Prednisone

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  • Identifiers

    CAS number
    53-03-2

    Molecular formula
    C21H26O5

    SMILES
    C[C@]12CC(=O)[C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C

    Safety labels

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Woody 55.19%
    Spicy 29.27%
    Fruity 27.29%
    Sweet 26.66%
    Cedar 26.23%
    Mint 25.15%
    Odorless 25.11%
    Tobacco 22.74%
    Dry 21.2%
    Camphoreous 21.06%

     

    Flavor
    Bitter 84.56%
    Sweet-like 20.71%
    Cedarleaf 20.18%
    Fenugreek 19.97%
    Lovage 19.56%
    Leaves 19.24%
    Odorless 19.18%
    Seedy 19.1%
    Basil 19.0%
    Extremely sweet 18.93%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.5

    pKa est.
    5.6 (weak acid)

    Molecular weight
    358.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    318°C

    Melting point expt.

    • 451 to 455 °F (DEC) (NTP, 1992)
    • 230 - 235 °C (decomposes)
    • 234 °C (decomposes)
    • 233 - 235 °C

    Flash point

    • 275.46 ˚C est.

    Solubility expt.

    • Very slightly soluble (NTP, 1992)
    • Very slightly soluble
    • Very slightly soluble in water; 1 g soluble in 150 mL alcohol, in 200 mL chloroform; slightly soluble in methanol
    • 1.11e-01 g/L

  • Synonyms

    • prednisone
    • 53-03-2
    • Dehydrocortisone
    • Decortin
    • Deltasone
    • Supercortil
    • Meticorten
    • Orasone
    • Metacortandracin
    • 1,2-Dehydrocortisone
    • Dacortin
    • Encorton
    • Paracort
    • Ancortone
    • Decortancyl
    • Decortisyl
    • Deltacortisone
    • Deltacortone
    • Prednilonga
    • Prednison
    • Rectodelt
    • Servisone
    • Sterapred
    • Ultracorten
    • Colisone
    • Deltison
    • Lodotra
    • Cortan
    • Liquid Pred
    • Prednicen-M
    • Delta-Dome
    • Di-Adreson
    • Ultracortene
    • Bicortone
    • Cortidelt
    • Dekortin
    • Diadreson
    • Encortone
    • Enkorton
    • Hostacortin
    • Lisacort
    • Panafcort
    • Prednisonum
    • Prednizon
    • Pronison
    • Zenadrid
    • Adasone
    • Cotone
    • Deltra
    • Juvason
    • Nurison
    • Wojtab
    • delta-Cortisone
    • Prednisone Intensol
    • Delta-Cortelan
    • Delta E
    • In-Sone
    • Novoprednisone
    • Cartancyl
    • Dacorten
    • Dellacort
    • Deltisona
    • Econosone
    • Incocortyl
    • Parmenison
    • Pehacort
    • Predeltin
    • Prednicorm
    • Prednicort
    • Prednicot
    • Prednisona
    • Prednitone
    • Prednovister
    • Retrocortine
    • Fiasone
    • Nisona
    • Presone
    • Winpred
    • delta cortelan
    • Nizon
    • Dellacort A
    • 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
    • SK-Prednisone
    • Me-Korti
    • Origen Prednisone
    • Prednisone tablets
    • delta-1-Cortisone
    • prednisone anhydrous
    • Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-
    • Deltisone
    • Rayos
    • Prednisonum [INN-Latin]
    • Prednisona [INN-Spanish]
    • Zenadrid (veterinary)
    • 1-Cortisone
    • 1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
    • Fernisone
    • 1-Dehydrocortisone
    • 3en3hg4wsw
    • delta(sup 1)-Cortisone
    • delta-1-Dehydrocortisone
    • Lodtra
    • delta(sup 1)-Dehydrocortisone
    • NSC-10023
    • NCI-C04897
    • NSC 10023
    • CCRIS 2646
    • CHEBI:8382
    • U 6020
    • HSDB 3168
    • UNII-VB0R961HZT
    • EINECS 200-160-3
    • VB0R961HZT
    • MFCD00003608
    • Deltadehydrocortisone
    • Prednisone(Adasone)
    • Prednidib
    • Panasol
    • Sone
    • DTXSID4021185
    • Zenadrid [veterinary]
    • Apo-Prednisone
    • AI3-52939
    • Deltacortene
    • Prednisone [USP:INN:BAN]
    • DTXCID701185
    • (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
    • .delta.-Cortisone

  • Applications

    Prednisone (CAS 53-03-2) is primarily used as an active pharmaceutical ingredient (API) in corticosteroid medications for humans and animals, providing systemic anti-inflammatory and immunosuppressive effects. In pharmaceutical manufacturing, prednisone serves as the active ingredient in products such as tablets and other dosage forms, and it supports formulation development and generic drug production. In steroid drug research and development, prednisone is employed as a reference material for analytical method development and for studying structure-activity relationships within corticosteroids. It is also used in veterinary medicines for similar indications. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 8.91
    methanol 23.76
    isopropanol 5.91
    water 0.11
    ethyl acetate 4.7
    n-propanol 7.96
    acetone 13.25
    n-butanol 4.76
    acetonitrile 9.48
    DMF 42.28
    toluene 3.67
    isobutanol 3.32
    1,4-dioxane 20.52
    methyl acetate 5.53
    THF 42.13
    2-butanone 8.31
    n-pentanol 1.98
    sec-butanol 1.73
    n-hexane 0.08
    ethylene glycol 6.02
    NMP 19.2
    cyclohexane 0.29
    DMSO 57.0
    n-butyl acetate 3.94
    n-octanol 1.11
    chloroform 22.28
    n-propyl acetate 3.0
    acetic acid 12.32
    dichloromethane 12.56
    cyclohexanone 15.35
    propylene glycol 3.78
    isopropyl acetate 4.02
    DMAc 27.58
    2-ethoxyethanol 11.46
    isopentanol 3.42
    n-heptane 0.07
    ethyl formate 4.52
    1,2-dichloroethane 7.31
    n-hexanol 3.55
    2-methoxyethanol 35.69
    isobutyl acetate 2.12
    tetrachloromethane 2.3
    n-pentyl acetate 3.57
    transcutol 15.99
    n-heptanol 2.48
    ethylbenzene 1.38
    MIBK 5.07
    2-propoxyethanol 24.31
    tert-butanol 4.66
    MTBE 1.14
    2-butoxyethanol 11.42
    propionic acid 5.03
    o-xylene 2.03
    formic acid 14.21
    diethyl ether 3.04
    m-xylene 2.3
    p-xylene 1.82
    chlorobenzene 3.8
    dimethyl carbonate 8.73
    n-octane 0.05
    formamide 23.27
    cyclopentanone 23.49
    2-pentanone 6.71
    anisole 4.59
    cyclopentyl methyl ether 5.4
    gamma-butyrolactone 19.63
    1-methoxy-2-propanol 22.73
    pyridine 15.64
    3-pentanone 5.51
    furfural 18.45
    n-dodecane 0.04
    diethylene glycol 28.43
    diisopropyl ether 0.75
    tert-amyl alcohol 1.59
    acetylacetone 11.89
    n-hexadecane 0.04
    acetophenone 6.35
    methyl propionate 6.47
    isopentyl acetate 4.09
    trichloroethylene 18.09
    n-nonanol 1.42
    cyclohexanol 3.0
    benzyl alcohol 5.79
    2-ethylhexanol 1.54
    isooctanol 1.98
    dipropyl ether 1.78
    1,2-dichlorobenzene 3.86
    ethyl lactate 4.3
    propylene carbonate 7.44
    n-methylformamide 23.2
    2-pentanol 1.59
    n-pentane 0.1
    1-propoxy-2-propanol 10.61
    1-methoxy-2-propyl acetate 9.73
    2-(2-methoxypropoxy) propanol 8.95
    mesitylene 1.28
    ε-caprolactone 9.3
    p-cymene 1.03
    epichlorohydrin 23.44
    1,1,1-trichloroethane 4.93
    2-aminoethanol 9.76
    morpholine-4-carbaldehyde 30.2
    sulfolane 30.17
    2,2,4-trimethylpentane 0.06
    2-methyltetrahydrofuran 6.15
    n-hexyl acetate 3.31
    isooctane 0.06
    2-(2-butoxyethoxy)ethanol 10.51
    sec-butyl acetate 1.95
    tert-butyl acetate 4.53
    decalin 0.14
    glycerin 12.58
    diglyme 20.71
    acrylic acid 6.91
    isopropyl myristate 1.34
    n-butyric acid 7.15
    acetyl acetate 5.32
    di(2-ethylhexyl) phthalate 3.32
    ethyl propionate 3.41
    nitromethane 25.2
    1,2-diethoxyethane 4.01
    benzonitrile 6.27
    trioctyl phosphate 2.07
    1-bromopropane 2.13
    gamma-valerolactone 34.78
    n-decanol 0.86
    triethyl phosphate 2.99
    4-methyl-2-pentanol 1.61
    propionitrile 7.62
    vinylene carbonate 9.66
    1,1,2-trichlorotrifluoroethane 23.2
    DMS 5.99
    cumene 0.92
    2-octanol 1.03
    2-hexanone 3.66
    octyl acetate 1.81
    limonene 1.12
    1,2-dimethoxyethane 18.01
    ethyl orthosilicate 2.56
    tributyl phosphate 1.94
    diacetone alcohol 9.6
    N,N-dimethylaniline 3.24
    acrylonitrile 13.15
    aniline 6.21
    1,3-propanediol 15.0
    bromobenzene 3.33
    dibromomethane 6.61
    1,1,2,2-tetrachloroethane 12.55
    2-methyl-cyclohexyl acetate 3.86
    tetrabutyl urea 3.23
    diisobutyl methanol 1.13
    2-phenylethanol 7.83
    styrene 1.56
    dioctyl adipate 3.03
    dimethyl sulfate 13.97
    ethyl butyrate 3.27
    methyl lactate 9.57
    butyl lactate 5.02
    diethyl carbonate 2.77
    propanediol butyl ether 6.46
    triethyl orthoformate 3.36
    p-tert-butyltoluene 0.97
    methyl 4-tert-butylbenzoate 7.54
    morpholine 22.12
    tert-butylamine 1.44
    n-dodecanol 0.53
    dimethoxymethane 34.77
    ethylene carbonate 8.01
    cyrene 12.5
    2-ethoxyethyl acetate 7.41
    2-ethylhexyl acetate 2.9
    1,2,4-trichlorobenzene 5.5
    4-methylpyridine 9.37
    dibutyl ether 0.85
    2,6-dimethyl-4-heptanol 1.13
    DEF 7.63
    dimethyl isosorbide 15.31
    tetrachloroethylene 9.92
    eugenol 10.08
    triacetin 5.62
    span 80 6.37
    1,4-butanediol 3.57
    1,1-dichloroethane 4.83
    2-methyl-1-pentanol 1.64
    methyl formate 14.38
    2-methyl-1-butanol 2.26
    n-decane 0.08
    butyronitrile 4.84
    3,7-dimethyl-1-octanol 1.09
    1-chlorooctane 0.44
    1-chlorotetradecane 0.15
    n-nonane 0.06
    undecane 0.05
    tert-butylcyclohexane 0.1
    cyclooctane 0.1
    cyclopentanol 4.4
    tetrahydropyran 8.31
    tert-amyl methyl ether 1.03
    2,5,8-trioxanonane 14.32
    1-hexene 0.4
    2-isopropoxyethanol 5.96
    2,2,2-trifluoroethanol 7.68
    methyl butyrate 4.09

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction