(R)-2-hydroxypalmitic acid

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  • Identifiers

    CAS number
    16452-51-0

    Molecular formula
    C16H32O3

    SMILES
    CCCCCCCCCCCCCC[C@H](C(=O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Waxy 64.44%
    Fatty 62.53%
    Oily 38.56%
    Odorless 34.9%
    Creamy 29.92%
    Milky 29.42%
    Dairy 27.76%
    Buttery 26.21%
    Citrus 23.55%
    Sweet 22.75%

     

    Flavor
    Fatty 48.78%
    Waxy 46.37%
    Mild 39.33%
    Odorless 35.6%
    Bland 34.11%
    Fat 30.08%
    Oily 29.73%
    Faint 29.38%
    Coconut 24.57%
    Slightly waxy 24.55%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.4

    pKa est.
    6.18 (neutral)

    Molecular weight
    272.42 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    359°C

    Flash point

    • 184.66 ˚C est.

  • Synonyms

    • (R)-2-hydroxypalmitic acid
    • (R)-2OH PA
    • (2R)-2-hydroxyhexadecanoic acid
    • (R)-2-hydroxyhexadecanoic acid
    • 16452-51-0
    • 2R-hydroxypalmitic acid
    • 2R-hydroxyhexadecanoic acid
    • SCHEMBL6241060
    • CHEBI:75972
    • DTXSID90453980
    • LMFA01050423
    • (R)-(+)-2-hydroxyhexadecanoic acid
    • Q27145666
    • 16452-51-0

  • Applications

    (R)-2-hydroxypalmitic acid, CAS 16452-51-0, is an alpha-hydroxy fatty acid with several practical applications: in cosmetics and personal care as an emollient and conditioning agent; as a building block for the synthesis of esters and specialty polymers, including polyesters used in coatings and plastics; as a precursor for surfactants and cleaning formulations in household and industrial products; as an additive in lubricants and plasticizers to adjust viscosity and lubricity in industrial formulations; and as a potential chiral building block for pharmaceutical intermediates in fine chemicals.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 124.9
    methanol 137.15
    isopropanol 137.55
    water 0.04
    ethyl acetate 164.31
    n-propanol 127.78
    acetone 131.76
    n-butanol 123.53
    acetonitrile 41.42
    DMF 296.33
    toluene 48.84
    isobutanol 118.59
    1,4-dioxane 184.5
    methyl acetate 109.22
    THF 625.98
    2-butanone 171.78
    n-pentanol 115.12
    sec-butanol 139.14
    n-hexane 34.07
    ethylene glycol 10.5
    NMP 483.47
    cyclohexane 80.67
    DMSO 606.07
    n-butyl acetate 266.71
    n-octanol 102.13
    chloroform 216.47
    n-propyl acetate 250.1
    acetic acid 85.15
    dichloromethane 232.67
    cyclohexanone 476.78
    propylene glycol 37.65
    isopropyl acetate 193.67
    DMAc 372.39
    2-ethoxyethanol 220.22
    isopentanol 164.82
    n-heptane 33.02
    ethyl formate 80.57
    1,2-dichloroethane 260.62
    n-hexanol 118.84
    2-methoxyethanol 234.73
    isobutyl acetate 173.11
    tetrachloromethane 73.19
    n-pentyl acetate 314.95
    transcutol 746.32
    n-heptanol 113.76
    ethylbenzene 55.26
    MIBK 198.81
    2-propoxyethanol 232.55
    tert-butanol 256.24
    MTBE 228.44
    2-butoxyethanol 247.94
    propionic acid 102.69
    o-xylene 61.93
    formic acid 23.44
    diethyl ether 146.45
    m-xylene 56.59
    p-xylene 74.64
    chlorobenzene 84.94
    dimethyl carbonate 45.75
    n-octane 17.74
    formamide 57.91
    cyclopentanone 500.75
    2-pentanone 200.61
    anisole 106.48
    cyclopentyl methyl ether 311.11
    gamma-butyrolactone 442.37
    1-methoxy-2-propanol 264.82
    pyridine 151.55
    3-pentanone 145.28
    furfural 269.33
    n-dodecane 9.27
    diethylene glycol 107.41
    diisopropyl ether 89.85
    tert-amyl alcohol 222.78
    acetylacetone 240.77
    n-hexadecane 11.06
    acetophenone 155.76
    methyl propionate 132.92
    isopentyl acetate 274.8
    trichloroethylene 347.72
    n-nonanol 97.35
    cyclohexanol 205.49
    benzyl alcohol 88.64
    2-ethylhexanol 111.34
    isooctanol 119.64
    dipropyl ether 172.76
    1,2-dichlorobenzene 122.87
    ethyl lactate 106.22
    propylene carbonate 242.88
    n-methylformamide 100.1
    2-pentanol 123.63
    n-pentane 22.81
    1-propoxy-2-propanol 257.46
    1-methoxy-2-propyl acetate 238.3
    2-(2-methoxypropoxy) propanol 167.39
    mesitylene 55.01
    ε-caprolactone 409.01
    p-cymene 57.79
    epichlorohydrin 416.5
    1,1,1-trichloroethane 224.04
    2-aminoethanol 48.06
    morpholine-4-carbaldehyde 345.02
    sulfolane 883.94
    2,2,4-trimethylpentane 25.96
    2-methyltetrahydrofuran 378.16
    n-hexyl acetate 279.73
    isooctane 18.53
    2-(2-butoxyethoxy)ethanol 273.23
    sec-butyl acetate 199.92
    tert-butyl acetate 303.2
    decalin 38.38
    glycerin 57.5
    diglyme 514.63
    acrylic acid 60.73
    isopropyl myristate 96.74
    n-butyric acid 225.71
    acetyl acetate 105.52
    di(2-ethylhexyl) phthalate 73.15
    ethyl propionate 175.69
    nitromethane 161.53
    1,2-diethoxyethane 310.56
    benzonitrile 93.95
    trioctyl phosphate 71.09
    1-bromopropane 151.91
    gamma-valerolactone 566.38
    n-decanol 64.47
    triethyl phosphate 105.94
    4-methyl-2-pentanol 101.44
    propionitrile 61.96
    vinylene carbonate 145.73
    1,1,2-trichlorotrifluoroethane 295.4
    DMS 133.15
    cumene 52.77
    2-octanol 107.44
    2-hexanone 207.35
    octyl acetate 115.91
    limonene 106.58
    1,2-dimethoxyethane 348.15
    ethyl orthosilicate 111.3
    tributyl phosphate 88.0
    diacetone alcohol 314.43
    N,N-dimethylaniline 99.72
    acrylonitrile 61.34
    aniline 67.52
    1,3-propanediol 104.41
    bromobenzene 96.53
    dibromomethane 178.75
    1,1,2,2-tetrachloroethane 405.04
    2-methyl-cyclohexyl acetate 201.71
    tetrabutyl urea 129.47
    diisobutyl methanol 93.42
    2-phenylethanol 94.7
    styrene 56.51
    dioctyl adipate 145.43
    dimethyl sulfate 128.38
    ethyl butyrate 213.19
    methyl lactate 87.93
    butyl lactate 213.67
    diethyl carbonate 111.31
    propanediol butyl ether 192.21
    triethyl orthoformate 167.79
    p-tert-butyltoluene 59.48
    methyl 4-tert-butylbenzoate 197.97
    morpholine 308.09
    tert-butylamine 166.59
    n-dodecanol 45.71
    dimethoxymethane 178.04
    ethylene carbonate 148.3
    cyrene 180.16
    2-ethoxyethyl acetate 283.88
    2-ethylhexyl acetate 221.64
    1,2,4-trichlorobenzene 144.98
    4-methylpyridine 151.55
    dibutyl ether 179.89
    2,6-dimethyl-4-heptanol 93.42
    DEF 264.83
    dimethyl isosorbide 345.27
    tetrachloroethylene 264.98
    eugenol 155.21
    triacetin 234.46
    span 80 173.26
    1,4-butanediol 46.59
    1,1-dichloroethane 175.39
    2-methyl-1-pentanol 126.61
    methyl formate 56.42
    2-methyl-1-butanol 133.25
    n-decane 20.81
    butyronitrile 92.51
    3,7-dimethyl-1-octanol 112.09
    1-chlorooctane 94.29
    1-chlorotetradecane 29.02
    n-nonane 20.96
    undecane 13.09
    tert-butylcyclohexane 33.62
    cyclooctane 26.7
    cyclopentanol 210.83
    tetrahydropyran 311.05
    tert-amyl methyl ether 184.23
    2,5,8-trioxanonane 297.93
    1-hexene 82.87
    2-isopropoxyethanol 195.2
    2,2,2-trifluoroethanol 41.68
    methyl butyrate 263.75

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction