Propylparaben

Overview IFRA Request a quote

  • Identifiers

    CAS number
    94-13-3

    Molecular formula
    C10H12O3

    SMILES
    CCCOC(=O)C1=CC=C(C=C1)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 64.98%
    Phenolic 60.37%
    Balsamic 47.4%
    Vanilla 45.16%
    Aromatic 40.24%
    Herbal 38.77%
    Floral 38.57%
    Woody 37.8%
    Spicy 36.57%
    Medicinal 34.76%

     

    Flavor
    Balsam 51.37%
    Sweet 47.74%
    Floral 38.78%
    Wintergreen 38.43%
    Powdery 35.5%
    Bitter 34.13%
    Herbal 32.04%
    Balsamic 31.03%
    Faint 30.52%
    Vanilla 28.12%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.0

    pKa est.
    8.21 (weak base)

    Molecular weight
    180.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 203 to 208 °F (NTP, 1992)
    • 96.1 °C
    • 96 - 97 °C

    Boiling point

    • 271 °F at 1 mmHg (NTP, 1992)
    • 294.00 to 295.00 °C. @ 760.00 mm Hg

    Flash point

    • 133.44 ˚C est.

    Solubility expt.

    • less than 1 mg/mL at 54 °F (NTP, 1992)
    • In water, 5.00X10+2 mg/L at 25 °C
    • Soluble in 2000 parts water; slightly soluble in boiling water
    • In water, 463 mg/L at 20 °C
    • Soluble in ethanol, ethyl ether; slightly soluble in chloroform
    • For more Solubility (Complete) data for PROPYLPARABEN (6 total), please visit the HSDB record page.
    • 0.5 mg/mL at 25 °C

  • Synonyms

    • PROPYLPARABEN
    • Propyl 4-hydroxybenzoate
    • 94-13-3
    • Propyl paraben
    • Propyl p-hydroxybenzoate
    • Nipasol
    • Nipazol
    • Propagin
    • 4-Hydroxybenzoic acid propyl ester
    • Tegosept P
    • Nipagin P
    • Propyl parahydroxybenzoate
    • Chemacide pk
    • Propyl Parasept
    • Propyl Butex
    • Propyl Chemosept
    • Betacide P
    • N-Propyl p-hydroxybenzoate
    • n-Propyl 4-hydroxybenzoate
    • Propyl aseptoform
    • Propylparasept
    • 4-Hydroxybenzoic acid, propyl ester
    • Chemocide pk
    • Aseptoform P
    • p-Hydroxypropyl benzoate
    • Betacine P
    • Protaben P
    • Nipasol P
    • Solbrol P
    • p-Hydroxybenzoic acid propyl ester
    • Paseptol
    • p-Hydroxybenzoic propyl ester
    • Preserval P
    • n-propyl paraben
    • Bonomold OP
    • Nipasol M
    • Propyl-4-hydroxybenzoate
    • N-Propylparaben
    • FEMA No. 2951
    • Propyl chemsept
    • Propyl-paraben
    • Caswell No. 714
    • Paratexin p
    • Benzoic acid, 4-hydroxy-, propyl ester
    • Paraben p
    • Bayer D 206
    • FEMA Number 2951
    • propyl para-hydroxybenzoate
    • Benzoic acid, p-hydroxy-, propyl ester
    • Propylparaben e216
    • propyl hydroxybenzoate
    • HSDB 203
    • UNII-Z8IX2SC1OH
    • Chemoside PK
    • Lexgard P
    • p-Oxybenzoesaurepropylester
    • Pulvis conservans
    • Z8IX2SC1OH
    • NSC-8511
    • p-Hydroxybenzoic acid, propyl ester
    • EINECS 202-307-7
    • MFCD00002354
    • NSC 23515
    • NSC-23515
    • EPA Pesticide Chemical Code 061203
    • BRN 1103245
    • DTXSID4022527
    • CHEBI:32063
    • n-PROPYL-p-HYDROXYBENZOATE
    • Propylis hydroxybenzoas
    • AI3-01341
    • propyl 4-oxidanylbenzoate
    • Propylester kyseliny p-hydroxybenzoove
    • p-Oxybenzoesaeurepropylester
    • MLS002152934
    • DTXCID602527
    • EC 202-307-7
    • 4-Hydroxybenzoic acid-propyl ester
    • PROPYL (4-HYDROXYBENZOATE)
    • 4-10-00-00374 (Beilstein Handbook Reference)
    • NSC23515
    • p-Hydroxybenzoic acid n-propyl ester
    • NCGC00090965-03
    • NCGC00090965-04
    • SMR000112070
    • PROPYLPARABEN (II)
    • PROPYLPARABEN [II]
    • WLN: QR DVO3
    • Propyl parahydroxybenzoate;Propyl 4-hydroxybenzoate
    • PROPYLPARABEN (USP-RS)
    • PROPYLPARABEN [USP-RS]
    • Propylparaben [USAN]
    • Propyl 4-hydroxybenzoate, >=99%
    • Pulvis conservans (VAN)
    • 4-Hydroxybenzoic acid-propyl ester 1000 microg/mL in Acetonitrile
    • PROPYL HYDROXYBENZOATE (MART.)
    • PROPYL HYDROXYBENZOATE [MART.]
    • CAS-94-13-3
    • Propyl 4-?Hydroxybenzoate(Propyl Paraben)
    • PEPH
    • PROPYL PARAHYDROXYBENZOATE (EP IMPURITY)
    • PROPYL PARAHYDROXYBENZOATE [EP IMPURITY]
    • PROPYL PARAHYDROXYBENZOATE (EP MONOGRAPH)
    • PROPYL PARAHYDROXYBENZOATE [EP MONOGRAPH]
    • 85403-59-4
    • p-Oxybenzoesaurepropylester [German]
    • Propylparaben [USAN:NF]
    • 4-Hydroxybenzoic acid-propyl ester D7 (propyl D7)
    • METHYL PARAHYDROXYBENZOATE IMPURITY C (EP IMPURITY)
    • METHYL PARAHYDROXYBENZOATE IMPURITY C [EP IMPURITY]
    • Propylester kyseliny p-hydroxybenzoove [Czech]
    • 4-Hydroxybenzoic acid propylester
    • (Propyl Paraben)
    • 36M
    • propyl p-oxybenzoate
    • Propylparaben (NF)
    • Propylparaben, USAN
    • Propylparaben (Standard)
    • Propylis parahydroxybenzoas
    • Propyl 4-?Hydroxybenzoate
    • SCHEMBL977
    • n-propyl-4-hydroxybenzoate
    • PROPYLPARABEN [MI]
    • PROPYLPARABEN [FCC]
    • cid_7175
    • n-propyl-p-hydroxy-benzoate
    • PROPYLPARABEN [HSDB]
    • PROPYLPARABEN [VANDF]

  • Applications

    Propylparaben is widely used as a preservative in cosmetics and personal care products to inhibit microbial growth, including yeasts, molds, and bacteria. It is also employed in pharmaceutical formulations to extend shelf life by providing antimicrobial protection. In some household cleaning products and air fresheners, it serves as a preservative additive to maintain product integrity. In coatings and inks, propylparaben may be used as a preservative additive to prevent microbial degradation during storage and on the finished product.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 732.12
    methanol 959.22
    isopropanol 568.26
    water 0.31
    ethyl acetate 581.42
    n-propanol 507.61
    acetone 1096.67
    n-butanol 475.85
    acetonitrile 368.78
    DMF 1952.43
    toluene 116.28
    isobutanol 370.04
    1,4-dioxane 730.01
    methyl acetate 552.28
    THF 962.37
    2-butanone 649.89
    n-pentanol 358.27
    sec-butanol 496.38
    n-hexane 7.93
    ethylene glycol 143.43
    NMP 814.01
    cyclohexane 8.86
    DMSO 1756.62
    n-butyl acetate 525.05
    n-octanol 152.18
    chloroform 521.84
    n-propyl acetate 427.46
    acetic acid 818.47
    dichloromethane 606.08
    cyclohexanone 596.48
    propylene glycol 213.48
    isopropyl acetate 338.64
    DMAc 1054.01
    2-ethoxyethanol 573.35
    isopentanol 427.17
    n-heptane 5.19
    ethyl formate 377.55
    1,2-dichloroethane 506.59
    n-hexanol 283.95
    2-methoxyethanol 929.32
    isobutyl acetate 223.98
    tetrachloromethane 24.51
    n-pentyl acetate 209.0
    transcutol 1983.71
    n-heptanol 126.34
    ethylbenzene 84.27
    MIBK 316.15
    2-propoxyethanol 486.78
    tert-butanol 823.23
    MTBE 516.96
    2-butoxyethanol 263.05
    propionic acid 413.39
    o-xylene 92.8
    formic acid 289.38
    diethyl ether 418.91
    m-xylene 98.56
    p-xylene 107.28
    chlorobenzene 209.81
    dimethyl carbonate 198.73
    n-octane 3.77
    formamide 616.21
    cyclopentanone 803.8
    2-pentanone 566.88
    anisole 288.39
    cyclopentyl methyl ether 335.25
    gamma-butyrolactone 926.71
    1-methoxy-2-propanol 703.06
    pyridine 480.54
    3-pentanone 300.49
    furfural 661.11
    n-dodecane 6.27
    diethylene glycol 403.7
    diisopropyl ether 91.03
    tert-amyl alcohol 650.5
    acetylacetone 588.39
    n-hexadecane 7.36
    acetophenone 294.07
    methyl propionate 423.67
    isopentyl acetate 394.84
    trichloroethylene 956.01
    n-nonanol 128.63
    cyclohexanol 284.41
    benzyl alcohol 271.29
    2-ethylhexanol 152.07
    isooctanol 104.1
    dipropyl ether 134.53
    1,2-dichlorobenzene 181.53
    ethyl lactate 170.41
    propylene carbonate 422.68
    n-methylformamide 719.64
    2-pentanol 364.8
    n-pentane 7.01
    1-propoxy-2-propanol 339.99
    1-methoxy-2-propyl acetate 358.23
    2-(2-methoxypropoxy) propanol 282.9
    mesitylene 58.48
    ε-caprolactone 515.01
    p-cymene 51.23
    epichlorohydrin 932.87
    1,1,1-trichloroethane 228.02
    2-aminoethanol 315.86
    morpholine-4-carbaldehyde 769.77
    sulfolane 971.93
    2,2,4-trimethylpentane 11.25
    2-methyltetrahydrofuran 617.17
    n-hexyl acetate 312.84
    isooctane 8.91
    2-(2-butoxyethoxy)ethanol 457.7
    sec-butyl acetate 248.91
    tert-butyl acetate 347.37
    decalin 12.23
    glycerin 286.56
    diglyme 794.13
    acrylic acid 387.93
    isopropyl myristate 102.67
    n-butyric acid 547.83
    acetyl acetate 299.54
    di(2-ethylhexyl) phthalate 94.77
    ethyl propionate 289.3
    nitromethane 1320.97
    1,2-diethoxyethane 416.03
    benzonitrile 293.23
    trioctyl phosphate 73.6
    1-bromopropane 195.16
    gamma-valerolactone 865.68
    n-decanol 96.81
    triethyl phosphate 96.12
    4-methyl-2-pentanol 177.34
    propionitrile 308.53
    vinylene carbonate 394.44
    1,1,2-trichlorotrifluoroethane 536.76
    DMS 244.09
    cumene 60.11
    2-octanol 98.43
    2-hexanone 403.42
    octyl acetate 140.41
    limonene 80.03
    1,2-dimethoxyethane 836.02
    ethyl orthosilicate 88.99
    tributyl phosphate 101.72
    diacetone alcohol 473.54
    N,N-dimethylaniline 163.82
    acrylonitrile 448.26
    aniline 248.06
    1,3-propanediol 471.07
    bromobenzene 186.84
    dibromomethane 324.87
    1,1,2,2-tetrachloroethane 663.25
    2-methyl-cyclohexyl acetate 164.53
    tetrabutyl urea 131.65
    diisobutyl methanol 87.63
    2-phenylethanol 219.52
    styrene 120.18
    dioctyl adipate 152.08
    dimethyl sulfate 317.9
    ethyl butyrate 263.27
    methyl lactate 230.74
    butyl lactate 176.64
    diethyl carbonate 169.14
    propanediol butyl ether 323.8
    triethyl orthoformate 146.71
    p-tert-butyltoluene 52.09
    methyl 4-tert-butylbenzoate 192.53
    morpholine 918.38
    tert-butylamine 380.71
    n-dodecanol 70.36
    dimethoxymethane 757.26
    ethylene carbonate 308.07
    cyrene 225.85
    2-ethoxyethyl acetate 313.68
    2-ethylhexyl acetate 262.52
    1,2,4-trichlorobenzene 237.79
    4-methylpyridine 536.84
    dibutyl ether 166.01
    2,6-dimethyl-4-heptanol 87.63
    DEF 621.61
    dimethyl isosorbide 348.66
    tetrachloroethylene 349.38
    eugenol 215.7
    triacetin 260.94
    span 80 212.31
    1,4-butanediol 183.37
    1,1-dichloroethane 397.82
    2-methyl-1-pentanol 311.77
    methyl formate 523.86
    2-methyl-1-butanol 370.47
    n-decane 9.28
    butyronitrile 350.64
    3,7-dimethyl-1-octanol 149.63
    1-chlorooctane 68.8
    1-chlorotetradecane 27.36
    n-nonane 7.51
    undecane 7.59
    tert-butylcyclohexane 13.79
    cyclooctane 3.3
    cyclopentanol 298.53
    tetrahydropyran 570.63
    tert-amyl methyl ether 336.52
    2,5,8-trioxanonane 478.12
    1-hexene 77.05
    2-isopropoxyethanol 377.64
    2,2,2-trifluoroethanol 191.92
    methyl butyrate 425.84

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction