Pyrazine, 2-methyl-6-propyl-

Overview IFRA Request a quote

  • Identifiers

    CAS number
    29444-46-0

    Molecular formula
    C8H12N2

    SMILES
    CCCC1=NC(=CN=C1)C

    Safety labels

  • Odor profile

    Fragrance
    Nutty 66.22%
    Roasted 65.27%
    Earthy 50.62%
    Hazelnut 48.84%
    Cocoa 46.25%
    Green 42.92%
    Musty 41.56%
    Burnt 41.31%
    Potato 38.72%
    Coffee 38.36%

     

    Flavor
    Roasted 53.5%
    Nutty 51.31%
    Earthy 46.77%
    Potato 39.68%
    Green 38.64%
    Meaty 37.28%
    Musty 36.92%
    Vegetable 36.79%
    Coffee 35.66%
    Cocoa 33.89%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.4

    pKa est.
    4.36 (weak acid)

    Molecular weight
    136.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    200°C

    Flash point

    • 77.45 ˚C est.

  • Synonyms

    • 2-Methyl-6-propylpyrazine
    • Pyrazine, 2-methyl-6-propyl-
    • 29444-46-0
    • URR3O3MU9V
    • EINECS 249-631-5
    • UNII-URR3O3MU9V
    • 6-Methyl-2-propylpyrazine
    • DTXSID0067470
    • RefChem:177446
    • DTXCID0037998
    • RMVVGACFOGJRMQ-UHFFFAOYSA-N
    • 2-Methyl-6-propylpyrazin
    • SCHEMBL295054
    • SCHEMBL295055
    • SCHEMBL2407821
    • SCHEMBL30480965
    • NS00028699
    • 29444-46-0

  • Applications

    Pyrazine, 2-methyl-6-propyl-, CAS 29444-46-0, is a fragrance and aroma compound used in perfumery and cosmetics, providing roasted and nutty notes with a savory character. In the food industry, it is evaluated as a flavor ingredient for savory profiles such as roasted or meat-like notes. In cosmetics and personal care, it serves as a fragrance ingredient; in household products and cleaners, it is used to impart scent. It may function as an intermediate in the synthesis of more complex fragrance and flavor chemicals for industrial manufacturing. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 331.17
    methanol 479.0
    isopropanol 184.01
    water 1.41
    ethyl acetate 165.76
    n-propanol 244.27
    acetone 240.43
    n-butanol 244.19
    acetonitrile 189.57
    DMF 435.91
    toluene 171.41
    isobutanol 196.75
    1,4-dioxane 346.63
    methyl acetate 154.39
    THF 539.49
    2-butanone 190.34
    n-pentanol 207.15
    sec-butanol 189.52
    n-hexane 59.68
    ethylene glycol 84.88
    NMP 447.1
    cyclohexane 119.79
    DMSO 438.79
    n-butyl acetate 350.07
    n-octanol 136.42
    chloroform 1019.91
    n-propyl acetate 132.32
    acetic acid 390.63
    dichloromethane 971.96
    cyclohexanone 419.45
    propylene glycol 96.92
    isopropyl acetate 97.78
    DMAc 307.28
    2-ethoxyethanol 180.84
    isopentanol 189.44
    n-heptane 91.24
    ethyl formate 207.25
    1,2-dichloroethane 411.81
    n-hexanol 362.47
    2-methoxyethanol 289.42
    isobutyl acetate 103.33
    tetrachloromethane 194.26
    n-pentyl acetate 143.24
    transcutol 478.71
    n-heptanol 137.54
    ethylbenzene 97.4
    MIBK 108.04
    2-propoxyethanol 335.57
    tert-butanol 188.26
    MTBE 154.31
    2-butoxyethanol 179.74
    propionic acid 213.78
    o-xylene 114.69
    formic acid 138.49
    diethyl ether 179.33
    m-xylene 115.1
    p-xylene 139.21
    chlorobenzene 320.68
    dimethyl carbonate 79.86
    n-octane 28.23
    formamide 121.08
    cyclopentanone 415.26
    2-pentanone 170.36
    anisole 143.61
    cyclopentyl methyl ether 248.22
    gamma-butyrolactone 445.65
    1-methoxy-2-propanol 191.16
    pyridine 411.58
    3-pentanone 139.1
    furfural 506.84
    n-dodecane 25.71
    diethylene glycol 216.02
    diisopropyl ether 59.88
    tert-amyl alcohol 173.76
    acetylacetone 167.44
    n-hexadecane 28.63
    acetophenone 151.27
    methyl propionate 144.11
    isopentyl acetate 254.37
    trichloroethylene 801.82
    n-nonanol 113.7
    cyclohexanol 232.62
    benzyl alcohol 156.03
    2-ethylhexanol 222.49
    isooctanol 100.67
    dipropyl ether 211.91
    1,2-dichlorobenzene 294.37
    ethyl lactate 83.66
    propylene carbonate 338.68
    n-methylformamide 208.98
    2-pentanol 133.41
    n-pentane 58.97
    1-propoxy-2-propanol 252.9
    1-methoxy-2-propyl acetate 194.23
    2-(2-methoxypropoxy) propanol 167.71
    mesitylene 79.15
    ε-caprolactone 326.28
    p-cymene 120.36
    epichlorohydrin 444.59
    1,1,1-trichloroethane 404.28
    2-aminoethanol 152.16
    morpholine-4-carbaldehyde 370.95
    sulfolane 546.88
    2,2,4-trimethylpentane 34.01
    2-methyltetrahydrofuran 368.44
    n-hexyl acetate 208.93
    isooctane 22.52
    2-(2-butoxyethoxy)ethanol 208.39
    sec-butyl acetate 81.79
    tert-butyl acetate 102.33
    decalin 51.67
    glycerin 122.6
    diglyme 343.32
    acrylic acid 203.03
    isopropyl myristate 90.98
    n-butyric acid 302.94
    acetyl acetate 119.96
    di(2-ethylhexyl) phthalate 115.64
    ethyl propionate 106.32
    nitromethane 311.95
    1,2-diethoxyethane 216.22
    benzonitrile 283.01
    trioctyl phosphate 88.07
    1-bromopropane 315.74
    gamma-valerolactone 449.79
    n-decanol 89.01
    triethyl phosphate 97.23
    4-methyl-2-pentanol 78.6
    propionitrile 205.04
    vinylene carbonate 344.54
    1,1,2-trichlorotrifluoroethane 343.44
    DMS 144.23
    cumene 78.94
    2-octanol 88.72
    2-hexanone 156.6
    octyl acetate 123.32
    limonene 185.56
    1,2-dimethoxyethane 301.95
    ethyl orthosilicate 93.55
    tributyl phosphate 110.95
    diacetone alcohol 124.35
    N,N-dimethylaniline 122.28
    acrylonitrile 236.3
    aniline 194.08
    1,3-propanediol 178.22
    bromobenzene 360.16
    dibromomethane 662.9
    1,1,2,2-tetrachloroethane 621.18
    2-methyl-cyclohexyl acetate 172.28
    tetrabutyl urea 137.71
    diisobutyl methanol 101.8
    2-phenylethanol 214.76
    styrene 125.06
    dioctyl adipate 142.98
    dimethyl sulfate 126.31
    ethyl butyrate 188.61
    methyl lactate 96.97
    butyl lactate 128.78
    diethyl carbonate 136.65
    propanediol butyl ether 168.31
    triethyl orthoformate 134.21
    p-tert-butyltoluene 104.24
    methyl 4-tert-butylbenzoate 151.77
    morpholine 362.26
    tert-butylamine 148.94
    n-dodecanol 73.81
    dimethoxymethane 227.61
    ethylene carbonate 263.78
    cyrene 154.21
    2-ethoxyethyl acetate 165.02
    2-ethylhexyl acetate 218.44
    1,2,4-trichlorobenzene 309.77
    4-methylpyridine 373.87
    dibutyl ether 160.1
    2,6-dimethyl-4-heptanol 101.8
    DEF 233.83
    dimethyl isosorbide 281.5
    tetrachloroethylene 439.99
    eugenol 162.13
    triacetin 155.41
    span 80 178.78
    1,4-butanediol 103.68
    1,1-dichloroethane 384.34
    2-methyl-1-pentanol 180.77
    methyl formate 192.86
    2-methyl-1-butanol 199.94
    n-decane 36.22
    butyronitrile 279.59
    3,7-dimethyl-1-octanol 127.65
    1-chlorooctane 119.3
    1-chlorotetradecane 55.09
    n-nonane 37.55
    undecane 29.52
    tert-butylcyclohexane 44.95
    cyclooctane 39.33
    cyclopentanol 250.78
    tetrahydropyran 384.11
    tert-amyl methyl ether 128.6
    2,5,8-trioxanonane 252.12
    1-hexene 155.47
    2-isopropoxyethanol 126.46
    2,2,2-trifluoroethanol 103.75
    methyl butyrate 166.0

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction