Propylene glycol dipropionate

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  • Identifiers

    CAS number
    10108-80-2

    Molecular formula
    C9H16O4

    SMILES
    CCC(=O)OCC(C)OC(=O)CC

  • Odor profile

    Fragrance
    Fruity 94.03%
    Sweet 47.76%
    Winey 46.25%
    Ethereal 42.53%
    Buttery 40.96%
    Pineapple 37.17%
    Tropical 36.87%
    Fatty 35.93%
    Apple 34.96%
    Oily 33.61%

     

    Flavor
    Fruity 91.22%
    Sweet 59.0%
    Bitter 49.03%
    Green 47.3%
    Apple 45.47%
    Pineapple 45.28%
    Tropical 45.14%
    Floral 38.18%
    Fruit 36.85%
    Grape 36.26%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.4

    pKa est.
    7.65 (neutral)

    Molecular weight
    188.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    210°C

    Flash point

    • 97.76 ˚C est.

    Solubility expt.

    • Very slightly soluble in water
    • Soluble (in ethanol)

  • Synonyms

    • Propylene glycol dipropionate
    • 10108-80-2
    • Propane-1,2-diyl dipropionate
    • 2-propanoyloxypropyl propanoate
    • Propyleneglycol dipropionate
    • 1,2-Propanediol, dipropanoate
    • Propylene glycol 1,2-dipropionate
    • 1,2-Propanediol, dipropionate
    • EINECS 233-298-8
    • 1,2-Propanediol, 1,2-dipropanoate
    • UNII-4DZ729T8XW
    • BRN 1775906
    • 4DZ729T8XW
    • AI3-28581
    • FEMA NO. 4465
    • 4-02-00-00715 (Beilstein Handbook Reference)
    • (+/-)-PROPYLENEGLYCOL DIPROPIONATE
    • PROPYLENEGLYCOL DIPROPIONATE, (+/-)-
    • 1,2-Propanediol, dipropanoate (9CI)
    • SCHEMBL181935
    • Propane-1,2-diyl dipropanoate
    • DTXSID50864210
    • MFCD01697973
    • PROPIONIC ACID, PROPYLENE ESTER
    • NS00044645
    • 1-(PROPANOYLOXY)PROPAN-2-YL PROPANOATE
    • Q27259465
    • 233-298-8

  • Applications

    Propylene glycol dipropionate (CAS 10108-80-2) is commonly used as a fragrance solvent and fixative in perfumery, helping dissolve volatile aroma chemicals and extend scent persistence in formulations. It also serves as an emollient and solvent in cosmetics and personal care products, aiding skin feel and ingredient solubilization. In industrial contexts, it can function as a processing aid and plasticizer for certain polymers and coatings, contributing to flexibility and formulation stability. It may be employed as a solvent or intermediate in chemical synthesis and formulation work, including flavor/fragrance systems, and can be found in some household products as a humectant or solvent. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 677.55
    methanol 1235.81
    isopropanol 584.23
    water 11.24
    ethyl acetate 1166.14
    n-propanol 507.18
    acetone 2261.48
    n-butanol 446.55
    acetonitrile 2354.92
    DMF 2891.39
    toluene 489.6
    isobutanol 439.05
    1,4-dioxane 1337.72
    methyl acetate 1386.97
    THF 1354.65
    2-butanone 1344.84
    n-pentanol 406.94
    sec-butanol 565.7
    n-hexane 91.31
    ethylene glycol 185.68
    NMP 2308.47
    cyclohexane 102.51
    DMSO 3195.88
    n-butyl acetate 681.41
    n-octanol 187.46
    chloroform 2534.06
    n-propyl acetate 729.11
    acetic acid 2293.76
    dichloromethane 3082.3
    cyclohexanone 1485.06
    propylene glycol 193.68
    isopropyl acetate 674.87
    DMAc 3203.76
    2-ethoxyethanol 969.74
    isopentanol 459.33
    n-heptane 30.15
    ethyl formate 1024.61
    1,2-dichloroethane 1911.62
    n-hexanol 257.73
    2-methoxyethanol 1375.38
    isobutyl acetate 402.2
    tetrachloromethane 375.03
    n-pentyl acetate 392.1
    transcutol 1583.73
    n-heptanol 133.83
    ethylbenzene 338.25
    MIBK 525.04
    2-propoxyethanol 626.49
    tert-butanol 884.2
    MTBE 995.67
    2-butoxyethanol 342.51
    propionic acid 894.89
    o-xylene 402.01
    formic acid 943.36
    diethyl ether 776.09
    m-xylene 323.58
    p-xylene 515.82
    chlorobenzene 887.99
    dimethyl carbonate 498.33
    n-octane 22.07
    formamide 1416.19
    cyclopentanone 1684.54
    2-pentanone 893.59
    anisole 761.35
    cyclopentyl methyl ether 694.3
    gamma-butyrolactone 2182.04
    1-methoxy-2-propanol 775.22
    pyridine 1359.69
    3-pentanone 829.32
    furfural 2124.68
    n-dodecane 21.09
    diethylene glycol 495.59
    diisopropyl ether 224.17
    tert-amyl alcohol 848.81
    acetylacetone 1450.15
    n-hexadecane 24.34
    acetophenone 861.74
    methyl propionate 878.3
    isopentyl acetate 574.18
    trichloroethylene 3321.39
    n-nonanol 164.25
    cyclohexanol 527.79
    benzyl alcohol 603.41
    2-ethylhexanol 199.89
    isooctanol 125.16
    dipropyl ether 257.18
    1,2-dichlorobenzene 919.26
    ethyl lactate 304.89
    propylene carbonate 1215.62
    n-methylformamide 1583.82
    2-pentanol 329.45
    n-pentane 58.35
    1-propoxy-2-propanol 386.65
    1-methoxy-2-propyl acetate 544.59
    2-(2-methoxypropoxy) propanol 417.05
    mesitylene 199.44
    ε-caprolactone 1371.44
    p-cymene 158.09
    epichlorohydrin 2072.8
    1,1,1-trichloroethane 1587.69
    2-aminoethanol 346.56
    morpholine-4-carbaldehyde 2030.82
    sulfolane 2526.58
    2,2,4-trimethylpentane 60.79
    2-methyltetrahydrofuran 1134.52
    n-hexyl acetate 536.5
    isooctane 29.2
    2-(2-butoxyethoxy)ethanol 481.58
    sec-butyl acetate 456.15
    tert-butyl acetate 694.99
    decalin 86.4
    glycerin 335.28
    diglyme 1190.88
    acrylic acid 935.83
    isopropyl myristate 190.09
    n-butyric acid 1025.32
    acetyl acetate 1085.73
    di(2-ethylhexyl) phthalate 225.51
    ethyl propionate 649.51
    nitromethane 4255.77
    1,2-diethoxyethane 651.31
    benzonitrile 990.08
    trioctyl phosphate 141.08
    1-bromopropane 860.32
    gamma-valerolactone 2209.0
    n-decanol 117.27
    triethyl phosphate 272.93
    4-methyl-2-pentanol 198.61
    propionitrile 1061.2
    vinylene carbonate 1226.42
    1,1,2-trichlorotrifluoroethane 1489.03
    DMS 600.49
    cumene 225.47
    2-octanol 122.52
    2-hexanone 678.89
    octyl acetate 249.03
    limonene 226.58
    1,2-dimethoxyethane 1862.43
    ethyl orthosilicate 247.56
    tributyl phosphate 235.38
    diacetone alcohol 636.81
    N,N-dimethylaniline 555.43
    acrylonitrile 1552.31
    aniline 602.09
    1,3-propanediol 513.41
    bromobenzene 955.89
    dibromomethane 1770.77
    1,1,2,2-tetrachloroethane 2485.18
    2-methyl-cyclohexyl acetate 360.18
    tetrabutyl urea 293.65
    diisobutyl methanol 132.05
    2-phenylethanol 371.46
    styrene 463.51
    dioctyl adipate 328.49
    dimethyl sulfate 1034.25
    ethyl butyrate 487.36
    methyl lactate 408.83
    butyl lactate 308.2
    diethyl carbonate 387.94
    propanediol butyl ether 335.99
    triethyl orthoformate 316.99
    p-tert-butyltoluene 149.37
    methyl 4-tert-butylbenzoate 460.4
    morpholine 1457.43
    tert-butylamine 531.12
    n-dodecanol 89.57
    dimethoxymethane 1157.34
    ethylene carbonate 1024.3
    cyrene 483.05
    2-ethoxyethyl acetate 584.45
    2-ethylhexyl acetate 462.98
    1,2,4-trichlorobenzene 1028.49
    4-methylpyridine 1738.14
    dibutyl ether 315.91
    2,6-dimethyl-4-heptanol 132.05
    DEF 1376.61
    dimethyl isosorbide 713.58
    tetrachloroethylene 1617.24
    eugenol 424.72
    triacetin 606.58
    span 80 312.41
    1,4-butanediol 263.06
    1,1-dichloroethane 1616.14
    2-methyl-1-pentanol 433.98
    methyl formate 1292.81
    2-methyl-1-butanol 458.53
    n-decane 34.76
    butyronitrile 933.12
    3,7-dimethyl-1-octanol 214.98
    1-chlorooctane 162.6
    1-chlorotetradecane 67.58
    n-nonane 33.58
    undecane 25.96
    tert-butylcyclohexane 77.15
    cyclooctane 32.74
    cyclopentanol 549.76
    tetrahydropyran 955.53
    tert-amyl methyl ether 776.95
    2,5,8-trioxanonane 704.84
    1-hexene 300.55
    2-isopropoxyethanol 589.16
    2,2,2-trifluoroethanol 821.04
    methyl butyrate 959.73

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction