Quaternium 22

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  • Identifiers

    CAS number
    51812-80-7

    Molecular formula
    C13H29ClN2O7

    SMILES
    C[N+](C)(CCCNC(=O)[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)CCO.[Cl-]

    Safety labels

  • Odor profile

    Fragrance
    Odorless 56.83%
    Sweet 33.44%
    Cooling 32.73%
    Savory 27.87%
    Fishy 26.81%
    Mint 24.09%
    Alcoholic 23.38%
    Milky 20.41%
    Oily 19.61%
    Bitter 16.9%

     

    Flavor
    Odorless 58.89%
    Bland 33.27%
    Mild 29.72%
    Sweet-like 29.06%
    Bitter 28.15%
    Sweet 27.75%
    Very slight 20.25%
    Very mild 19.6%
    Yeasty 19.57%
    Sandalwood 19.44%

     

    Odor impact est.
    Odorless

  • Properties

    pKa est.
    4.78 (weak acid)

    Molecular weight
    360.83 g/mol

    Flash point

    • 62.8 ˚C est.

  • Synonyms

    • QUATERNIUM-22
    • 51812-80-7
    • QUATERNIUM 22
    • CERAPHYL 60
    • MXO138JCBP
    • DTXSID601014646
    • gamma-Gluconamidopropyl dimethyl 2-hydroxyethyl ammonium chloride
    • 1-Propanaminium, 3-(D-gluconoylamino)-N-(2-hydroxyethyl)-N,N-dimethyl-, chloride
    • 3-(D-gluconylamino)propyl-(2-hydroxyethyl)dimethylammonium chloride
    • RefChem:178052
    • DTXCID101437186
    • (2-hydroxyethyl)dimethyl(3-(2,3,4,5,6-pentahydroxyhexanamido)propyl)azanium chloride
    • 257-440-3
    • 3-(D-Gluconoylamino)propyl(2-hydroxyethyl)dimethylammonium chloride
    • Ceraphyl 60 (Technical Grade)
    • 1-Propanaminium, 3-(D-gluconoylamino)-N-(2-hydroxyethyl)-N,N-dimethyl-, chloride (1:1)
    • UNII-MXO138JCBP
    • EINECS 257-440-3
    • SCHEMBL2390520
    • QUATERNIUM 22 [VANDF]
    • (alpha-Gluconamidopropyl)dimethyl-2-hydroxyethylammonium chloride
    • DB-251970
    • NS00014027
    • Q27284281
    • 3-(D-Gluconoylamino)-N-(2-hydroxyethyl)-N,N-dimethyl-1-propanamin- ium chloride
    • 3-(D-GLUCONOYLAMINO)-N-(2-HYDROXYETHYL)-N,N-DIMETHYL-1-PROPANAMINIUM CHLORIDE
    • N-.GAMMA.-GLUCONAMIDOPROPYL-N,N-DIMETHYL-N-HYDROXYETHYL AMMONIUM CHLORIDE
    • 2-hydroxyethyl-dimethyl-[3-[[(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoyl]amino]propyl]azanium;chloride
    • N-(2-Hydroxyethyl)-N,N-dimethyl-3-{[(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoyl]amino}propan-1-aminium chloride
    • 51812-80-7

  • Applications

    Quaternium 22 (CAS 51812-80-7) is a quaternary ammonium salt that functions as a cationic surfactant and conditioning agent. In cosmetics and personal care, it is used as a conditioning ingredient in hair care and skin care formulations to improve softness and manageability. In household cleaning products, it serves as a surfactant and fabric-softening component in detergents and cleaners. In textiles, it acts as a fabric softener and anti-static finish. In polymers/plastics and coatings/inks, it can serve as a surfactant or dispersion aid to improve wetting, pigment dispersion and finish. In industrial manufacturing, it may be used as an emulsifier or processing aid in various formulations. Usage is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.47
    methanol 5.45
    isopropanol 0.11
    water 730.16
    ethyl acetate 0.07
    n-propanol 0.38
    acetone 0.07
    n-butanol 0.18
    acetonitrile 0.08
    DMF 10.58
    toluene 0.04
    isobutanol 0.16
    1,4-dioxane 0.2
    methyl acetate 0.09
    THF 0.2
    2-butanone 0.1
    n-pentanol 0.07
    sec-butanol 0.17
    n-hexane 0.01
    ethylene glycol 35.93
    NMP 32.88
    cyclohexane 0.08
    DMSO 30.28
    n-butyl acetate 0.04
    n-octanol 0.08
    chloroform 0.09
    n-propyl acetate 0.04
    acetic acid 12.22
    dichloromethane 0.09
    cyclohexanone 0.4
    propylene glycol 11.46
    isopropyl acetate 0.04
    DMAc 10.21
    2-ethoxyethanol 1.21
    isopentanol 0.1
    n-heptane 0.04
    ethyl formate 0.18
    1,2-dichloroethane 0.09
    n-hexanol 0.15
    2-methoxyethanol 5.86
    isobutyl acetate 0.02
    tetrachloromethane 0.1
    n-pentyl acetate 0.05
    transcutol 2.25
    n-heptanol 0.17
    ethylbenzene 0.03
    MIBK 0.06
    2-propoxyethanol 1.15
    tert-butanol 0.13
    MTBE 0.03
    2-butoxyethanol 0.74
    propionic acid 2.0
    o-xylene 0.09
    formic acid 360.26
    diethyl ether 0.04
    m-xylene 0.06
    p-xylene 0.03
    chlorobenzene 0.02
    dimethyl carbonate 0.55
    n-octane 0.02
    formamide 106.07
    cyclopentanone 0.53
    2-pentanone 0.08
    anisole 0.04
    cyclopentyl methyl ether 0.24
    gamma-butyrolactone 1.1
    1-methoxy-2-propanol 2.04
    pyridine 0.23
    3-pentanone 0.14
    furfural 2.1
    n-dodecane 0.01
    diethylene glycol 7.36
    diisopropyl ether 0.02
    tert-amyl alcohol 0.22
    acetylacetone 0.21
    n-hexadecane 0.01
    acetophenone 0.13
    methyl propionate 0.29
    isopentyl acetate 0.04
    trichloroethylene 0.21
    n-nonanol 0.08
    cyclohexanol 0.46
    benzyl alcohol 0.19
    2-ethylhexanol 0.09
    isooctanol 0.1
    dipropyl ether 0.07
    1,2-dichlorobenzene 0.04
    ethyl lactate 0.48
    propylene carbonate 0.46
    n-methylformamide 7.81
    2-pentanol 0.1
    n-pentane 0.02
    1-propoxy-2-propanol 0.56
    1-methoxy-2-propyl acetate 0.26
    2-(2-methoxypropoxy) propanol 0.83
    mesitylene 0.06
    ε-caprolactone 0.57
    p-cymene 0.05
    epichlorohydrin 0.32
    1,1,1-trichloroethane 0.04
    2-aminoethanol 15.82
    morpholine-4-carbaldehyde 9.31
    sulfolane 12.59
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 0.13
    n-hexyl acetate 0.06
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 1.09
    sec-butyl acetate 0.03
    tert-butyl acetate 0.07
    decalin 0.02
    glycerin 81.12
    diglyme 1.48
    acrylic acid 6.09
    isopropyl myristate 0.02
    n-butyric acid 0.83
    acetyl acetate 0.12
    di(2-ethylhexyl) phthalate 0.09
    ethyl propionate 0.07
    nitromethane 3.92
    1,2-diethoxyethane 0.07
    benzonitrile 0.06
    trioctyl phosphate 0.08
    1-bromopropane 0.03
    gamma-valerolactone 1.89
    n-decanol 0.06
    triethyl phosphate 0.15
    4-methyl-2-pentanol 0.05
    propionitrile 0.07
    vinylene carbonate 0.53
    1,1,2-trichlorotrifluoroethane 10.07
    DMS 0.2
    cumene 0.03
    2-octanol 0.07
    2-hexanone 0.03
    octyl acetate 0.04
    limonene 0.09
    1,2-dimethoxyethane 0.41
    ethyl orthosilicate 0.13
    tributyl phosphate 0.08
    diacetone alcohol 0.6
    N,N-dimethylaniline 0.1
    acrylonitrile 0.21
    aniline 0.18
    1,3-propanediol 4.74
    bromobenzene 0.02
    dibromomethane 0.05
    1,1,2,2-tetrachloroethane 0.25
    2-methyl-cyclohexyl acetate 0.09
    tetrabutyl urea 0.16
    diisobutyl methanol 0.05
    2-phenylethanol 0.18
    styrene 0.02
    dioctyl adipate 0.06
    dimethyl sulfate 3.33
    ethyl butyrate 0.06
    methyl lactate 3.21
    butyl lactate 0.32
    diethyl carbonate 0.05
    propanediol butyl ether 1.41
    triethyl orthoformate 0.11
    p-tert-butyltoluene 0.06
    methyl 4-tert-butylbenzoate 0.38
    morpholine 0.56
    tert-butylamine 0.05
    n-dodecanol 0.04
    dimethoxymethane 0.92
    ethylene carbonate 0.3
    cyrene 3.32
    2-ethoxyethyl acetate 0.11
    2-ethylhexyl acetate 0.03
    1,2,4-trichlorobenzene 0.07
    4-methylpyridine 0.1
    dibutyl ether 0.03
    2,6-dimethyl-4-heptanol 0.05
    DEF 0.78
    dimethyl isosorbide 1.24
    tetrachloroethylene 0.4
    eugenol 0.51
    triacetin 0.26
    span 80 0.96
    1,4-butanediol 1.33
    1,1-dichloroethane 0.03
    2-methyl-1-pentanol 0.06
    methyl formate 2.9
    2-methyl-1-butanol 0.17
    n-decane 0.01
    butyronitrile 0.04
    3,7-dimethyl-1-octanol 0.05
    1-chlorooctane 0.02
    1-chlorotetradecane 0.01
    n-nonane 0.02
    undecane 0.01
    tert-butylcyclohexane 0.01
    cyclooctane 0.05
    cyclopentanol 0.53
    tetrahydropyran 0.11
    tert-amyl methyl ether 0.08
    2,5,8-trioxanonane 1.42
    1-hexene 0.02
    2-isopropoxyethanol 0.36
    2,2,2-trifluoroethanol 16.9
    methyl butyrate 0.09

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction