Prednisolone

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  • Identifiers

    CAS number
    50-24-8

    Molecular formula
    C21H28O5

    SMILES
    C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C)O

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Woody 46.69%
    Odorless 32.45%
    Sweet 31.53%
    Spicy 29.86%
    Mint 26.73%
    Fruity 24.38%
    Balsamic 21.65%
    Cedar 21.03%
    Camphoreous 20.43%
    Herbal 20.19%

     

    Flavor
    Bitter 85.4%
    Sweet-like 21.87%
    Cedarleaf 20.71%
    Odorless 20.4%
    Fenugreek 19.8%
    Lovage 19.69%
    Leaves 19.59%
    Bland 19.33%
    Seedy 19.21%
    Ripe apricot 19.17%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    5.97 (weak acid)

    Molecular weight
    360.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    299°C

    Melting point expt.

    • 235 °C
    • 235 °C with some decomposition
    • CRYSTALS FROM ETHANOL; MP: 266-273 °C /TEBUTATE/

    Flash point

    • 279.58 ˚C est.

    Solubility expt.

    • 223 mg/L (at 25 °C)
    • SPECIFIC OPTICAL ROTATION: +102.5 DEG @ 25 °C/D; PH OF 1% SOLN 7.5 TO 8.5; SOL IN WATER, METHANOL, ETHANOL. /PHOSPHATE SODIUM/
    • 1 g dissolves in about 30 mL of alc, in about 180 mL of chloroform, in about 50 mL of acetone; sol in methanol, dioxane.
    • In water, 2.23X10+2 mg/L at 25 °C
    • 2.39e-01 g/L

  • Synonyms

    • prednisolone
    • 50-24-8
    • Metacortandralone
    • Hydroretrocortine
    • Delta-Cortef
    • Deltacortril
    • Deltahydrocortisone
    • Codelcortone
    • Cortalone
    • Meticortelone
    • Predonine
    • Prenolone
    • Hydroretrocortin
    • Meti-Derm
    • Deltacortenol
    • Hydrodeltalone
    • Hydrodeltisone
    • Precortancyl
    • Predniliderm
    • Cotogesic
    • Decaprednil
    • Delcortol
    • Deltisilone
    • Dicortol
    • Donisolone
    • Dydeltrone
    • Erbacort
    • Erbasona
    • Estilsona
    • Fernisolone
    • Hydeltra
    • Hydeltrone
    • Lentosone
    • Paracortol
    • Paracotol
    • PRDL
    • Precortilon
    • Precortisyl
    • Prednelan
    • Prednicen
    • Predonin
    • Rolisone
    • Scherisolon
    • Sterolone
    • Cordrol
    • Prednis
    • Prelone
    • Steran
    • Sterane
    • Ulacort
    • Delta-stab
    • Fernisolone P
    • Hostacortin H
    • Ultracorten H
    • Ultracortene-H
    • Predne-Dome
    • Decortin H
    • CO-Hydeltra
    • Eazolin D
    • Di-adreson F
    • Delta F
    • Derpo PD
    • Solone
    • 1-Dehydrohydrocortisone
    • Fernisolone-P
    • delta(1)-Hydrocortisone
    • delta(1)-Dehydrocortisol
    • Delta-Ef-Cortelan
    • Predniretard
    • Prednisolona
    • Dexa-Cortidelt hostacortin H
    • Panafcortelone
    • Prednisolonum
    • Cotolone
    • 1,2-Dehydrohydrocortisone
    • delta(1)-Cortisol
    • Deltasolone
    • Supercortisol
    • Klismacort
    • Prednisolonum [INN-Latin]
    • Prednisolona [INN-Spanish]
    • Bubbli-Pred
    • delta(sup 1)-Cortisol
    • Delta(1)-dehydrohydrocortisone
    • 1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
    • Ultracortene-hydrogen
    • 11beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione
    • delta(sup 1)-Hydrocortisone
    • delta(sup 1)-Dehydrocortisol
    • CCRIS 980
    • (11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
    • 1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
    • K 1557
    • HSDB 3385
    • UNII-9PHQ9Y1OLM
    • 3,20-Dioxo-11beta,17alpha,21-trihydroxy-1,4-pregnadiene
    • 9PHQ9Y1OLM
    • delta(sup 1)-Dehydrohydrocortisone
    • NSC 9120
    • NSC-9120
    • NSC-9900
    • EINECS 200-021-7
    • delta-hydrocortisone
    • MFCD00003649
    • 11beta,17alpha,21-Trihydroxypregna-1,4-diene-3,20-dione
    • delta-dehydrocortisol
    • DELTA.1-Cortisol
    • APREDNISLON
    • BRN 1354103
    • EQUISOLON
    • VETSOLONE
    • CHEBI:8378
    • (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
    • DTXSID9021184
    • .DELTA.1-Cortisol
    • Prednisolone (Standard)
    • delta-dehydrohydrocortisone
    • (+)-PREDNISOLONE
    • .DELTA.1-Hydrocortisone
    • .DELTA.1-Dehydrocortisol
    • CHEMBL131
    • PREDNISOLONE ANHYDROUS
    • DTXCID301184
    • .DELTA.1-Dehydrohydrocortisone
    • .delta.-Cortef
    • 1-Dehydrocortisol
    • Neo-Delta-Cortef
    • NSC9120

  • Applications

    Prednisolone (CAS 50-24-8) is used as an active pharmaceutical ingredient in corticosteroid medicines for humans and animals, formulated for oral, injectable, or topical routes in pharmaceutical products. It is often employed as a precursor/intermediate in the synthesis of other corticosteroids and can serve as a reference standard or analytical reagent in pharmacology laboratories for corticosteroid quantification. In research and development, prednisolone features in formulation development and testing of steroid-containing products. These applications are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 15.37
    methanol 50.22
    isopropanol 6.69
    water 0.21
    ethyl acetate 4.66
    n-propanol 10.0
    acetone 14.01
    n-butanol 5.37
    acetonitrile 8.97
    DMF 51.28
    toluene 2.62
    isobutanol 3.45
    1,4-dioxane 21.06
    methyl acetate 4.79
    THF 50.6
    2-butanone 6.88
    n-pentanol 1.93
    sec-butanol 1.64
    n-hexane 0.09
    ethylene glycol 9.71
    NMP 17.34
    cyclohexane 0.29
    DMSO 73.87
    n-butyl acetate 3.48
    n-octanol 1.46
    chloroform 14.92
    n-propyl acetate 2.53
    acetic acid 13.91
    dichloromethane 9.41
    cyclohexanone 12.09
    propylene glycol 5.06
    isopropyl acetate 3.84
    DMAc 25.14
    2-ethoxyethanol 14.39
    isopentanol 3.32
    n-heptane 0.1
    ethyl formate 4.71
    1,2-dichloroethane 6.01
    n-hexanol 3.89
    2-methoxyethanol 50.05
    isobutyl acetate 1.75
    tetrachloromethane 2.06
    n-pentyl acetate 3.8
    transcutol 17.79
    n-heptanol 3.14
    ethylbenzene 1.17
    MIBK 4.85
    2-propoxyethanol 26.62
    tert-butanol 4.74
    MTBE 1.22
    2-butoxyethanol 13.2
    propionic acid 5.0
    o-xylene 1.7
    formic acid 20.42
    diethyl ether 3.58
    m-xylene 2.06
    p-xylene 1.37
    chlorobenzene 2.76
    dimethyl carbonate 8.56
    n-octane 0.07
    formamide 31.85
    cyclopentanone 21.47
    2-pentanone 6.44
    anisole 3.88
    cyclopentyl methyl ether 6.14
    gamma-butyrolactone 18.18
    1-methoxy-2-propanol 29.2
    pyridine 12.76
    3-pentanone 4.7
    furfural 16.76
    n-dodecane 0.04
    diethylene glycol 33.54
    diisopropyl ether 0.82
    tert-amyl alcohol 1.5
    acetylacetone 11.7
    n-hexadecane 0.05
    acetophenone 5.24
    methyl propionate 6.32
    isopentyl acetate 3.52
    trichloroethylene 13.61
    n-nonanol 1.76
    cyclohexanol 2.69
    benzyl alcohol 5.11
    2-ethylhexanol 1.6
    isooctanol 2.34
    dipropyl ether 2.05
    1,2-dichlorobenzene 2.9
    ethyl lactate 4.02
    propylene carbonate 6.61
    n-methylformamide 31.01
    2-pentanol 1.66
    n-pentane 0.13
    1-propoxy-2-propanol 11.57
    1-methoxy-2-propyl acetate 9.66
    2-(2-methoxypropoxy) propanol 9.09
    mesitylene 1.21
    ε-caprolactone 7.93
    p-cymene 0.97
    epichlorohydrin 23.17
    1,1,1-trichloroethane 3.35
    2-aminoethanol 15.84
    morpholine-4-carbaldehyde 29.35
    sulfolane 28.35
    2,2,4-trimethylpentane 0.06
    2-methyltetrahydrofuran 5.94
    n-hexyl acetate 3.54
    isooctane 0.07
    2-(2-butoxyethoxy)ethanol 11.71
    sec-butyl acetate 1.63
    tert-butyl acetate 4.41
    decalin 0.13
    glycerin 17.3
    diglyme 22.22
    acrylic acid 7.15
    isopropyl myristate 1.29
    n-butyric acid 7.02
    acetyl acetate 5.06
    di(2-ethylhexyl) phthalate 3.08
    ethyl propionate 2.95
    nitromethane 26.31
    1,2-diethoxyethane 4.2
    benzonitrile 4.74
    trioctyl phosphate 2.09
    1-bromopropane 1.8
    gamma-valerolactone 33.18
    n-decanol 1.02
    triethyl phosphate 2.56
    4-methyl-2-pentanol 1.65
    propionitrile 6.44
    vinylene carbonate 8.5
    1,1,2-trichlorotrifluoroethane 23.32
    DMS 5.36
    cumene 0.82
    2-octanol 1.26
    2-hexanone 3.06
    octyl acetate 1.82
    limonene 1.08
    1,2-dimethoxyethane 19.81
    ethyl orthosilicate 2.28
    tributyl phosphate 1.78
    diacetone alcohol 9.18
    N,N-dimethylaniline 2.92
    acrylonitrile 11.48
    aniline 5.1
    1,3-propanediol 19.98
    bromobenzene 2.19
    dibromomethane 4.92
    1,1,2,2-tetrachloroethane 9.48
    2-methyl-cyclohexyl acetate 3.3
    tetrabutyl urea 2.96
    diisobutyl methanol 1.18
    2-phenylethanol 7.23
    styrene 1.22
    dioctyl adipate 2.76
    dimethyl sulfate 13.76
    ethyl butyrate 2.88
    methyl lactate 10.21
    butyl lactate 5.4
    diethyl carbonate 2.3
    propanediol butyl ether 8.04
    triethyl orthoformate 3.02
    p-tert-butyltoluene 0.94
    methyl 4-tert-butylbenzoate 7.34
    morpholine 22.32
    tert-butylamine 1.46
    n-dodecanol 0.6
    dimethoxymethane 45.16
    ethylene carbonate 7.08
    cyrene 11.98
    2-ethoxyethyl acetate 7.74
    2-ethylhexyl acetate 2.47
    1,2,4-trichlorobenzene 3.91
    4-methylpyridine 6.95
    dibutyl ether 0.91
    2,6-dimethyl-4-heptanol 1.18
    DEF 7.17
    dimethyl isosorbide 14.96
    tetrachloroethylene 8.69
    eugenol 9.79
    triacetin 5.46
    span 80 6.88
    1,4-butanediol 4.47
    1,1-dichloroethane 3.39
    2-methyl-1-pentanol 1.48
    methyl formate 18.03
    2-methyl-1-butanol 2.18
    n-decane 0.1
    butyronitrile 4.11
    3,7-dimethyl-1-octanol 1.26
    1-chlorooctane 0.51
    1-chlorotetradecane 0.16
    n-nonane 0.08
    undecane 0.06
    tert-butylcyclohexane 0.1
    cyclooctane 0.12
    cyclopentanol 4.18
    tetrahydropyran 7.66
    tert-amyl methyl ether 1.01
    2,5,8-trioxanonane 15.08
    1-hexene 0.4
    2-isopropoxyethanol 6.53
    2,2,2-trifluoroethanol 8.19
    methyl butyrate 3.54

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction