Pyridine-2-Carbaldehyde

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  • Identifiers

    CAS number
    1121-60-4

    Molecular formula
    C6H5NO

    SMILES
    C1=CC=NC(=C1)C=O

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Nutty 73.21%
    Almond 52.12%
    Burnt 50.17%
    Roasted 45.24%
    Spicy 41.83%
    Pungent 39.42%
    Coffee 39.14%
    Musty 38.54%
    Caramellic 35.83%
    Bitter 35.51%

     

    Flavor
    Sulfur 40.44%
    Almond 35.74%
    Nutty 33.51%
    Bitter 29.8%
    Oily 29.71%
    Woody 26.8%
    Popcorn 25.93%
    Burnt sugar 25.08%
    Furfural 24.13%
    Fragrant 24.1%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.4

    pKa est.
    5.32 (weak acid)

    Molecular weight
    107.11 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    209°C

    Flash point

    • 77.8 ˚C est.

  • Synonyms

    • 2-Pyridinecarboxaldehyde
    • Picolinaldehyde
    • 1121-60-4
    • Pyridine-2-carbaldehyde
    • Pyridine-2-carboxaldehyde
    • 2-Formylpyridine
    • Pyridine-2-aldehyde
    • Picolinal
    • 2-Picolinaldehyde
    • 2-Pyridaldehyde
    • o-Nicotinaldehyde
    • Picolinic aldehyde
    • 2-Picolinealdehyde
    • Pyridinecarboxaldehyde
    • 2-Pyridylaldehyde
    • 2-Pyridylcarboxaldehyde
    • 2-Pyridinecarbaldehyde
    • 26445-06-7
    • 2-Pyridine carboxaldehyde
    • alpha-Picolinaldehyde
    • 2-pyridylformaldehyde
    • MFCD00006290
    • .alpha.-Picolinaldehyde
    • NSC 8951
    • 2-formyl-pyridine
    • 2-Pyridinealdehyde
    • KH86K8FHZ2
    • CHEBI:73012
    • NSC-8951
    • EINECS 214-333-6
    • AI3-33230
    • DTXSID1061522
    • EC 214-333-6
    • pyridine, 2-formyl-
    • formylpyridine
    • picolinealdehyde
    • 2Formylpyridine
    • oNicotinaldehyde
    • 2Pyridaldehyde
    • picolin aldehyde
    • 2Picolinaldehyde
    • 2Pyridylaldehyde
    • carbonyl-pyridine
    • picoline aldehyde
    • pyridine aldehyde
    • 2Picolinealdehyde
    • Pyridine2aldehyde
    • 2-formyl pyridine
    • Pyridinecarbaldehyde
    • 2-Pyridinecarboxaldehyde; 2-Formylpyridine; 2-Picolinaldehyde; 2-Pyridaldehyde; Picolinic Aldehyde; Pyridine-2-aldehyde
    • pyridincarboxaldehyde
    • 2-pyridine aldehyde
    • 2-pyridylcarbaldehyde
    • 2pyridylcarboxaldehyde
    • 2pyridinecarboxaldehyde
    • pyridine-carboxaldehyde
    • 2-pyridinecarboaldehyde
    • 2-pyridinecarboxaldeyde
    • pyridin-2-carbaldehyde
    • pyridin-2-yl-methanone
    • pyridine-2 carbaldehyde
    • pyridine-2-formaldehyde
    • Picolinaldehyde (8CI)
    • pyridine2-carboxaldehyde
    • 2-pyridyl carboxaldehyde
    • 2-pyridyl-carboxaldehyde
    • (pyridin-2-yl)methanone
    • 2-pyridine-carboxaldehyde
    • pyridine 2-carboxaldehyde
    • UNII-KH86K8FHZ2
    • SCHEMBL55278
    • SCHEMBL730714
    • 2-Pyridinecarboxaldehyde, 99%
    • CHEMBL274794
    • PYRIDIN-2-CARBOXALDEHYDE
    • DTXCID3033276
    • 2-Formylpyridine, Picolinaldehyde
    • NSC8951
    • Picolinaldehyde;Pyridine-2-aldehyde
    • BCP21804
    • BBL027574
    • STL146657
    • AKOS000119317
    • AB00680
    • AC-5098
    • CS-W007336
    • FP05593
    • PS-9301
    • DB-015971
    • NS00005186
    • P0425
    • EN300-18999
    • A20908
    • D77679
    • doi:10.14272/CSDSSGBPEUDDEE-UHFFFAOYSA-N.1
    • Q4596887
    • F2190-0594
    • Z104472152
    • Picolinaldehyde; 2-Pyridinecarbaldehyde; Pyridine-2-aldehyde
    • 214-333-6

  • Applications

    2-Pyridinecarboxaldehyde, a versatile building block in organic synthesis, serves as a precursor for pyridine-containing heterocycles and intermediates in pharmaceutical or agrochemical development. It provides a reactive aldehyde handle for formylation and for forming Schiff bases with amines, enabling the preparation of chelating ligands such as pyridyl-imine derivatives and related metal complexes used in catalysis and materials science. In fragrance and flavor chemistry, it may be used as an aroma intermediate or precursor to pyridine-based odorants. It is also employed in research settings to develop coordination chemistry tools, functional materials, and sensors that rely on pyridine-derived ligands.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 69.72
    methanol 142.43
    isopropanol 36.67
    water 6.09
    ethyl acetate 137.25
    n-propanol 59.3
    acetone 109.44
    n-butanol 45.18
    acetonitrile 133.96
    DMF 606.22
    toluene 51.9
    isobutanol 38.74
    1,4-dioxane 218.28
    methyl acetate 163.06
    THF 123.84
    2-butanone 110.16
    n-pentanol 36.48
    sec-butanol 32.7
    n-hexane 2.21
    ethylene glycol 69.03
    NMP 304.23
    cyclohexane 4.85
    DMSO 549.14
    n-butyl acetate 84.34
    n-octanol 23.66
    chloroform 191.52
    n-propyl acetate 75.95
    acetic acid 178.52
    dichloromethane 223.51
    cyclohexanone 140.5
    propylene glycol 30.35
    isopropyl acetate 50.38
    DMAc 389.8
    2-ethoxyethanol 107.64
    isopentanol 41.95
    n-heptane 4.89
    ethyl formate 110.89
    1,2-dichloroethane 202.87
    n-hexanol 45.76
    2-methoxyethanol 206.77
    isobutyl acetate 41.06
    tetrachloromethane 27.2
    n-pentyl acetate 41.89
    transcutol 771.03
    n-heptanol 21.92
    ethylbenzene 22.3
    MIBK 41.8
    2-propoxyethanol 120.99
    tert-butanol 53.43
    MTBE 38.99
    2-butoxyethanol 71.52
    propionic acid 140.82
    o-xylene 41.45
    formic acid 177.78
    diethyl ether 55.84
    m-xylene 36.88
    p-xylene 31.14
    chlorobenzene 114.96
    dimethyl carbonate 89.83
    n-octane 1.88
    formamide 324.02
    cyclopentanone 143.26
    2-pentanone 74.24
    anisole 75.72
    cyclopentyl methyl ether 61.24
    gamma-butyrolactone 270.78
    1-methoxy-2-propanol 108.19
    pyridine 244.25
    3-pentanone 72.74
    furfural 366.93
    n-dodecane 2.15
    diethylene glycol 148.73
    diisopropyl ether 13.03
    tert-amyl alcohol 40.21
    acetylacetone 108.09
    n-hexadecane 2.46
    acetophenone 87.54
    methyl propionate 129.01
    isopentyl acetate 59.98
    trichloroethylene 375.6
    n-nonanol 22.67
    cyclohexanol 44.18
    benzyl alcohol 59.96
    2-ethylhexanol 31.26
    isooctanol 19.85
    dipropyl ether 40.1
    1,2-dichlorobenzene 105.12
    ethyl lactate 49.6
    propylene carbonate 142.7
    n-methylformamide 311.42
    2-pentanol 25.99
    n-pentane 2.57
    1-propoxy-2-propanol 80.12
    1-methoxy-2-propyl acetate 91.56
    2-(2-methoxypropoxy) propanol 97.67
    mesitylene 21.41
    ε-caprolactone 142.6
    p-cymene 19.97
    epichlorohydrin 251.99
    1,1,1-trichloroethane 113.58
    2-aminoethanol 78.42
    morpholine-4-carbaldehyde 368.78
    sulfolane 315.28
    2,2,4-trimethylpentane 2.55
    2-methyltetrahydrofuran 81.3
    n-hexyl acetate 54.6
    isooctane 2.11
    2-(2-butoxyethoxy)ethanol 141.02
    sec-butyl acetate 40.62
    tert-butyl acetate 47.38
    decalin 4.45
    glycerin 84.67
    diglyme 317.24
    acrylic acid 173.86
    isopropyl myristate 22.02
    n-butyric acid 125.1
    acetyl acetate 82.64
    di(2-ethylhexyl) phthalate 27.3
    ethyl propionate 67.57
    nitromethane 494.38
    1,2-diethoxyethane 134.16
    benzonitrile 114.72
    trioctyl phosphate 19.04
    1-bromopropane 63.2
    gamma-valerolactone 270.63
    n-decanol 18.15
    triethyl phosphate 34.46
    4-methyl-2-pentanol 19.89
    propionitrile 121.82
    vinylene carbonate 175.1
    1,1,2-trichlorotrifluoroethane 231.89
    DMS 93.44
    cumene 17.64
    2-octanol 14.26
    2-hexanone 58.04
    octyl acetate 29.26
    limonene 26.0
    1,2-dimethoxyethane 205.39
    ethyl orthosilicate 30.03
    tributyl phosphate 27.15
    diacetone alcohol 72.79
    N,N-dimethylaniline 49.77
    acrylonitrile 217.25
    aniline 94.93
    1,3-propanediol 87.84
    bromobenzene 98.95
    dibromomethane 116.83
    1,1,2,2-tetrachloroethane 257.98
    2-methyl-cyclohexyl acetate 40.62
    tetrabutyl urea 42.76
    diisobutyl methanol 20.61
    2-phenylethanol 63.52
    styrene 34.15
    dioctyl adipate 40.42
    dimethyl sulfate 161.92
    ethyl butyrate 65.41
    methyl lactate 83.9
    butyl lactate 47.22
    diethyl carbonate 52.5
    propanediol butyl ether 68.5
    triethyl orthoformate 45.46
    p-tert-butyltoluene 17.62
    methyl 4-tert-butylbenzoate 59.38
    morpholine 208.21
    tert-butylamine 29.21
    n-dodecanol 14.44
    dimethoxymethane 185.33
    ethylene carbonate 126.11
    cyrene 77.65
    2-ethoxyethyl acetate 87.07
    2-ethylhexyl acetate 46.07
    1,2,4-trichlorobenzene 123.05
    4-methylpyridine 181.28
    dibutyl ether 34.17
    2,6-dimethyl-4-heptanol 20.61
    DEF 186.48
    dimethyl isosorbide 146.05
    tetrachloroethylene 187.26
    eugenol 73.77
    triacetin 79.47
    span 80 61.61
    1,4-butanediol 38.24
    1,1-dichloroethane 119.07
    2-methyl-1-pentanol 33.99
    methyl formate 225.96
    2-methyl-1-butanol 36.45
    n-decane 2.94
    butyronitrile 84.85
    3,7-dimethyl-1-octanol 28.54
    1-chlorooctane 15.82
    1-chlorotetradecane 7.53
    n-nonane 2.61
    undecane 2.49
    tert-butylcyclohexane 4.02
    cyclooctane 1.97
    cyclopentanol 45.32
    tetrahydropyran 101.36
    tert-amyl methyl ether 33.63
    2,5,8-trioxanonane 215.04
    1-hexene 11.54
    2-isopropoxyethanol 62.52
    2,2,2-trifluoroethanol 110.3
    methyl butyrate 96.67

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction