Potassium methoxysalicylate

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  • Identifiers

    CAS number
    152312-71-5

    Molecular formula
    C8H7KO4

    SMILES
    COC1=CC(=C(C=C1)C(=O)[O-])O.[K+]

    Safety labels

  • Odor profile

    Fragrance
    Sweet 67.9%
    Phenolic 53.88%
    Vanilla 42.86%
    Odorless 38.38%
    Balsamic 38.29%
    Powdery 32.05%
    Aromatic 30.29%
    Creamy 27.79%
    Spicy 27.76%
    Bitter 27.1%

     

    Flavor
    Bitter 44.85%
    Odorless 40.99%
    Phenolic 36.17%
    Mild 31.96%
    Faint 25.36%
    Bland 22.67%
    Ethyl benzoate 21.36%
    Cadaverous 21.02%
    Urine 20.95%
    Orange flower 20.94%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.06 (weak acid)

    Molecular weight
    206.24 g/mol

    Flash point

    • 141.56 ˚C est.

  • Synonyms

    • 152312-71-5
    • Potassium 4-methoxysalicylate
    • Potassium methoxysalicylate
    • Benzoic acid, 2-hydroxy-4-methoxy-, monopotassium salt
    • UNII-5G3H7U4Y7F
    • 5G3H7U4Y7F
    • Benzoic acid, 2-hydroxy-4-methoxy-, potassium salt (1:1)
    • DTXSID80164997
    • RefChem:175521
    • DTXCID6087488
    • POTASSIUM METHOXYSALICYLATE [INCI]
    • Potassium 2-hydroxy-4-methoxybenzoate
    • potassium;2-hydroxy-4-methoxybenzoate
    • C8H7KO4
    • MFCD13194966
    • potassium,2-hydroxy-4-methoxybenzoate
    • SCHEMBL154118
    • orb2802059
    • MSK11398
    • Potassium2-hydroxy-4-methoxybenzoate
    • AKOS015890796
    • AS-63106
    • 2-Hydroxy-4-methoxybenzoic acid (potassium)
    • CS-0150500
    • G68415
    • Q27262075
    • 152312-71-5

  • Applications

    Potassium methoxysalicylate (CAS 152312-71-5) is typically used as an intermediate in organic synthesis to access salicylate-derived compounds, including applications in pharmaceutical and specialty chemical synthesis; it can function as a chelating/complexing agent in cleaning formulations and industrial detergents; it can act as a corrosion inhibitor or stabilizer in coatings, paints, and metalworking fluids; it serves as a sequestrant/dispersing agent in polymers, inks, and plastic formulations; and it may be used as a buffering or stabilizing additive in cosmetics and personal care formulations, subject to formulation limits and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 61.29
    methanol 79.6
    isopropanol 41.06
    water 1.26
    ethyl acetate 44.15
    n-propanol 38.19
    acetone 108.25
    n-butanol 29.96
    acetonitrile 29.56
    DMF 321.8
    toluene 4.74
    isobutanol 21.51
    1,4-dioxane 49.0
    methyl acetate 52.01
    THF 213.85
    2-butanone 65.63
    n-pentanol 22.01
    sec-butanol 33.8
    n-hexane 1.55
    ethylene glycol 47.88
    NMP 324.44
    cyclohexane 0.74
    DMSO 692.82
    n-butyl acetate 26.21
    n-octanol 9.02
    chloroform 13.3
    n-propyl acetate 25.46
    acetic acid 47.92
    dichloromethane 22.39
    cyclohexanone 50.18
    propylene glycol 44.92
    isopropyl acetate 28.02
    DMAc 246.6
    2-ethoxyethanol 88.09
    isopentanol 25.19
    n-heptane 1.28
    ethyl formate 32.09
    1,2-dichloroethane 28.32
    n-hexanol 22.08
    2-methoxyethanol 164.77
    isobutyl acetate 8.82
    tetrachloromethane 4.7
    n-pentyl acetate 13.22
    transcutol 219.88
    n-heptanol 10.35
    ethylbenzene 4.74
    MIBK 33.21
    2-propoxyethanol 79.33
    tert-butanol 57.16
    MTBE 30.32
    2-butoxyethanol 33.29
    propionic acid 40.48
    o-xylene 6.76
    formic acid 75.3
    diethyl ether 36.39
    m-xylene 6.18
    p-xylene 4.42
    chlorobenzene 7.75
    dimethyl carbonate 50.71
    n-octane 0.35
    formamide 170.39
    cyclopentanone 111.24
    2-pentanone 57.03
    anisole 30.93
    cyclopentyl methyl ether 53.6
    gamma-butyrolactone 138.01
    1-methoxy-2-propanol 136.84
    pyridine 26.42
    3-pentanone 40.21
    furfural 105.94
    n-dodecane 0.3
    diethylene glycol 97.83
    diisopropyl ether 10.39
    tert-amyl alcohol 47.92
    acetylacetone 81.05
    n-hexadecane 0.35
    acetophenone 36.81
    methyl propionate 59.47
    isopentyl acetate 21.11
    trichloroethylene 42.66
    n-nonanol 8.22
    cyclohexanol 18.27
    benzyl alcohol 23.41
    2-ethylhexanol 11.88
    isooctanol 7.87
    dipropyl ether 17.82
    1,2-dichlorobenzene 11.56
    ethyl lactate 33.36
    propylene carbonate 59.05
    n-methylformamide 147.79
    2-pentanol 24.78
    n-pentane 1.47
    1-propoxy-2-propanol 54.25
    1-methoxy-2-propyl acetate 56.08
    2-(2-methoxypropoxy) propanol 58.81
    mesitylene 4.74
    ε-caprolactone 50.97
    p-cymene 5.66
    epichlorohydrin 127.18
    1,1,1-trichloroethane 15.34
    2-aminoethanol 59.14
    morpholine-4-carbaldehyde 176.55
    sulfolane 285.82
    2,2,4-trimethylpentane 1.21
    2-methyltetrahydrofuran 76.56
    n-hexyl acetate 19.66
    isooctane 0.89
    2-(2-butoxyethoxy)ethanol 62.73
    sec-butyl acetate 16.06
    tert-butyl acetate 41.47
    decalin 1.03
    glycerin 92.24
    diglyme 123.0
    acrylic acid 45.78
    isopropyl myristate 8.13
    n-butyric acid 35.27
    acetyl acetate 27.04
    di(2-ethylhexyl) phthalate 11.65
    ethyl propionate 32.73
    nitromethane 159.24
    1,2-diethoxyethane 32.97
    benzonitrile 14.8
    trioctyl phosphate 8.53
    1-bromopropane 11.17
    gamma-valerolactone 127.51
    n-decanol 5.88
    triethyl phosphate 19.6
    4-methyl-2-pentanol 14.68
    propionitrile 21.04
    vinylene carbonate 40.61
    1,1,2-trichlorotrifluoroethane 106.68
    DMS 33.11
    cumene 4.6
    2-octanol 6.23
    2-hexanone 34.3
    octyl acetate 11.32
    limonene 8.17
    1,2-dimethoxyethane 114.39
    ethyl orthosilicate 15.34
    tributyl phosphate 11.71
    diacetone alcohol 83.06
    N,N-dimethylaniline 27.17
    acrylonitrile 32.99
    aniline 17.38
    1,3-propanediol 61.33
    bromobenzene 5.5
    dibromomethane 12.77
    1,1,2,2-tetrachloroethane 36.41
    2-methyl-cyclohexyl acetate 20.44
    tetrabutyl urea 18.13
    diisobutyl methanol 8.25
    2-phenylethanol 22.75
    styrene 5.27
    dioctyl adipate 16.91
    dimethyl sulfate 133.55
    ethyl butyrate 24.44
    methyl lactate 70.44
    butyl lactate 22.33
    diethyl carbonate 19.27
    propanediol butyl ether 41.14
    triethyl orthoformate 19.73
    p-tert-butyltoluene 6.08
    methyl 4-tert-butylbenzoate 35.94
    morpholine 77.53
    tert-butylamine 24.52
    n-dodecanol 4.13
    dimethoxymethane 156.49
    ethylene carbonate 29.92
    cyrene 69.31
    2-ethoxyethyl acetate 29.74
    2-ethylhexyl acetate 15.62
    1,2,4-trichlorobenzene 15.4
    4-methylpyridine 27.45
    dibutyl ether 8.48
    2,6-dimethyl-4-heptanol 8.25
    DEF 81.53
    dimethyl isosorbide 99.98
    tetrachloroethylene 25.79
    eugenol 35.4
    triacetin 36.19
    span 80 33.14
    1,4-butanediol 25.27
    1,1-dichloroethane 15.38
    2-methyl-1-pentanol 18.78
    methyl formate 99.17
    2-methyl-1-butanol 24.06
    n-decane 0.52
    butyronitrile 18.3
    3,7-dimethyl-1-octanol 10.25
    1-chlorooctane 3.34
    1-chlorotetradecane 1.26
    n-nonane 0.48
    undecane 0.39
    tert-butylcyclohexane 1.12
    cyclooctane 0.45
    cyclopentanol 32.82
    tetrahydropyran 29.66
    tert-amyl methyl ether 31.3
    2,5,8-trioxanonane 90.67
    1-hexene 5.84
    2-isopropoxyethanol 46.52
    2,2,2-trifluoroethanol 38.47
    methyl butyrate 36.98

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction