Prudomestin

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  • Identifiers

    CAS number
    3443-28-5

    Molecular formula
    C17H14O7

    SMILES
    COC1=CC=C(C=C1)C2=C(C(=O)C3=C(O2)C(=C(C=C3O)O)OC)O

    Safety labels

  • Odor profile

    Fragrance
    Phenolic 60.44%
    Burnt 39.7%
    Vanilla 37.83%
    Odorless 36.98%
    Spicy 36.33%
    Smoky 35.86%
    Fruity 30.72%
    Sweet 30.59%
    Balsamic 29.4%
    Medicinal 28.04%

     

    Flavor
    Bitter 87.67%
    Bland 22.44%
    Odorless 22.0%
    Eugenol 21.56%
    Parsley 21.21%
    Sweet-like 20.83%
    Cedarleaf 20.1%
    Ham 20.02%
    Lovage 19.87%
    Allspice 19.69%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.8

    pKa est.
    9.29 (weak base)

    Molecular weight
    330.29 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1238°C

    Melting point expt.

    • 209 - 210 °C

    Flash point

    • 221.49 ˚C est.

  • Synonyms

    • prudomestin
    • 3443-28-5
    • 3,5,7-Trihydroxy-4',8-dimethoxyflavone
    • 3,5,7-trihydroxy-8-methoxy-2-(4-methoxyphenyl)chromen-4-one
    • Herbacetin 8,4'-dimethyl ether
    • 3,5,7-Trihydroxy-8-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
    • 5,7-Dihydroxy-4',8-dimethoxyflavonol
    • RefChem:176754
    • Prudomestin (Standard)
    • 3,5,7-Trihydroxy-8-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
    • CHEMBL478812
    • orb1309214
    • SCHEMBL30977124
    • HY-N1547R
    • CHEBI:174447
    • DTXSID301318110
    • HY-N1547
    • LMPK12113159
    • MFCD20260422
    • AKOS032948516
    • 5,7-dihydroxy-8,4'-dimethoxyflavonol
    • EBC-616270
    • AC-35077
    • DA-66973
    • MS-24954
    • CS-0017096
    • G14075
    • 3443-28-5

  • Applications

    Prudomestin (CAS 3443-28-5) has multiple practical applications across industries: it can function as an odorant and fragrance fixative in perfumery and personal care products; it is used as a fragrance additive in household and cleaning formulations; it may be employed as an additive in coatings and inks to improve fragrance release and compatibility; it can act as a plasticizer or stabilizer in polymer and plastic systems; and it may serve as an intermediate or processing reagent in industrial chemical synthesis, subject to regulatory and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.19
    methanol 0.21
    isopropanol 0.23
    water 0.0
    ethyl acetate 0.56
    n-propanol 0.41
    acetone 0.16
    n-butanol 0.37
    acetonitrile 0.14
    DMF 5.02
    toluene 0.05
    isobutanol 0.31
    1,4-dioxane 0.93
    methyl acetate 0.68
    THF 4.64
    2-butanone 0.92
    n-pentanol 0.24
    sec-butanol 0.56
    n-hexane 0.01
    ethylene glycol 0.48
    NMP 14.42
    cyclohexane 0.01
    DMSO 14.68
    n-butyl acetate 0.69
    n-octanol 0.28
    chloroform 0.15
    n-propyl acetate 0.45
    acetic acid 0.94
    dichloromethane 0.26
    cyclohexanone 1.54
    propylene glycol 0.59
    isopropyl acetate 0.47
    DMAc 12.8
    2-ethoxyethanol 2.2
    isopentanol 0.43
    n-heptane 0.02
    ethyl formate 0.27
    1,2-dichloroethane 0.33
    n-hexanol 0.3
    2-methoxyethanol 5.22
    isobutyl acetate 0.23
    tetrachloromethane 0.02
    n-pentyl acetate 0.62
    transcutol 8.54
    n-heptanol 0.36
    ethylbenzene 0.05
    MIBK 0.44
    2-propoxyethanol 3.82
    tert-butanol 0.51
    MTBE 0.39
    2-butoxyethanol 2.14
    propionic acid 1.06
    o-xylene 0.09
    formic acid 0.91
    diethyl ether 0.27
    m-xylene 0.06
    p-xylene 0.06
    chlorobenzene 0.06
    dimethyl carbonate 1.23
    n-octane 0.01
    formamide 1.95
    cyclopentanone 2.87
    2-pentanone 0.47
    anisole 0.32
    cyclopentyl methyl ether 1.15
    gamma-butyrolactone 4.7
    1-methoxy-2-propanol 4.49
    pyridine 0.93
    3-pentanone 0.59
    furfural 3.71
    n-dodecane 0.01
    diethylene glycol 4.16
    diisopropyl ether 0.1
    tert-amyl alcohol 0.93
    acetylacetone 0.94
    n-hexadecane 0.01
    acetophenone 0.62
    methyl propionate 1.25
    isopentyl acetate 0.86
    trichloroethylene 0.73
    n-nonanol 0.38
    cyclohexanol 0.61
    benzyl alcohol 0.43
    2-ethylhexanol 0.39
    isooctanol 0.4
    dipropyl ether 0.57
    1,2-dichlorobenzene 0.13
    ethyl lactate 1.08
    propylene carbonate 1.27
    n-methylformamide 1.43
    2-pentanol 0.34
    n-pentane 0.01
    1-propoxy-2-propanol 2.92
    1-methoxy-2-propyl acetate 2.66
    2-(2-methoxypropoxy) propanol 3.61
    mesitylene 0.04
    ε-caprolactone 2.19
    p-cymene 0.16
    epichlorohydrin 4.35
    1,1,1-trichloroethane 0.1
    2-aminoethanol 0.86
    morpholine-4-carbaldehyde 9.25
    sulfolane 17.26
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 1.64
    n-hexyl acetate 0.81
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 3.67
    sec-butyl acetate 0.41
    tert-butyl acetate 0.91
    decalin 0.01
    glycerin 3.63
    diglyme 8.33
    acrylic acid 1.36
    isopropyl myristate 0.41
    n-butyric acid 0.85
    acetyl acetate 0.39
    di(2-ethylhexyl) phthalate 0.62
    ethyl propionate 0.73
    nitromethane 2.47
    1,2-diethoxyethane 1.27
    benzonitrile 0.27
    trioctyl phosphate 0.47
    1-bromopropane 0.14
    gamma-valerolactone 6.32
    n-decanol 0.27
    triethyl phosphate 1.1
    4-methyl-2-pentanol 0.26
    propionitrile 0.35
    vinylene carbonate 0.94
    1,1,2-trichlorotrifluoroethane 7.92
    DMS 1.54
    cumene 0.06
    2-octanol 0.25
    2-hexanone 0.47
    octyl acetate 0.53
    limonene 0.27
    1,2-dimethoxyethane 3.64
    ethyl orthosilicate 0.96
    tributyl phosphate 0.55
    diacetone alcohol 2.81
    N,N-dimethylaniline 0.46
    acrylonitrile 0.67
    aniline 0.36
    1,3-propanediol 1.35
    bromobenzene 0.05
    dibromomethane 0.11
    1,1,2,2-tetrachloroethane 0.84
    2-methyl-cyclohexyl acetate 0.95
    tetrabutyl urea 1.05
    diisobutyl methanol 0.32
    2-phenylethanol 0.68
    styrene 0.04
    dioctyl adipate 0.88
    dimethyl sulfate 5.11
    ethyl butyrate 0.88
    methyl lactate 2.82
    butyl lactate 1.27
    diethyl carbonate 0.72
    propanediol butyl ether 1.8
    triethyl orthoformate 1.23
    p-tert-butyltoluene 0.18
    methyl 4-tert-butylbenzoate 2.03
    morpholine 2.55
    tert-butylamine 0.19
    n-dodecanol 0.19
    dimethoxymethane 2.9
    ethylene carbonate 0.66
    cyrene 4.16
    2-ethoxyethyl acetate 1.5
    2-ethylhexyl acetate 0.67
    1,2,4-trichlorobenzene 0.3
    4-methylpyridine 0.54
    dibutyl ether 0.39
    2,6-dimethyl-4-heptanol 0.32
    DEF 2.15
    dimethyl isosorbide 6.95
    tetrachloroethylene 0.45
    eugenol 2.12
    triacetin 1.82
    span 80 2.18
    1,4-butanediol 0.31
    1,1-dichloroethane 0.09
    2-methyl-1-pentanol 0.41
    methyl formate 0.79
    2-methyl-1-butanol 0.55
    n-decane 0.02
    butyronitrile 0.18
    3,7-dimethyl-1-octanol 0.36
    1-chlorooctane 0.1
    1-chlorotetradecane 0.05
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.01
    cyclooctane 0.01
    cyclopentanol 0.9
    tetrahydropyran 0.62
    tert-amyl methyl ether 0.75
    2,5,8-trioxanonane 6.14
    1-hexene 0.03
    2-isopropoxyethanol 1.38
    2,2,2-trifluoroethanol 0.66
    methyl butyrate 0.84

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction