p,p'-Oxybis(benzenesulfonyl hydrazide)

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  • Identifiers

    CAS number
    80-51-3

    Molecular formula
    C12H14N4O5S2

    SMILES
    C1=CC(=CC=C1OC2=CC=C(C=C2)S(=O)(=O)NN)S(=O)(=O)NN

    Safety labels

    Flammable
    Flammable

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 78.37%
    Savory 26.78%
    Cooked 25.89%
    Meaty 20.5%
    Pungent 18.78%
    Roasted 18.68%
    Sulfurous 18.3%
    Burnt 16.75%
    Bitter 16.09%
    Garlic 12.92%

     

    Flavor
    Bitter 87.23%
    Odorless 33.21%
    Bland 23.31%
    Nitrile 20.35%
    Sweet-like 18.07%
    Taco 17.99%
    Very strong 17.83%
    Bread crust 17.8%
    Cedarleaf 17.77%
    Indole 17.7%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    -0.1

    pKa est.
    9.06 (weak base)

    Molecular weight
    358.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    757°C

    Melting point expt.

    • 150-160 °C (decomposes)

    Flash point

    • 333.91 ˚C est.

    Solubility expt.

    • Soluble in acetone; moderately soluble in ethanol and polyethylene glycols; insoluble in water and gasoline

  • Synonyms

    • 4,4'-Oxybis(benzenesulfonyl hydrazide)
    • Celogen OT
    • Serogen
    • Genitron ob
    • Zhenitron OV
    • Cellmic S
    • Celmike S
    • Cenitron OB
    • 4,4'-Oxybis(benzenesulfonhydrazide)
    • 4,4'-Oxydibenzenesulfonic acid dihydrazide
    • Diphenyloxide-4,4'-disulfohydrazide
    • Oxybis(benzenesulfonylhydrazide)
    • P,P'-OXYBIS(BENZENESULFONYL HYDRAZIDE)
    • 4,4'-Oxydi(benzenesulfonyl dihydrazide)
    • HSDB 5237
    • NSC 5318
    • EINECS 201-286-1
    • Oxybisbenzenesulfonic acid dihydrazide
    • 4,4'-Oxydi(benzenesulphonohydrazide)
    • p,p'-Oxybisbenzene disulfonylhydrazide
    • Benzenesulfonic acid, 4,4'-oxybis-, dihydrazide
    • BRN 2954604
    • NEOCELLBORN N
    • 4,4'-Oxydi(benzenesulfonic acid hydrazide)
    • NSC-5318
    • 4,4'-Oxybis(benzenesulfonic acid) dihydrazide
    • Benzenesulfonic acid, 4,4'-oxydi-, dihydrazide
    • 70377EJ95Z
    • Benzenesulfonic acid, oxybis-, dihydrazide
    • EC 201-286-1
    • 4-11-00-00597 (Beilstein Handbook Reference)
    • Benzenesulfonic acid, 4,4'-oxybis-, 1,1'-dihydrazide
    • S-250
    • 4,4'-OXY-BIS(BENZENE SULFONHYDRAZIDE)
    • RefChem:857891
    • Diphenyloxide4,4'disulfohydrazide
    • p,p'Oxybis(benzenesulfohydrazide)
    • 4,4'Oxybis(benzenesulfonhydrazide)
    • Diphenyl ether 4,4'disulfohydrazide
    • p,p'Oxybis(benzenesulfonylhydrazine)
    • p,p'Oxybisbenzene disulfonylhydrazide
    • 4,4'Oxybis(benzenesulfonyl hydrazide)
    • Oxybisbenzenesulfonic acid dihydrazide.
    • p,p'-oxybis(benzenesulfonyl) hydrazine
    • 4,4'Oxydi(benzenesulfonyl dihydrazide)
    • 4,4'Oxydibenzenesulfonic acid dihydrazide
    • 4,4'Oxydi(benzenesulfonic acid hydrazide)
    • 4,4'Oxybis(benzenesulfonic acid hydrazide)
    • 4,4'Oxybis(benzenesulfonic acid) dihydrazide
    • Benzenesulfonic acid, 4,4'oxybis, dihydrazide
    • Benzenesulfonic acid, 4,4'oxydi, dihydrazide
    • Benzenesulfonic acid, oxybis-, dihydrazide (9CI)
    • 201-286-1
    • 80-51-3
    • 4,4'-oxydibenzenesulfonohydrazide
    • Celogen
    • OBSH
    • 4-[4-(hydrazinesulfonyl)phenoxy]benzenesulfonohydrazide
    • 4,4'-Oxydibenzenesulfonyl hydrazide
    • p,p'-Oxybis(benzenesulfohydrazide)
    • Diphenyl ether 4,4'-disulfohydrazide
    • p,p'-Oxybis(benzenesulfonylhydrazine)
    • DTXSID7026499
    • 4,4-Oxydibenzenesulfonohydrazide
    • 4,4'-oxybis(benzenesulfohydrazide)
    • C12H14N4O5S2
    • 4,4'-Oxybis(benzenesulfonic acid hydrazide)
    • UNII-70377EJ95Z
    • 4, hydrazide)
    • Oprea1_874031
    • SCHEMBL36774
    • DTXCID706499
    • SCHEMBL9233875
    • CHEMBL1882501
    • 4-[4-(hydrazinesulfonyl)phenoxy]benzene-1-sulfonohydrazide
    • NSC5318
    • NBOCQTNZUPTTEI-UHFFFAOYSA-N
    • 4,4'-oxydi(benzenesulphonohydrazide
    • p,p'-Oxybis(benzenesulfonhydrazide)
    • Tox21_301976
    • MFCD00007587
    • 4,4'-Oxybis(benzenesulfonyl)hydrazide
    • AKOS001426105
    • CAS-80-51-3
    • 4,4'-Oxydi(benzene-1-sulfonohydrazide)
    • NCGC00164109-01
    • NCGC00255179-01
    • AS-14554
    • dihydrazide4,4'-oxybis-benzenesulfonic acid
    • P,P' OXYBIS-BENZENESULFONYLHYDRAZIDE
    • Benzenesulfonic acid,4'-oxybis-, dihydrazide
    • Benzenesulfonic acid,4'-oxydi-, dihydrazide
    • NS00004831
    • EN300-20352
    • 080O513
    • F240777
    • Q27265828
    • Z104477848
    • 80-51-3

  • Applications

    p,p'-Oxybis(benzenesulfonyl hydrazide) (CAS 80-51-3) can function as a curing agent and/or crosslinking agent for epoxy resins and other thermoset polymer systems, helping to improve network formation, hardness, and thermal stability; in plastics and coatings industries it may be used as a reactive additive or curing aid in coatings, inks, and sealants; it is also employed as a chemical synthesis intermediate for preparing other sulfonyl hydrazide derivatives; in polyurethane foam formulations it has been explored as a solid blowing agent to generate gas and create cellular structures; and in industrial manufacturing it serves as a building block in polymer and resin systems to tailor performance.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.52
    methanol 1.49
    isopropanol 0.24
    water 0.07
    ethyl acetate 0.46
    n-propanol 0.26
    acetone 4.2
    n-butanol 0.12
    acetonitrile 1.22
    DMF 44.54
    toluene 0.02
    isobutanol 0.09
    1,4-dioxane 1.34
    methyl acetate 1.49
    THF 3.18
    2-butanone 2.72
    n-pentanol 0.07
    sec-butanol 0.24
    n-hexane 0.0
    ethylene glycol 0.83
    NMP 23.72
    cyclohexane 0.0
    DMSO 35.91
    n-butyl acetate 0.42
    n-octanol 0.16
    chloroform 0.07
    n-propyl acetate 0.31
    acetic acid 2.97
    dichloromethane 0.12
    cyclohexanone 1.87
    propylene glycol 0.9
    isopropyl acetate 0.31
    DMAc 42.53
    2-ethoxyethanol 2.76
    isopentanol 0.08
    n-heptane 0.01
    ethyl formate 1.22
    1,2-dichloroethane 0.11
    n-hexanol 0.08
    2-methoxyethanol 7.16
    isobutyl acetate 0.08
    tetrachloromethane 0.01
    n-pentyl acetate 0.42
    transcutol 5.78
    n-heptanol 0.17
    ethylbenzene 0.01
    MIBK 0.31
    2-propoxyethanol 2.36
    tert-butanol 0.22
    MTBE 0.21
    2-butoxyethanol 1.62
    propionic acid 0.95
    o-xylene 0.03
    formic acid 5.39
    diethyl ether 0.18
    m-xylene 0.01
    p-xylene 0.02
    chlorobenzene 0.03
    dimethyl carbonate 1.1
    n-octane 0.01
    formamide 17.01
    cyclopentanone 5.29
    2-pentanone 0.79
    anisole 0.17
    cyclopentyl methyl ether 0.2
    gamma-butyrolactone 5.99
    1-methoxy-2-propanol 3.51
    pyridine 0.85
    3-pentanone 0.8
    furfural 7.24
    n-dodecane 0.0
    diethylene glycol 3.36
    diisopropyl ether 0.03
    tert-amyl alcohol 0.25
    acetylacetone 2.54
    n-hexadecane 0.0
    acetophenone 0.49
    methyl propionate 0.86
    isopentyl acetate 0.31
    trichloroethylene 0.24
    n-nonanol 0.19
    cyclohexanol 0.1
    benzyl alcohol 0.2
    2-ethylhexanol 0.05
    isooctanol 0.11
    dipropyl ether 0.18
    1,2-dichlorobenzene 0.04
    ethyl lactate 0.81
    propylene carbonate 1.73
    n-methylformamide 9.39
    2-pentanol 0.07
    n-pentane 0.0
    1-propoxy-2-propanol 1.69
    1-methoxy-2-propyl acetate 1.41
    2-(2-methoxypropoxy) propanol 2.47
    mesitylene 0.01
    ε-caprolactone 1.45
    p-cymene 0.03
    epichlorohydrin 1.83
    1,1,1-trichloroethane 0.04
    2-aminoethanol 0.98
    morpholine-4-carbaldehyde 17.66
    sulfolane 14.39
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 0.57
    n-hexyl acetate 0.45
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 2.62
    sec-butyl acetate 0.15
    tert-butyl acetate 0.44
    decalin 0.0
    glycerin 3.43
    diglyme 6.95
    acrylic acid 1.6
    isopropyl myristate 0.18
    n-butyric acid 0.6
    acetyl acetate 0.48
    di(2-ethylhexyl) phthalate 0.34
    ethyl propionate 0.31
    nitromethane 19.51
    1,2-diethoxyethane 0.84
    benzonitrile 0.25
    trioctyl phosphate 0.22
    1-bromopropane 0.03
    gamma-valerolactone 15.11
    n-decanol 0.13
    triethyl phosphate 0.4
    4-methyl-2-pentanol 0.04
    propionitrile 0.37
    vinylene carbonate 1.54
    1,1,2-trichlorotrifluoroethane 3.94
    DMS 0.68
    cumene 0.01
    2-octanol 0.11
    2-hexanone 0.45
    octyl acetate 0.31
    limonene 0.06
    1,2-dimethoxyethane 5.8
    ethyl orthosilicate 0.3
    tributyl phosphate 0.28
    diacetone alcohol 1.53
    N,N-dimethylaniline 0.15
    acrylonitrile 1.04
    aniline 0.12
    1,3-propanediol 0.92
    bromobenzene 0.01
    dibromomethane 0.04
    1,1,2,2-tetrachloroethane 0.21
    2-methyl-cyclohexyl acetate 0.3
    tetrabutyl urea 0.8
    diisobutyl methanol 0.06
    2-phenylethanol 0.26
    styrene 0.02
    dioctyl adipate 0.52
    dimethyl sulfate 4.23
    ethyl butyrate 0.48
    methyl lactate 2.62
    butyl lactate 0.93
    diethyl carbonate 0.39
    propanediol butyl ether 1.64
    triethyl orthoformate 0.5
    p-tert-butyltoluene 0.03
    methyl 4-tert-butylbenzoate 1.18
    morpholine 2.13
    tert-butylamine 0.06
    n-dodecanol 0.09
    dimethoxymethane 5.48
    ethylene carbonate 0.86
    cyrene 3.16
    2-ethoxyethyl acetate 1.21
    2-ethylhexyl acetate 0.2
    1,2,4-trichlorobenzene 0.07
    4-methylpyridine 0.45
    dibutyl ether 0.17
    2,6-dimethyl-4-heptanol 0.06
    DEF 2.53
    dimethyl isosorbide 3.62
    tetrachloroethylene 0.12
    eugenol 1.35
    triacetin 1.52
    span 80 1.29
    1,4-butanediol 0.3
    1,1-dichloroethane 0.05
    2-methyl-1-pentanol 0.06
    methyl formate 6.64
    2-methyl-1-butanol 0.09
    n-decane 0.01
    butyronitrile 0.23
    3,7-dimethyl-1-octanol 0.1
    1-chlorooctane 0.04
    1-chlorotetradecane 0.02
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.0
    cyclooctane 0.0
    cyclopentanol 0.24
    tetrahydropyran 0.28
    tert-amyl methyl ether 0.2
    2,5,8-trioxanonane 4.91
    1-hexene 0.01
    2-isopropoxyethanol 0.88
    2,2,2-trifluoroethanol 1.92
    methyl butyrate 0.59

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction