Propionyl chloride

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  • Identifiers

    CAS number
    79-03-8

    Molecular formula
    C3H5ClO

    SMILES
    CCC(=O)Cl

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Cheesy 55.57%
    Caramellic 43.12%
    Fruity 42.64%
    Buttery 41.43%
    Pungent 41.32%
    Sour 39.18%
    Dairy 33.21%
    Ethereal 32.03%
    Sharp 31.54%
    Nutty 30.73%

     

    Flavor
    Pungent 31.98%
    Odorless 31.56%
    Cheese 29.36%
    Acidic 27.07%
    Sour 25.47%
    Sulfurous 24.37%
    Mousy 23.26%
    Mustard 22.79%
    Fishy 22.24%
    Soy 22.04%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.2

    pKa est.
    7.44 (neutral)

    Molecular weight
    92.52 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -94 °C

    Boiling point

    • 80 °C

    Flash point

    • 8.58 ˚C est.
    • 54 °F (NFPA, 2010)
    • 54 °F (12 °C)

    Solubility expt.

    • Soluble in ether

  • Synonyms

    • Propionyl chloride
    • PROPANOYL CHLORIDE
    • 79-03-8
    • Propionic acid chloride
    • Propionic chloride
    • Propionylchloride
    • UNII-MB6VL5OMB9
    • EINECS 201-170-0
    • MFCD00000745
    • NSC 83547
    • NSC-83547
    • UN1815
    • MB6VL5OMB9
    • PROPIONYL CHLORIDE [MI]
    • DTXSID4058819
    • HSDB 8374
    • EC 201-170-0
    • UN 1815
    • UN-1815
    • propanoylchloride
    • propanoic chloride
    • propionyl-chloride
    • EtCOCl
    • proprionyl chloride
    • ethylcarbonyl chloride
    • Propionyl chloride, 98%
    • CHLORO ETHYL KETONE
    • DTXCID0048133
    • NSC83547
    • STR00513
    • STL146550
    • AKOS000121232
    • DB-004079
    • NS00009840
    • P0516
    • EN300-19539
    • F87490
    • Propionyl chloride [UN1815] [Flammable liquid]
    • Q13534584
    • F2146-0406

  • Applications

    Propionyl chloride (CAS 79-03-8) is a reactive acylating agent widely used to introduce the propionyl group in organic synthesis. It is employed to make amides and esters, including N-propionyl derivatives used as protecting groups in peptide synthesis, and to prepare pharmaceutical and agrochemical intermediates. In fragrance and flavor chemistry, it is used for propionylation steps that generate certain aroma compounds. It also serves as a building block in polymer and coating formulations to impart propionyl functionality, supporting downstream material modification and performance. Overall, it is typically used in industrial manufacturing under proper handling and regulatory controls to access a range of propionylated products.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 502.26
    methanol 636.21
    isopropanol 398.46
    water 28.95
    ethyl acetate 581.03
    n-propanol 347.88
    acetone 1344.71
    n-butanol 343.72
    acetonitrile 1214.55
    DMF 1982.38
    toluene 288.51
    isobutanol 291.08
    1,4-dioxane 784.29
    methyl acetate 862.18
    THF 675.54
    2-butanone 932.88
    n-pentanol 321.94
    sec-butanol 396.68
    n-hexane 80.18
    ethylene glycol 141.81
    NMP 2170.36
    cyclohexane 82.29
    DMSO 1643.79
    n-butyl acetate 450.99
    n-octanol 223.09
    chloroform 1304.03
    n-propyl acetate 482.61
    acetic acid 1244.76
    dichloromethane 1322.75
    cyclohexanone 1113.04
    propylene glycol 146.39
    isopropyl acetate 351.5
    DMAc 1825.34
    2-ethoxyethanol 498.1
    isopentanol 319.38
    n-heptane 46.89
    ethyl formate 546.9
    1,2-dichloroethane 804.46
    n-hexanol 226.3
    2-methoxyethanol 649.09
    isobutyl acetate 252.17
    tetrachloromethane 281.53
    n-pentyl acetate 367.56
    transcutol 1397.85
    n-heptanol 155.26
    ethylbenzene 259.72
    MIBK 324.53
    2-propoxyethanol 386.24
    tert-butanol 481.26
    MTBE 476.57
    2-butoxyethanol 295.59
    propionic acid 621.33
    o-xylene 297.35
    formic acid 509.54
    diethyl ether 360.23
    m-xylene 225.88
    p-xylene 456.43
    chlorobenzene 569.64
    dimethyl carbonate 290.75
    n-octane 31.97
    formamide 814.57
    cyclopentanone 1139.06
    2-pentanone 599.0
    anisole 561.77
    cyclopentyl methyl ether 398.21
    gamma-butyrolactone 1299.61
    1-methoxy-2-propanol 477.27
    pyridine 937.03
    3-pentanone 545.65
    furfural 1538.78
    n-dodecane 29.28
    diethylene glycol 309.24
    diisopropyl ether 148.32
    tert-amyl alcohol 486.92
    acetylacetone 883.32
    n-hexadecane 33.05
    acetophenone 745.67
    methyl propionate 518.61
    isopentyl acetate 386.49
    trichloroethylene 1803.48
    n-nonanol 184.37
    cyclohexanol 362.82
    benzyl alcohol 449.29
    2-ethylhexanol 179.17
    isooctanol 140.57
    dipropyl ether 183.05
    1,2-dichlorobenzene 620.23
    ethyl lactate 205.13
    propylene carbonate 742.56
    n-methylformamide 931.34
    2-pentanol 273.15
    n-pentane 65.28
    1-propoxy-2-propanol 280.6
    1-methoxy-2-propyl acetate 356.74
    2-(2-methoxypropoxy) propanol 396.2
    mesitylene 167.93
    ε-caprolactone 914.99
    p-cymene 161.05
    epichlorohydrin 1029.13
    1,1,1-trichloroethane 862.92
    2-aminoethanol 240.58
    morpholine-4-carbaldehyde 1502.09
    sulfolane 1617.26
    2,2,4-trimethylpentane 61.24
    2-methyltetrahydrofuran 677.9
    n-hexyl acetate 505.02
    isooctane 33.17
    2-(2-butoxyethoxy)ethanol 469.13
    sec-butyl acetate 306.06
    tert-butyl acetate 379.91
    decalin 72.55
    glycerin 204.06
    diglyme 922.3
    acrylic acid 705.44
    isopropyl myristate 182.87
    n-butyric acid 583.41
    acetyl acetate 519.9
    di(2-ethylhexyl) phthalate 194.39
    ethyl propionate 378.99
    nitromethane 2335.48
    1,2-diethoxyethane 544.05
    benzonitrile 836.59
    trioctyl phosphate 133.95
    1-bromopropane 391.81
    gamma-valerolactone 1452.62
    n-decanol 137.56
    triethyl phosphate 186.44
    4-methyl-2-pentanol 158.91
    propionitrile 547.38
    vinylene carbonate 813.3
    1,1,2-trichlorotrifluoroethane 836.55
    DMS 503.24
    cumene 193.69
    2-octanol 159.31
    2-hexanone 544.78
    octyl acetate 232.01
    limonene 221.65
    1,2-dimethoxyethane 940.71
    ethyl orthosilicate 176.81
    tributyl phosphate 194.51
    diacetone alcohol 431.46
    N,N-dimethylaniline 450.56
    acrylonitrile 883.89
    aniline 386.63
    1,3-propanediol 350.49
    bromobenzene 574.81
    dibromomethane 795.95
    1,1,2,2-tetrachloroethane 1201.67
    2-methyl-cyclohexyl acetate 288.06
    tetrabutyl urea 264.29
    diisobutyl methanol 124.43
    2-phenylethanol 322.74
    styrene 360.79
    dioctyl adipate 285.25
    dimethyl sulfate 624.23
    ethyl butyrate 330.09
    methyl lactate 260.18
    butyl lactate 272.83
    diethyl carbonate 246.17
    propanediol butyl ether 336.04
    triethyl orthoformate 226.72
    p-tert-butyltoluene 149.77
    methyl 4-tert-butylbenzoate 415.22
    morpholine 780.19
    tert-butylamine 305.33
    n-dodecanol 108.26
    dimethoxymethane 554.68
    ethylene carbonate 555.82
    cyrene 392.28
    2-ethoxyethyl acetate 506.16
    2-ethylhexyl acetate 336.25
    1,2,4-trichlorobenzene 740.39
    4-methylpyridine 1172.45
    dibutyl ether 263.23
    2,6-dimethyl-4-heptanol 124.43
    DEF 943.26
    dimethyl isosorbide 554.87
    tetrachloroethylene 852.42
    eugenol 398.65
    triacetin 543.72
    span 80 334.59
    1,4-butanediol 197.66
    1,1-dichloroethane 815.94
    2-methyl-1-pentanol 329.64
    methyl formate 752.19
    2-methyl-1-butanol 311.13
    n-decane 44.94
    butyronitrile 542.01
    3,7-dimethyl-1-octanol 221.64
    1-chlorooctane 157.38
    1-chlorotetradecane 70.7
    n-nonane 45.26
    undecane 35.32
    tert-butylcyclohexane 71.72
    cyclooctane 32.33
    cyclopentanol 402.42
    tetrahydropyran 539.41
    tert-amyl methyl ether 397.99
    2,5,8-trioxanonane 633.85
    1-hexene 241.61
    2-isopropoxyethanol 354.99
    2,2,2-trifluoroethanol 507.08
    methyl butyrate 584.01

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction