Potassium Glycyrrhetinate

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  • Identifiers

    CAS number
    85985-61-1

    Molecular formula
    C30H45KO4

    SMILES
    C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)(C)C(=O)[O-].[K+]

    Safety labels

  • Odor profile

    Fragrance
    Woody 82.77%
    Amber 54.1%
    Cedar 52.26%
    Dry 48.93%
    Musk 39.41%
    Camphoreous 35.87%
    Balsamic 34.69%
    Vetiver 34.56%
    Earthy 33.34%
    Spicy 33.31%

     

    Flavor
    Bitter 49.4%
    Woody 48.3%
    Camphor 43.44%
    Pine 34.39%
    Balsam 28.68%
    Herbal 28.3%
    Minty 27.62%
    Spicy 25.16%
    Ripe apricot 23.68%
    Patchouli 23.35%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    4.52 (weak acid)

    Molecular weight
    508.8 g/mol

    Flash point

    • 260.36 ˚C est.

  • Synonyms

    • Potassium glycyrrhetinate
    • 85985-61-1
    • Monopotassium glycyrrhetin
    • UNII-5850KHR68O
    • 5850KHR68O
    • Glycyrrhetic acid potassium salt vinyals
    • ENOXOLONE POTASSIUM
    • ENOXOLONE MONOPOTASSIUM
    • DTXSID50235325
    • Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, monopotassium salt, (3beta,20beta)-
    • Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, potassium salt (1:1), (3beta,20beta)-
    • GLYCYRRHETIC ACID POTASSIUM SALT
    • Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, monopotassium salt, (3.beta.,20.beta.)-
    • OLEAN-12-EN-29-OIC ACID, 3-HYDROXY-11-OXO-, POTASSIUM SALT (1:1), (3.BETA.,20.BETA.)-
    • RefChem:175485
    • DTXCID50157816
    • POTASSIUM GLYCYRRHETINATE [INCI]
    • 617-789-8
    • Enoxolone potassium [WHO-DD]
    • potassium;(2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylate
    • 18beta-Glycyrrhetinic acid potassium salt
    • SCHEMBL29673752
    • PWEZHTCCMJFGJY-IHMBCTQLSA-M
    • Potassium 3beta-hydroxy-11-oxoolean-12-en-30-oate
    • Q27261557
    • 85985-61-1

  • Applications

    Potassium Glycyrrhetinate (CAS 85985-61-1) is used primarily in cosmetics and personal care as a water-soluble surfactant/emulsifier derived from glycyrrhetinic acid from licorice; in these formulations it can act as a mild cleansing aid and may contribute skin-soothing or anti-irritant properties. It is also encountered in household detergents and cleaners as a surfactant and foaming agent. In pharmaceutical and topical products, it may serve as an excipient, solubilizer, or formulation stabilizer, helping compatibility among active ingredients and other excipients. In coatings, inks, and other industrial formulations, it can function as a wetting or dispersing additive to improve spread and stability. Depending on the product and regulatory context, it may be used as a processing aid or compatibility enhancer in polymer or latex formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 97.35
    methanol 47.31
    isopropanol 79.68
    water 0.01
    ethyl acetate 21.24
    n-propanol 112.18
    acetone 39.41
    n-butanol 59.56
    acetonitrile 10.57
    DMF 430.23
    toluene 27.56
    isobutanol 49.46
    1,4-dioxane 160.37
    methyl acetate 19.99
    THF 330.72
    2-butanone 41.92
    n-pentanol 36.75
    sec-butanol 33.31
    n-hexane 0.78
    ethylene glycol 6.46
    NMP 124.04
    cyclohexane 0.98
    DMSO 76.07
    n-butyl acetate 17.02
    n-octanol 9.07
    chloroform 63.22
    n-propyl acetate 13.01
    acetic acid 26.01
    dichloromethane 34.5
    cyclohexanone 55.39
    propylene glycol 21.89
    isopropyl acetate 17.89
    DMAc 131.0
    2-ethoxyethanol 77.93
    isopentanol 26.76
    n-heptane 0.53
    ethyl formate 13.03
    1,2-dichloroethane 23.47
    n-hexanol 33.57
    2-methoxyethanol 156.54
    isobutyl acetate 10.58
    tetrachloromethane 6.42
    n-pentyl acetate 19.24
    transcutol 98.63
    n-heptanol 17.25
    ethylbenzene 9.85
    MIBK 18.84
    2-propoxyethanol 154.26
    tert-butanol 30.53
    MTBE 17.77
    2-butoxyethanol 61.01
    propionic acid 21.73
    o-xylene 10.29
    formic acid 11.23
    diethyl ether 39.32
    m-xylene 13.68
    p-xylene 9.53
    chlorobenzene 20.16
    dimethyl carbonate 24.98
    n-octane 0.22
    formamide 19.35
    cyclopentanone 103.58
    2-pentanone 35.64
    anisole 29.48
    cyclopentyl methyl ether 59.87
    gamma-butyrolactone 86.24
    1-methoxy-2-propanol 158.25
    pyridine 102.97
    3-pentanone 23.74
    furfural 60.5
    n-dodecane 0.11
    diethylene glycol 70.02
    diisopropyl ether 5.68
    tert-amyl alcohol 15.72
    acetylacetone 32.87
    n-hexadecane 0.14
    acetophenone 22.17
    methyl propionate 34.9
    isopentyl acetate 16.21
    trichloroethylene 55.08
    n-nonanol 9.99
    cyclohexanol 21.54
    benzyl alcohol 34.48
    2-ethylhexanol 9.22
    isooctanol 11.09
    dipropyl ether 14.85
    1,2-dichlorobenzene 14.52
    ethyl lactate 13.56
    propylene carbonate 25.21
    n-methylformamide 87.64
    2-pentanol 21.37
    n-pentane 1.01
    1-propoxy-2-propanol 77.15
    1-methoxy-2-propyl acetate 44.83
    2-(2-methoxypropoxy) propanol 30.89
    mesitylene 5.71
    ε-caprolactone 47.52
    p-cymene 4.21
    epichlorohydrin 124.53
    1,1,1-trichloroethane 16.41
    2-aminoethanol 39.0
    morpholine-4-carbaldehyde 213.94
    sulfolane 82.46
    2,2,4-trimethylpentane 0.42
    2-methyltetrahydrofuran 76.56
    n-hexyl acetate 20.7
    isooctane 0.4
    2-(2-butoxyethoxy)ethanol 53.33
    sec-butyl acetate 9.37
    tert-butyl acetate 17.99
    decalin 0.67
    glycerin 28.35
    diglyme 85.05
    acrylic acid 19.74
    isopropyl myristate 5.47
    n-butyric acid 33.18
    acetyl acetate 12.16
    di(2-ethylhexyl) phthalate 9.99
    ethyl propionate 12.44
    nitromethane 38.59
    1,2-diethoxyethane 28.12
    benzonitrile 20.37
    trioctyl phosphate 6.61
    1-bromopropane 14.28
    gamma-valerolactone 182.08
    n-decanol 5.23
    triethyl phosphate 6.47
    4-methyl-2-pentanol 10.42
    propionitrile 20.64
    vinylene carbonate 28.3
    1,1,2-trichlorotrifluoroethane 61.92
    DMS 19.75
    cumene 5.07
    2-octanol 7.42
    2-hexanone 19.14
    octyl acetate 8.68
    limonene 4.76
    1,2-dimethoxyethane 99.23
    ethyl orthosilicate 7.07
    tributyl phosphate 5.91
    diacetone alcohol 31.6
    N,N-dimethylaniline 19.67
    acrylonitrile 26.05
    aniline 38.55
    1,3-propanediol 62.6
    bromobenzene 17.95
    dibromomethane 21.75
    1,1,2,2-tetrachloroethane 45.34
    2-methyl-cyclohexyl acetate 12.06
    tetrabutyl urea 9.69
    diisobutyl methanol 4.92
    2-phenylethanol 36.56
    styrene 11.99
    dioctyl adipate 10.79
    dimethyl sulfate 33.33
    ethyl butyrate 10.89
    methyl lactate 30.33
    butyl lactate 23.71
    diethyl carbonate 6.48
    propanediol butyl ether 44.29
    triethyl orthoformate 12.26
    p-tert-butyltoluene 4.5
    methyl 4-tert-butylbenzoate 24.8
    morpholine 269.67
    tert-butylamine 11.06
    n-dodecanol 2.7
    dimethoxymethane 211.45
    ethylene carbonate 23.03
    cyrene 40.32
    2-ethoxyethyl acetate 35.85
    2-ethylhexyl acetate 11.77
    1,2,4-trichlorobenzene 22.24
    4-methylpyridine 69.82
    dibutyl ether 5.71
    2,6-dimethyl-4-heptanol 4.92
    DEF 50.0
    dimethyl isosorbide 57.67
    tetrachloroethylene 28.63
    eugenol 30.38
    triacetin 20.73
    span 80 30.53
    1,4-butanediol 20.47
    1,1-dichloroethane 23.05
    2-methyl-1-pentanol 15.85
    methyl formate 37.87
    2-methyl-1-butanol 25.86
    n-decane 0.32
    butyronitrile 19.75
    3,7-dimethyl-1-octanol 6.92
    1-chlorooctane 2.4
    1-chlorotetradecane 0.55
    n-nonane 0.26
    undecane 0.17
    tert-butylcyclohexane 0.6
    cyclooctane 0.41
    cyclopentanol 44.58
    tetrahydropyran 102.32
    tert-amyl methyl ether 12.18
    2,5,8-trioxanonane 46.95
    1-hexene 4.67
    2-isopropoxyethanol 41.61
    2,2,2-trifluoroethanol 8.46
    methyl butyrate 15.62

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction