Piracetam

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  • Identifiers

    CAS number
    7491-74-9

    Molecular formula
    C6H10N2O2

    SMILES
    C1CC(=O)N(C1)CC(=O)N

    Safety labels

  • Odor profile

    Fragrance
    Odorless 52.58%
    Sweet 39.9%
    Nutty 29.09%
    Popcorn 28.0%
    Savory 24.94%
    Fishy 23.61%
    Burnt 23.19%
    Roasted 22.99%
    Caramellic 21.23%
    Meaty 18.28%

     

    Flavor
    Bitter 38.91%
    Odorless 34.74%
    Roasted 32.39%
    Cooked 26.11%
    Nutty 25.66%
    Roast 22.56%
    Taco 21.72%
    Roasted peanuts 21.12%
    Bread crust 20.97%
    Very mild 20.07%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.3

    pKa est.
    6.49 (neutral)

    Molecular weight
    142.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 152
    • 151.5 - 152.5 °C

    Boiling point

    • Decomposes

    Flash point

    • 169.74 ˚C est.

  • Synonyms

    • piracetam
    • 7491-74-9
    • 2-(2-oxopyrrolidin-1-yl)acetamide
    • Nootropil
    • 2-Oxo-1-pyrrolidineacetamide
    • Nootropyl
    • Normabrain
    • Pyracetam
    • Pyramem
    • Pirazetam
    • Myocalm
    • 2-Pyrrolidinoneacetamide
    • Piracetamum
    • Nootrop
    • Cl-871
    • 1-Acetamido-2-pyrrolidinone
    • 2-Ketopyrrolidine-1-ylacetamide
    • DTXSID5044491
    • NSC-758191
    • ZH516LNZ10
    • DTXCID3024491
    • Piracetam RPh
    • Piracetam-RPh
    • Memo Puren
    • 2-Pyrrolidone-N-Acetamide
    • UCB6215
    • Nootrop 400
    • Nootrop 800
    • Nootrop 1200
    • RefChem:6146
    • N06BX03
    • 231-312-7
    • 1-Pyrrolidineacetamide, 2-oxo-
    • Euvifor
    • Gabacet
    • Genogris
    • Pirroxil
    • Nootron
    • 2-Oxo-pyrrolidine acetamide
    • 2-Pyrrolidoneacetamide
    • UCB 6215
    • UCB-6215
    • 2-Oxo-pyrrolidin-1-ylacetamide
    • MLS000069719
    • MFCD00079246
    • SMR000058196
    • Ciclofalina
    • NCGC00015821-02
    • CAS-7491-74-9
    • 2-(2-oxopyrrolidinyl)acetamide
    • Naofukang [Chinese]
    • 2-(2-oxo-pyrrolidin-1-yl)acetamide
    • KT-801
    • Cerebroforte
    • Avigilen
    • Breinox
    • Naofukang
    • Norzetam
    • Axonyl
    • Geram
    • Piracetamum [INN-Latin]
    • SR-01000076071
    • EINECS 231-312-7
    • BRN 1526393
    • UNII-ZH516LNZ10
    • Encetrop
    • Piracetam [USAN:INN:BAN]
    • 2-(2-Oxopyrrolidino)acetamide
    • Piracetam CRS
    • HSDB 7529
    • Prestwick_870
    • 2-(2-Oxo-1-pyrrolidinyl)acetamide
    • Myocalm (TN)
    • Piracetam (Standard)
    • Piracetam, EP6.0
    • Spectrum_001421
    • PIRACETAM [INN]
    • PIRACETAM [JAN]
    • PIRACETAM [MI]
    • PIRACETAM [HSDB]
    • PIRACETAM [USAN]
    • Opera_ID_1766
    • Prestwick0_000537
    • Prestwick1_000537
    • Prestwick2_000537
    • Prestwick3_000537
    • Spectrum2_001074
    • Spectrum3_001523
    • Spectrum4_000742
    • Spectrum5_001037
    • Lopac-P-5295
    • PIRACETAM [MART.]
    • (2-Oxopyrrolidino)acetamide
    • cid_4843
    • PIRACETAM [WHO-DD]
    • Lopac0_000949
    • Oprea1_512927
    • SCHEMBL20172
    • BSPBio_000553
    • BSPBio_002906
    • KBioGR_001064
    • KBioSS_001901
    • 5-21-06-00360 (Beilstein Handbook Reference)
    • Piracetam (JAN/USAN/INN)
    • 2-Oxo-1-pyrrolidinylacetamide
    • CHEMBL36715
    • DivK1c_000259
    • SPECTRUM1502195
    • Piracetam - Bio-X trade mark
    • SPBio_001088
    • SPBio_002474
    • 2-(2-ketopyrrolidino)acetamide
    • BPBio1_000609
    • GTPL4288
    • orb1310628
    • SCHEMBL7769433
    • PIRACETAM [EP MONOGRAPH]
    • BDBM62877
    • CHEBI:32010
    • Cl-781
    • HMS500M21
    • HY-B0585R
    • KBio1_000259
    • KBio2_001901
    • KBio2_004469
    • KBio2_007037
    • KBio3_002406
    • 7491-74-9

  • Applications

    Piracetam is commonly used as an active pharmaceutical ingredient (API) in cognitive-function medications in certain markets, where it is formulated into tablets or capsules and evaluated for CNS-related performance within regulatory limits. It is also used in neuroscience and pharmacology research as a tool compound for studying mechanisms of synaptic plasticity and neuronal signaling, and in analytical laboratories as a reference material and standard for method development and quality control (e.g., HPLC/LC-MS) to quantify piracetam in dosage forms. In pharmaceutical development, it is often evaluated for formulation performance and stability with various excipients. Additionally, it is sold as a fine chemical for research and development purposes and may serve as a starting point for medicinal-chemistry work and the synthesis of related racetam derivatives. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 48.48
    methanol 166.78
    isopropanol 15.48
    water 208.19
    ethyl acetate 4.97
    n-propanol 18.19
    acetone 10.47
    n-butanol 11.88
    acetonitrile 12.45
    DMF 204.87
    toluene 0.88
    isobutanol 10.19
    1,4-dioxane 8.85
    methyl acetate 6.92
    THF 17.28
    2-butanone 6.14
    n-pentanol 7.64
    sec-butanol 8.36
    n-hexane 0.07
    ethylene glycol 80.49
    NMP 90.49
    cyclohexane 0.04
    DMSO 183.37
    n-butyl acetate 4.72
    n-octanol 3.6
    chloroform 10.17
    n-propyl acetate 3.23
    acetic acid 55.8
    dichloromethane 14.4
    cyclohexanone 11.12
    propylene glycol 57.08
    isopropyl acetate 3.02
    DMAc 129.65
    2-ethoxyethanol 49.92
    isopentanol 9.08
    n-heptane 0.08
    ethyl formate 33.92
    1,2-dichloroethane 5.73
    n-hexanol 5.99
    2-methoxyethanol 133.78
    isobutyl acetate 2.17
    tetrachloromethane 1.88
    n-pentyl acetate 3.66
    transcutol 28.93
    n-heptanol 4.13
    ethylbenzene 0.94
    MIBK 4.02
    2-propoxyethanol 36.82
    tert-butanol 10.76
    MTBE 2.11
    2-butoxyethanol 20.43
    propionic acid 21.66
    o-xylene 1.31
    formic acid 278.09
    diethyl ether 1.22
    m-xylene 1.33
    p-xylene 1.4
    chlorobenzene 2.85
    dimethyl carbonate 6.43
    n-octane 0.07
    formamide 152.76
    cyclopentanone 20.62
    2-pentanone 4.55
    anisole 4.72
    cyclopentyl methyl ether 3.34
    gamma-butyrolactone 36.01
    1-methoxy-2-propanol 54.22
    pyridine 10.25
    3-pentanone 2.44
    furfural 80.31
    n-dodecane 0.1
    diethylene glycol 69.54
    diisopropyl ether 0.41
    tert-amyl alcohol 7.98
    acetylacetone 9.52
    n-hexadecane 0.11
    acetophenone 7.99
    methyl propionate 6.33
    isopentyl acetate 5.04
    trichloroethylene 12.63
    n-nonanol 3.21
    cyclohexanol 3.83
    benzyl alcohol 12.18
    2-ethylhexanol 2.78
    isooctanol 3.22
    dipropyl ether 1.15
    1,2-dichlorobenzene 4.56
    ethyl lactate 9.95
    propylene carbonate 22.18
    n-methylformamide 130.51
    2-pentanol 3.44
    n-pentane 0.06
    1-propoxy-2-propanol 16.52
    1-methoxy-2-propyl acetate 9.36
    2-(2-methoxypropoxy) propanol 16.3
    mesitylene 0.9
    ε-caprolactone 15.69
    p-cymene 1.26
    epichlorohydrin 30.0
    1,1,1-trichloroethane 3.08
    2-aminoethanol 85.19
    morpholine-4-carbaldehyde 83.16
    sulfolane 57.54
    2,2,4-trimethylpentane 0.09
    2-methyltetrahydrofuran 6.31
    n-hexyl acetate 4.78
    isooctane 0.07
    2-(2-butoxyethoxy)ethanol 19.36
    sec-butyl acetate 2.01
    tert-butyl acetate 3.05
    decalin 0.11
    glycerin 126.08
    diglyme 33.37
    acrylic acid 31.78
    isopropyl myristate 1.77
    n-butyric acid 23.39
    acetyl acetate 5.01
    di(2-ethylhexyl) phthalate 6.02
    ethyl propionate 3.26
    nitromethane 74.44
    1,2-diethoxyethane 3.81
    benzonitrile 12.09
    trioctyl phosphate 3.73
    1-bromopropane 1.74
    gamma-valerolactone 55.75
    n-decanol 2.27
    triethyl phosphate 4.16
    4-methyl-2-pentanol 2.74
    propionitrile 7.57
    vinylene carbonate 27.94
    1,1,2-trichlorotrifluoroethane 56.92
    DMS 5.59
    cumene 1.04
    2-octanol 2.27
    2-hexanone 3.21
    octyl acetate 2.86
    limonene 1.26
    1,2-dimethoxyethane 39.28
    ethyl orthosilicate 3.41
    tributyl phosphate 4.06
    diacetone alcohol 11.93
    N,N-dimethylaniline 4.83
    acrylonitrile 20.31
    aniline 4.81
    1,3-propanediol 70.58
    bromobenzene 2.15
    dibromomethane 5.18
    1,1,2,2-tetrachloroethane 10.06
    2-methyl-cyclohexyl acetate 4.35
    tetrabutyl urea 6.41
    diisobutyl methanol 1.7
    2-phenylethanol 9.47
    styrene 1.04
    dioctyl adipate 3.84
    dimethyl sulfate 22.5
    ethyl butyrate 3.58
    methyl lactate 24.04
    butyl lactate 9.12
    diethyl carbonate 3.38
    propanediol butyl ether 22.47
    triethyl orthoformate 3.53
    p-tert-butyltoluene 1.13
    methyl 4-tert-butylbenzoate 10.39
    morpholine 15.75
    tert-butylamine 2.95
    n-dodecanol 1.6
    dimethoxymethane 27.58
    ethylene carbonate 16.72
    cyrene 27.23
    2-ethoxyethyl acetate 6.67
    2-ethylhexyl acetate 3.5
    1,2,4-trichlorobenzene 5.27
    4-methylpyridine 12.76
    dibutyl ether 1.23
    2,6-dimethyl-4-heptanol 1.7
    DEF 16.09
    dimethyl isosorbide 22.84
    tetrachloroethylene 7.11
    eugenol 15.98
    triacetin 7.18
    span 80 12.01
    1,4-butanediol 32.39
    1,1-dichloroethane 3.67
    2-methyl-1-pentanol 6.56
    methyl formate 90.37
    2-methyl-1-butanol 8.32
    n-decane 0.14
    butyronitrile 9.56
    3,7-dimethyl-1-octanol 3.34
    1-chlorooctane 0.76
    1-chlorotetradecane 0.36
    n-nonane 0.12
    undecane 0.12
    tert-butylcyclohexane 0.13
    cyclooctane 0.03
    cyclopentanol 8.2
    tetrahydropyran 2.39
    tert-amyl methyl ether 2.09
    2,5,8-trioxanonane 25.78
    1-hexene 0.39
    2-isopropoxyethanol 17.2
    2,2,2-trifluoroethanol 41.19
    methyl butyrate 6.44

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction