
    • Pale yellow prismatic crystals from methanol; mp: 57-58 °C; UV max (ethanol): 326 nm (E=1,550, 1%, 1 cm) /Retinol acetate/
    • Amorphous or crystalline; mp: 28-29 °C; UV max (ethanol); 325-328 nm (E=975, 1%, 1 cm) /Retinol palmitate/
    • 61 - 63 °C

    Boiling point

    • 279 to 280 °F at 1e-06 mmHg (NTP, 1992)
    • 137-138 °C at 1X10-6 mm Hg

    Solubility expt.

    • Practically insoluble (NTP, 1992)
    • 0.671 mg/L
    • Practically insoluble in water or glycerol; soluble in absolute alcohol, methanol, chloroform, ether, fats and oils
    • Sol in ethanol and acetone and benzene

  • Synonyms

    • retinol
    • all-trans-Retinol
    • 68-26-8
    • trans-retinol
    • Veroftal
    • Agoncal
    • Bentavit A
    • Homagenets Aoral
    • Sehkraft A
    • Testavol S
    • all-trans-Vitamin A
    • All-trans retinol
    • Super A
    • Axerophtholum
    • Wachstumsvitamin
    • Vitaminum A
    • Vitamine A
    • Retinolo
    • Retinolum
    • Retinol, all trans-
    • (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol
    • Ro-a-vit
    • Antixerophthalmisches Vitamin
    • (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol
    • (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
    • G2SH0XKK91
    • NSC-122759
    • DTXSID3023556
    • DTXCID203556
    • CHEBI:17336
    • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol, (all-E)-
    • (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraen-1-ol
    • All Trans Retinol
    • CHEBI:50211
    • Nepalm
    • RerinolCream
    • Recovery Cream
    • Surfree Firming
    • Firming Cream
    • Highy-Stable
    • Neck Firming
    • Pure Retinol
    • Anti-aging cream
    • Bean Moisturizing
    • Vitamin A 1
    • CVC Retinol collagen
    • Ultra Brightening Fade
    • RefChem:6198
    • Anti Wrinkle Eye Cream
    • RETINOL VITAMIN E
    • retinolum densatum oleosum
    • Moisturizing Anti-Aging Cream
    • LANIMPRESS Anti-aging cream
    • A11CA01
    • D10AD02
    • R01AX02
    • S01XA02
    • LANIMPRESS Dark Anti-aging cream
    • 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-nona-2,4,6,8-tetraen-1-ol
    • Retinol cream for face moisturizer face cream
    • 3,7-Dimethyl-9-(2,6, 6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
    • 200-683-7
    • Vitamin A
    • Vitamin A1
    • Alphalin
    • Chocola A
    • Apostavit
    • Axerophthol
    • Epiteliol
    • Prepalin
    • Testavol
    • Agiolan
    • Apexol
    • Avibon
    • Avitol
    • Axerol
    • Vaflol
    • Vitpex
    • Aoral
    • Vogan
    • Vitamin A alcohol
    • Anatola A
    • A-Mulsal
    • Alphasterol
    • Aquasynth
    • Biosterol
    • Ophthalamin
    • Vi-Alpha
    • 11103-57-4
    • Anatola
    • Myvpack
    • Dofsol
    • Disatabs Tabs
    • Oleovitamin A
    • Lard Factor
    • all-trans-Retinyl alcohol
    • Dohyfral A
    • Vitamin A1 alcohol
    • A-Sol
    • Alcovit A
    • Vogan-Neu
    • Plivit A
    • A-Vitan
    • ATAV
    • Atars
    • Vafol
    • all-trans-Vitamin A alcohol
    • Retrovitamin A
    • Hi-A-Vita
    • Nio-A-Let
    • A-Vi-Pel
    • ACON
    • Anti-infective vitamin
    • Solu-A
    • Vio-A
    • Antixerophthalmic vitamin
    • Vitavel A
    • Thalasphere
    • beta-Retinol
    • all-trans-Vitamin A1
    • trans-Vitamin A alcohol
    • Vitamin A alcohol, all-trans-
    • Vitamin A1, all-trans-
    • MFCD00001552
    • .beta.-Retinol
    • Vitamin A1 alcohol, all-trans-
    • C20H30O
    • 11103-57-4

  • Applications

    Retinol (CAS 68-26-8) is primarily applied in cosmetics and personal care as an active ingredient for skin conditioning and moisturizing, and it also serves as a vitamin A source in dietary supplements and fortified foods. In agriculture and animal nutrition, retinol is used as a feed additive to provide vitamin A to livestock. In pharmaceuticals, retinol acts as a starting material for the synthesis of retinoid derivatives used in dermatology and related therapies. In the food processing industry, retinol or retinyl esters are employed to fortify products with vitamin A.

    gpt-5-nano

1 3

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction