Procaine Hydrochloride

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  • Identifiers

    CAS number
    51-05-8

    Molecular formula
    C13H21ClN2O2

    SMILES
    CCN(CC)CCOC(=O)C1=CC=C(C=C1)N.Cl

    Safety labels

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 40.47%
    Grape 34.42%
    Fishy 31.03%
    Cheesy 27.45%
    Savory 26.65%
    Sweet 26.5%
    Meaty 26.43%
    Animal 25.52%
    Citrus 24.08%
    Cooling 24.01%

     

    Flavor
    Fruity 48.51%
    Mild 32.86%
    Odorless 32.0%
    Bitter 30.26%
    Grape 22.46%
    Floral 21.99%
    Bland 21.11%
    Orange flower 21.01%
    Herbal 20.9%
    Petitgrain 20.86%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.99 (weak acid)

    Molecular weight
    272.77 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    371°C

    Flash point

    • 181.43 ˚C est.

  • Synonyms

    • PROCAINE HYDROCHLORIDE
    • 51-05-8
    • Procaine Hcl
    • Naucaine
    • Neocaine
    • Omnicain
    • Planocaine
    • Anestil
    • Jenacaine
    • Medaject
    • Syntocain
    • Rocain
    • Enpro
    • Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester, monohydrochloride
    • DTXSID1044435
    • 95URV01IDQ
    • SP01A
    • NSC-757280
    • SP-01A
    • Procaini hydrochloridum
    • 2-(Diethylamino)ethyl p-aminobenzoate monohydrochloride
    • DTXCID9024435
    • Pasconeural n
    • Hydrochloride, Procaine
    • RefChem:55917
    • 2-(Diethylamino)ethyl 4-aminobenzoate monohydrochloride
    • 200-077-2
    • NSC169497
    • 2-(diethylamino)ethyl 4-aminobenzoate hydrochloride
    • Novocain
    • Procaine (hydrochloride)
    • Allocaine
    • MFCD00013000
    • Procaine (Novocaine) HCl
    • procaine.hcl
    • 4-Aminobenzoic acid 2-(diethylamino)ethyl ester hydrochloride
    • Gerovital H3
    • s4023
    • geriocaine
    • Atoxicocaine
    • Chlorocaine
    • Neotonocaine
    • Aminocaine
    • Anadolor
    • Anesthesol
    • Bernocaine
    • Ethocaine
    • Eugerase
    • Herocaine
    • Irocaine
    • Juvocaine
    • Kerocaine
    • Lactocaine
    • Novocainum
    • Paracain
    • Sevicaine
    • Topokain
    • Westocaine
    • Cetain
    • Isocaine-heisler
    • Rocaine
    • 2-(diethylamino)ethyl 4-aminobenzoate;hydrochloride
    • MLS001304095
    • Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester, hydrochloride (1:1)
    • Novocaine hydrochloride
    • 2-(diethylamino)ethyl 4-aminobenzoate, chloride
    • CAS-51-05-8
    • SR-01000076096
    • NCGC00015864-02
    • SMR000718771
    • EINECS 200-077-2
    • UNII-95URV01IDQ
    • Procaine hydrochloride [JAN]
    • Gero
    • AI3-02404
    • Novocaine HCl
    • Procain HCl
    • p-Aminobenzoyldiethylaminoethanol hydrochloride
    • Diethylaminoethanol 4-aminobenzoate hydrochloride
    • Procaine hydrochloride [USP:JAN]
    • 2-diethylaminoethyl 4-aminobenzoate hydrochloride
    • 2-Diethylaminoethyl p-aminobenzoate hydrochloride
    • Novocain (TN)
    • Prestwick_530
    • p-Aminobenzoic acid 2-diethylaminoethyl ester hydrochloride
    • Procaine, hydrochloride
    • Procaine hydrochloride RS
    • Procaine hydrochloride CRS
    • EC 200-077-2
    • SCHEMBL27720
    • MLS001336055
    • MLS001336056
    • SPECTRUM1500504
    • CHEBI:8431
    • HY-B0546AR
    • orb1310278
    • CHEMBL1200841
    • Procaine hydrochloride, >=97%
    • HY-B0546A
    • HMS1568I03
    • HMS1920L06
    • HMS5082N17
    • Pharmakon1600-01500504
    • PROCAINE HYDROCHLORIDE [MI]
    • BB_SC-01493
    • Procaine (hydrochloride) (Standard)
    • Procaine For System Suitability CRS
    • Procaine hydrochloride (JP18/USP)
    • Tox21_110248
    • Tox21_302114
    • Tox21_500966
    • Benzoic acid, p-amino-, 2-(diethylamino)ethyl ester, monohydrochloride
    • CCG-39234
    • EBC-03727
    • NSC757280
    • SBB001081
    • PROCAINE HYDROCHLORIDE [VANDF]
    • AKOS006029122
    • PROCAINE HYDROCHLORIDE [MART.]
    • Tox21_110248_1
    • BS-4445
    • FP32177
    • KS-5259
    • LP00966
    • NC00527
    • NSC 757280
    • PROCAINE HYDROCHLORIDE [USP-RS]
    • 51-05-8

  • Applications

    Procaine Hydrochloride is primarily used as a local anesthetic for injections in dentistry and minor surgical procedures to achieve nerve blockade. It is employed in human medicine in injectable local anesthetic formulations and is also used in veterinary medicine for similar anesthetic purposes. As the water-soluble hydrochloride salt, it is incorporated into pharmaceutical formulations and compounding for injectable anesthetic preparations. In addition, it serves as a research and analytical reagent in pharmacology and analytical chemistry studies. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 64.97
    methanol 129.04
    isopropanol 22.1
    water 2.91
    ethyl acetate 56.84
    n-propanol 40.07
    acetone 56.68
    n-butanol 35.63
    acetonitrile 34.33
    DMF 221.31
    toluene 15.15
    isobutanol 24.11
    1,4-dioxane 43.91
    methyl acetate 42.09
    THF 67.66
    2-butanone 44.55
    n-pentanol 24.55
    sec-butanol 22.53
    n-hexane 1.11
    ethylene glycol 39.01
    NMP 264.62
    cyclohexane 1.96
    DMSO 571.84
    n-butyl acetate 36.12
    n-octanol 3.38
    chloroform 241.81
    n-propyl acetate 26.08
    acetic acid 273.81
    dichloromethane 324.57
    cyclohexanone 101.56
    propylene glycol 37.58
    isopropyl acetate 31.29
    DMAc 292.98
    2-ethoxyethanol 83.93
    isopentanol 29.78
    n-heptane 0.63
    ethyl formate 48.79
    1,2-dichloroethane 213.59
    n-hexanol 16.73
    2-methoxyethanol 157.24
    isobutyl acetate 16.25
    tetrachloromethane 25.3
    n-pentyl acetate 13.79
    transcutol 361.13
    n-heptanol 7.37
    ethylbenzene 7.55
    MIBK 22.29
    2-propoxyethanol 65.97
    tert-butanol 31.75
    MTBE 19.54
    2-butoxyethanol 31.71
    propionic acid 85.25
    o-xylene 16.61
    formic acid 240.16
    diethyl ether 19.86
    m-xylene 13.37
    p-xylene 11.58
    chlorobenzene 50.61
    dimethyl carbonate 38.2
    n-octane 0.25
    formamide 377.84
    cyclopentanone 123.37
    2-pentanone 38.78
    anisole 24.78
    cyclopentyl methyl ether 37.16
    gamma-butyrolactone 180.42
    1-methoxy-2-propanol 81.92
    pyridine 72.9
    3-pentanone 43.09
    furfural 211.99
    n-dodecane 0.21
    diethylene glycol 94.95
    diisopropyl ether 5.41
    tert-amyl alcohol 32.59
    acetylacetone 76.18
    n-hexadecane 0.24
    acetophenone 41.92
    methyl propionate 56.96
    isopentyl acetate 33.6
    trichloroethylene 412.06
    n-nonanol 3.86
    cyclohexanol 33.36
    benzyl alcohol 37.55
    2-ethylhexanol 9.72
    isooctanol 6.67
    dipropyl ether 9.41
    1,2-dichlorobenzene 63.72
    ethyl lactate 28.8
    propylene carbonate 101.63
    n-methylformamide 145.23
    2-pentanol 16.2
    n-pentane 1.06
    1-propoxy-2-propanol 38.38
    1-methoxy-2-propyl acetate 59.51
    2-(2-methoxypropoxy) propanol 51.9
    mesitylene 8.7
    ε-caprolactone 97.28
    p-cymene 6.79
    epichlorohydrin 213.61
    1,1,1-trichloroethane 104.59
    2-aminoethanol 71.19
    morpholine-4-carbaldehyde 195.88
    sulfolane 345.72
    2,2,4-trimethylpentane 1.28
    2-methyltetrahydrofuran 46.84
    n-hexyl acetate 14.94
    isooctane 0.66
    2-(2-butoxyethoxy)ethanol 62.83
    sec-butyl acetate 18.04
    tert-butyl acetate 34.21
    decalin 1.5
    glycerin 85.95
    diglyme 135.94
    acrylic acid 107.06
    isopropyl myristate 6.33
    n-butyric acid 107.83
    acetyl acetate 62.31
    di(2-ethylhexyl) phthalate 15.49
    ethyl propionate 26.4
    nitromethane 333.33
    1,2-diethoxyethane 41.37
    benzonitrile 36.71
    trioctyl phosphate 8.31
    1-bromopropane 45.32
    gamma-valerolactone 186.21
    n-decanol 2.99
    triethyl phosphate 26.28
    4-methyl-2-pentanol 10.71
    propionitrile 28.71
    vinylene carbonate 94.44
    1,1,2-trichlorotrifluoroethane 287.04
    DMS 41.47
    cumene 6.78
    2-octanol 3.13
    2-hexanone 22.95
    octyl acetate 8.85
    limonene 9.08
    1,2-dimethoxyethane 83.67
    ethyl orthosilicate 23.01
    tributyl phosphate 14.54
    diacetone alcohol 52.71
    N,N-dimethylaniline 23.55
    acrylonitrile 52.22
    aniline 51.3
    1,3-propanediol 82.1
    bromobenzene 46.23
    dibromomethane 153.9
    1,1,2,2-tetrachloroethane 319.08
    2-methyl-cyclohexyl acetate 27.84
    tetrabutyl urea 18.02
    diisobutyl methanol 6.23
    2-phenylethanol 32.96
    styrene 10.47
    dioctyl adipate 18.45
    dimethyl sulfate 115.69
    ethyl butyrate 28.3
    methyl lactate 55.11
    butyl lactate 23.22
    diethyl carbonate 27.71
    propanediol butyl ether 30.32
    triethyl orthoformate 25.39
    p-tert-butyltoluene 6.69
    methyl 4-tert-butylbenzoate 34.17
    morpholine 73.28
    tert-butylamine 15.2
    n-dodecanol 2.34
    dimethoxymethane 73.94
    ethylene carbonate 72.38
    cyrene 64.62
    2-ethoxyethyl acetate 39.54
    2-ethylhexyl acetate 26.14
    1,2,4-trichlorobenzene 94.09
    4-methylpyridine 66.44
    dibutyl ether 5.48
    2,6-dimethyl-4-heptanol 6.23
    DEF 89.48
    dimethyl isosorbide 95.38
    tetrachloroethylene 195.12
    eugenol 39.1
    triacetin 38.71
    span 80 32.56
    1,4-butanediol 32.93
    1,1-dichloroethane 105.53
    2-methyl-1-pentanol 25.95
    methyl formate 83.75
    2-methyl-1-butanol 28.92
    n-decane 0.3
    butyronitrile 24.56
    3,7-dimethyl-1-octanol 5.91
    1-chlorooctane 2.2
    1-chlorotetradecane 1.06
    n-nonane 0.25
    undecane 0.24
    tert-butylcyclohexane 1.2
    cyclooctane 0.76
    cyclopentanol 34.02
    tetrahydropyran 31.54
    tert-amyl methyl ether 20.15
    2,5,8-trioxanonane 100.22
    1-hexene 4.94
    2-isopropoxyethanol 42.63
    2,2,2-trifluoroethanol 131.61
    methyl butyrate 38.37

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction