Progesterone

Overview IFRA Request a quote

  • Identifiers

    CAS number
    57-83-0

    Molecular formula
    C21H30O2

    SMILES
    CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C

    Safety labels

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Woody 86.19%
    Cedar 50.27%
    Amber 48.4%
    Fruity 46.98%
    Dry 44.14%
    Orris 42.36%
    Musk 38.74%
    Tobacco 35.3%
    Floral 34.25%
    Powdery 31.99%

     

    Flavor
    Minty 34.02%
    Fruity 29.64%
    Sweet 27.21%
    Spicy 24.98%
    Mint 24.15%
    Fresh 24.07%
    Herbal 24.04%
    Woody 23.03%
    Spice 22.22%
    Camphor 21.93%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.9

    pKa est.
    7.32 (neutral)

    Molecular weight
    314.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 250 to 252 °F (NTP, 1992)
    • 128-132
    • 129 °C
    • 121 °C
    • 250-252 °F

    Boiling point

    • 394.13°C (rough estimate)

    Flash point

    • 206.68 ˚C est.

    Solubility expt.

    • less than 1 mg/mL at 66 °F (NTP, 1992)
    • <0.1 g/100 mL at 19 ºC
    • Sol in alcohol, acetone, dioxane /beta-Progesterone/
    • Soluble in alcohol, acetone, dioxane, concentrated sulfuric acid; sparingly soluble in vegetable oils
    • In double-distilled water, 9.12 mg/L
    • In water, 8.81 mg/L at 25 °C
    • 0.00881 mg/mL at 25 °C

  • Synonyms

    • progesterone
    • 57-83-0
    • Pregn-4-ene-3,20-dione
    • Agolutin
    • Crinone
    • 4-Pregnene-3,20-dione
    • Prometrium
    • Utrogestan
    • Progestin
    • Luteol
    • Gestormone
    • Glanducorpin
    • Pregnenedione
    • Progesterol
    • Progesteronum
    • Progestone
    • Progestron
    • Syngesterone
    • Corlutin
    • Hormoflaveine
    • Lutociclina
    • Methylpregnone
    • Progestasert
    • Progestosol
    • Progestronol
    • Syngestrets
    • Corporin
    • Cyclogest
    • Flavolutan
    • Fologenon
    • Gestone
    • Gestron
    • Gynlutin
    • Gynolutone
    • Hormoluton
    • Lingusorbs
    • Lucorteum
    • Luteodyn
    • Luteogan
    • Luteopur
    • Luteosan
    • Luteostab
    • Luteovis
    • Lutidon
    • Lutocylin
    • Lutoform
    • Membrettes
    • Nalutron
    • Piaponon
    • Primolut
    • Progekan
    • Prolets
    • Protormone
    • Syntolutan
    • Lutren
    • Lucorteum Sol
    • Bio-luton
    • Lutocyclin M
    • Luteocrin normale
    • Corlutina
    • Corluvite
    • Gesterol
    • Luteinique
    • Lutocyclin
    • Lutromone
    • Prochieve
    • Prolidon
    • Proluton
    • Prolutone
    • Lutogyl
    • Lutex
    • Lutin
    • 17alpha-Progesterone
    • Lipo-Lutin
    • Synovex S
    • Gynoluton
    • Projestaject
    • Percutacrine Luteinique
    • Gesterol 100
    • Akrolutin
    • Gesterol 50
    • Pregnene-3,20-dione
    • Cyclogesterin
    • Endometrin
    • Progesteron
    • Prolutin
    • (S)-Progesterone
    • 3,20-Pregnene-4
    • Gelbkoerperhormon
    • Colprosterone
    • Progestogel
    • Progeston
    • Crinone progesterone gel
    • Progesterona
    • Gestiron
    • Lugesteron
    • Progestol
    • Vitarrine
    • Luteol (VAN)
    • NSC-9704
    • Lutocuclin M
    • (S)-4-Pregnene-3,20-dione
    • Delta(4)-pregnene-3,20-dione
    • (S)-Pregn-4-en-3,20-dione
    • .beta.-Progesterone
    • delta(sup 4)-Pregnene-3,20-dione
    • Percutacrine
    • Progeffik
    • Utrogest
    • Luteum
    • Progesteronum [INN-Latin]
    • Progesterona [INN-Spanish]
    • CCRIS 533
    • HSDB 3389
    • AI3-51682
    • Prontogest
    • Lipolutin
    • Lutogynon
    • Estima
    • Progesterone, micronized
    • 17.alpha.-Progesterone
    • 6alpha-Methylpregn-4-en-17alpha-ol-3,20-dione
    • Progesterone [Progestins]
    • NSC 9704
    • Prometrium (TN)
    • EINECS 200-350-6
    • Pregn-4-en-3,20-dione
    • UNII-4G7DS2Q64Y

  • Applications

    Progesterone (CAS 57-83-0) is primarily used as an intermediate in pharmaceutical manufacturing, especially for the synthesis of progestin steroids and related hormones. It also serves as a reference standard in steroid analysis and quantification in analytical laboratories. In research and development, progesterone functions as a starting material for steroid chemistry and related synthetic routes. Additionally, it is used as a building block in industrial chemical processes related to steroid synthesis.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 66.77
    methanol 67.33
    isopropanol 53.8
    water 0.39
    ethyl acetate 107.71
    n-propanol 72.42
    acetone 180.82
    n-butanol 76.23
    acetonitrile 122.84
    DMF 177.04
    toluene 399.21
    isobutanol 44.88
    1,4-dioxane 314.1
    methyl acetate 71.45
    THF 485.34
    2-butanone 101.19
    n-pentanol 21.74
    sec-butanol 19.72
    n-hexane 1.48
    ethylene glycol 9.16
    NMP 71.59
    cyclohexane 15.9
    DMSO 59.12
    n-butyl acetate 56.77
    n-octanol 8.57
    chloroform 442.21
    n-propyl acetate 43.72
    acetic acid 42.92
    dichloromethane 269.26
    cyclohexanone 196.26
    propylene glycol 11.07
    isopropyl acetate 95.32
    DMAc 99.7
    2-ethoxyethanol 50.61
    isopentanol 54.95
    n-heptane 1.54
    ethyl formate 44.11
    1,2-dichloroethane 161.16
    n-hexanol 35.14
    2-methoxyethanol 138.44
    isobutyl acetate 40.98
    tetrachloromethane 39.34
    n-pentyl acetate 36.06
    transcutol 224.95
    n-heptanol 17.51
    ethylbenzene 49.72
    MIBK 80.09
    2-propoxyethanol 123.59
    tert-butanol 42.72
    MTBE 29.19
    2-butoxyethanol 57.48
    propionic acid 35.26
    o-xylene 92.39
    formic acid 17.66
    diethyl ether 85.58
    m-xylene 154.59
    p-xylene 58.36
    chlorobenzene 171.93
    dimethyl carbonate 60.72
    n-octane 0.63
    formamide 42.14
    cyclopentanone 222.06
    2-pentanone 114.71
    anisole 99.56
    cyclopentyl methyl ether 135.42
    gamma-butyrolactone 183.44
    1-methoxy-2-propanol 128.03
    pyridine 321.24
    3-pentanone 82.49
    furfural 163.96
    n-dodecane 0.59
    diethylene glycol 86.28
    diisopropyl ether 21.5
    tert-amyl alcohol 14.09
    acetylacetone 164.73
    n-hexadecane 0.76
    acetophenone 77.08
    methyl propionate 88.35
    isopentyl acetate 64.19
    trichloroethylene 312.69
    n-nonanol 10.17
    cyclohexanol 61.32
    benzyl alcohol 71.23
    2-ethylhexanol 18.52
    isooctanol 16.07
    dipropyl ether 29.22
    1,2-dichlorobenzene 117.27
    ethyl lactate 28.57
    propylene carbonate 84.98
    n-methylformamide 84.05
    2-pentanol 29.23
    n-pentane 3.52
    1-propoxy-2-propanol 75.59
    1-methoxy-2-propyl acetate 121.23
    2-(2-methoxypropoxy) propanol 52.03
    mesitylene 60.08
    ε-caprolactone 125.96
    p-cymene 23.29
    epichlorohydrin 246.24
    1,1,1-trichloroethane 131.24
    2-aminoethanol 27.99
    morpholine-4-carbaldehyde 163.49
    sulfolane 110.41
    2,2,4-trimethylpentane 1.31
    2-methyltetrahydrofuran 119.18
    n-hexyl acetate 35.82
    isooctane 1.85
    2-(2-butoxyethoxy)ethanol 71.63
    sec-butyl acetate 39.89
    tert-butyl acetate 82.0
    decalin 3.98
    glycerin 25.61
    diglyme 152.0
    acrylic acid 32.42
    isopropyl myristate 17.81
    n-butyric acid 83.66
    acetyl acetate 90.32
    di(2-ethylhexyl) phthalate 26.0
    ethyl propionate 49.04
    nitromethane 107.63
    1,2-diethoxyethane 63.95
    benzonitrile 117.35
    trioctyl phosphate 15.09
    1-bromopropane 79.03
    gamma-valerolactone 316.08
    n-decanol 7.43
    triethyl phosphate 27.76
    4-methyl-2-pentanol 25.2
    propionitrile 124.0
    vinylene carbonate 104.78
    1,1,2-trichlorotrifluoroethane 101.11
    DMS 61.98
    cumene 25.32
    2-octanol 8.03
    2-hexanone 36.88
    octyl acetate 18.74
    limonene 22.35
    1,2-dimethoxyethane 105.15
    ethyl orthosilicate 26.69
    tributyl phosphate 17.79
    diacetone alcohol 73.08
    N,N-dimethylaniline 49.03
    acrylonitrile 146.77
    aniline 210.97
    1,3-propanediol 68.71
    bromobenzene 186.14
    dibromomethane 170.5
    1,1,2,2-tetrachloroethane 232.12
    2-methyl-cyclohexyl acetate 45.69
    tetrabutyl urea 23.63
    diisobutyl methanol 15.9
    2-phenylethanol 82.69
    styrene 64.05
    dioctyl adipate 29.1
    dimethyl sulfate 63.9
    ethyl butyrate 46.32
    methyl lactate 44.41
    butyl lactate 35.29
    diethyl carbonate 35.45
    propanediol butyl ether 34.56
    triethyl orthoformate 40.45
    p-tert-butyltoluene 22.18
    methyl 4-tert-butylbenzoate 60.27
    morpholine 276.84
    tert-butylamine 25.11
    n-dodecanol 5.51
    dimethoxymethane 220.6
    ethylene carbonate 95.66
    cyrene 60.15
    2-ethoxyethyl acetate 78.51
    2-ethylhexyl acetate 46.32
    1,2,4-trichlorobenzene 131.49
    4-methylpyridine 289.03
    dibutyl ether 13.29
    2,6-dimethyl-4-heptanol 15.9
    DEF 72.14
    dimethyl isosorbide 105.89
    tetrachloroethylene 140.53
    eugenol 64.7
    triacetin 59.55
    span 80 39.31
    1,4-butanediol 14.96
    1,1-dichloroethane 151.35
    2-methyl-1-pentanol 18.28
    methyl formate 52.63
    2-methyl-1-butanol 33.65
    n-decane 1.11
    butyronitrile 100.07
    3,7-dimethyl-1-octanol 13.52
    1-chlorooctane 6.37
    1-chlorotetradecane 2.6
    n-nonane 0.84
    undecane 0.77
    tert-butylcyclohexane 2.65
    cyclooctane 3.76
    cyclopentanol 51.7
    tetrahydropyran 246.67
    tert-amyl methyl ether 16.98
    2,5,8-trioxanonane 94.38
    1-hexene 8.19
    2-isopropoxyethanol 37.44
    2,2,2-trifluoroethanol 24.7
    methyl butyrate 51.95

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction