Resveratrol

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  • Identifiers

    CAS number
    501-36-0

    Molecular formula
    C14H12O3

    SMILES
    C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 65.72%
    Spicy 41.59%
    Fruity 36.18%
    Medicinal 35.81%
    Woody 31.66%
    Odorless 29.63%
    Burnt 29.45%
    Balsamic 28.74%
    Smoky 28.63%
    Animal 26.99%

     

    Flavor
    Bitter 79.07%
    Phenolic 23.73%
    Nitrile 22.53%
    Very strong 21.93%
    Almond shell 21.47%
    Indole 21.37%
    Flat 21.0%
    Curry 20.82%
    Naphthelene 20.29%
    Moth ball 20.26%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.1

    pKa est.
    11.84 (strong base)

    Molecular weight
    228.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    492°C

    Melting point expt.

    • 254 °C
    • 253-255 °C
    • MP: 261 °C (decomposes)

    Flash point

    • 226.07 ˚C est.

    Solubility expt.

    • In water, 3 mg/100 mL
    • Soluble in organic solvents such as ethanol, DMSO and dimethyl formamide at approximately 65 mg/mL; solubility in PBS (phosphate buffered saline) at pH 7.2 is approximately 100 ug/mL

  • Synonyms

    • resveratrol
    • 501-36-0
    • trans-resveratrol
    • 3,4',5-Trihydroxystilbene
    • (E)-resveratrol
    • Resvida
    • 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
    • 3,4',5-Stilbenetriol
    • 3,4',5-Trihydroxy-trans-stilbene
    • 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol
    • Biofort
    • Cuspidatin
    • Jotrol
    • SRT-501
    • (E)-5-(p-Hydroxystyryl)resorcinol
    • Resveratrol p 5
    • SRT501
    • Melinjo resveratrol 20
    • Srt 501m
    • 5-[(E)-2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol
    • NSC-327430
    • DTXSID4031980
    • CHEBI:45713
    • Ca 1201
    • BIA 6-512
    • BIA-6-512
    • NSC327430
    • Q369O8926L
    • 5-((1E)-2-(4-Hydroxyphenyl)ethenyl)-1,3-benzenediol
    • DTXCID2011980
    • CHEBI:27881
    • 5-[(1E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
    • 5-((E)-2-(4-HYDROXYPHENYL)-ETHENYL) BENZENE-1,3 DIOL
    • 5-((E)-2-(4-hydroxyphenyl)ethenyl)benzene-1,3-diol
    • 5-((E)-2-(4-hydroxyphenyl)vinyl)benzene-1,3-diol
    • 5-((1E)-2-(4-hydroxyphenyl)ethenyl)benzene-1,3-diol
    • 1,3-Benzenediol, 5-((E)-2-(4-hydroxyphenyl)ethenyl)-
    • 1,3-Benzenediol, 5-[(E)-2-(4-hydroxyphenyl)ethenyl]-
    • Resveratrol(e)-
    • (E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol
    • Resveratrol 3 sulfate
    • RefChem:6197
    • trans Resveratrol 3 O sulfate
    • Resveratrol NMN Collagen Serum
    • 610-504-8
    • cis Resveratrol
    • trans Resveratrol
    • (E)-5-(4-Hydroxystyryl)benzene-1,3-diol
    • 3,5,4'-Trihydroxystilbene
    • Resveratol
    • MFCD00133799
    • 3,5,4'-Trihydroxy-trans-stilbene
    • 1,3-Benzenediol, 5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-
    • Resveratrol(e)-form
    • Resveratrol (Standard)
    • trans-1,2-(3,4',5-Trihydroxydiphenyl)ethylene
    • CHEMBL165
    • (E)-5-[2-(4-hydroxyphenyl)ethenyl]-1,3-benzendiol
    • MLS000069735
    • 1,3-Benzenediol, 5-(2-(4-hydroxyphenyl)ethenyl)-, (E)-
    • trans-3,4',5 - trihydroxystilbene
    • s1396
    • trans-3,4',5-trihydroxystilbene
    • SMR000058206
    • 5-[2-(4-hydroxyphenyl)vinyl]-1,3-benzenediol
    • trans-3,4,5-trihydroxystilbene
    • 3,4',5-trihydroxy-stilbene
    • SRT 501
    • SR-01000000163
    • 5-[(1E)-2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol
    • NSC 327430
    • t-resveratrol
    • E-resveratrol
    • CCRIS 8952
    • Resveratrol CRS
    • UNII-Q369O8926L
    • HSDB 7571
    • 3fts
    • 4jaz
    • 4qer
    • Resveratrol, E-
    • KUC104385N
    • Stilbene, 2f
    • NCGC00015894-02
    • CAS-501-36-0
    • STL
    • Prestwick_619
    • Resveratrol (GMP)
    • Resveratrol, trans-
    • KSC-10-164
    • RM-1812
    • Opera_ID_586
    • RESVERATROL [MI]
    • Prestwick2_000508
    • Prestwick3_000508
    • Spectrum5_000552
    • RESVERATROL [HSDB]
    • RESVERATROL [USAN]
    • 3,4',5-Stilbenetriol;
    • R 5010
    • RESVERATROL [VANDF]
    • 1,3-Benzenediol, 5-[(1Z)-2-(4-hydroxyphenyl)ethenyl]-
    • RESVERATROL [MART.]
    • RSV-0
    • Lopac0_001111
    • REGID_for_CID_6240
    • SCHEMBL19425
    • BSPBio_000435
    • BSPBio_001114
    • BSPBio_003461
    • RESVERATROL [WHO-DD]
    • MLS001055357
    • MLS001076538
    • MLS001424228
    • MLS002207121
    • MLS002222231
    • SPECTRUM1502223
    • CU-01000001503-3
    • 5-[(E)-2-(4-Hydroxyphenyl)vinyl]-1,3-benzenediol
    • BPBio1_000479
    • cid_445154
    • GTPL8741
    • orb1308192
    • SCHEMBL3684840
    • SGCUT00007
    • Resveratrol, analytical standard
    • 3,4',5-trihydrohydroxystilbene
    • resveratrol

  • Applications

    Resveratrol (CAS 501-36-0) is used as an antioxidant additive in cosmetics and personal care formulations, helping stabilize actives and extend shelf life; it is evaluated as a functional ingredient in foods and as a dietary supplement; in pharmaceutical research it is studied as a bioactive polyphenol with potential applications in drug development and formulation, though it is not an approved medicine; it is explored as an antioxidant stabilizer or additive in polymers and coatings to improve oxidation resistance; and it is sometimes considered for use in nutraceuticals and functional foods.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 76.92
    methanol 104.04
    isopropanol 33.51
    water 0.06
    ethyl acetate 36.72
    n-propanol 47.87
    acetone 255.47
    n-butanol 29.78
    acetonitrile 41.15
    DMF 68.91
    toluene 1.21
    isobutanol 18.29
    1,4-dioxane 82.72
    methyl acetate 47.77
    THF 381.83
    2-butanone 86.41
    n-pentanol 20.23
    sec-butanol 29.99
    n-hexane 0.11
    ethylene glycol 42.08
    NMP 20.34
    cyclohexane 0.06
    DMSO 628.89
    n-butyl acetate 14.74
    n-octanol 9.43
    chloroform 0.17
    n-propyl acetate 17.32
    acetic acid 50.38
    dichloromethane 0.02
    cyclohexanone 27.51
    propylene glycol 118.34
    isopropyl acetate 30.05
    DMAc 123.66
    2-ethoxyethanol 111.24
    isopentanol 24.94
    n-heptane 0.27
    ethyl formate 17.2
    1,2-dichloroethane 0.31
    n-hexanol 17.34
    2-methoxyethanol 231.4
    isobutyl acetate 12.59
    tetrachloromethane 0.23
    n-pentyl acetate 9.89
    transcutol 322.93
    n-heptanol 10.45
    ethylbenzene 1.21
    MIBK 36.26
    2-propoxyethanol 101.8
    tert-butanol 70.29
    MTBE 39.27
    2-butoxyethanol 44.15
    propionic acid 37.55
    o-xylene 1.46
    formic acid 27.93
    diethyl ether 20.28
    m-xylene 1.82
    p-xylene 1.29
    chlorobenzene 0.7
    dimethyl carbonate 26.21
    n-octane 0.14
    formamide 86.93
    cyclopentanone 81.96
    2-pentanone 46.19
    anisole 15.84
    cyclopentyl methyl ether 26.96
    gamma-butyrolactone 70.13
    1-methoxy-2-propanol 172.47
    pyridine 11.89
    3-pentanone 22.1
    furfural 35.22
    n-dodecane 0.34
    diethylene glycol 122.79
    diisopropyl ether 6.4
    tert-amyl alcohol 46.73
    acetylacetone 91.41
    n-hexadecane 0.37
    acetophenone 13.55
    methyl propionate 35.7
    isopentyl acetate 19.38
    trichloroethylene 1.26
    n-nonanol 10.25
    cyclohexanol 11.93
    benzyl alcohol 13.18
    2-ethylhexanol 10.27
    isooctanol 10.12
    dipropyl ether 17.64
    1,2-dichlorobenzene 1.08
    ethyl lactate 29.63
    propylene carbonate 24.45
    n-methylformamide 52.1
    2-pentanol 18.17
    n-pentane 0.09
    1-propoxy-2-propanol 70.07
    1-methoxy-2-propyl acetate 53.52
    2-(2-methoxypropoxy) propanol 72.54
    mesitylene 1.57
    ε-caprolactone 24.43
    p-cymene 2.52
    epichlorohydrin 54.32
    1,1,1-trichloroethane 1.18
    2-aminoethanol 85.46
    morpholine-4-carbaldehyde 61.74
    sulfolane 99.12
    2,2,4-trimethylpentane 0.44
    2-methyltetrahydrofuran 56.7
    n-hexyl acetate 16.29
    isooctane 0.46
    2-(2-butoxyethoxy)ethanol 96.91
    sec-butyl acetate 16.39
    tert-butyl acetate 51.84
    decalin 0.23
    glycerin 156.14
    diglyme 151.02
    acrylic acid 30.83
    isopropyl myristate 11.36
    n-butyric acid 35.74
    acetyl acetate 22.89
    di(2-ethylhexyl) phthalate 10.99
    ethyl propionate 20.85
    nitromethane 134.31
    1,2-diethoxyethane 52.27
    benzonitrile 6.4
    trioctyl phosphate 8.2
    1-bromopropane 0.29
    gamma-valerolactone 89.02
    n-decanol 8.28
    triethyl phosphate 15.78
    4-methyl-2-pentanol 16.47
    propionitrile 21.52
    vinylene carbonate 14.08
    1,1,2-trichlorotrifluoroethane 58.69
    DMS 19.73
    cumene 1.61
    2-octanol 6.0
    2-hexanone 25.03
    octyl acetate 12.37
    limonene 3.26
    1,2-dimethoxyethane 132.17
    ethyl orthosilicate 14.76
    tributyl phosphate 10.87
    diacetone alcohol 97.43
    N,N-dimethylaniline 10.01
    acrylonitrile 25.36
    aniline 6.32
    1,3-propanediol 92.88
    bromobenzene 0.36
    dibromomethane 0.04
    1,1,2,2-tetrachloroethane 2.57
    2-methyl-cyclohexyl acetate 17.57
    tetrabutyl urea 14.62
    diisobutyl methanol 12.06
    2-phenylethanol 15.38
    styrene 1.09
    dioctyl adipate 19.07
    dimethyl sulfate 43.93
    ethyl butyrate 17.76
    methyl lactate 57.82
    butyl lactate 20.28
    diethyl carbonate 14.79
    propanediol butyl ether 48.24
    triethyl orthoformate 20.72
    p-tert-butyltoluene 3.1
    methyl 4-tert-butylbenzoate 26.98
    morpholine 110.16
    tert-butylamine 19.31
    n-dodecanol 6.48
    dimethoxymethane 112.67
    ethylene carbonate 12.78
    cyrene 47.25
    2-ethoxyethyl acetate 27.16
    2-ethylhexyl acetate 11.69
    1,2,4-trichlorobenzene 2.19
    4-methylpyridine 7.27
    dibutyl ether 13.37
    2,6-dimethyl-4-heptanol 12.06
    DEF 22.85
    dimethyl isosorbide 99.0
    tetrachloroethylene 1.59
    eugenol 31.7
    triacetin 32.17
    span 80 41.19
    1,4-butanediol 26.33
    1,1-dichloroethane 0.35
    2-methyl-1-pentanol 19.89
    methyl formate 33.15
    2-methyl-1-butanol 20.68
    n-decane 0.42
    butyronitrile 16.58
    3,7-dimethyl-1-octanol 13.71
    1-chlorooctane 2.26
    1-chlorotetradecane 1.34
    n-nonane 0.3
    undecane 0.38
    tert-butylcyclohexane 0.44
    cyclooctane 0.05
    cyclopentanol 18.32
    tetrahydropyran 35.77
    tert-amyl methyl ether 26.99
    2,5,8-trioxanonane 124.83
    1-hexene 0.78
    2-isopropoxyethanol 62.57
    2,2,2-trifluoroethanol 12.72
    methyl butyrate 20.51

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction