Pyridoxine Hydrochloride

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  • Identifiers

    CAS number
    58-56-0

    Molecular formula
    C8H12ClNO3

    SMILES
    CC1=NC=C(C(=C1O)CO)CO.Cl

    Safety labels

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Odorless 54.86%
    Sweet 35.39%
    Phenolic 35.15%
    Vanilla 28.95%
    Bitter 28.35%
    Burnt 25.71%
    Smoky 24.05%
    Musty 23.99%
    Caramellic 23.88%
    Almond 23.45%

     

    Flavor
    Bitter 48.33%
    Sweet 39.85%
    Mild 36.35%
    Odorless 36.29%
    Musty 27.83%
    Phenolic 26.16%
    Coffee 24.01%
    Caramel 23.79%
    Alcoholic 23.66%
    Milky 22.95%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    -243224.03 (strong acid)

    Molecular weight
    205.64 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 207 °C

    Boiling point

    • Sublimes

    Flash point

    • 152.46 ˚C est.

    Solubility expt.

    • 5 to 10 mg/mL at 68 °F (NTP, 1992)
    • 1 g dissolves in about 4.5 ml water, 90 ml alcohol; sol in propylene glycol; sparingly sol in acetone; insol in ether, chloroform
    • Soluble in alc, acetone; slightly soluble in other organic solvents.
    • In water, 2.2X10+5 mg/l, temp not specified.

  • Synonyms

    • PYRIDOXINE HYDROCHLORIDE
    • 58-56-0
    • Pyridoxine HCl
    • Pyridoxol hydrochloride
    • Vitamin B6 hydrochloride
    • Hexa-Betalin
    • Aderoxine
    • Alestrol
    • Bonasanit
    • Hexavibex
    • Hexermin
    • Hexobion
    • Pyridipca
    • Becilan
    • Beesix
    • Benadon
    • Pyridoxine chloride
    • Pydox
    • Campoviton 6
    • Adermine hydrochloride
    • Hexabetalin
    • Aderoxin
    • Godabion
    • Paxadon
    • Pyridox
    • 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride
    • Aderomine hydrochloride
    • Hexabione hydrochloride
    • Pyridoxin hydrochloride
    • Hexa-Betalin (R)
    • Pyridoxinium chloride
    • Pyridoxinum hydrochloricum
    • Rodex (R)
    • 4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride
    • Pyridoxol, hydrochloride
    • Bendectin
    • Pyridoxine monohydrochloride
    • PN HCl
    • VibeX
    • 5-Hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride
    • Pyridoxine, hydrochloride
    • Pyridoxine (hydrochloride)
    • MFCD00012807
    • CCRIS 1903
    • Clorhidrato de piridoxina
    • HSDB 1212
    • 2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine hydrochloride
    • EINECS 200-386-2
    • UNII-68Y4CF58BV
    • NSC 36225
    • NSC-36225
    • 5-Hydroxy-6-methyl-3,4-pyridinedicarbinol hydrochloride
    • 68Y4CF58BV
    • DTXSID1040792
    • CHEBI:30961
    • AI3-19016
    • 3-Hydroxy-4,5-dimethylol-alpha-picoline hydrochloride
    • 5-Hydroxy-6-methyl-3,4-pyridinedimethanol, hydrochloride
    • (5-hydroxy-6-methylpyridine-3,4-diyl)dimethanol hydrochloride
    • 3-Hydroxy-4,5-dihydroxymethyl-2-methylpyridine hydrochloride
    • Adermin hydrochloride
    • 8064-77-5
    • 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol;hydrochloride
    • DTXCID4010780
    • 4,5-Bis(hydroxymethyl)-3-hydroxy-2-methylpyridine hydrochloride
    • Pyridoxine hydrogen chloride
    • Pyridoxine hydrochloride [USP:JAN]
    • Spondylonal
    • TPN COMPONENT PYRIDOXINE HYDROCHLORIDE
    • BONJESTA COMPONENT PYRIDOXINE HYDROCHLORIDE
    • DICLEGIS COMPONENT PYRIDOXINE HYDROCHLORIDE
    • BENDECTIN COMPONENT PYRIDOXINE HYDROCHLORIDE
    • DICLECTIN COMPONENT PYRIDOXINE HYDROCHLORIDE
    • Pyridoxin hydrochloride (Vitamin B6 hydrochloride)
    • Pyridoxol (hydrochloride);Vitamin B6 (hydrochloride)
    • 4,5-bis(hydroxymethyl)-2-methyl-3-pyridinol hydrochloride
    • Pyridoxine hydrochloride (USP:JAN)
    • 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride (1:1)
    • PYRIDOXINE HYDROCHLORIDE (MART.)
    • PYRIDOXINE HYDROCHLORIDE [MART.]
    • PYRIDOXINE HYDROCHLORIDE (USP-RS)
    • PYRIDOXINE HYDROCHLORIDE [USP-RS]
    • Pyridoxinum hydrochloricum (Hungarian)
    • SMR000674613
    • Hexa-betalin (TN)
    • NSC36225
    • component of Alestrol
    • PYRIDOXINE HYDROCHLORIDE (EP IMPURITY)
    • PYRIDOXINE HYDROCHLORIDE [EP IMPURITY]
    • Tex Six T.R.
    • PYRIDOXINE HYDROCHLORIDE (EP MONOGRAPH)
    • PYRIDOXINE HYDROCHLORIDE (USP MONOGRAPH)
    • PYRIDOXINE HYDROCHLORIDE [EP MONOGRAPH]
    • PYRIDOXINE HYDROCHLORIDE [USP MONOGRAPH]
    • NCGC00164317-01
    • Vitamin B6-hydrochloride
    • Vitamin B6, hydrochloride
    • Pyridoxine hydrochloride [JAN]
    • CitraNatalB-Calm
    • Prestwick_925
    • Rodex(R)
    • PYRIDOXINE HCI
    • B-6 Pyridoxine HCL
    • Pyridoxini hydrochloridum
    • SCHEMBL42293
    • MLS001074329
    • MLS002153915
    • PYRIDOXINE HCL [VANDF]
    • Pyridoxine hydrochloride, 98%
    • 3-Hydroxy-4,5-dimethylol-.alpha.-picoline hydrochloride
    • CHEMBL1200756
    • HY-N0682R
    • HMS1569N08
    • HY-N0682
    • PXB92112
    • Tox21_302476
    • PYRIDOXINE HYDROCHLORIDE [MI]
    • s3113
    • 3-Hydroxy-4,5-Dimethylol-Alpha-Pic
    • Pyridoxine hydrochloride (JP17/USP)
    • PYRIDOXINE HYDROCHLORIDE [FCC]
    • AKOS015891679
    • Pyridoxine (hydrochloride) (Standard)
    • CCG-220623
    • CS-W020418
    • FP27320
    • PYRIDOXINE HYDROCHLORIDE [HSDB]
    • 3, 5-hydroxy-6-methyl-, hydrochloride

  • Applications

    Pyridoxine Hydrochloride (CAS 58-56-0) is primarily used as a vitamin B6 source in pharmaceutical and nutraceutical formulations, appearing in oral tablets, capsules, and liquid supplements. It is also employed for the fortification of foods and beverages to help meet daily intake targets. In animal nutrition, it serves as a feed additive to supply vitamin B6 for livestock and poultry. In cosmetics and personal care, it is used as a nutrient ingredient in topical and hair/skin formulations to support formulation stability and product performance. In research and diagnostics, pyridoxine hydrochloride can function as a biochemical reagent or cofactor in enzyme assays and laboratory media.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.84
    methanol 25.2
    isopropanol 1.92
    water 183.83
    ethyl acetate 0.32
    n-propanol 3.51
    acetone 0.33
    n-butanol 2.55
    acetonitrile 0.46
    DMF 53.48
    toluene 0.07
    isobutanol 1.69
    1,4-dioxane 3.28
    methyl acetate 0.34
    THF 4.38
    2-butanone 0.44
    n-pentanol 2.81
    sec-butanol 1.63
    n-hexane 0.12
    ethylene glycol 68.76
    NMP 51.91
    cyclohexane 0.12
    DMSO 174.83
    n-butyl acetate 0.66
    n-octanol 1.99
    chloroform 0.7
    n-propyl acetate 0.48
    acetic acid 6.07
    dichloromethane 1.62
    cyclohexanone 2.35
    propylene glycol 9.99
    isopropyl acetate 0.24
    DMAc 37.22
    2-ethoxyethanol 21.42
    isopentanol 1.76
    n-heptane 0.3
    ethyl formate 1.42
    1,2-dichloroethane 1.49
    n-hexanol 2.93
    2-methoxyethanol 44.01
    isobutyl acetate 0.24
    tetrachloromethane 0.66
    n-pentyl acetate 1.01
    transcutol 10.44
    n-heptanol 3.66
    ethylbenzene 0.19
    MIBK 0.44
    2-propoxyethanol 14.83
    tert-butanol 2.44
    MTBE 0.32
    2-butoxyethanol 9.88
    propionic acid 2.52
    o-xylene 0.29
    formic acid 100.35
    diethyl ether 0.37
    m-xylene 0.22
    p-xylene 0.24
    chlorobenzene 0.14
    dimethyl carbonate 0.86
    n-octane 0.18
    formamide 77.23
    cyclopentanone 2.97
    2-pentanone 0.46
    anisole 0.51
    cyclopentyl methyl ether 1.25
    gamma-butyrolactone 5.84
    1-methoxy-2-propanol 13.76
    pyridine 0.92
    3-pentanone 0.47
    furfural 10.35
    n-dodecane 0.1
    diethylene glycol 41.28
    diisopropyl ether 0.15
    tert-amyl alcohol 2.12
    acetylacetone 0.67
    n-hexadecane 0.11
    acetophenone 1.29
    methyl propionate 0.74
    isopentyl acetate 0.63
    trichloroethylene 1.36
    n-nonanol 1.99
    cyclohexanol 1.9
    benzyl alcohol 2.17
    2-ethylhexanol 1.59
    isooctanol 2.55
    dipropyl ether 0.99
    1,2-dichlorobenzene 0.48
    ethyl lactate 2.58
    propylene carbonate 2.18
    n-methylformamide 22.61
    2-pentanol 0.95
    n-pentane 0.1
    1-propoxy-2-propanol 6.26
    1-methoxy-2-propyl acetate 1.71
    2-(2-methoxypropoxy) propanol 6.11
    mesitylene 0.28
    ε-caprolactone 3.06
    p-cymene 0.54
    epichlorohydrin 5.59
    1,1,1-trichloroethane 0.35
    2-aminoethanol 39.97
    morpholine-4-carbaldehyde 32.9
    sulfolane 32.94
    2,2,4-trimethylpentane 0.07
    2-methyltetrahydrofuran 1.42
    n-hexyl acetate 1.21
    isooctane 0.04
    2-(2-butoxyethoxy)ethanol 8.88
    sec-butyl acetate 0.24
    tert-butyl acetate 0.39
    decalin 0.1
    glycerin 53.82
    diglyme 14.13
    acrylic acid 4.23
    isopropyl myristate 0.47
    n-butyric acid 2.46
    acetyl acetate 0.26
    di(2-ethylhexyl) phthalate 1.63
    ethyl propionate 0.56
    nitromethane 5.71
    1,2-diethoxyethane 1.32
    benzonitrile 0.83
    trioctyl phosphate 1.63
    1-bromopropane 0.48
    gamma-valerolactone 11.22
    n-decanol 1.44
    triethyl phosphate 1.31
    4-methyl-2-pentanol 0.72
    propionitrile 0.68
    vinylene carbonate 2.28
    1,1,2-trichlorotrifluoroethane 20.15
    DMS 1.02
    cumene 0.3
    2-octanol 1.61
    2-hexanone 0.65
    octyl acetate 0.83
    limonene 0.66
    1,2-dimethoxyethane 12.5
    ethyl orthosilicate 1.23
    tributyl phosphate 1.19
    diacetone alcohol 2.86
    N,N-dimethylaniline 1.34
    acrylonitrile 1.42
    aniline 0.5
    1,3-propanediol 26.64
    bromobenzene 0.1
    dibromomethane 0.87
    1,1,2,2-tetrachloroethane 2.05
    2-methyl-cyclohexyl acetate 1.14
    tetrabutyl urea 2.52
    diisobutyl methanol 0.9
    2-phenylethanol 2.49
    styrene 0.12
    dioctyl adipate 1.08
    dimethyl sulfate 5.49
    ethyl butyrate 0.75
    methyl lactate 4.47
    butyl lactate 2.77
    diethyl carbonate 0.63
    propanediol butyl ether 7.95
    triethyl orthoformate 1.05
    p-tert-butyltoluene 0.51
    methyl 4-tert-butylbenzoate 3.46
    morpholine 6.53
    tert-butylamine 0.97
    n-dodecanol 1.0
    dimethoxymethane 8.29
    ethylene carbonate 1.67
    cyrene 13.31
    2-ethoxyethyl acetate 1.63
    2-ethylhexyl acetate 0.57
    1,2,4-trichlorobenzene 0.63
    4-methylpyridine 0.67
    dibutyl ether 0.56
    2,6-dimethyl-4-heptanol 0.9
    DEF 3.8
    dimethyl isosorbide 9.0
    tetrachloroethylene 2.45
    eugenol 5.66
    triacetin 1.58
    span 80 5.76
    1,4-butanediol 15.91
    1,1-dichloroethane 0.27
    2-methyl-1-pentanol 1.96
    methyl formate 8.2
    2-methyl-1-butanol 1.84
    n-decane 0.16
    butyronitrile 0.68
    3,7-dimethyl-1-octanol 1.16
    1-chlorooctane 0.46
    1-chlorotetradecane 0.21
    n-nonane 0.16
    undecane 0.12
    tert-butylcyclohexane 0.08
    cyclooctane 0.09
    cyclopentanol 3.05
    tetrahydropyran 0.82
    tert-amyl methyl ether 0.51
    2,5,8-trioxanonane 11.38
    1-hexene 0.23
    2-isopropoxyethanol 6.85
    2,2,2-trifluoroethanol 10.26
    methyl butyrate 0.93

    Scent© AI

1 4

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IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction