Pyrazine, 2-ethyl-3-(2-methylpropyl)-

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  • Identifiers

    CAS number
    38028-70-5

    Molecular formula
    C10H16N2

    SMILES
    CCC1=NC=CN=C1CC(C)C

    Safety labels

  • Odor profile

    Fragrance
    Green 82.58%
    Earthy 59.54%
    Nutty 54.48%
    Vegetable 52.9%
    Roasted 40.97%
    Fruity 37.71%
    Musty 36.33%
    Leafy 35.26%
    Potato 34.85%
    Cocoa 33.99%

     

    Flavor
    Green 89.76%
    Herbal 55.61%
    Pepper 54.25%
    Earthy 53.14%
    Raw 38.19%
    Earth 38.14%
    Vegetable 37.72%
    Pea 37.65%
    Musty 37.23%
    Nutty 31.15%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.3

    pKa est.
    5.21 (weak acid)

    Molecular weight
    164.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    240°C

    Flash point

    • 90.04 ˚C est.

  • Synonyms

    • 2-Isobutyl-3-ethylpyrazine
    • Pyrazine, 2-ethyl-3-(2-methylpropyl)-
    • 38028-70-5
    • DTXSID1068061
    • RefChem:870434
    • DTXCID6039425
    • 2-ethyl-3-(2-methylpropyl)pyrazine
    • SCHEMBL13980103
    • SCHEMBL30610258
    • TZTYFJFAKSOJEG-UHFFFAOYSA-N
    • 38028-70-5

  • Applications

    Pyrazine, 2-ethyl-3-(2-methylpropyl)- is primarily used as an aroma and flavor ingredient, contributing roasted or meat-like notes in fragrance and flavor formulations; in cosmetics and personal care, it serves as a fragrance component in products such as shampoo, lotions, and soaps; in household products, it acts as a scent additive in detergents and cleaning formulations; in industrial manufacturing, it can be used as an intermediate in the synthesis of pharmaceuticals and other specialty chemicals; it may also be explored as a building block for specialty polymers or coatings in various industrial applications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 225.13
    methanol 172.6
    isopropanol 194.94
    water 0.28
    ethyl acetate 201.33
    n-propanol 232.49
    acetone 340.04
    n-butanol 223.39
    acetonitrile 201.28
    DMF 455.03
    toluene 274.47
    isobutanol 217.64
    1,4-dioxane 404.26
    methyl acetate 198.63
    THF 775.45
    2-butanone 279.79
    n-pentanol 176.17
    sec-butanol 210.88
    n-hexane 81.55
    ethylene glycol 42.49
    NMP 561.8
    cyclohexane 185.81
    DMSO 367.83
    n-butyl acetate 415.76
    n-octanol 160.34
    chloroform 1524.89
    n-propyl acetate 176.74
    acetic acid 274.35
    dichloromethane 1274.17
    cyclohexanone 700.27
    propylene glycol 79.97
    isopropyl acetate 137.21
    DMAc 325.66
    2-ethoxyethanol 145.07
    isopentanol 199.61
    n-heptane 110.02
    ethyl formate 243.94
    1,2-dichloroethane 607.96
    n-hexanol 349.59
    2-methoxyethanol 225.77
    isobutyl acetate 143.98
    tetrachloromethane 285.58
    n-pentyl acetate 200.29
    transcutol 364.49
    n-heptanol 161.14
    ethylbenzene 160.68
    MIBK 151.04
    2-propoxyethanol 295.22
    tert-butanol 202.5
    MTBE 197.27
    2-butoxyethanol 187.93
    propionic acid 216.78
    o-xylene 180.96
    formic acid 53.28
    diethyl ether 177.75
    m-xylene 178.76
    p-xylene 225.23
    chlorobenzene 494.93
    dimethyl carbonate 96.45
    n-octane 41.91
    formamide 65.52
    cyclopentanone 718.46
    2-pentanone 237.44
    anisole 185.99
    cyclopentyl methyl ether 354.0
    gamma-butyrolactone 724.89
    1-methoxy-2-propanol 181.26
    pyridine 585.81
    3-pentanone 197.81
    furfural 650.6
    n-dodecane 35.21
    diethylene glycol 152.51
    diisopropyl ether 75.4
    tert-amyl alcohol 202.72
    acetylacetone 237.78
    n-hexadecane 39.73
    acetophenone 212.43
    methyl propionate 187.76
    isopentyl acetate 326.5
    trichloroethylene 1215.65
    n-nonanol 133.79
    cyclohexanol 321.07
    benzyl alcohol 190.9
    2-ethylhexanol 248.36
    isooctanol 126.78
    dipropyl ether 233.4
    1,2-dichlorobenzene 438.3
    ethyl lactate 101.12
    propylene carbonate 513.05
    n-methylformamide 194.5
    2-pentanol 152.57
    n-pentane 71.1
    1-propoxy-2-propanol 259.6
    1-methoxy-2-propyl acetate 227.93
    2-(2-methoxypropoxy) propanol 162.77
    mesitylene 126.03
    ε-caprolactone 491.0
    p-cymene 173.28
    epichlorohydrin 638.72
    1,1,1-trichloroethane 684.07
    2-aminoethanol 92.43
    morpholine-4-carbaldehyde 394.5
    sulfolane 785.8
    2,2,4-trimethylpentane 45.37
    2-methyltetrahydrofuran 522.8
    n-hexyl acetate 274.21
    isooctane 30.48
    2-(2-butoxyethoxy)ethanol 197.17
    sec-butyl acetate 113.43
    tert-butyl acetate 150.03
    decalin 79.67
    glycerin 91.06
    diglyme 330.32
    acrylic acid 197.72
    isopropyl myristate 120.23
    n-butyric acid 334.29
    acetyl acetate 151.87
    di(2-ethylhexyl) phthalate 136.34
    ethyl propionate 140.14
    nitromethane 297.62
    1,2-diethoxyethane 196.72
    benzonitrile 382.96
    trioctyl phosphate 108.78
    1-bromopropane 431.1
    gamma-valerolactone 650.88
    n-decanol 104.48
    triethyl phosphate 124.66
    4-methyl-2-pentanol 93.64
    propionitrile 230.95
    vinylene carbonate 453.67
    1,1,2-trichlorotrifluoroethane 415.48
    DMS 177.27
    cumene 125.83
    2-octanol 120.62
    2-hexanone 209.81
    octyl acetate 161.01
    limonene 253.45
    1,2-dimethoxyethane 279.96
    ethyl orthosilicate 118.65
    tributyl phosphate 122.31
    diacetone alcohol 164.56
    N,N-dimethylaniline 153.92
    acrylonitrile 270.43
    aniline 262.7
    1,3-propanediol 140.63
    bromobenzene 568.32
    dibromomethane 931.27
    1,1,2,2-tetrachloroethane 1026.06
    2-methyl-cyclohexyl acetate 234.75
    tetrabutyl urea 166.07
    diisobutyl methanol 123.33
    2-phenylethanol 257.62
    styrene 192.32
    dioctyl adipate 182.8
    dimethyl sulfate 161.2
    ethyl butyrate 241.73
    methyl lactate 108.94
    butyl lactate 165.45
    diethyl carbonate 170.24
    propanediol butyl ether 176.32
    triethyl orthoformate 166.64
    p-tert-butyltoluene 151.54
    methyl 4-tert-butylbenzoate 204.44
    morpholine 423.03
    tert-butylamine 153.0
    n-dodecanol 88.26
    dimethoxymethane 217.89
    ethylene carbonate 355.23
    cyrene 192.84
    2-ethoxyethyl acetate 187.85
    2-ethylhexyl acetate 287.44
    1,2,4-trichlorobenzene 490.35
    4-methylpyridine 530.94
    dibutyl ether 187.84
    2,6-dimethyl-4-heptanol 123.33
    DEF 269.7
    dimethyl isosorbide 334.37
    tetrachloroethylene 675.48
    eugenol 187.07
    triacetin 190.15
    span 80 202.88
    1,4-butanediol 77.47
    1,1-dichloroethane 603.14
    2-methyl-1-pentanol 176.09
    methyl formate 197.64
    2-methyl-1-butanol 212.95
    n-decane 51.66
    butyronitrile 301.07
    3,7-dimethyl-1-octanol 144.74
    1-chlorooctane 169.97
    1-chlorotetradecane 74.5
    n-nonane 54.72
    undecane 40.75
    tert-butylcyclohexane 66.91
    cyclooctane 61.99
    cyclopentanol 341.65
    tetrahydropyran 536.72
    tert-amyl methyl ether 166.31
    2,5,8-trioxanonane 244.46
    1-hexene 193.79
    2-isopropoxyethanol 120.94
    2,2,2-trifluoroethanol 85.33
    methyl butyrate 224.92

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction