Propylene glycol hydroxystearate

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  • Identifiers

    CAS number
    38621-51-1

    Molecular formula
    C21H42O4

    SMILES
    CCCCCCC(CCCCCCCCCCC(=O)O)OC(C)CO

    Safety labels

  • Odor profile

    Fragrance
    Fatty 50.61%
    Waxy 46.91%
    Oily 40.56%
    Odorless 31.63%
    Citrus 31.14%
    Fresh 29.91%
    Milky 29.15%
    Lactonic 27.33%
    Peach 26.5%
    Savory 24.82%

     

    Flavor
    Fatty 45.58%
    Waxy 44.06%
    Mild 37.15%
    Oily 35.42%
    Bland 29.13%
    Fat 29.01%
    Odorless 26.94%
    Soapy 25.21%
    Faint 24.39%
    Slightly waxy 23.98%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.6

    pKa est.
    6.29 (neutral)

    Molecular weight
    358.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    428°C

    Flash point

    • 208.12 ˚C est.

  • Synonyms

    • 38621-51-1
    • Propylene glycol hydroxystearate
    • UNII-G0ZI1T6T6W
    • G0ZI1T6T6W
    • 12-Hydroxyoctadecanoic acid, monoester with propane-1,2-diol
    • DTXSID801021744
    • EINECS 254-045-8
    • NS00124201
    • 38621-51-1

  • Applications

    Propylene glycol hydroxystearate (CAS 38621-51-1) is primarily used in cosmetics and personal care as a nonionic surfactant, emollient, and emulsifier, helping to improve moisturization, skin and hair feel, and to stabilize oil-water mixtures in creams, lotions, and cleansers. It also functions as a lubricating agent contributing to slip and conditioning in topical formulations, and can serve as a processing aid or solvent for active ingredients and fragrance components. In broader product formulations, it may be used as a softening or processing aid in coatings, inks, or cleaning formulations, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 68.32
    methanol 108.52
    isopropanol 56.85
    water 0.12
    ethyl acetate 103.23
    n-propanol 64.08
    acetone 85.92
    n-butanol 69.83
    acetonitrile 24.24
    DMF 186.67
    toluene 30.81
    isobutanol 58.86
    1,4-dioxane 131.42
    methyl acetate 65.45
    THF 416.77
    2-butanone 96.17
    n-pentanol 61.67
    sec-butanol 63.03
    n-hexane 8.49
    ethylene glycol 7.21
    NMP 391.42
    cyclohexane 31.75
    DMSO 429.97
    n-butyl acetate 143.98
    n-octanol 63.25
    chloroform 190.67
    n-propyl acetate 158.84
    acetic acid 83.56
    dichloromethane 211.24
    cyclohexanone 336.67
    propylene glycol 21.93
    isopropyl acetate 129.33
    DMAc 352.72
    2-ethoxyethanol 152.95
    isopentanol 96.81
    n-heptane 8.45
    ethyl formate 62.75
    1,2-dichloroethane 172.82
    n-hexanol 57.43
    2-methoxyethanol 156.18
    isobutyl acetate 118.02
    tetrachloromethane 49.89
    n-pentyl acetate 227.53
    transcutol 700.79
    n-heptanol 65.48
    ethylbenzene 32.32
    MIBK 149.91
    2-propoxyethanol 149.47
    tert-butanol 112.79
    MTBE 115.46
    2-butoxyethanol 176.9
    propionic acid 70.19
    o-xylene 41.03
    formic acid 31.08
    diethyl ether 65.2
    m-xylene 36.02
    p-xylene 43.99
    chlorobenzene 56.26
    dimethyl carbonate 34.04
    n-octane 5.14
    formamide 49.73
    cyclopentanone 326.71
    2-pentanone 128.8
    anisole 75.24
    cyclopentyl methyl ether 192.59
    gamma-butyrolactone 297.49
    1-methoxy-2-propanol 169.98
    pyridine 102.35
    3-pentanone 96.21
    furfural 220.01
    n-dodecane 3.61
    diethylene glycol 75.73
    diisopropyl ether 38.54
    tert-amyl alcohol 115.98
    acetylacetone 176.87
    n-hexadecane 4.28
    acetophenone 116.54
    methyl propionate 85.78
    isopentyl acetate 168.57
    trichloroethylene 257.33
    n-nonanol 62.62
    cyclohexanol 127.29
    benzyl alcohol 65.07
    2-ethylhexanol 58.43
    isooctanol 71.05
    dipropyl ether 82.34
    1,2-dichlorobenzene 80.71
    ethyl lactate 75.96
    propylene carbonate 176.32
    n-methylformamide 69.4
    2-pentanol 57.83
    n-pentane 5.44
    1-propoxy-2-propanol 148.54
    1-methoxy-2-propyl acetate 171.63
    2-(2-methoxypropoxy) propanol 144.48
    mesitylene 32.22
    ε-caprolactone 324.36
    p-cymene 31.9
    epichlorohydrin 289.67
    1,1,1-trichloroethane 152.98
    2-aminoethanol 30.76
    morpholine-4-carbaldehyde 280.11
    sulfolane 608.03
    2,2,4-trimethylpentane 10.62
    2-methyltetrahydrofuran 245.2
    n-hexyl acetate 208.3
    isooctane 6.09
    2-(2-butoxyethoxy)ethanol 212.95
    sec-butyl acetate 128.88
    tert-butyl acetate 198.2
    decalin 17.16
    glycerin 44.12
    diglyme 445.12
    acrylic acid 47.45
    isopropyl myristate 62.51
    n-butyric acid 167.3
    acetyl acetate 78.75
    di(2-ethylhexyl) phthalate 63.17
    ethyl propionate 118.76
    nitromethane 140.39
    1,2-diethoxyethane 186.59
    benzonitrile 62.61
    trioctyl phosphate 50.16
    1-bromopropane 79.79
    gamma-valerolactone 465.57
    n-decanol 38.36
    triethyl phosphate 78.45
    4-methyl-2-pentanol 54.44
    propionitrile 32.58
    vinylene carbonate 129.09
    1,1,2-trichlorotrifluoroethane 255.35
    DMS 94.68
    cumene 30.39
    2-octanol 55.42
    2-hexanone 135.13
    octyl acetate 82.21
    limonene 58.83
    1,2-dimethoxyethane 271.32
    ethyl orthosilicate 83.2
    tributyl phosphate 63.91
    diacetone alcohol 221.32
    N,N-dimethylaniline 67.45
    acrylonitrile 35.0
    aniline 46.55
    1,3-propanediol 68.15
    bromobenzene 60.35
    dibromomethane 130.41
    1,1,2,2-tetrachloroethane 278.48
    2-methyl-cyclohexyl acetate 136.66
    tetrabutyl urea 95.07
    diisobutyl methanol 44.32
    2-phenylethanol 65.2
    styrene 33.84
    dioctyl adipate 114.83
    dimethyl sulfate 103.41
    ethyl butyrate 136.03
    methyl lactate 64.59
    butyl lactate 166.26
    diethyl carbonate 72.93
    propanediol butyl ether 154.88
    triethyl orthoformate 117.94
    p-tert-butyltoluene 31.67
    methyl 4-tert-butylbenzoate 161.04
    morpholine 222.66
    tert-butylamine 62.11
    n-dodecanol 25.69
    dimethoxymethane 120.61
    ethylene carbonate 122.53
    cyrene 154.25
    2-ethoxyethyl acetate 234.63
    2-ethylhexyl acetate 131.71
    1,2,4-trichlorobenzene 98.88
    4-methylpyridine 102.49
    dibutyl ether 99.99
    2,6-dimethyl-4-heptanol 44.32
    DEF 195.02
    dimethyl isosorbide 280.29
    tetrachloroethylene 197.43
    eugenol 129.77
    triacetin 224.01
    span 80 140.27
    1,4-butanediol 30.67
    1,1-dichloroethane 113.93
    2-methyl-1-pentanol 81.55
    methyl formate 44.64
    2-methyl-1-butanol 79.76
    n-decane 8.4
    butyronitrile 47.34
    3,7-dimethyl-1-octanol 67.22
    1-chlorooctane 48.67
    1-chlorotetradecane 13.36
    n-nonane 7.67
    undecane 5.07
    tert-butylcyclohexane 13.42
    cyclooctane 9.19
    cyclopentanol 117.93
    tetrahydropyran 205.64
    tert-amyl methyl ether 111.69
    2,5,8-trioxanonane 249.21
    1-hexene 28.25
    2-isopropoxyethanol 130.58
    2,2,2-trifluoroethanol 43.78
    methyl butyrate 180.05

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction