Pyrithione Sodium

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  • Identifiers

    CAS number
    15922-78-8

    Molecular formula
    C5H4NNaOS

    SMILES
    C1=CC(=S)N(C=C1)[O-].[Na+]

    Safety labels

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 61.16%
    Burnt 36.49%
    Roasted 29.42%
    Sulfurous 26.62%
    Meaty 24.87%
    Pungent 23.41%
    Bitter 23.34%
    Cooked 22.49%
    Savory 22.01%
    Nutty 19.89%

     

    Flavor
    Bitter 59.46%
    Nutty 33.52%
    Odorless 28.61%
    Mild 23.89%
    Bread crust 22.65%
    Nitrile 22.51%
    Roasted peanuts 22.1%
    Very strong 21.68%
    Taco 21.39%
    Indole 21.36%

     

    Odor impact est.
    High

  • Properties

    pKa est.
    5.01 (weak acid)

    Molecular weight
    149.15 g/mol

    Flash point

    • 79.34 ˚C est.

  • Synonyms

    • Sodium pyrithione
    • PYRITHIONE SODIUM
    • Sodium Omadine
    • 15922-78-8
    • Omacide 24
    • Sodium 2-pyridinethiol-1-oxide
    • 2(1H)-Pyridinethione, 1-hydroxy-, sodium salt
    • AL02725
    • DTXSID6034920
    • NSC-4483
    • RefChem:177802
    • DTXCID4014920
    • 240-062-8
    • 6L3991491R
    • AL-02725
    • Pyrithione sodium salt
    • Tomicide s
    • Topcide 280
    • 3811-73-2
    • sodium;1-oxidopyridine-2-thione
    • Pyrithione sodium [USAN]
    • Sodium 2-thioxopyridin-1(2H)-olate
    • 1-Hydroxy-2(1H)-pyridinethione, sodium salt
    • Omadine-sodium
    • Caswell No. 790A
    • Pyrithione sodium (USAN)
    • 2-Mercaptopyridine n-oxide sodium
    • C5H4NNaOS
    • Sodium 1-hydroxypyridine-2-thione
    • EINECS 240-062-8
    • EPA Pesticide Chemical Code 088004
    • SQ 3277
    • 1-Hydroxy-2(1H)-pyridinethionato sodium
    • Pyrithione (sodium)
    • Sodium omadine (TN)
    • Sel de sodium de 1-hydroxy-2 (1H)-pyridinethione [French]
    • Sel de sodium de 1-hydroxy-2 (1H)-pyridinethione
    • SCHEMBL271923
    • HY-B1747A
    • Sodium 2-sulfidopyridine 1-oxide
    • CHEBI:201738
    • 2-mercaptopyridinen-oxidesodiumsalt
    • MSK166453Na-100M
    • MSK166453Na-1000M
    • AKOS015891512
    • DA-49434
    • Sodium 2-sulfanylidenepyridin-1(2H)-olate
    • NS00054613
    • D05662
    • 2-Mercaptopyridine N-oxide sodium salt Solution in Methanol, 1000ug/mL
    • 2-Mercaptopyridine N-oxide sodium salt Solution in Methanol, 100ug/mL
    • 15922-78-8

  • Applications

    Pyrithione Sodium (CAS 15922-78-8) is used primarily as an antimicrobial biocide and antifungal agent in formulated products. In cosmetics and personal care, it serves as an antimicrobial additive in shampoos, cleansers, and other skin-care preparations. In household cleaning products, it provides mold and odor control in detergents and surface cleaners. In paints and coatings, it functions as a biocidal additive to inhibit microbial growth on coated surfaces. In industrial manufacturing, it is employed in metalworking fluids, process waters, and cooling systems to control bacteria and fungi. It can also be used as an intermediate in the synthesis of other pyrithione-based biocides used across various sectors.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 65.16
    methanol 95.05
    isopropanol 41.39
    water 2.21
    ethyl acetate 370.84
    n-propanol 58.14
    acetone 564.75
    n-butanol 54.08
    acetonitrile 591.85
    DMF 682.84
    toluene 113.27
    isobutanol 42.39
    1,4-dioxane 370.92
    methyl acetate 535.39
    THF 258.53
    2-butanone 406.7
    n-pentanol 63.39
    sec-butanol 55.73
    n-hexane 7.74
    ethylene glycol 53.62
    NMP 665.33
    cyclohexane 14.96
    DMSO 740.04
    n-butyl acetate 209.52
    n-octanol 48.03
    chloroform 482.72
    n-propyl acetate 245.86
    acetic acid 270.49
    dichloromethane 653.93
    cyclohexanone 397.39
    propylene glycol 32.5
    isopropyl acetate 145.97
    DMAc 635.28
    2-ethoxyethanol 209.56
    isopentanol 55.88
    n-heptane 11.13
    ethyl formate 254.11
    1,2-dichloroethane 464.12
    n-hexanol 55.79
    2-methoxyethanol 258.68
    isobutyl acetate 103.28
    tetrachloromethane 56.92
    n-pentyl acetate 118.01
    transcutol 1242.24
    n-heptanol 31.22
    ethylbenzene 75.2
    MIBK 116.29
    2-propoxyethanol 159.48
    tert-butanol 69.98
    MTBE 99.16
    2-butoxyethanol 98.02
    propionic acid 153.44
    o-xylene 94.06
    formic acid 131.47
    diethyl ether 134.45
    m-xylene 81.41
    p-xylene 102.77
    chlorobenzene 243.26
    dimethyl carbonate 189.53
    n-octane 5.28
    formamide 322.32
    cyclopentanone 414.5
    2-pentanone 237.98
    anisole 238.65
    cyclopentyl methyl ether 126.62
    gamma-butyrolactone 530.39
    1-methoxy-2-propanol 147.33
    pyridine 426.06
    3-pentanone 264.35
    furfural 712.62
    n-dodecane 6.09
    diethylene glycol 186.1
    diisopropyl ether 42.72
    tert-amyl alcohol 76.87
    acetylacetone 465.55
    n-hexadecane 7.02
    acetophenone 296.32
    methyl propionate 310.16
    isopentyl acetate 147.11
    trichloroethylene 1017.18
    n-nonanol 46.77
    cyclohexanol 71.47
    benzyl alcohol 150.77
    2-ethylhexanol 53.27
    isooctanol 29.04
    dipropyl ether 77.33
    1,2-dichlorobenzene 249.54
    ethyl lactate 110.03
    propylene carbonate 269.79
    n-methylformamide 324.74
    2-pentanol 44.06
    n-pentane 7.89
    1-propoxy-2-propanol 114.53
    1-methoxy-2-propyl acetate 206.64
    2-(2-methoxypropoxy) propanol 183.32
    mesitylene 50.59
    ε-caprolactone 344.86
    p-cymene 47.4
    epichlorohydrin 545.72
    1,1,1-trichloroethane 349.6
    2-aminoethanol 60.87
    morpholine-4-carbaldehyde 683.51
    sulfolane 582.23
    2,2,4-trimethylpentane 7.79
    2-methyltetrahydrofuran 205.02
    n-hexyl acetate 158.34
    isooctane 5.59
    2-(2-butoxyethoxy)ethanol 237.75
    sec-butyl acetate 132.62
    tert-butyl acetate 141.35
    decalin 12.6
    glycerin 76.44
    diglyme 500.98
    acrylic acid 208.68
    isopropyl myristate 69.44
    n-butyric acid 141.2
    acetyl acetate 303.88
    di(2-ethylhexyl) phthalate 70.35
    ethyl propionate 220.63
    nitromethane 1197.13
    1,2-diethoxyethane 299.71
    benzonitrile 311.88
    trioctyl phosphate 48.09
    1-bromopropane 137.91
    gamma-valerolactone 625.53
    n-decanol 37.73
    triethyl phosphate 87.19
    4-methyl-2-pentanol 34.55
    propionitrile 228.36
    vinylene carbonate 330.06
    1,1,2-trichlorotrifluoroethane 373.66
    DMS 279.83
    cumene 44.69
    2-octanol 27.09
    2-hexanone 210.62
    octyl acetate 87.18
    limonene 63.69
    1,2-dimethoxyethane 410.04
    ethyl orthosilicate 71.2
    tributyl phosphate 77.69
    diacetone alcohol 163.85
    N,N-dimethylaniline 133.43
    acrylonitrile 414.34
    aniline 127.5
    1,3-propanediol 79.82
    bromobenzene 261.16
    dibromomethane 332.28
    1,1,2,2-tetrachloroethane 530.81
    2-methyl-cyclohexyl acetate 108.13
    tetrabutyl urea 102.1
    diisobutyl methanol 39.04
    2-phenylethanol 117.72
    styrene 120.89
    dioctyl adipate 127.09
    dimethyl sulfate 321.27
    ethyl butyrate 168.85
    methyl lactate 137.55
    butyl lactate 109.82
    diethyl carbonate 138.75
    propanediol butyl ether 120.19
    triethyl orthoformate 100.84
    p-tert-butyltoluene 40.67
    methyl 4-tert-butylbenzoate 146.86
    morpholine 286.32
    tert-butylamine 39.4
    n-dodecanol 31.13
    dimethoxymethane 280.5
    ethylene carbonate 238.2
    cyrene 184.02
    2-ethoxyethyl acetate 245.42
    2-ethylhexyl acetate 123.86
    1,2,4-trichlorobenzene 287.96
    4-methylpyridine 357.99
    dibutyl ether 90.17
    2,6-dimethyl-4-heptanol 39.04
    DEF 362.86
    dimethyl isosorbide 297.34
    tetrachloroethylene 358.09
    eugenol 159.63
    triacetin 264.3
    span 80 121.02
    1,4-butanediol 56.39
    1,1-dichloroethane 320.64
    2-methyl-1-pentanol 68.67
    methyl formate 362.23
    2-methyl-1-butanol 54.04
    n-decane 8.4
    butyronitrile 162.22
    3,7-dimethyl-1-octanol 58.26
    1-chlorooctane 38.87
    1-chlorotetradecane 19.36
    n-nonane 7.61
    undecane 7.1
    tert-butylcyclohexane 10.43
    cyclooctane 6.29
    cyclopentanol 69.69
    tetrahydropyran 181.35
    tert-amyl methyl ether 95.46
    2,5,8-trioxanonane 368.54
    1-hexene 37.79
    2-isopropoxyethanol 138.17
    2,2,2-trifluoroethanol 159.98
    methyl butyrate 275.44

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction