Pyridinolcarbamate

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  • Identifiers

    CAS number
    1882-26-4

    Molecular formula
    C11H15N3O4

    SMILES
    CNC(=O)OCC1=NC(=CC=C1)COC(=O)NC

    Safety labels

  • Odor profile

    Fragrance
    Odorless 50.49%
    Savory 36.87%
    Meaty 36.13%
    Roasted 35.19%
    Sulfurous 31.62%
    Cheesy 27.14%
    Cooked 26.3%
    Milky 22.44%
    Grape 21.82%
    Fruity 20.7%

     

    Flavor
    Fruity 59.42%
    Odorless 34.78%
    Grape 30.04%
    Mild 27.78%
    Very mild 24.68%
    Musty 23.1%
    Yeast 21.11%
    Cooked 20.49%
    Strawberry 20.35%
    Orange flower 20.35%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.2

    pKa est.
    5.23 (weak acid)

    Molecular weight
    253.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    156°C

    Flash point

    • 208.13 ˚C est.

  • Synonyms

    • Pyridinolcarbamate
    • RefChem:389248
    • 2,6-Pyridinedimethanol-bis-(N-methylcarbamate)
    • Pyricarbate
    • 1882-26-4
    • pyridinol carbamate
    • Anginin
    • Angioxine
    • Parmidine
    • Prodectin
    • Colesterinex
    • Duvaline
    • Vasoverin
    • Atover
    • Movecil
    • Vasocil
    • Parmidine R
    • Aterosan
    • Cicloven
    • Ravenil
    • Sospitan
    • Vasagin
    • Pyricarbate [INN]
    • Sospitan 500
    • Piridinol carbamato
    • pyridine-2,6-diyldi(methylene) bis(methylcarbamate)
    • H-3749
    • [6-(methylcarbamoyloxymethyl)pyridin-2-yl]methyl N-methylcarbamate
    • MFCD00473700
    • 2,6-Pyridinedimethanol, bis(methylcarbamate) (ester)
    • 2,6-Pyridinediyldimethylene bis(methylcarbamate)
    • Methylcarbamic acid 2,6-pyridinediyldimethylene ester
    • Carbamic acid, methyl-, 2,6-pyridinediyldimethylene ester
    • Veranterol
    • DTXSID5045708
    • Vasapril
    • (6-{[(methylcarbamoyl)oxy]methyl}pyridin-2-yl)methyl N-methylcarbamate
    • Pyridine-2,6-diylbis(methylene) bis(methylcarbamate)
    • 81R511UV73
    • NCGC00074022-02
    • [6-(methylcarbamoyloxymethyl)-2-pyridyl]methyl N-methylcarbamate
    • Pyridinol carbamate (JAN)
    • PYRIDINOL CARBAMATE [JAN]
    • Prodectine
    • Pyricarbato
    • Pyricarbatum
    • Parmidin
    • MLS000040427
    • Pyricarbatum [INN-Latin]
    • Pyricarbato [INN-Spanish]
    • Piridinol carbamato [Spanish]
    • SMR000045425
    • EINECS 217-538-9
    • BRN 1544252
    • piricarbato
    • UNII-81R511UV73
    • Angioxine (TN)
    • Anginin (TN)
    • PYRICARBATE [MART.]
    • Oprea1_494883
    • PYRICARBATE [WHO-DD]
    • 5-21-04-00441 (Beilstein Handbook Reference)
    • SCHEMBL253857
    • CHEMBL1620144
    • DTXCID3025708
    • PYRIDINOL CARBAMATE [MI]
    • BDBM55239
    • CHEBI:32075
    • cid_6602723
    • HMS1612N04
    • ALBB-014890
    • Tox21_110989
    • STL048564
    • AKOS001642843
    • CCG-110891
    • LS-04729
    • CAS-1882-26-4
    • NS00004979
    • D01396
    • H30916
    • 2,6-Pyridinedimethanol bis(methylcarbamate) ester
    • 2,6-PYRIDINEDIMETHANOL, BIS(METHYLCARBAMATE)
    • pyridine-2,6-diyldimethanediyl bis(methylcarbamate)
    • 2,6-PYRIDINYLENEBIS(METHYL-N-METHYLCARBAMATE)
    • Q27114774
    • (Pyridine-2,6-diyl)bis(methylene) bis(methylcarbamate)
    • 2,6-PYRIDINEDIMETHANOL BIS(METHYLCARBAMATE) (ESTER)
    • [6-({[(methylamino)carbonyl]oxy}methyl)-2-pyridinyl]methyl methylcarbamate
    • [6-(methylcarbamoyloxymethyl)pyridin-2-yl]methyl N-methylcarbamate;hydrochloride
    • N-methylcarbamic acid [6-(methylcarbamoyloxymethyl)-2-pyridinyl]methyl ester;hydrochloride
    • N-methylcarbamic acid [6-(methylcarbamoyloxymethyl)-2-pyridyl]methyl ester;hydrochloride
    • 1882-26-4

  • Applications

    Pyridinolcarbamate is primarily used as an intermediate in organic synthesis, serving as a building block for carbamate-containing compounds in pharmaceutical and agrochemical development. It is also considered a precursor for specialty chemicals and pyridine-based polymers. In industrial manufacturing, it may be evaluated as an input material for formulation components bearing the carbamate group and is used in specialty coatings and adhesives formulations. Additionally, it is employed in research and development to explore reaction pathways and as a reference substrate in catalysis studies.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 32.86
    methanol 61.59
    isopropanol 23.37
    water 8.38
    ethyl acetate 37.56
    n-propanol 20.53
    acetone 74.19
    n-butanol 18.04
    acetonitrile 54.79
    DMF 254.01
    toluene 12.86
    isobutanol 14.9
    1,4-dioxane 58.23
    methyl acetate 46.52
    THF 93.96
    2-butanone 50.33
    n-pentanol 14.93
    sec-butanol 22.46
    n-hexane 0.86
    ethylene glycol 14.36
    NMP 190.57
    cyclohexane 1.09
    DMSO 396.1
    n-butyl acetate 13.38
    n-octanol 2.61
    chloroform 40.37
    n-propyl acetate 16.18
    acetic acid 134.18
    dichloromethane 69.69
    cyclohexanone 57.27
    propylene glycol 12.09
    isopropyl acetate 16.54
    DMAc 404.17
    2-ethoxyethanol 68.01
    isopentanol 16.67
    n-heptane 0.59
    ethyl formate 40.59
    1,2-dichloroethane 44.66
    n-hexanol 6.35
    2-methoxyethanol 108.68
    isobutyl acetate 6.24
    tetrachloromethane 4.25
    n-pentyl acetate 6.47
    transcutol 65.09
    n-heptanol 4.02
    ethylbenzene 6.16
    MIBK 12.13
    2-propoxyethanol 32.76
    tert-butanol 29.79
    MTBE 19.3
    2-butoxyethanol 17.61
    propionic acid 34.48
    o-xylene 10.6
    formic acid 163.22
    diethyl ether 18.43
    m-xylene 6.23
    p-xylene 10.14
    chlorobenzene 15.62
    dimethyl carbonate 31.32
    n-octane 0.29
    formamide 306.42
    cyclopentanone 80.12
    2-pentanone 28.42
    anisole 19.76
    cyclopentyl methyl ether 24.08
    gamma-butyrolactone 108.65
    1-methoxy-2-propanol 48.03
    pyridine 81.56
    3-pentanone 25.93
    furfural 132.25
    n-dodecane 0.22
    diethylene glycol 42.37
    diisopropyl ether 3.34
    tert-amyl alcohol 29.38
    acetylacetone 43.49
    n-hexadecane 0.25
    acetophenone 28.1
    methyl propionate 38.98
    isopentyl acetate 12.02
    trichloroethylene 76.57
    n-nonanol 2.87
    cyclohexanol 17.67
    benzyl alcohol 27.08
    2-ethylhexanol 4.1
    isooctanol 3.5
    dipropyl ether 6.71
    1,2-dichlorobenzene 14.79
    ethyl lactate 14.09
    propylene carbonate 48.57
    n-methylformamide 112.89
    2-pentanol 10.51
    n-pentane 0.73
    1-propoxy-2-propanol 17.25
    1-methoxy-2-propyl acetate 20.65
    2-(2-methoxypropoxy) propanol 21.87
    mesitylene 3.53
    ε-caprolactone 49.69
    p-cymene 3.26
    epichlorohydrin 109.87
    1,1,1-trichloroethane 18.4
    2-aminoethanol 25.3
    morpholine-4-carbaldehyde 139.28
    sulfolane 137.22
    2,2,4-trimethylpentane 0.65
    2-methyltetrahydrofuran 53.65
    n-hexyl acetate 6.74
    isooctane 0.21
    2-(2-butoxyethoxy)ethanol 23.55
    sec-butyl acetate 9.51
    tert-butyl acetate 14.35
    decalin 0.77
    glycerin 31.74
    diglyme 60.37
    acrylic acid 45.78
    isopropyl myristate 3.08
    n-butyric acid 36.62
    acetyl acetate 26.92
    di(2-ethylhexyl) phthalate 6.63
    ethyl propionate 16.93
    nitromethane 258.5
    1,2-diethoxyethane 16.85
    benzonitrile 24.89
    trioctyl phosphate 3.59
    1-bromopropane 15.33
    gamma-valerolactone 125.78
    n-decanol 2.28
    triethyl phosphate 12.06
    4-methyl-2-pentanol 5.32
    propionitrile 28.42
    vinylene carbonate 45.74
    1,1,2-trichlorotrifluoroethane 93.17
    DMS 16.11
    cumene 3.8
    2-octanol 2.58
    2-hexanone 17.34
    octyl acetate 4.3
    limonene 3.89
    1,2-dimethoxyethane 91.49
    ethyl orthosilicate 10.89
    tributyl phosphate 5.24
    diacetone alcohol 26.63
    N,N-dimethylaniline 17.3
    acrylonitrile 47.47
    aniline 33.05
    1,3-propanediol 37.43
    bromobenzene 13.14
    dibromomethane 33.82
    1,1,2,2-tetrachloroethane 57.76
    2-methyl-cyclohexyl acetate 10.65
    tetrabutyl urea 9.22
    diisobutyl methanol 2.91
    2-phenylethanol 14.77
    styrene 8.25
    dioctyl adipate 6.97
    dimethyl sulfate 69.06
    ethyl butyrate 13.96
    methyl lactate 29.03
    butyl lactate 8.53
    diethyl carbonate 13.06
    propanediol butyl ether 12.3
    triethyl orthoformate 12.75
    p-tert-butyltoluene 2.85
    methyl 4-tert-butylbenzoate 17.59
    morpholine 83.19
    tert-butylamine 11.4
    n-dodecanol 1.81
    dimethoxymethane 82.78
    ethylene carbonate 37.56
    cyrene 33.84
    2-ethoxyethyl acetate 15.01
    2-ethylhexyl acetate 9.12
    1,2,4-trichlorobenzene 21.31
    4-methylpyridine 68.78
    dibutyl ether 3.94
    2,6-dimethyl-4-heptanol 2.91
    DEF 66.05
    dimethyl isosorbide 35.45
    tetrachloroethylene 35.06
    eugenol 17.8
    triacetin 14.59
    span 80 12.37
    1,4-butanediol 19.12
    1,1-dichloroethane 24.77
    2-methyl-1-pentanol 15.15
    methyl formate 83.62
    2-methyl-1-butanol 16.74
    n-decane 0.35
    butyronitrile 24.99
    3,7-dimethyl-1-octanol 3.04
    1-chlorooctane 1.42
    1-chlorotetradecane 0.7
    n-nonane 0.31
    undecane 0.27
    tert-butylcyclohexane 0.53
    cyclooctane 0.43
    cyclopentanol 23.2
    tetrahydropyran 29.96
    tert-amyl methyl ether 17.6
    2,5,8-trioxanonane 41.17
    1-hexene 3.72
    2-isopropoxyethanol 33.0
    2,2,2-trifluoroethanol 68.15
    methyl butyrate 25.38

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction