Polygodial

Overview IFRA Request a quote

  • Identifiers

    CAS number
    6754-20-7

    Molecular formula
    C15H22O2

    SMILES
    C[C@]12CCCC([C@@H]1CC=C([C@@H]2C=O)C=O)(C)C

    Safety labels

  • Odor profile

    Fragrance
    Woody 61.31%
    Green 59.05%
    Herbal 44.19%
    Spicy 38.22%
    Fresh 36.53%
    Mint 33.89%
    Aldehydic 32.87%
    Dry 29.02%
    Sweet 28.19%
    Leafy 27.89%

     

    Flavor
    Sweet 58.36%
    Spicy 45.48%
    Spice 41.97%
    Woody 41.15%
    Minty 33.97%
    Cinnamon 32.64%
    Herbal 31.9%
    Fresh 30.84%
    Mint 29.4%
    Balsam 27.27%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    3.2

    pKa est.
    7.38 (neutral)

    Molecular weight
    234.33 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    334°C

    Flash point

    • 148.09 ˚C est.

  • Synonyms

    • 6754-20-7
    • Tadeonal
    • Poligodial
    • Drim-7-ene-11,12-dial
    • (-)-Tadeonal
    • (1R,4aS,8aS)-5,5,8a-trimethyl-1,4,4a,6,7,8-hexahydronaphthalene-1,2-dicarbaldehyde
    • 5FAF7T66M7
    • DTXSID901027214
    • 1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde
    • RefChem:929786
    • DTXCID901511489
    • (1R,8aS)-5,5,8a-trimethyl-1,4,4a,6,7,8-hexahydronaphthalene-1,2-dicarbaldehyde
    • Tadeodal
    • (1r,4as,8as)-5,5,8a-trimethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalene-1,2-dicarbaldehyde
    • A00RAV0W57
    • CHEMBL254550
    • 33118-34-2
    • NSC372407
    • Poligodial;Tadeonal
    • 1,2-Naphthalenedicarboxaldehyde, 1,4,4a,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-, (1R,4aS,8aS)-
    • UNII-5FAF7T66M7
    • UNII-A00RAV0W57
    • CCRIS 1712
    • QUIRAL TADEODAL
    • (1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde
    • SCHEMBL258239
    • CHEBI:8305
    • orb1305705
    • GTPL10293
    • BDBM50318479
    • AKOS024457471
    • FP65137
    • NSC-372407
    • 1,2-Naphthalenedicarboxaldehyde, 1,4,4a,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-, (1R-(1alpha,4abeta,8aalpha))-
    • 1,2-Naphthalenedicarboxaldehyde, 1,4,4a,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-, (2R,4aS,8aS)-
    • 1,2-Naphthalenedicarboxaldehyde, 1alpha,4,4aalpha,5,6,7,8,8a-octahydro-5,5,8abata-trimethyl-
    • DA-48562
    • NCI60_003460
    • HY-108450
    • CS-0028712
    • C09712
    • G12538
    • Q3395581
    • (1R,8aS)-5,5,8a-Trimethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalene-1,2-dicarbaldehyde
    • 1,2-NAPHTHALENEDICARBOXALDEHYDE, 1,4,4A,5,6,7,8,8A-OCTAHYDRO-5,5,8A-TRIMETHYL-, (1R,4AS,8AS)-REL-
    • 6754-20-7

  • Applications

    Polygodial (CAS 6754-20-7) is a naturally occurring sesquiterpene dialdehyde whose spicy, peppery aroma and reactive dialdehyde functionality underpin several industrial uses. It is commonly evaluated as an odorant/fragrance ingredient in perfumery and cosmetic formulations, and may be used as a flavor component in natural food and beverage applications where permitted. It has been studied for antimicrobial and antifungal activity and may be used as an active ingredient in cleaning formulations or household products. Its irritant and reactive aldehyde nature has spurred exploration of insect-repellent applications in agriculture and pest control. Additionally, as a reactive aldehyde, it has been investigated as a crosslinking or functional additive in specialty polymer systems, subject to regulatory limits. All uses are subject to local regulations and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 83.91
    methanol 115.65
    isopropanol 43.04
    water 0.36
    ethyl acetate 358.4
    n-propanol 84.84
    acetone 336.93
    n-butanol 59.76
    acetonitrile 281.57
    DMF 507.85
    toluene 440.8
    isobutanol 46.54
    1,4-dioxane 472.84
    methyl acetate 320.07
    THF 1020.27
    2-butanone 324.39
    n-pentanol 30.78
    sec-butanol 38.42
    n-hexane 4.57
    ethylene glycol 24.14
    NMP 843.48
    cyclohexane 21.46
    DMSO 420.74
    n-butyl acetate 195.1
    n-octanol 20.28
    chloroform 973.62
    n-propyl acetate 140.24
    acetic acid 129.67
    dichloromethane 1072.76
    cyclohexanone 550.74
    propylene glycol 25.31
    isopropyl acetate 187.46
    DMAc 326.66
    2-ethoxyethanol 90.57
    isopentanol 52.05
    n-heptane 4.46
    ethyl formate 192.82
    1,2-dichloroethane 698.61
    n-hexanol 68.33
    2-methoxyethanol 212.46
    isobutyl acetate 75.44
    tetrachloromethane 122.78
    n-pentyl acetate 96.84
    transcutol 585.24
    n-heptanol 28.73
    ethylbenzene 103.38
    MIBK 133.93
    2-propoxyethanol 198.81
    tert-butanol 47.6
    MTBE 65.26
    2-butoxyethanol 84.19
    propionic acid 121.51
    o-xylene 176.46
    formic acid 84.88
    diethyl ether 148.24
    m-xylene 214.57
    p-xylene 114.72
    chlorobenzene 541.87
    dimethyl carbonate 184.97
    n-octane 1.48
    formamide 185.96
    cyclopentanone 951.71
    2-pentanone 255.43
    anisole 214.87
    cyclopentyl methyl ether 364.4
    gamma-butyrolactone 1151.14
    1-methoxy-2-propanol 149.12
    pyridine 787.08
    3-pentanone 233.66
    furfural 865.49
    n-dodecane 0.98
    diethylene glycol 134.22
    diisopropyl ether 36.24
    tert-amyl alcohol 37.34
    acetylacetone 383.15
    n-hexadecane 1.26
    acetophenone 231.56
    methyl propionate 344.32
    isopentyl acetate 159.6
    trichloroethylene 1547.68
    n-nonanol 19.68
    cyclohexanol 95.93
    benzyl alcohol 148.2
    2-ethylhexanol 43.85
    isooctanol 23.6
    dipropyl ether 66.84
    1,2-dichlorobenzene 426.2
    ethyl lactate 70.03
    propylene carbonate 432.76
    n-methylformamide 360.29
    2-pentanol 34.0
    n-pentane 5.85
    1-propoxy-2-propanol 128.79
    1-methoxy-2-propyl acetate 274.97
    2-(2-methoxypropoxy) propanol 108.23
    mesitylene 96.38
    ε-caprolactone 481.4
    p-cymene 57.95
    epichlorohydrin 1231.05
    1,1,1-trichloroethane 516.46
    2-aminoethanol 50.33
    morpholine-4-carbaldehyde 577.99
    sulfolane 976.96
    2,2,4-trimethylpentane 3.43
    2-methyltetrahydrofuran 536.11
    n-hexyl acetate 124.24
    isooctane 3.28
    2-(2-butoxyethoxy)ethanol 132.36
    sec-butyl acetate 100.5
    tert-butyl acetate 171.5
    decalin 11.2
    glycerin 52.54
    diglyme 313.14
    acrylic acid 141.39
    isopropyl myristate 36.54
    n-butyric acid 165.18
    acetyl acetate 235.62
    di(2-ethylhexyl) phthalate 53.76
    ethyl propionate 155.07
    nitromethane 521.41
    1,2-diethoxyethane 150.54
    benzonitrile 299.89
    trioctyl phosphate 32.88
    1-bromopropane 233.2
    gamma-valerolactone 971.91
    n-decanol 13.68
    triethyl phosphate 68.48
    4-methyl-2-pentanol 25.62
    propionitrile 212.51
    vinylene carbonate 423.33
    1,1,2-trichlorotrifluoroethane 420.28
    DMS 216.75
    cumene 55.42
    2-octanol 14.56
    2-hexanone 118.09
    octyl acetate 48.69
    limonene 69.17
    1,2-dimethoxyethane 207.66
    ethyl orthosilicate 60.74
    tributyl phosphate 46.23
    diacetone alcohol 159.97
    N,N-dimethylaniline 117.11
    acrylonitrile 359.58
    aniline 364.19
    1,3-propanediol 71.97
    bromobenzene 576.41
    dibromomethane 605.3
    1,1,2,2-tetrachloroethane 827.96
    2-methyl-cyclohexyl acetate 106.75
    tetrabutyl urea 56.79
    diisobutyl methanol 26.21
    2-phenylethanol 165.52
    styrene 138.52
    dioctyl adipate 68.73
    dimethyl sulfate 310.32
    ethyl butyrate 130.7
    methyl lactate 123.56
    butyl lactate 81.22
    diethyl carbonate 97.04
    propanediol butyl ether 69.54
    triethyl orthoformate 86.28
    p-tert-butyltoluene 52.4
    methyl 4-tert-butylbenzoate 135.94
    morpholine 526.94
    tert-butylamine 29.6
    n-dodecanol 9.58
    dimethoxymethane 343.94
    ethylene carbonate 324.45
    cyrene 154.26
    2-ethoxyethyl acetate 210.95
    2-ethylhexyl acetate 125.07
    1,2,4-trichlorobenzene 499.63
    4-methylpyridine 747.09
    dibutyl ether 31.53
    2,6-dimethyl-4-heptanol 26.21
    DEF 257.84
    dimethyl isosorbide 309.63
    tetrachloroethylene 536.25
    eugenol 127.88
    triacetin 152.25
    span 80 80.58
    1,4-butanediol 20.97
    1,1-dichloroethane 512.48
    2-methyl-1-pentanol 31.0
    methyl formate 320.1
    2-methyl-1-butanol 45.75
    n-decane 1.98
    butyronitrile 151.38
    3,7-dimethyl-1-octanol 27.88
    1-chlorooctane 20.72
    1-chlorotetradecane 5.88
    n-nonane 1.81
    undecane 1.34
    tert-butylcyclohexane 7.5
    cyclooctane 7.84
    cyclopentanol 137.09
    tetrahydropyran 441.32
    tert-amyl methyl ether 58.96
    2,5,8-trioxanonane 181.15
    1-hexene 23.65
    2-isopropoxyethanol 62.61
    2,2,2-trifluoroethanol 91.97
    methyl butyrate 179.01

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction