Piperonyl Butoxide

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  • Identifiers

    CAS number
    51-03-6

    Molecular formula
    C19H30O5

    SMILES
    CCCCOCCOCCOCC1=CC2=C(C=C1CCC)OCO2

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Floral 44.12%
    Sweet 37.7%
    Fruity 36.81%
    Vanilla 27.56%
    Balsamic 27.23%
    Fresh 26.22%
    Spicy 22.32%
    Aromatic 21.47%
    Rose 20.47%
    Warm 20.21%

     

    Flavor
    Earthy 34.05%
    Sweet 30.36%
    Floral 27.38%
    Oily 27.23%
    Fatty 26.84%
    Mushroom 26.72%
    Musty 25.0%
    Creamy 24.42%
    Mild 23.3%
    Bitter 21.8%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.7

    pKa est.
    5.97 (weak acid)

    Molecular weight
    338.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point

    • 356 °F at 1 mmHg (NTP, 1992)
    • 180 °C at 1 mm Hg /Technical/
    • at 0.13kPa: 180 °C
    • 356 ° at 1 mmHg

    Flash point

    • 151.37 ˚C est.
    • 340 °F (NTP, 1992)
    • 171 °C
    • 340 °F (171 °C) (open cup)
    • 340 °F

    Solubility expt.

    • less than 1 mg/mL at 64 °F (NTP, 1992)
    • Miscible with methanol, ethanol, benzene, Freons, Geons, petroleum oils, and other organic solvents
    • In water, 14.3 mg/L at 25 °C
    • Solubility in water: none

  • Synonyms

    • PIPERONYL BUTOXIDE
    • 51-03-6
    • Butacide
    • Butocide
    • Pyrenone 606
    • Butyl carbitol 6-propylpiperonyl ether
    • Butoxide (synergist)
    • 6-Propylpiperonyl butyl diethylene glycol ether
    • Butoxide, Piperonyl
    • NCI-C02813
    • FMC 5273
    • NIA 5273
    • Piperonyl butoxyde
    • DTXSID1021166
    • ENT 14,250
    • 2-(2-Butoxyethoxy)ethyl 6-propylpiperonyl ether
    • NSC-8401
    • Piperonyl butoxide, technical
    • LWK91TU9AH
    • 5-[2-(2-Butoxyethoxy)ethoxymethyl]-6-propyl-1,3-benzodioxole
    • Piperonyl butoxide technical
    • 1,3-Benzodioxole, 5-((2-(2-butoxyethoxy)ethoxy)methyl)-6-propyl-
    • 6-(Propylpiperonyl)-butyl carbityl ether
    • Butyl-carbityl (6-propylpiperonyl) ether
    • 3,4-Methylenedioxy-6-propylbenzyl n-butyl diethyleneglycol ether
    • 1,3-Benzodioxole, 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-
    • alpha-(2-(2-n-Butoxyethoxy)-ethoxy)-4,5-methylenedioxy-2-propyltoluene
    • 5-((2-(2-Butoxyethoxy)ethoxy)methyl)-6-propyl-1,3-benzodioxole
    • 5-Propyl-4-(2,5,8-trioxa-dodecyl)-1,3-benzodioxole
    • DTXCID501166
    • CHEBI:32687
    • NSC8401
    • alpha-(2-(2-Butoxyethoxy)ethoxy)-4,5-methylenedioxy-2-propyltoluene
    • FAC 5273
    • Toluene, alpha-(2-(2-butoxyethoxy)ethoxy)-4,5-(methylenedioxy)-2-propyl-
    • 5-Propyl-4-(2,5,8-trioxa-dodecyl)-1,3-benzodioxol
    • 3,4-Methylenedioxy-6-propylbenzyl-n-butyl-diaethylenglykolaether
    • 5-(2-(2-Butoxyethoxy)ethoxymethyl)-6-propyl-1,3-benzodioxole
    • 5-[[2-(2-Butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole
    • 5-{[2-(2-butoxyethoxy)ethoxy]methyl}-6-propyl-1,3-benzodioxole
    • 5-{[2-(2-butoxyethoxy)ethoxy]methyl}-6-propyl-2H-1,3-benzodioxole
    • alpha-[2-(2-butoxyethoxy)ethoxy]-4,5-(methylenedioxy)-2-propyltoluene
    • 5-((2-(2-butoxyethoxy)ethoxy)methyl)-6-propyl-2H-1,3-benzodioxole
    • alpha-(2-(2-Butoxyethoxy)ethoxy)-4,5-(methylenedioxy)-2-propyltoluene
    • RefChem:174462
    • NCI CO28l3
    • 200-076-7
    • Butoxide
    • Piperonylbutoxide
    • 5-((2-(2-Butoxyethoxy)ethoxy)methyl)-6-propylbenzo[d][1,3]dioxole
    • Ethanol butoxide
    • 6-(Propylpiperonyl)butylcarbityl ether
    • Piperonyl butoxide [BAN]
    • NSC 8401
    • MFCD00005842
    • Piperonyl butoxide in solvent
    • (Butylcarbityl)(6-propylpiperonyl)ether
    • ENT-14250
    • PBO
    • 3,4-Methylendioxy-6-propylbenzyl-n-butyl-diaethylenglykolaether
    • Butylcarbityl (6-propylpiperonyl) ether
    • NCGC00090874-02
    • NCGC00090874-04
    • (3,4-Methylenedioxy-6-propylbenzyl) (butyl) diethylene glycol ether
    • Piperonyl butoxide (BAN)
    • Piperonyl Butoxide (~90%)
    • Caswell No. 670
    • 4,5-Methylenedioxy-2-propylbenzyldiethyleneglycol butyl ether
    • Alleviate
    • 5-{[(2-{[2-(butyloxy)ethyl]oxy}ethyl)oxy]methyl}-6-propyl-1,3-benzodioxole
    • 2-(2-butoxyethoxy)-1-[(6-propyl(2H-benzo[d]1,3-dioxolen-5-yl))methoxy]ethane
    • CAS-51-03-6
    • CCRIS 522
    • HSDB 1755
    • Piperonyl butoxyde [ISO-French]
    • 2-(2-Butoxyethoxy)ethyl (6-propylpiperonyl) ether
    • EINECS 200-076-7
    • UNII-LWK91TU9AH
    • EPA Pesticide Chemical Code 067501
    • BRN 0288063
    • Pyrenon
    • AI3-14250
    • Piperonyl butoxide [BSI:ISO]
    • .alpha.(2-(2-Butoxyethoxy)ethoxy)-4,5-methylenedioxy-2-propyltoluene
    • .alpha.-(2-(2-n-Butoxyethoxy)-ethoxy)-4,5-methylenedioxy-2-propyltoluene
    • .alpha.-[2-(2-N-Butoxyethoxy)-ethoxy]-4,5-methylenedioxy-2-propyltoluene
    • .alpha.[2-(2-Butoxyethoxy)ethoxy]-4,5-methylenedioxy-2-propyltoluene
    • piperonyl-butoxide
    • Rid Mousse (TN)
    • Scourge (Salt/Mix)
    • Para Pio (TN)
    • 3,4-Methylenedioxy-6-propylbenzyl n-butyldiethyleneglycol ether
    • 5-Propyl-4-(2,5,8-trioxa-dodecyl)-1,3-benzodioxol [German]
    • 3,4-Methylendioxy-6-propylbenzyl-n-butyl-diaethylenglykolaether [German]
    • 3,4-Methylenedioxy-6-propylbenzyl-n-butyl-diaethylenglykolaether [German]
    • EC 200-076-7
    • SCHEMBL5490
    • 4-19-00-00779 (Beilstein Handbook Reference)
    • Piperonyl butoxide (Standard)
    • orb1310344
    • Anvil 2+2 ULV (Salt/Mix)
    • PIPERONYL BUTOXIDE [MI]
    • CHEMBL1201131
    • PIPERONYL BUTOXIDE [ISO]
    • SCHEMBL29386186
    • HY-B1198R
    • PIPERONYL BUTOXIDE [HSDB]
    • PIPERONYL BUTOXIDE [IARC]
    • BDBM181115
    • GLXC-23004
    • HMS3264A07
    • HMS5083H10
    • PIPERONYL BUTOXIDE [VANDF]
    • US9138393, Piperonyl butoxide
    • US9144538, Piperonyl butoxide
    • Anvil 10+10 ULV (Salt/Mix)
    • PIPERONYL BUTOXIDE [MART.]
    • HY-B1198
    • MSK20400
    • PIPERONYL BUTOXIDE [WHO-DD]
    • Tox21_111034
    • Tox21_400086
    • EBC-26645
    • s4831
    • AKOS015951348
    • Toluene,5-(methylenedioxy)-2-propyl-
    • Tox21_111034_1
    • 51-03-6

  • Applications

    Piperonyl Butoxide is widely used as a pesticide synergist that enhances the efficacy of pyrethrin and pyrethroid insecticides by inhibiting insect cytochrome P450–mediated detoxification. In practice, it is formulated with pyrethroids for agricultural crop protection, incorporated into household and garden pest-control products (aerosols, sprays, and bait formulations), and included in veterinary pest-control products for companion animals to combat fleas and ticks. It is also encountered in some public health vector-control formulations to improve performance against disease vectors, within allowable regulatory limits. As an additive, it extends the active insecticide’s effective life rather than acting as a stand-alone insecticide.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 532.11
    methanol 693.67
    isopropanol 330.15
    water 3.71
    ethyl acetate 1046.23
    n-propanol 443.0
    acetone 1039.83
    n-butanol 427.09
    acetonitrile 790.71
    DMF 638.12
    toluene 220.37
    isobutanol 328.09
    1,4-dioxane 927.75
    methyl acetate 811.7
    THF 948.52
    2-butanone 690.77
    n-pentanol 277.85
    sec-butanol 348.39
    n-hexane 14.52
    ethylene glycol 161.07
    NMP 638.39
    cyclohexane 90.3
    DMSO 1496.69
    n-butyl acetate 398.98
    n-octanol 121.62
    chloroform 3077.04
    n-propyl acetate 544.96
    acetic acid 1427.97
    dichloromethane 3722.79
    cyclohexanone 1066.8
    propylene glycol 161.37
    isopropyl acetate 545.73
    DMAc 817.84
    2-ethoxyethanol 678.83
    isopentanol 338.6
    n-heptane 16.12
    ethyl formate 691.88
    1,2-dichloroethane 2224.82
    n-hexanol 179.35
    2-methoxyethanol 835.69
    isobutyl acetate 338.41
    tetrachloromethane 398.46
    n-pentyl acetate 370.54
    transcutol 1472.63
    n-heptanol 116.59
    ethylbenzene 119.82
    MIBK 325.69
    2-propoxyethanol 405.31
    tert-butanol 357.38
    MTBE 307.85
    2-butoxyethanol 326.17
    propionic acid 688.03
    o-xylene 157.55
    formic acid 562.86
    diethyl ether 456.99
    m-xylene 149.81
    p-xylene 173.13
    chlorobenzene 543.49
    dimethyl carbonate 412.91
    n-octane 12.3
    formamide 734.5
    cyclopentanone 946.58
    2-pentanone 577.77
    anisole 285.45
    cyclopentyl methyl ether 450.3
    gamma-butyrolactone 1257.48
    1-methoxy-2-propanol 493.29
    pyridine 814.49
    3-pentanone 498.96
    furfural 938.47
    n-dodecane 12.78
    diethylene glycol 371.09
    diisopropyl ether 121.67
    tert-amyl alcohol 318.09
    acetylacetone 844.22
    n-hexadecane 14.62
    acetophenone 373.74
    methyl propionate 688.77
    isopentyl acetate 334.68
    trichloroethylene 3168.81
    n-nonanol 117.58
    cyclohexanol 473.39
    benzyl alcohol 304.46
    2-ethylhexanol 131.88
    isooctanol 112.19
    dipropyl ether 164.58
    1,2-dichlorobenzene 541.92
    ethyl lactate 275.07
    propylene carbonate 741.99
    n-methylformamide 536.1
    2-pentanol 249.67
    n-pentane 19.51
    1-propoxy-2-propanol 273.05
    1-methoxy-2-propyl acetate 390.46
    2-(2-methoxypropoxy) propanol 286.19
    mesitylene 98.37
    ε-caprolactone 975.61
    p-cymene 85.81
    epichlorohydrin 1636.6
    1,1,1-trichloroethane 1323.04
    2-aminoethanol 273.12
    morpholine-4-carbaldehyde 717.55
    sulfolane 1155.58
    2,2,4-trimethylpentane 19.18
    2-methyltetrahydrofuran 678.42
    n-hexyl acetate 373.74
    isooctane 11.56
    2-(2-butoxyethoxy)ethanol 395.24
    sec-butyl acetate 350.97
    tert-butyl acetate 408.7
    decalin 31.9
    glycerin 285.09
    diglyme 912.82
    acrylic acid 584.12
    isopropyl myristate 135.82
    n-butyric acid 1056.03
    acetyl acetate 852.25
    di(2-ethylhexyl) phthalate 143.55
    ethyl propionate 457.92
    nitromethane 1985.71
    1,2-diethoxyethane 488.13
    benzonitrile 418.11
    trioctyl phosphate 106.24
    1-bromopropane 744.8
    gamma-valerolactone 1122.08
    n-decanol 83.89
    triethyl phosphate 204.34
    4-methyl-2-pentanol 138.23
    propionitrile 507.13
    vinylene carbonate 765.95
    1,1,2-trichlorotrifluoroethane 1214.7
    DMS 405.15
    cumene 86.44
    2-octanol 89.71
    2-hexanone 368.86
    octyl acetate 175.89
    limonene 121.9
    1,2-dimethoxyethane 757.25
    ethyl orthosilicate 187.22
    tributyl phosphate 147.44
    diacetone alcohol 380.97
    N,N-dimethylaniline 164.77
    acrylonitrile 673.13
    aniline 332.45
    1,3-propanediol 483.06
    bromobenzene 610.55
    dibromomethane 2017.29
    1,1,2,2-tetrachloroethane 2360.72
    2-methyl-cyclohexyl acetate 260.16
    tetrabutyl urea 173.57
    diisobutyl methanol 77.77
    2-phenylethanol 223.65
    styrene 166.86
    dioctyl adipate 234.81
    dimethyl sulfate 568.25
    ethyl butyrate 329.4
    methyl lactate 344.09
    butyl lactate 285.81
    diethyl carbonate 291.92
    propanediol butyl ether 264.87
    triethyl orthoformate 251.49
    p-tert-butyltoluene 71.46
    methyl 4-tert-butylbenzoate 292.1
    morpholine 1006.81
    tert-butylamine 179.19
    n-dodecanol 64.57
    dimethoxymethane 627.3
    ethylene carbonate 761.69
    cyrene 302.15
    2-ethoxyethyl acetate 539.39
    2-ethylhexyl acetate 277.97
    1,2,4-trichlorobenzene 605.84
    4-methylpyridine 590.01
    dibutyl ether 184.19
    2,6-dimethyl-4-heptanol 77.77
    DEF 621.58
    dimethyl isosorbide 437.29
    tetrachloroethylene 1569.25
    eugenol 276.09
    triacetin 489.49
    span 80 228.45
    1,4-butanediol 241.11
    1,1-dichloroethane 1480.79
    2-methyl-1-pentanol 259.91
    methyl formate 504.93
    2-methyl-1-butanol 337.05
    n-decane 21.09
    butyronitrile 485.1
    3,7-dimethyl-1-octanol 126.68
    1-chlorooctane 116.19
    1-chlorotetradecane 43.39
    n-nonane 18.78
    undecane 15.58
    tert-butylcyclohexane 20.73
    cyclooctane 23.8
    cyclopentanol 421.63
    tetrahydropyran 880.58
    tert-amyl methyl ether 234.79
    2,5,8-trioxanonane 566.78
    1-hexene 71.55
    2-isopropoxyethanol 426.16
    2,2,2-trifluoroethanol 683.47
    methyl butyrate 585.74

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction