Pyranine

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  • Identifiers

    CAS number
    6358-69-6

    Molecular formula
    C16H7Na3O10S3

    SMILES
    C1=CC2=C3C(=C(C=C2S(=O)(=O)[O-])S(=O)(=O)[O-])C=CC4=C(C=C(C1=C43)O)S(=O)(=O)[O-].[Na+].[Na+].[Na+]

    Safety labels

  • Odor profile

    Fragrance
    Odorless 86.45%
    Cooked 17.33%
    Savory 15.8%
    Burnt 14.83%
    Bitter 14.74%
    Clean 13.23%
    Pungent 11.12%
    Roasted 10.82%
    Sulfurous 10.38%
    Sharp 9.52%

     

    Flavor
    Bitter 90.74%
    Odorless 32.62%
    Bland 20.16%
    Nitrile 18.95%
    Very strong 17.0%
    Taco 16.8%
    Indole 16.78%
    Bread crust 16.69%
    Rotten 16.62%
    Sweet-like 16.55%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    -0.14 (strong acid)

    Molecular weight
    524.4 g/mol

    Flash point

    • 378.76 ˚C est.

  • Synonyms

    • Pyranine
    • Solvent green 7
    • Green 8
    • Japan Green 204
    • 11389 Green
    • Pyrene 1
    • Japan Green No. 204
    • Pyranine 120
    • D&C Green 8
    • Green 204
    • Green No. 204
    • Trisodium 1-hydroxy-3,6,8-pyrenetrisulfonate
    • 8-Hydroxypyrene-1,3,6-trisulfonic acid sodium salt
    • DTXSID00275670
    • RefChem:870405
    • D.C. Green No. 8
    • DTXCID00196937
    • 6358-69-6
    • Sodium 8-hydroxypyrene-1,3,6-trisulfonate
    • HPTS
    • D & C Green no. 8
    • D&C Green No. 8
    • C.I. Solvent Green 7
    • 1,3,6-Pyrenetrisulfonic acid, 8-hydroxy-, trisodium salt
    • 8-Hydroxypyrene-1,3,6-trisulfonic acid trisodium salt
    • 8-HYDROXY-1,3,6-PYRENETRISULFONIC ACID TRISODIUM SALT
    • CI 59040
    • C.I. 59040
    • Trisodium 8-hydroxypyrene-1,3,6-trisulfonate
    • 8-Hydroxypyrene-1,3,6-trisulfonic acid, trisodium salt
    • HPTS;Solvent Green 7
    • MFCD00037575
    • I2W85YOX9L
    • trisodium;8-hydroxypyrene-1,3,6-trisulfonate
    • C16H7Na3O10S3
    • NSC-97285
    • Trisodium 8-hydroxypyrene-1,3,6-trisulphonate
    • EINECS 228-783-6
    • NSC 97285
    • UNII-I2W85YOX9L
    • Pyranine Green
    • 8-Hydroxypyrene-1,3,6-trisulfonic Acid Trisodium Salt (Technical Grade)
    • HPTS (Pyranine)
    • 8-Hydroxy-1,3,6-pyrenetrisulfonic acid, trisodium salt
    • PYRANINE [MI]
    • Solvent Green 7 hydrate
    • MIDORI204
    • DC GREEN NO. 8
    • VIBRACOLOR GREEN SGR7
    • SCHEMBL112075
    • DTXSID4041739
    • SCHEMBL29406702
    • CHEBI:52083
    • MSK5874
    • AKOS022173509
    • FP41139
    • AS-13900
    • DA-77936
    • PD063571
    • SY076605
    • NS00080923
    • D70398
    • H-7400
    • 8-hydroxypyrene-1,3,6-trisulfonate sodium salt
    • Q414789
    • 7,8-Hydroxypyrene-1,3,6-trisulfonicacid,trisodiumsalt
    • 8-Hydroxypyrene-1,3,6-trisulfonic acid,trisodium salt
    • 8-Hydroxy-1,3,6-pyrenetrisulfonic acid trisodium salt
    • 1,3,6-Pyrenetrisulfonic acid, 8-hydroxy-, sodium salt (1:3)
    • 8-Hydroxypyrene-1,3,6-trisulfonic acid trisodium salt, >=97%
    • TRISODIUM SALT OF 8-HYDROXY-1,3,6-PYRENE-TRISULFONIC ACID
    • 6358-69-6

  • Applications

    Pyranine (CAS 6358-69-6) is a water-soluble fluorescent dye primarily used as a pH-sensitive indicator in analytical and biochemical applications, enabling quantitative pH measurements and pH mapping in buffers, biological samples, and live-cell imaging; it also serves as a fluorescent tracer and marker for process monitoring and leak testing in aqueous systems, coatings, and inks to enable fluorescence-based tracking and quality control; additionally it is used as a reporter dye in chromatography, capillary electrophoresis, and microfluidic assays for analytical detection.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.61
    methanol 0.97
    isopropanol 0.25
    water 0.04
    ethyl acetate 0.97
    n-propanol 0.36
    acetone 0.8
    n-butanol 0.17
    acetonitrile 0.54
    DMF 30.49
    toluene 0.19
    isobutanol 0.15
    1,4-dioxane 2.91
    methyl acetate 1.38
    THF 4.12
    2-butanone 1.18
    n-pentanol 0.09
    sec-butanol 0.25
    n-hexane 0.0
    ethylene glycol 1.79
    NMP 28.15
    cyclohexane 0.01
    DMSO 8.55
    n-butyl acetate 1.14
    n-octanol 0.26
    chloroform 0.12
    n-propyl acetate 0.52
    acetic acid 1.17
    dichloromethane 0.18
    cyclohexanone 1.23
    propylene glycol 0.93
    isopropyl acetate 0.67
    DMAc 24.57
    2-ethoxyethanol 2.41
    isopentanol 0.1
    n-heptane 0.01
    ethyl formate 0.69
    1,2-dichloroethane 0.2
    n-hexanol 0.17
    2-methoxyethanol 9.26
    isobutyl acetate 0.15
    tetrachloromethane 0.01
    n-pentyl acetate 0.88
    transcutol 7.03
    n-heptanol 0.3
    ethylbenzene 0.06
    MIBK 0.31
    2-propoxyethanol 5.45
    tert-butanol 0.2
    MTBE 0.19
    2-butoxyethanol 2.91
    propionic acid 1.12
    o-xylene 0.16
    formic acid 3.58
    diethyl ether 0.36
    m-xylene 0.11
    p-xylene 0.06
    chlorobenzene 0.08
    dimethyl carbonate 3.79
    n-octane 0.01
    formamide 9.04
    cyclopentanone 3.32
    2-pentanone 0.63
    anisole 0.56
    cyclopentyl methyl ether 0.88
    gamma-butyrolactone 6.5
    1-methoxy-2-propanol 6.14
    pyridine 2.67
    3-pentanone 0.67
    furfural 6.5
    n-dodecane 0.01
    diethylene glycol 7.18
    diisopropyl ether 0.07
    tert-amyl alcohol 0.24
    acetylacetone 2.02
    n-hexadecane 0.01
    acetophenone 1.0
    methyl propionate 2.15
    isopentyl acetate 0.65
    trichloroethylene 0.47
    n-nonanol 0.29
    cyclohexanol 0.18
    benzyl alcohol 0.48
    2-ethylhexanol 0.13
    isooctanol 0.18
    dipropyl ether 0.51
    1,2-dichlorobenzene 0.12
    ethyl lactate 1.42
    propylene carbonate 1.86
    n-methylformamide 7.21
    2-pentanol 0.12
    n-pentane 0.0
    1-propoxy-2-propanol 4.04
    1-methoxy-2-propyl acetate 4.74
    2-(2-methoxypropoxy) propanol 3.41
    mesitylene 0.06
    ε-caprolactone 1.98
    p-cymene 0.13
    epichlorohydrin 2.94
    1,1,1-trichloroethane 0.04
    2-aminoethanol 1.63
    morpholine-4-carbaldehyde 26.8
    sulfolane 9.73
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 0.99
    n-hexyl acetate 0.82
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 3.89
    sec-butyl acetate 0.31
    tert-butyl acetate 0.79
    decalin 0.0
    glycerin 5.42
    diglyme 8.27
    acrylic acid 2.02
    isopropyl myristate 0.35
    n-butyric acid 0.67
    acetyl acetate 0.75
    di(2-ethylhexyl) phthalate 0.57
    ethyl propionate 0.72
    nitromethane 5.19
    1,2-diethoxyethane 1.47
    benzonitrile 0.47
    trioctyl phosphate 0.37
    1-bromopropane 0.06
    gamma-valerolactone 11.68
    n-decanol 0.2
    triethyl phosphate 0.71
    4-methyl-2-pentanol 0.06
    propionitrile 0.53
    vinylene carbonate 1.93
    1,1,2-trichlorotrifluoroethane 5.17
    DMS 2.66
    cumene 0.04
    2-octanol 0.19
    2-hexanone 0.3
    octyl acetate 0.56
    limonene 0.16
    1,2-dimethoxyethane 3.87
    ethyl orthosilicate 0.52
    tributyl phosphate 0.39
    diacetone alcohol 1.92
    N,N-dimethylaniline 0.47
    acrylonitrile 1.49
    aniline 0.58
    1,3-propanediol 1.29
    bromobenzene 0.05
    dibromomethane 0.07
    1,1,2,2-tetrachloroethane 0.4
    2-methyl-cyclohexyl acetate 0.66
    tetrabutyl urea 1.03
    diisobutyl methanol 0.1
    2-phenylethanol 0.84
    styrene 0.08
    dioctyl adipate 0.75
    dimethyl sulfate 8.24
    ethyl butyrate 0.91
    methyl lactate 5.54
    butyl lactate 1.65
    diethyl carbonate 0.77
    propanediol butyl ether 1.99
    triethyl orthoformate 1.05
    p-tert-butyltoluene 0.14
    methyl 4-tert-butylbenzoate 2.27
    morpholine 4.49
    tert-butylamine 0.07
    n-dodecanol 0.14
    dimethoxymethane 9.75
    ethylene carbonate 1.16
    cyrene 3.88
    2-ethoxyethyl acetate 2.74
    2-ethylhexyl acetate 0.52
    1,2,4-trichlorobenzene 0.3
    4-methylpyridine 1.24
    dibutyl ether 0.23
    2,6-dimethyl-4-heptanol 0.1
    DEF 3.3
    dimethyl isosorbide 6.68
    tetrachloroethylene 0.26
    eugenol 2.69
    triacetin 2.51
    span 80 2.15
    1,4-butanediol 0.33
    1,1-dichloroethane 0.07
    2-methyl-1-pentanol 0.06
    methyl formate 3.97
    2-methyl-1-butanol 0.13
    n-decane 0.01
    butyronitrile 0.23
    3,7-dimethyl-1-octanol 0.15
    1-chlorooctane 0.06
    1-chlorotetradecane 0.03
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.0
    cyclooctane 0.01
    cyclopentanol 0.4
    tetrahydropyran 0.6
    tert-amyl methyl ether 0.28
    2,5,8-trioxanonane 6.18
    1-hexene 0.01
    2-isopropoxyethanol 1.09
    2,2,2-trifluoroethanol 1.19
    methyl butyrate 0.74

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction