Raspberry Ketone

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  • Identifiers

    CAS number
    5471-51-2

    Molecular formula
    C10H12O2

    SMILES
    CC(=O)CCC1=CC=C(C=C1)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fruity 81.38%
    Sweet 79.04%
    Floral 76.37%
    Woody 58.49%
    Berry 50.5%
    Balsamic 47.22%
    Raspberry 41.45%
    Spicy 41.26%
    Cherry 40.46%
    Vanilla 39.96%

    Scent© AI

  • Properties

    XLogP3-AA
    1.5

    pKa est.
    10.25 (weak base)

    Molecular weight
    164.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 82.5 °C

    Boiling point

    • Decomposes
    • 200.00 °C. @ 760.00 mm Hg

    Flash point est.
    135.16 ˚C

    Solubility expt.

    • 1 g in 1 mL 98% alcohol
    • Soluble in oils; moderately soluble in ethanol
    • very slightly
    • insoluble in water; soluble in oils
    • moderately soluble (in ethanol)

  • Synonyms

    • 4-(4-Hydroxyphenyl)-2-butanone
    • 5471-51-2
    • Raspberry ketone
    • 4-(4-Hydroxyphenyl)butan-2-one
    • Frambinone
    • Oxyphenalon
    • Rheosmin
    • 4-(p-Hydroxyphenyl)-2-butanone
    • 4-Hydroxybenzylacetone
    • 2-Butanone, 4-(4-hydroxyphenyl)-
    • Rasketone
    • p-Hydroxybenzyl acetone
    • 4-(3-Oxobutyl)phenol
    • 1-(p-Hydroxyphenyl)-3-butanone
    • 1-(4-Hydroxyphenyl)-3-butanone
    • (p-Hydroxybenzyl)acetone
    • 2-BUTANONE, 4-(p-HYDROXYPHENYL)-
    • Oxyphenylon
    • rasberry ketone
    • FEMA No. 2588
    • Hydroxyphenylbutanone, p-
    • RASPBERRYKETONE
    • NSC 26515
    • p-hydroxyphenylbutan-2-one
    • EINECS 226-806-4
    • 7QY1MH15BG
    • BRN 0776080
    • DTXSID5044495
    • CHEBI:68656
    • 4-(p-Hydroxyphenyl)-2-butanone (natural)
    • AI3-31812
    • HSDB 8163
    • 4-(4'-hydroxyphenyl)-2-butanone
    • MFCD00002394
    • NSC-26515
    • RASPBERRY KETONE [MI]
    • P-HYDROXY-BENZYLACETONE
    • CHEMBL105912
    • DTXCID3024495
    • RASPBERRY KETONE [VANDF]
    • EC 226-806-4
    • RASPBERRY KETONE [USP-RS]
    • 4(P-HYDROXYPHENYL)-2-BUTANONE
    • RASPBERRY KETONE [USP IMPURITY]
    • DOBUTAMINE IMPURITY B [EP IMPURITY]
    • 4-(P-HYDROXYPHENYL)-2-BUTANONE [FCC]
    • 4-(P-HYDROXYPHENYL)-2-BUTANONE [FHFI]
    • 4-(4-HYDROXYPHENYL)BUTAN-2-ONE [WHO-DD]
    • DOBUTAMINE HYDROCHLORIDE IMPURITY B [EP IMPURITY]
    • 4-[4-hydroxyphenyl]butan-2-one
    • RASPBERRY KETONE (USP-RS)
    • RASPBERRY KETONE (USP IMPURITY)
    • DOBUTAMINE IMPURITY B (EP IMPURITY)
    • UNII-7QY1MH15BG
    • DOBUTAMINE HYDROCHLORIDE IMPURITY B (EP IMPURITY)
    • Himbeerketon
    • Frambione
    • Rastone
    • Rheosmine
    • Dobutamine Hydrochloride Imp. B (EP); Dobutamine Imp. B (EP); 4-(4-Hydroxyphenyl)butan-2-one; Dobutamine Hydrochloride Impurity B; Dobutamine Impurity B
    • p-Hydroxy benzylacetone
    • DOBUTAMINE_met018
    • (4-Hydroxybenzyl)acetone
    • Raspberry ketone synthetic
    • 4-hydroxyphenylbutan-2-one
    • Raspberry ketone (Standard)
    • SCHEMBL43308
    • WLN: QR D2V1
    • RASPBERRY KETONE [INCI]
    • FEMA 2588
    • HY-N1426R
    • 4-(4-hydroxyphenyl) butan-2-one
    • 4-(4-hydroxyphenyl)-butan-2-one
    • HY-N1426
    • NSC26515
    • 1-(4-hydroxy-phenyl)-butan-3-one
    • Tox21_301459
    • 4-(4-Hydroxy-phenyl)-butan-2-one
    • BBL009822
    • BDBM50315100
    • s9480
    • STK801275
    • AKOS000120840
    • FR11967
    • PS-4612
    • 4-(4-Hydroxyphenyl)-2-butanone, 99%
    • NCGC00255780-01
    • AC-24193
    • SY004032
    • CAS-5471-51-2
    • DB-003440
    • CS-0016855
    • H0604
    • NS00001157
    • EN300-18634
    • D70581
    • AE-473/30684056
    • Q414484
    • 4-(4-Hydroxyphenyl)-2-butanone, >=98%, FCC, FG
    • 4-(4-Hydroxyphenyl)-2-butanone, analytical standard
    • Z87001611
    • 4-(4-Hydroxyphenyl)-2-butanone, natural, >=98%, FCC, FG
    • 4-(4-Hydroxyphenyl)-2-butanone, certified reference material, TraceCERT(R)
    • Raspberry ketone, United States Pharmacopeia (USP) Reference Standard
    • RACTOPAMINE HYDROCHLORIDE SUSPENSION IMPURITY, RASPBERRY KETONE- [USP IMPURITY]
    • 226-806-4
    • BKZ

  • Applications

    4-(4-Hydroxyphenyl)-2-butanone, better known as raspberry ketone, is the natural flavor molecule responsible for the characteristic aroma of red raspberries and finds extensive use in the food industry to intensify the taste of candies, baked goods, beverages and sugar-free formulations; in perfumery and cosmetics it imparts a fresh fruity top note and masks base-material off-odors; in sports nutrition and dietary supplements it is marketed as a weight-management and antioxidant ingredient, although clinical evidence remains limited; in pharmaceutical and biological research it serves as a chromatographic reference standard and is investigated for anti-inflammatory, neuroprotective and tyrosinase-inhibiting properties aimed at skin-lightening products; additionally, owing to its good solubility in ethanol and glycerol, it can be readily incorporated into solutions, gels, essential-oil blends or microcapsules, thereby enhancing fragrance longevity and formulation stability.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 902.04
    methanol 961.75
    isopropanol 649.84
    water 9.92
    ethyl acetate 450.44
    n-propanol 482.98
    acetone 953.36
    n-butanol 355.42
    acetonitrile 445.21
    DMF 603.49
    toluene 35.97
    isobutanol 283.21
    1,4-dioxane 851.69
    methyl acetate 563.55
    THF 592.8
    2-butanone 442.02
    n-pentanol 244.66
    sec-butanol 306.57
    n-hexane 1.58
    ethylene glycol 390.25
    NMP 139.11
    cyclohexane 2.22
    DMSO 518.66
    n-butyl acetate 147.36
    n-octanol 96.45
    chloroform 157.13
    n-propyl acetate 176.07
    acetic acid 519.03
    dichloromethane 126.01
    cyclohexanone 235.81
    propylene glycol 691.77
    isopropyl acetate 215.33
    DMAc 534.05
    2-ethoxyethanol 641.37
    isopentanol 242.24
    n-heptane 3.98
    ethyl formate 246.68
    1,2-dichloroethane 83.98
    n-hexanol 211.8
    2-methoxyethanol 1062.41
    isobutyl acetate 109.31
    tetrachloromethane 14.62
    n-pentyl acetate 71.78
    transcutol 1110.67
    n-heptanol 92.27
    ethylbenzene 30.36
    MIBK 149.93
    2-propoxyethanol 476.73
    tert-butanol 689.94
    MTBE 230.52
    2-butoxyethanol 218.98
    propionic acid 395.65
    o-xylene 33.84
    formic acid 303.28
    diethyl ether 161.71
    m-xylene 38.27
    p-xylene 39.77
    chlorobenzene 49.72
    dimethyl carbonate 140.47
    n-octane 3.22
    formamide 543.84
    cyclopentanone 309.14
    2-pentanone 284.38
    anisole 185.44
    cyclopentyl methyl ether 144.17
    gamma-butyrolactone 384.36
    1-methoxy-2-propanol 723.32
    pyridine 178.48
    3-pentanone 136.68
    furfural 305.32
    n-dodecane 4.97
    diethylene glycol 560.91
    diisopropyl ether 41.2
    tert-amyl alcohol 325.98
    acetylacetone 339.01
    n-hexadecane 5.35
    acetophenone 128.28
    methyl propionate 290.79
    isopentyl acetate 126.89
    trichloroethylene 190.94
    n-nonanol 85.04
    cyclohexanol 146.7
    benzyl alcohol 167.48
    2-ethylhexanol 85.8
    isooctanol 68.71
    dipropyl ether 78.24
    1,2-dichlorobenzene 46.16
    ethyl lactate 123.55
    propylene carbonate 189.48
    n-methylformamide 448.45
    2-pentanol 190.82
    n-pentane 1.47
    1-propoxy-2-propanol 290.03
    1-methoxy-2-propyl acetate 239.53
    2-(2-methoxypropoxy) propanol 205.16
    mesitylene 23.24
    ε-caprolactone 217.76
    p-cymene 24.11
    epichlorohydrin 417.14
    1,1,1-trichloroethane 95.19
    2-aminoethanol 639.88
    morpholine-4-carbaldehyde 458.25
    sulfolane 238.24
    2,2,4-trimethylpentane 3.49
    2-methyltetrahydrofuran 288.15
    n-hexyl acetate 122.52
    isooctane 4.02
    2-(2-butoxyethoxy)ethanol 324.64
    sec-butyl acetate 116.52
    tert-butyl acetate 202.3
    decalin 4.37
    glycerin 639.75
    diglyme 522.82
    acrylic acid 293.14
    isopropyl myristate 52.99
    n-butyric acid 426.26
    acetyl acetate 212.61
    di(2-ethylhexyl) phthalate 54.61
    ethyl propionate 159.45
    nitromethane 827.94
    1,2-diethoxyethane 248.75
    benzonitrile 121.2
    trioctyl phosphate 40.32
    1-bromopropane 35.51
    gamma-valerolactone 514.18
    n-decanol 68.48
    triethyl phosphate 55.89
    4-methyl-2-pentanol 111.79
    propionitrile 266.86
    vinylene carbonate 176.07
    1,1,2-trichlorotrifluoroethane 302.74
    DMS 130.31
    cumene 25.56
    2-octanol 58.7
    2-hexanone 165.33
    octyl acetate 70.48
    limonene 31.47
    1,2-dimethoxyethane 619.6
    ethyl orthosilicate 52.99
    tributyl phosphate 50.61
    diacetone alcohol 334.4
    N,N-dimethylaniline 90.07
    acrylonitrile 307.21
    aniline 119.27
    1,3-propanediol 716.81
    bromobenzene 35.92
    dibromomethane 53.31
    1,1,2,2-tetrachloroethane 153.74
    2-methyl-cyclohexyl acetate 81.67
    tetrabutyl urea 69.2
    diisobutyl methanol 54.51
    2-phenylethanol 145.34
    styrene 37.06
    dioctyl adipate 76.65
    dimethyl sulfate 167.17
    ethyl butyrate 113.54
    methyl lactate 203.83
    butyl lactate 88.2
    diethyl carbonate 81.22
    propanediol butyl ether 257.42
    triethyl orthoformate 77.61
    p-tert-butyltoluene 25.1
    methyl 4-tert-butylbenzoate 116.02
    morpholine 817.53
    tert-butylamine 228.08
    n-dodecanol 54.17
    dimethoxymethane 450.44
    ethylene carbonate 155.41
    cyrene 154.33
    2-ethoxyethyl acetate 155.43
    2-ethylhexyl acetate 80.29
    1,2,4-trichlorobenzene 64.21
    4-methylpyridine 177.41
    dibutyl ether 84.21
    2,6-dimethyl-4-heptanol 54.51
    DEF 216.93
    dimethyl isosorbide 248.28
    tetrachloroethylene 75.62
    eugenol 132.7
    triacetin 156.84
    span 80 154.12
    1,4-butanediol 277.02
    1,1-dichloroethane 115.41
    2-methyl-1-pentanol 166.51
    methyl formate 351.89
    2-methyl-1-butanol 198.4
    n-decane 7.15
    butyronitrile 241.53
    3,7-dimethyl-1-octanol 86.59
    1-chlorooctane 32.38
    1-chlorotetradecane 16.14
    n-nonane 5.99
    undecane 5.8
    tert-butylcyclohexane 6.25
    cyclooctane 1.3
    cyclopentanol 194.83
    tetrahydropyran 306.38
    tert-amyl methyl ether 126.88
    2,5,8-trioxanonane 370.32
    1-hexene 18.6
    2-isopropoxyethanol 370.28
    2,2,2-trifluoroethanol 166.49
    methyl butyrate 196.47

    Scent© AI

1 4

IFRA standard 51

Recommendation
Restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 0.68 % Category 7A
Rinse-off products applied to the hair with some hand contact
 0.41 %
Category 2
Products applied to the axillae
 1 % Category 7B
Leave-on products applied to the hair with some hand contact
 0.41 %
Category 3
Products applied to the face/body using fingertips
 0.27 % Category 8
Products with significant anogenital exposure
 0.045 %
Category 4
Products related to fine fragrance
 1 % Category 9
Products with body and hand exposure, primarily rinse off
 1 %
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 1 % Category 10A
Household care products with mostly hand contact
 1 %
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 0.14 % Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 1 %
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 0.27 % Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 0.045 %
Category 5D
Baby Creams, baby Oils and baby talc
 0.045 % Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 0.045 %
Category 6
Products with oral and lip exposure
 0.82 % Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 78 %