Piroctone Olamine

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  • Identifiers

    CAS number
    68890-66-4

    Molecular formula
    C16H30N2O3

    SMILES
    CC1=CC(=O)N(C(=C1)CC(C)CC(C)(C)C)O.C(CO)N

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Woody 43.57%
    Dry 34.6%
    Animal 34.13%
    Leathery 29.28%
    Musk 28.02%
    Vetiver 25.87%
    Amber 25.85%
    Spicy 24.73%
    Fatty 24.19%
    Phenolic 24.01%

     

    Flavor
    Bitter 32.48%
    Woody 27.82%
    Mild 26.62%
    Herbal 26.09%
    Spice 24.94%
    Musty 24.23%
    Green 23.27%
    Green pepper 22.29%
    Phenolic 22.2%
    Camphor 21.41%

     

    Odor impact est.
    Medium

  • Properties

    pKa est.
    7.29 (neutral)

    Molecular weight
    298.42 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    419°C

    Flash point

    • 135.17 ˚C est.

  • Synonyms

    • PIROCTONE OLAMINE
    • 68890-66-4
    • Octopirox
    • Octopyrox
    • Piroctone ethanolamine
    • Piroctone ethanolamine salt
    • Allermyl
    • A4V5C6R9FB
    • NSC-759894
    • PIROCTONE ETHANOLAMINE SALT (1:1)
    • FORTE Magnetic S3 Oil Control Anti-Dandfuff
    • DTXCID2026735
    • Keratolux
    • RefChem:57832
    • GZE Black Castor Oil EdgeControl
    • 272-574-2
    • CHEBI:59008
    • DTXSID4046735
    • Kopirox
    • Piroctoneolamine
    • Piroctone olamine [USAN]
    • 2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
    • MFCD01690792
    • Piroctone olamine (USAN)
    • 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one 2-aminoethanol salt
    • 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethan-1-ol (1:1)
    • EINECS 272-574-2
    • UNII-A4V5C6R9FB
    • Octopirox (TN)
    • Ethanol, 2-amino-, compd. with 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone (1:1) (9CI); 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine salt; Octopirox; Octopyrox; Piroctone ethanolamine salt; Piroctone olamine
    • 1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt
    • EC 272-574-2
    • SCHEMBL2843
    • Piroctone olamine (Standard)
    • 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone compound with 2-aminoethanol (1:1)
    • 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
    • 2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compound with 2-aminoethanol (1:1)
    • orb1310350
    • CHEMBL2107154
    • HY-B1345R
    • BTSZTGGZJQFALU-UHFFFAOYSA-N
    • PIROCTONE OLAMINE [MART.]
    • HMS5084D15
    • PIROCTONE OLAMINE [USP-RS]
    • HY-B1345
    • MSK21074
    • s5213
    • Piroctone olamine, analytical standard
    • AKOS025149526
    • CCG-267454
    • CS-7659
    • FP15907
    • NSC 759894
    • PIROCTONE ETHANOLAMINE [WHO-DD]
    • 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt
    • AC-37618
    • AS-15254
    • DA-66751
    • P2178
    • D05505
    • SBI-0653392.0001
    • PIROCTONE ETHANOLAMINE SALT (1:1) [MI]
    • 890P664
    • Q412572
    • 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone Ethanolamine
    • Piroctone olamine, United States Pharmacopeia (USP) Reference Standard
    • 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-1,2-dihydropyridin-2-one; 2-aminoethan-1-ol
    • 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine salt
    • 1-HYDROXY-4-METHYL-6-(2,4,4-TRIMETHYLPENTYL)-2-PYRIDONE MONOETHANOLAMINE, (+/-)-
    • 2(1H)-Pyridinone,1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-,compd.with2-aminoethanol(1:1)
    • 68890-66-4

  • Applications

    Piroctone Olamine (CAS 68890-66-4) is widely used as an antifungal active ingredient in cosmetic and pharmaceutical formulations. In cosmetics and personal care, it is a common active in anti-dandruff shampoos, scalp treatments, and related cleansers, where it helps control Malassezia-related conditions. In pharmaceuticals, it appears in topical dermatological products as an antifungal agent for fungal skin infections. It may also be evaluated for use in cleaning products and other antimicrobial applications, where its broad-spectrum activity can complement formulation safety and performance, subject to regulatory requirements.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 545.4
    methanol 618.57
    isopropanol 368.7
    water 0.52
    ethyl acetate 578.1
    n-propanol 438.24
    acetone 518.04
    n-butanol 417.41
    acetonitrile 343.08
    DMF 814.85
    toluene 265.11
    isobutanol 357.41
    1,4-dioxane 489.4
    methyl acetate 447.64
    THF 1116.82
    2-butanone 502.61
    n-pentanol 240.55
    sec-butanol 330.4
    n-hexane 35.21
    ethylene glycol 104.38
    NMP 951.31
    cyclohexane 33.15
    DMSO 491.19
    n-butyl acetate 641.39
    n-octanol 167.47
    chloroform 906.95
    n-propyl acetate 308.84
    acetic acid 540.1
    dichloromethane 737.94
    cyclohexanone 746.11
    propylene glycol 218.61
    isopropyl acetate 426.2
    DMAc 673.41
    2-ethoxyethanol 342.21
    isopentanol 384.85
    n-heptane 21.69
    ethyl formate 339.05
    1,2-dichloroethane 618.59
    n-hexanol 563.64
    2-methoxyethanol 675.04
    isobutyl acetate 246.21
    tetrachloromethane 109.69
    n-pentyl acetate 281.16
    transcutol 1420.65
    n-heptanol 189.27
    ethylbenzene 132.54
    MIBK 395.92
    2-propoxyethanol 799.81
    tert-butanol 471.66
    MTBE 448.09
    2-butoxyethanol 350.83
    propionic acid 383.28
    o-xylene 171.52
    formic acid 240.39
    diethyl ether 332.43
    m-xylene 245.7
    p-xylene 167.74
    chlorobenzene 385.03
    dimethyl carbonate 224.24
    n-octane 9.24
    formamide 261.9
    cyclopentanone 912.2
    2-pentanone 545.75
    anisole 287.11
    cyclopentyl methyl ether 631.06
    gamma-butyrolactone 1008.5
    1-methoxy-2-propanol 640.22
    pyridine 476.59
    3-pentanone 347.73
    furfural 776.4
    n-dodecane 6.89
    diethylene glycol 469.1
    diisopropyl ether 134.37
    tert-amyl alcohol 387.7
    acetylacetone 554.92
    n-hexadecane 8.02
    acetophenone 295.24
    methyl propionate 474.83
    isopentyl acetate 599.67
    trichloroethylene 1231.96
    n-nonanol 145.44
    cyclohexanol 368.35
    benzyl alcohol 252.2
    2-ethylhexanol 304.62
    isooctanol 154.25
    dipropyl ether 222.58
    1,2-dichlorobenzene 357.51
    ethyl lactate 185.5
    propylene carbonate 620.86
    n-methylformamide 458.87
    2-pentanol 301.32
    n-pentane 28.34
    1-propoxy-2-propanol 578.46
    1-methoxy-2-propyl acetate 688.79
    2-(2-methoxypropoxy) propanol 328.72
    mesitylene 135.96
    ε-caprolactone 730.94
    p-cymene 130.18
    epichlorohydrin 1153.86
    1,1,1-trichloroethane 611.86
    2-aminoethanol 266.34
    morpholine-4-carbaldehyde 817.39
    sulfolane 1013.86
    2,2,4-trimethylpentane 26.1
    2-methyltetrahydrofuran 798.64
    n-hexyl acetate 409.39
    isooctane 23.78
    2-(2-butoxyethoxy)ethanol 473.47
    sec-butyl acetate 256.16
    tert-butyl acetate 519.84
    decalin 29.6
    glycerin 240.13
    diglyme 693.72
    acrylic acid 328.95
    isopropyl myristate 133.16
    n-butyric acid 593.06
    acetyl acetate 347.62
    di(2-ethylhexyl) phthalate 147.67
    ethyl propionate 280.89
    nitromethane 744.55
    1,2-diethoxyethane 360.65
    benzonitrile 325.21
    trioctyl phosphate 110.25
    1-bromopropane 344.23
    gamma-valerolactone 1157.88
    n-decanol 106.27
    triethyl phosphate 140.26
    4-methyl-2-pentanol 218.42
    propionitrile 313.61
    vinylene carbonate 479.87
    1,1,2-trichlorotrifluoroethane 659.69
    DMS 349.87
    cumene 103.2
    2-octanol 119.02
    2-hexanone 280.86
    octyl acetate 191.17
    limonene 193.09
    1,2-dimethoxyethane 460.42
    ethyl orthosilicate 144.09
    tributyl phosphate 145.01
    diacetone alcohol 564.07
    N,N-dimethylaniline 210.5
    acrylonitrile 371.16
    aniline 322.88
    1,3-propanediol 357.78
    bromobenzene 371.93
    dibromomethane 508.56
    1,1,2,2-tetrachloroethane 939.08
    2-methyl-cyclohexyl acetate 295.69
    tetrabutyl urea 168.17
    diisobutyl methanol 142.32
    2-phenylethanol 380.08
    styrene 139.88
    dioctyl adipate 185.81
    dimethyl sulfate 331.54
    ethyl butyrate 332.68
    methyl lactate 294.48
    butyl lactate 279.99
    diethyl carbonate 191.74
    propanediol butyl ether 359.19
    triethyl orthoformate 210.18
    p-tert-butyltoluene 130.85
    methyl 4-tert-butylbenzoate 286.59
    morpholine 719.44
    tert-butylamine 278.03
    n-dodecanol 75.33
    dimethoxymethane 544.43
    ethylene carbonate 412.25
    cyrene 292.39
    2-ethoxyethyl acetate 404.36
    2-ethylhexyl acetate 457.64
    1,2,4-trichlorobenzene 433.93
    4-methylpyridine 581.44
    dibutyl ether 148.12
    2,6-dimethyl-4-heptanol 142.32
    DEF 514.18
    dimethyl isosorbide 621.45
    tetrachloroethylene 514.07
    eugenol 281.32
    triacetin 318.17
    span 80 300.29
    1,4-butanediol 132.38
    1,1-dichloroethane 652.24
    2-methyl-1-pentanol 249.64
    methyl formate 370.78
    2-methyl-1-butanol 356.44
    n-decane 12.57
    butyronitrile 404.28
    3,7-dimethyl-1-octanol 201.34
    1-chlorooctane 105.3
    1-chlorotetradecane 32.03
    n-nonane 12.22
    undecane 9.11
    tert-butylcyclohexane 31.11
    cyclooctane 14.72
    cyclopentanol 384.52
    tetrahydropyran 561.51
    tert-amyl methyl ether 337.28
    2,5,8-trioxanonane 428.6
    1-hexene 143.22
    2-isopropoxyethanol 273.97
    2,2,2-trifluoroethanol 211.96
    methyl butyrate 369.2

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction