Pyrazinemethanol

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  • Identifiers

    CAS number
    6705-33-5

    Molecular formula
    C5H6N2O

    SMILES
    C1=CN=C(C=N1)CO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Nutty 78.29%
    Roasted 71.02%
    Hazelnut 48.78%
    Popcorn 45.38%
    Coffee 45.11%
    Musty 43.5%
    Earthy 43.24%
    Meaty 40.71%
    Almond 40.51%
    Cocoa 40.33%

     

    Flavor
    Bitter 53.33%
    Nutty 47.22%
    Coffee 46.22%
    Musty 41.41%
    Roasted 39.21%
    Fatty 38.01%
    Chocolate 34.47%
    Bread 34.05%
    Roast 32.79%
    Popcorn 31.95%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    -1.0

    pKa est.
    5.11 (weak acid)

    Molecular weight
    110.11 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very slow

    Boiling point est.
    281°C

    Flash point

    • 130.54 ˚C est.

  • Synonyms

    • 6705-33-5
    • pyrazin-2-ylmethanol
    • Pyrazinemethanol
    • 2-PYRAZINEMETHANOL
    • 2-Hydroxymethylpyrazine
    • 2-(Hydroxymethyl)pyrazine
    • BRN 0110057
    • UNII-C27Z7QI77D
    • C27Z7QI77D
    • (HYDROXYMETHYL)PYRAZINE
    • DTXSID00217338
    • 5-23-11-00154 (Beilstein Handbook Reference)
    • RefChem:177451
    • DTXCID00139829
    • 2-Pyrazinylmethanol
    • (pyrazin-2-yl)methanol
    • (2-Hydroxymethyl)pyrazine
    • Pyrazin-2-yl-methanol
    • MFCD01693938
    • 2-pyrazinemethanol hydrochloride
    • pyrazin-2-yl methanol
    • pyrazin-2-ylmethan-1-ol
    • SCHEMBL284256
    • SCHEMBL344601
    • orb3030313
    • SCHEMBL2445401
    • SCHEMBL4933630
    • SCHEMBL6360852
    • 2-pyrazinylmethanol, AldrichCPR
    • SCHEMBL29408010
    • ALBB-022758
    • SBB054824
    • AKOS009358705
    • CS-W018634
    • PB21779
    • PS-3553
    • BL002777
    • BP-11245
    • SY004183
    • DB-013467
    • P2129
    • EN300-81801
    • 705P335
    • F067738
    • Q27275091
    • 6705-33-5

  • Applications

    Pyrazinemethanol (CAS 6705-33-5) is a versatile organic intermediate used as a building block in the synthesis of pyrazine-containing compounds. In industry, it is commonly explored as a precursor for fragrance- and flavor-related pyrazine materials used in perfumery and flavor applications; it also serves as a building block for specialty polymers and coatings with pyrazine motifs; and it is evaluated as an intermediate in pharmaceutical and agrochemical synthesis. In cosmetics and personal care, it may appear as a fragrance-related ingredient, subject to formulation rules and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 51.16
    methanol 89.92
    isopropanol 35.23
    water 81.0
    ethyl acetate 28.05
    n-propanol 45.69
    acetone 46.34
    n-butanol 33.01
    acetonitrile 41.59
    DMF 346.47
    toluene 10.87
    isobutanol 34.67
    1,4-dioxane 91.34
    methyl acetate 38.79
    THF 91.46
    2-butanone 43.15
    n-pentanol 23.48
    sec-butanol 29.07
    n-hexane 0.68
    ethylene glycol 53.22
    NMP 368.93
    cyclohexane 1.13
    DMSO 615.32
    n-butyl acetate 24.48
    n-octanol 7.83
    chloroform 42.6
    n-propyl acetate 18.59
    acetic acid 131.07
    dichloromethane 60.74
    cyclohexanone 86.01
    propylene glycol 30.49
    isopropyl acetate 13.32
    DMAc 300.48
    2-ethoxyethanol 72.03
    isopentanol 25.81
    n-heptane 2.28
    ethyl formate 51.01
    1,2-dichloroethane 43.04
    n-hexanol 23.39
    2-methoxyethanol 128.06
    isobutyl acetate 9.74
    tetrachloromethane 12.09
    n-pentyl acetate 12.46
    transcutol 81.48
    n-heptanol 12.98
    ethylbenzene 3.91
    MIBK 15.37
    2-propoxyethanol 60.53
    tert-butanol 42.58
    MTBE 17.41
    2-butoxyethanol 33.68
    propionic acid 78.78
    o-xylene 11.57
    formic acid 211.07
    diethyl ether 10.79
    m-xylene 10.14
    p-xylene 6.8
    chlorobenzene 22.34
    dimethyl carbonate 18.9
    n-octane 0.75
    formamide 197.99
    cyclopentanone 114.57
    2-pentanone 27.4
    anisole 14.32
    cyclopentyl methyl ether 38.77
    gamma-butyrolactone 192.89
    1-methoxy-2-propanol 69.21
    pyridine 83.95
    3-pentanone 23.11
    furfural 201.08
    n-dodecane 0.62
    diethylene glycol 78.64
    diisopropyl ether 3.82
    tert-amyl alcohol 35.37
    acetylacetone 31.74
    n-hexadecane 0.68
    acetophenone 25.15
    methyl propionate 36.81
    isopentyl acetate 17.29
    trichloroethylene 88.84
    n-nonanol 7.35
    cyclohexanol 33.11
    benzyl alcohol 25.55
    2-ethylhexanol 13.26
    isooctanol 10.79
    dipropyl ether 13.57
    1,2-dichlorobenzene 21.37
    ethyl lactate 20.46
    propylene carbonate 72.73
    n-methylformamide 203.81
    2-pentanol 15.63
    n-pentane 1.02
    1-propoxy-2-propanol 41.26
    1-methoxy-2-propyl acetate 27.82
    2-(2-methoxypropoxy) propanol 28.35
    mesitylene 6.61
    ε-caprolactone 77.36
    p-cymene 7.7
    epichlorohydrin 142.73
    1,1,1-trichloroethane 26.99
    2-aminoethanol 72.4
    morpholine-4-carbaldehyde 227.23
    sulfolane 274.37
    2,2,4-trimethylpentane 1.29
    2-methyltetrahydrofuran 66.34
    n-hexyl acetate 12.46
    isooctane 0.9
    2-(2-butoxyethoxy)ethanol 34.69
    sec-butyl acetate 9.74
    tert-butyl acetate 13.75
    decalin 1.06
    glycerin 83.01
    diglyme 74.85
    acrylic acid 87.2
    isopropyl myristate 5.38
    n-butyric acid 75.93
    acetyl acetate 16.71
    di(2-ethylhexyl) phthalate 9.64
    ethyl propionate 15.9
    nitromethane 210.7
    1,2-diethoxyethane 18.01
    benzonitrile 40.9
    trioctyl phosphate 8.05
    1-bromopropane 15.42
    gamma-valerolactone 191.93
    n-decanol 5.85
    triethyl phosphate 13.69
    4-methyl-2-pentanol 9.7
    propionitrile 37.7
    vinylene carbonate 70.32
    1,1,2-trichlorotrifluoroethane 126.06
    DMS 15.55
    cumene 4.31
    2-octanol 6.94
    2-hexanone 17.14
    octyl acetate 7.94
    limonene 10.9
    1,2-dimethoxyethane 78.73
    ethyl orthosilicate 12.04
    tributyl phosphate 9.47
    diacetone alcohol 35.22
    N,N-dimethylaniline 16.48
    acrylonitrile 72.73
    aniline 37.2
    1,3-propanediol 71.19
    bromobenzene 16.0
    dibromomethane 33.35
    1,1,2,2-tetrachloroethane 61.12
    2-methyl-cyclohexyl acetate 13.62
    tetrabutyl urea 16.11
    diisobutyl methanol 8.7
    2-phenylethanol 23.51
    styrene 4.87
    dioctyl adipate 10.24
    dimethyl sulfate 66.47
    ethyl butyrate 19.02
    methyl lactate 39.98
    butyl lactate 18.16
    diethyl carbonate 13.25
    propanediol butyl ether 26.03
    triethyl orthoformate 15.31
    p-tert-butyltoluene 7.03
    methyl 4-tert-butylbenzoate 24.67
    morpholine 123.92
    tert-butylamine 17.48
    n-dodecanol 4.66
    dimethoxymethane 58.48
    ethylene carbonate 52.81
    cyrene 46.83
    2-ethoxyethyl acetate 19.61
    2-ethylhexyl acetate 13.15
    1,2,4-trichlorobenzene 28.67
    4-methylpyridine 77.69
    dibutyl ether 6.07
    2,6-dimethyl-4-heptanol 8.7
    DEF 86.6
    dimethyl isosorbide 51.71
    tetrachloroethylene 45.28
    eugenol 27.85
    triacetin 17.69
    span 80 21.38
    1,4-butanediol 38.36
    1,1-dichloroethane 28.81
    2-methyl-1-pentanol 19.06
    methyl formate 113.12
    2-methyl-1-butanol 28.69
    n-decane 0.9
    butyronitrile 34.99
    3,7-dimethyl-1-octanol 9.07
    1-chlorooctane 3.86
    1-chlorotetradecane 1.82
    n-nonane 0.82
    undecane 0.73
    tert-butylcyclohexane 1.16
    cyclooctane 0.68
    cyclopentanol 55.44
    tetrahydropyran 39.32
    tert-amyl methyl ether 15.88
    2,5,8-trioxanonane 52.89
    1-hexene 2.67
    2-isopropoxyethanol 36.17
    2,2,2-trifluoroethanol 90.99
    methyl butyrate 26.95

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction