Pramoxine Hydrochloride

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  • Identifiers

    CAS number
    637-58-1

    Molecular formula
    C17H28ClNO3

    SMILES
    CCCCOC1=CC=C(C=C1)OCCCN2CCOCC2.Cl

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 44.97%
    Floral 32.19%
    Vanilla 30.46%
    Fruity 23.68%
    Animal 23.39%
    Odorless 21.74%
    Aromatic 21.42%
    Herbal 21.03%
    Fresh 19.39%
    Mint 19.37%

     

    Flavor
    Floral 34.26%
    Sweet 31.24%
    Earthy 30.77%
    Bitter 30.22%
    Fruity 26.44%
    Oily 24.91%
    Green 23.95%
    Spicy 23.76%
    Mild 22.7%
    Mushroom 22.46%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    7.11 (neutral)

    Molecular weight
    329.9 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    411°C

    Melting point expt.

    • 181-183 °C

    Flash point

    • 171.21 ˚C est.

    Solubility expt.

    • Freely soluble in water
    • >49.5 [ug/mL] (The mean of the results at pH 7.4)

  • Synonyms

    • Pramoxine hydrochloride
    • 637-58-1
    • Pramoxine HCl
    • Pramocaine hydrochloride
    • Tronothane
    • NSC-25573
    • DTXSID2047777
    • 88AYB867L5
    • 4-(3-(p-Butoxyphenoxy)propyl)morpholine hydrochloride
    • Pramoxine hydrochloride (USP)
    • Pramoxine hydrochloride [USP]
    • DTXCID2027757
    • NSC25573
    • 4-[3-(p-Butoxyphenoxy)propyl]morpholine hydrochloride
    • Curasore
    • Reeses
    • Dermal-Soothe
    • Proctofoam NS
    • Suffusion P
    • Honey Pot
    • Pramoxine HCI
    • Ivy Wash
    • Poison Ivy Wash
    • Deter-X
    • Pramox-1
    • Comfort Conditioner
    • Pramox Creme rinse
    • Anti-Itch Soothing
    • Licefreee AfterLice
    • Walgreen Anti-Itch
    • Pramoxine Anti Itch
    • Pramoxine HCl 1%
    • COCOSKIN
    • VetraSeb CeraDerm P
    • Pramoxine Itch relief
    • Suffusion P MOUSSE
    • Leader Poison Ivy Wash
    • RefChem:55902
    • Davis Pramoxine Anti-Itch
    • Reeses Pinworm Itch Relief
    • CVS Itch relief moisturizing
    • pramoxine hydrochloride lotion
    • VetraSeb CeraDerm P MOUSSE
    • Cvs Fragrance Free Anti-itch
    • Sally Hansen Zero bump bikini
    • First Aid Sensitive Anti-Itch
    • Pramoxine Hydrochloride 1.0%
    • Private Label Poison Ivy Wash
    • Prosoria Anti-Itch Moisturizer
    • DerMend Moisturizing Anti-Itch
    • LOLA Vaginal Itch Relief Wipes
    • CeraSoothe P ANTI-ITCH MOUSSE
    • First Degree Maximum Strength Burn
    • Peviderm Pramoxine Hydrocholride 1%
    • CVS Health Maximum Strength Feminine
    • Aveeno Calm Plus Restore Itch Relief Balm
    • STRAWFIELD PETS ANTI-ITCH MEDICATED
    • dermabliss ANTI-ITCH and ALLERGY RELIEF
    • Anti Itch Soothing 1 Pramoxine Hydrochloride
    • Cvs Pharmacy Maximum Strength Feminine Wipes
    • Aveeno Restorative Skin Therapy Itch Relief Balm
    • Anti-Itch Soothing Wipes 1 Pramoxine Hydrochloride
    • Vagisil Anti-itch Medicated Wipes Maximum Strength
    • CeraVe Developed with Dermatologists Itch Relief Moisturizing
    • STRAWFIELD PETS ANTI-ITCH MEDICATED WITH PRAMOXINE HYDROCHLORIDE
    • 211-293-1
    • Prax Lotion
    • 4-(3-(4-butoxyphenoxy)propyl)morpholine hydrochloride
    • Morpholine, 4-[3-(4-butoxyphenoxy)propyl]-, hydrochloride
    • Pramocaine (hydrochloride)
    • 4-[3-(4-butoxyphenoxy)propyl]morpholine hydrochloride
    • MFCD00054323
    • MLS000028604
    • Tronolane
    • 4-[3-(4-butoxyphenoxy)propyl]morpholine;hydrochloride
    • 637-58-1 (HCl)
    • Morpholine, 4-(3-(4-butoxyphenoxy)propyl)-, hydrochloride
    • SMR000058670
    • Tronothane hydrochloride
    • ProctoFoam-NS
    • HSDB 7220
    • NCGC00016529-01
    • CAS-637-58-1
    • EINECS 211-293-1
    • NSC 25573
    • UNII-88AYB867L5
    • SR-01000000243
    • Pramoxine, HCl
    • Tronothane (TN)
    • Prestwick_1044
    • p-Butoxyphenyl gamma-morpholinopropyl ether hydrochloride
    • gamma-Morpholinopropyl 4-n-butoxyphenyl ether hydrochloride
    • Opera_ID_1593
    • MLS002222295
    • SCHEMBL180542
    • SPECTRUM1501139
    • CHEBI:8358
    • orb1310591
    • CHEMBL1201171
    • HY-B1319R
    • MSK38009A
    • Morpholine, 4-(3-(p-butoxyphenoxy)propyl)-, hydrochloride
    • SYCBXBCPLUFJID-UHFFFAOYSA-N
    • HMS1570O13
    • HMS1921J07
    • HMS5082G12
    • Pharmakon1600-01501139
    • AAA63758
    • HY-B1319
    • PRAMOXINE HYDROCHLORIDE [MI]
    • Tox21_110477
    • EBC-28050
    • NSC757847
    • s4092
    • PRAMOXINE HYDROCHLORIDE [HSDB]
    • AKOS015895041
    • Pramocaine (hydrochloride) (Standard)
    • Tox21_110477_1
    • AC-2094
    • CCG-212937
    • CS-4643
    • NSC-757847
    • PRAMOXINE HYDROCHLORIDE [VANDF]
    • WLN: T6N DOTJ A3OR DO4 &GH
    • PRAMOCAINE HYDROCHLORIDE [MART.]
    • PRAMOXINE HYDROCHLORIDE [USP-RS]
    • NCGC00016529-07
    • 637-58-1

  • Applications

    Pramoxine Hydrochloride (CAS 637-58-1) is used as a local anesthetic with antipruritic properties in topical pharmaceutical products (OTC creams, ointments, gels) to relieve itching, burning and discomfort from minor skin irritations, insect bites, and dermatitis; in cosmetics and personal care it serves as a soothing, temporary numbing agent in skin-care formulations and after-sun products; it is also used in hemorrhoidal relief preparations as a topical anesthetic; and it may appear in veterinary topical care formulations for minor irritations as a temporary numbing/soothing agent.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 114.12
    methanol 125.68
    isopropanol 60.34
    water 2.22
    ethyl acetate 282.76
    n-propanol 99.35
    acetone 234.74
    n-butanol 97.63
    acetonitrile 178.67
    DMF 144.12
    toluene 97.43
    isobutanol 75.52
    1,4-dioxane 265.66
    methyl acetate 219.96
    THF 305.62
    2-butanone 191.36
    n-pentanol 80.7
    sec-butanol 72.96
    n-hexane 10.68
    ethylene glycol 38.47
    NMP 178.2
    cyclohexane 33.76
    DMSO 758.14
    n-butyl acetate 139.27
    n-octanol 29.07
    chloroform 1370.32
    n-propyl acetate 156.18
    acetic acid 435.8
    dichloromethane 1638.12
    cyclohexanone 281.2
    propylene glycol 41.42
    isopropyl acetate 138.35
    DMAc 307.82
    2-ethoxyethanol 212.83
    isopentanol 85.86
    n-heptane 9.7
    ethyl formate 173.3
    1,2-dichloroethane 894.05
    n-hexanol 55.98
    2-methoxyethanol 223.88
    isobutyl acetate 92.18
    tetrachloromethane 170.13
    n-pentyl acetate 71.84
    transcutol 649.9
    n-heptanol 28.02
    ethylbenzene 41.65
    MIBK 84.51
    2-propoxyethanol 149.75
    tert-butanol 78.09
    MTBE 84.76
    2-butoxyethanol 86.28
    propionic acid 182.18
    o-xylene 66.53
    formic acid 173.04
    diethyl ether 136.72
    m-xylene 62.48
    p-xylene 58.66
    chlorobenzene 191.05
    dimethyl carbonate 83.69
    n-octane 4.52
    formamide 222.7
    cyclopentanone 267.42
    2-pentanone 146.51
    anisole 91.31
    cyclopentyl methyl ether 156.91
    gamma-butyrolactone 386.47
    1-methoxy-2-propanol 129.83
    pyridine 235.87
    3-pentanone 161.34
    furfural 365.29
    n-dodecane 4.02
    diethylene glycol 142.42
    diisopropyl ether 37.71
    tert-amyl alcohol 76.79
    acetylacetone 221.63
    n-hexadecane 4.59
    acetophenone 117.34
    methyl propionate 180.29
    isopentyl acetate 114.02
    trichloroethylene 1355.27
    n-nonanol 29.86
    cyclohexanol 126.66
    benzyl alcohol 92.1
    2-ethylhexanol 46.11
    isooctanol 28.03
    dipropyl ether 73.17
    1,2-dichlorobenzene 202.88
    ethyl lactate 86.02
    propylene carbonate 246.65
    n-methylformamide 123.5
    2-pentanol 56.57
    n-pentane 10.96
    1-propoxy-2-propanol 106.96
    1-methoxy-2-propyl acetate 147.43
    2-(2-methoxypropoxy) propanol 123.87
    mesitylene 40.8
    ε-caprolactone 270.51
    p-cymene 35.08
    epichlorohydrin 599.33
    1,1,1-trichloroethane 568.31
    2-aminoethanol 68.8
    morpholine-4-carbaldehyde 246.96
    sulfolane 442.37
    2,2,4-trimethylpentane 9.61
    2-methyltetrahydrofuran 210.25
    n-hexyl acetate 85.64
    isooctane 4.89
    2-(2-butoxyethoxy)ethanol 151.63
    sec-butyl acetate 98.8
    tert-butyl acetate 121.42
    decalin 14.91
    glycerin 84.32
    diglyme 346.39
    acrylic acid 167.28
    isopropyl myristate 38.94
    n-butyric acid 253.2
    acetyl acetate 262.72
    di(2-ethylhexyl) phthalate 49.71
    ethyl propionate 141.86
    nitromethane 596.94
    1,2-diethoxyethane 192.63
    benzonitrile 117.89
    trioctyl phosphate 31.42
    1-bromopropane 309.0
    gamma-valerolactone 351.18
    n-decanol 22.53
    triethyl phosphate 87.84
    4-methyl-2-pentanol 35.48
    propionitrile 122.41
    vinylene carbonate 250.84
    1,1,2-trichlorotrifluoroethane 474.63
    DMS 110.96
    cumene 33.06
    2-octanol 18.3
    2-hexanone 102.3
    octyl acetate 47.58
    limonene 48.72
    1,2-dimethoxyethane 276.21
    ethyl orthosilicate 82.87
    tributyl phosphate 55.09
    diacetone alcohol 112.66
    N,N-dimethylaniline 65.87
    acrylonitrile 144.96
    aniline 124.94
    1,3-propanediol 115.31
    bromobenzene 227.1
    dibromomethane 927.45
    1,1,2,2-tetrachloroethane 1066.9
    2-methyl-cyclohexyl acetate 101.96
    tetrabutyl urea 59.48
    diisobutyl methanol 30.5
    2-phenylethanol 72.79
    styrene 55.24
    dioctyl adipate 81.05
    dimethyl sulfate 164.71
    ethyl butyrate 133.17
    methyl lactate 90.14
    butyl lactate 74.29
    diethyl carbonate 114.82
    propanediol butyl ether 71.21
    triethyl orthoformate 109.73
    p-tert-butyltoluene 30.82
    methyl 4-tert-butylbenzoate 93.04
    morpholine 274.04
    tert-butylamine 46.06
    n-dodecanol 18.43
    dimethoxymethane 152.22
    ethylene carbonate 228.92
    cyrene 116.1
    2-ethoxyethyl acetate 140.05
    2-ethylhexyl acetate 99.07
    1,2,4-trichlorobenzene 242.15
    4-methylpyridine 174.9
    dibutyl ether 64.73
    2,6-dimethyl-4-heptanol 30.5
    DEF 180.09
    dimethyl isosorbide 194.43
    tetrachloroethylene 668.31
    eugenol 87.99
    triacetin 149.5
    span 80 83.37
    1,4-butanediol 62.15
    1,1-dichloroethane 605.44
    2-methyl-1-pentanol 82.98
    methyl formate 123.46
    2-methyl-1-butanol 90.59
    n-decane 6.75
    butyronitrile 116.24
    3,7-dimethyl-1-octanol 37.32
    1-chlorooctane 31.18
    1-chlorotetradecane 13.62
    n-nonane 6.15
    undecane 4.97
    tert-butylcyclohexane 10.1
    cyclooctane 11.97
    cyclopentanol 101.7
    tetrahydropyran 225.56
    tert-amyl methyl ether 86.62
    2,5,8-trioxanonane 243.02
    1-hexene 35.19
    2-isopropoxyethanol 129.99
    2,2,2-trifluoroethanol 225.27
    methyl butyrate 177.62

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction