Pyrantel

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  • Identifiers

    CAS number
    15686-83-6

    Molecular formula
    C11H14N2S

    SMILES
    CN1CCCN=C1/C=C/C2=CC=CS2

  • Odor profile

    Fragrance
    Roasted 63.32%
    Nutty 59.13%
    Meaty 50.45%
    Popcorn 39.98%
    Cooked 33.6%
    Burnt 28.47%
    Savory 26.9%
    Spicy 24.17%
    Beefy 23.84%
    Earthy 22.77%

     

    Flavor
    Roasted 50.73%
    Nutty 42.4%
    Bitter 34.86%
    Roast 34.13%
    Cooked 31.07%
    Corn 27.63%
    Chip 26.69%
    Popcorn 25.32%
    Taco 24.25%
    Nut 24.13%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    6.74 (neutral)

    Molecular weight
    206.31 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    393°C

    Melting point expt.

    • 178-179 °C
    • White crystals from hot methanol; max absorption (water): 312 nm (log e= 4.27); MP: 148-150 °C /Tartrate/

    Flash point

    • 129.66 ˚C est.

    Solubility expt.

    • insoluble in water
    • TASTELESS; PRACTICALLY INSOL IN ALCOHOL OR WATER /PAMOATE/
    • Tastelss, yellow crystalline powder. Insol in water. /Pamoate/
    • Insoluble in water, slightly soluble in dimethylformamide, and soluble in dimethyl sulfoxide.

  • Synonyms

    • PYRANTEL
    • 15686-83-6
    • Pyrequan
    • Strongid
    • Pirantel
    • Pyrantelum
    • Pirantele [DCIT]
    • Konvermex
    • Pirantele
    • Pyrantel [INN:BAN]
    • Pin-X
    • HSDB 3252
    • Pirantel [INN-Spanish]
    • Pyrantelum [INN-Latin]
    • EINECS 239-774-1
    • UNII-4QIH0N49E7
    • 4QIH0N49E7
    • CHEBI:8654
    • E-1,4,5,6-Tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)pyrimidine
    • (E)-1-Methyl-2-(2-(thiophen-2-yl)vinyl)-1,4,5,6-tetrahydropyrimidine
    • Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)ethenyl)-, (E)-
    • DTXSID5023538
    • Pyrantel (INN)
    • PYRANTEL [INN]
    • Pirantel (INN-Spanish)
    • Pyrantelum (INN-Latin)
    • 1-methyl-2-[(E)-2-thiophen-2-ylethenyl]-5,6-dihydro-4H-pyrimidine
    • Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)-, (E)-
    • 1-Methyl-2-(2-(thiophen-2-yl)vinyl)-1,4,5,6-tetrahydropyrimidine
    • 1-methyl-2-[(E)-2-(thiophen-2-yl)ethenyl]-1,4,5,6-tetrahydropyrimidine
    • PYRIMIDINE, 1,4,5,6-TETRAHYDRO-1-METHYL-2-(2-(2-THIENYL)ETHENYL)-
    • 5686-02-2
    • pyrantel-pamoate
    • 1-methyl-2-((E)-2-(2-thienyl)vinyl)-1,4,5,6-tetrahydropyrimidine
    • 1-methyl-2-[(E)-2-(2-thienyl)vinyl]-1,4,5,6-tetrahydropyrimidine
    • Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-[2-(2-thienyl)ethenyl]-
    • (Z)-1-Methyl-2-(2-(thiophen-2-yl)vinyl)-1,4,5,6-tetrahydropyrimidine
    • Pin-Rid
    • Konvermex (TN)
    • 36700-38-6
    • PYRANTEL [HSDB]
    • PYRANTEL [MI]
    • PYRANTEL [VANDF]
    • PYRANTEL [WHO-DD]
    • MLS006011881
    • SCHEMBL164730
    • 1-methyl-2-(2-thiophen-2-ylethenyl)-5,6-dihydro-4H-pyrimidine
    • DTXCID403538
    • CHEMBL1626223
    • CHEBI:94685
    • P02CC01
    • HMS1541D15
    • 1-methyl-2-[(E)-2-(2-thienyl)vinyl]-5,6-dihydro-4H-pyrimidine
    • HY-12641A
    • STK676402
    • AKOS005594318
    • DB11156
    • NCGC00174007-01
    • NCGC00174007-02
    • SMR004703508
    • CS-0013762
    • NS00004940
    • C07409
    • D08451
    • E-1,4,5,6-TETRAHYDRO-1-METHYL-2-
    • AB00053538-07
    • AB00053538_08
    • EN300-8684101
    • Q426897
    • SR-01000802778
    • SR-01000802778-4
    • BRD-K20672254-046-02-1
    • BRD-K20672254-046-03-9
    • BRD-K20672254-046-04-7
    • BRD-K20672254-096-03-4
    • BRD-K20672254-096-05-9
    • BRD-K63072637-046-01-2
    • 1-Methyl-2-[(E)-2-(2-thienyl)ethenyl]-1,4,5,6-tetrahydropyrimidine
    • 1-Methyl-2-[(E)-2-(2-thienyl)ethenyl]-1,4,5,6-tetrahydropyrimidine #
    • 239-774-1

  • Applications

    Pyrantel (CAS 15686-83-6) is primarily used as an active pharmaceutical ingredient in antiparasitic medicines for humans and animals. In pharmaceuticals, it is formulated as salt forms such as pyrantel tartrate and pyrantel pamoate to create oral dosage forms. In veterinary medicine, it is widely used for deworming companion animals and livestock, typically supplied as tablets, suspensions, or boluses. In formulation and drug-development contexts, its salt forms are evaluated to improve solubility and bioavailability, and the compound is commonly considered as a lead scaffold for antiparasitic research. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 150.11
    methanol 240.37
    isopropanol 62.8
    water 4.3
    ethyl acetate 185.73
    n-propanol 104.71
    acetone 175.25
    n-butanol 105.21
    acetonitrile 141.08
    DMF 352.63
    toluene 197.69
    isobutanol 71.98
    1,4-dioxane 380.8
    methyl acetate 182.34
    THF 315.11
    2-butanone 175.9
    n-pentanol 84.43
    sec-butanol 64.0
    n-hexane 6.12
    ethylene glycol 96.94
    NMP 290.61
    cyclohexane 22.12
    DMSO 285.75
    n-butyl acetate 124.29
    n-octanol 27.06
    chloroform 839.82
    n-propyl acetate 101.57
    acetic acid 404.89
    dichloromethane 727.14
    cyclohexanone 222.02
    propylene glycol 82.4
    isopropyl acetate 95.74
    DMAc 434.19
    2-ethoxyethanol 220.28
    isopentanol 86.47
    n-heptane 7.71
    ethyl formate 166.55
    1,2-dichloroethane 369.27
    n-hexanol 68.77
    2-methoxyethanol 324.35
    isobutyl acetate 79.41
    tetrachloromethane 104.42
    n-pentyl acetate 60.38
    transcutol 666.17
    n-heptanol 35.51
    ethylbenzene 50.13
    MIBK 73.08
    2-propoxyethanol 205.11
    tert-butanol 62.21
    MTBE 79.19
    2-butoxyethanol 110.61
    propionic acid 145.69
    o-xylene 87.6
    formic acid 269.57
    diethyl ether 132.08
    m-xylene 87.38
    p-xylene 68.96
    chlorobenzene 260.25
    dimethyl carbonate 125.01
    n-octane 2.77
    formamide 303.55
    cyclopentanone 208.93
    2-pentanone 124.53
    anisole 147.66
    cyclopentyl methyl ether 138.36
    gamma-butyrolactone 248.59
    1-methoxy-2-propanol 159.45
    pyridine 471.49
    3-pentanone 133.99
    furfural 462.49
    n-dodecane 3.02
    diethylene glycol 220.79
    diisopropyl ether 30.66
    tert-amyl alcohol 60.82
    acetylacetone 191.51
    n-hexadecane 3.48
    acetophenone 149.55
    methyl propionate 150.85
    isopentyl acetate 106.42
    trichloroethylene 885.25
    n-nonanol 29.69
    cyclohexanol 102.13
    benzyl alcohol 161.4
    2-ethylhexanol 52.94
    isooctanol 31.68
    dipropyl ether 65.45
    1,2-dichlorobenzene 207.3
    ethyl lactate 73.52
    propylene carbonate 183.68
    n-methylformamide 193.19
    2-pentanol 51.53
    n-pentane 9.62
    1-propoxy-2-propanol 121.44
    1-methoxy-2-propyl acetate 149.42
    2-(2-methoxypropoxy) propanol 127.68
    mesitylene 43.04
    ε-caprolactone 188.24
    p-cymene 35.94
    epichlorohydrin 403.67
    1,1,1-trichloroethane 271.28
    2-aminoethanol 131.19
    morpholine-4-carbaldehyde 404.93
    sulfolane 243.5
    2,2,4-trimethylpentane 8.25
    2-methyltetrahydrofuran 203.09
    n-hexyl acetate 67.43
    isooctane 4.68
    2-(2-butoxyethoxy)ethanol 175.77
    sec-butyl acetate 71.99
    tert-butyl acetate 83.82
    decalin 10.66
    glycerin 150.91
    diglyme 365.51
    acrylic acid 203.66
    isopropyl myristate 33.48
    n-butyric acid 192.87
    acetyl acetate 180.22
    di(2-ethylhexyl) phthalate 53.68
    ethyl propionate 88.9
    nitromethane 451.22
    1,2-diethoxyethane 177.92
    benzonitrile 171.93
    trioctyl phosphate 29.23
    1-bromopropane 146.56
    gamma-valerolactone 355.32
    n-decanol 23.93
    triethyl phosphate 63.15
    4-methyl-2-pentanol 37.0
    propionitrile 112.42
    vinylene carbonate 233.38
    1,1,2-trichlorotrifluoroethane 457.99
    DMS 109.27
    cumene 34.96
    2-octanol 19.11
    2-hexanone 89.48
    octyl acetate 44.06
    limonene 49.3
    1,2-dimethoxyethane 282.88
    ethyl orthosilicate 61.7
    tributyl phosphate 42.07
    diacetone alcohol 93.15
    N,N-dimethylaniline 91.86
    acrylonitrile 176.09
    aniline 251.72
    1,3-propanediol 156.19
    bromobenzene 271.95
    dibromomethane 398.16
    1,1,2,2-tetrachloroethane 540.79
    2-methyl-cyclohexyl acetate 85.48
    tetrabutyl urea 52.76
    diisobutyl methanol 28.77
    2-phenylethanol 125.63
    styrene 86.33
    dioctyl adipate 63.65
    dimethyl sulfate 164.01
    ethyl butyrate 98.19
    methyl lactate 102.29
    butyl lactate 58.48
    diethyl carbonate 82.09
    propanediol butyl ether 87.43
    triethyl orthoformate 86.5
    p-tert-butyltoluene 32.96
    methyl 4-tert-butylbenzoate 90.05
    morpholine 368.83
    tert-butylamine 41.4
    n-dodecanol 19.23
    dimethoxymethane 237.32
    ethylene carbonate 181.57
    cyrene 144.13
    2-ethoxyethyl acetate 136.62
    2-ethylhexyl acetate 92.06
    1,2,4-trichlorobenzene 278.34
    4-methylpyridine 340.78
    dibutyl ether 44.66
    2,6-dimethyl-4-heptanol 28.77
    DEF 195.48
    dimethyl isosorbide 191.0
    tetrachloroethylene 413.11
    eugenol 112.7
    triacetin 114.84
    span 80 92.22
    1,4-butanediol 80.06
    1,1-dichloroethane 274.59
    2-methyl-1-pentanol 80.77
    methyl formate 169.0
    2-methyl-1-butanol 82.37
    n-decane 4.17
    butyronitrile 110.15
    3,7-dimethyl-1-octanol 35.15
    1-chlorooctane 20.84
    1-chlorotetradecane 11.05
    n-nonane 3.31
    undecane 3.46
    tert-butylcyclohexane 8.4
    cyclooctane 7.79
    cyclopentanol 90.57
    tetrahydropyran 244.6
    tert-amyl methyl ether 68.66
    2,5,8-trioxanonane 256.9
    1-hexene 26.61
    2-isopropoxyethanol 133.31
    2,2,2-trifluoroethanol 185.28
    methyl butyrate 114.92

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction