Piconol

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  • Identifiers

    CAS number
    586-98-1

    Molecular formula
    C6H7NO

    SMILES
    C1=CC=NC(=C1)CO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 50.3%
    Nutty 49.62%
    Almond 43.09%
    Roasted 40.96%
    Caramellic 38.5%
    Burnt 38.48%
    Musty 36.93%
    Earthy 34.99%
    Coffee 34.4%
    Fatty 29.78%

     

    Flavor
    Bitter 54.24%
    Fatty 41.94%
    Sweet 41.6%
    Coffee 41.09%
    Musty 37.01%
    Nutty 33.7%
    Chocolate 32.69%
    Oily 32.53%
    Caramel 31.26%
    Roasted 30.54%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.1

    pKa est.
    6.02 (neutral)

    Molecular weight
    109.13 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    207°C

    Flash point

    • 105.53 ˚C est.

  • Synonyms

    • 2-PYRIDINEMETHANOL
    • pyridin-2-ylmethanol
    • Piconol
    • 2-Pyridylmethanol
    • Pyridine-2-methanol
    • 2-Pyridyl carbinol
    • Piconol [INN]
    • Piconolum [Latin]
    • UNII-7HQ8UT1TPS
    • 7HQ8UT1TPS
    • EINECS 209-592-7
    • NSC-760363
    • BRN 0107849
    • DTXSID8046531
    • DTXCID6026531
    • 5-21-02-00150 (Beilstein Handbook Reference)
    • Piconolum (Latin)
    • NSC 760363
    • 2pyridylcarbinol
    • 2pyridylmethanol
    • Pyridine2carbinol
    • 2Pyridinylmethanol
    • 2Pyridyl carbinol
    • alphaPicolyl alcohol
    • omegaHydroxy2picoline
    • 2(Hydroxymethyl)pyridine
    • RefChem:174165
    • InChI=1/C6H7NO/c8-5-6-3-1-2-4-7-6/h1-4,8H,5H
    • SHNUBALDGXWUJI-UHFFFAOYSA-N
    • 586-98-1
    • 2-(Hydroxymethyl)pyridine
    • 2-Pyridinylmethanol
    • 2-Pyridylcarbinol
    • (Pyridin-2-yl)methanol
    • Pyridine-2-carbinol
    • 2-hydroxymethylpyridine
    • MFCD00006348
    • 2-Pyridine methanol
    • Pyridin-2-Yl-Methanol
    • Pyridinemethanol
    • pyridine-methanol
    • 2-pyridinylcarbinol
    • 2-pyridine-methanol
    • .alpha.-Picolyl alcohol
    • NCGC00166075-01
    • alpha-Picolyl alcohol
    • Piconolum
    • CAS-586-98-1
    • pyridinyl-methanol
    • hydroxymethylpyridine
    • 2-pyridinyl carbinol
    • pyridine-2-ylmethanol
    • 2-pyridylmethan-1-ol
    • ?-Hydroxy-2-picoline
    • pyridine-2-yl-methanol
    • 2-hydroxymethyl pyridine
    • 2-hydroxymethyl-pyridine
    • 2-Pyridinemethanol, 98%
    • 2-(hydroxymethyl) pyridine
    • 2-(hydroxymethyl)-pyridine
    • pyridine, 2-hydroxymethyl-
    • SCHEMBL29266
    • SCHEMBL69808
    • orb1309732
    • SCHEMBL1383173
    • SCHEMBL1481683
    • SCHEMBL1809188
    • SCHEMBL1924238
    • SCHEMBL1924707
    • SCHEMBL1969351
    • CHEMBL2103981
    • SCHEMBL29530498
    • CHEBI:195070
    • HMS3264E03
    • Pharmakon1600-01506166
    • HY-Y0004
    • STR00171
    • Tox21_112305
    • AC7883
    • EBC-13143
    • NSC760363
    • SBB004348
    • AKOS000249319
    • Tox21_112305_1
    • CCG-214048
    • CS-W020042
    • FG-0436
    • FH24411
    • NCGC00166075-02
    • SY005684
    • DB-021521
    • NS00034000
    • P0556
    • EN300-18423
    • AB01563256_01
    • AE-641/00340018
    • F043374
    • SR-01000944286
    • doi:10.14272/SHNUBALDGXWUJI-UHFFFAOYSA-N.1
    • SR-01000944286-1
    • BRD-K28492574-001-01-6
    • Q27268311
    • Z57921252
    • F0001-1533
    • 586-98-1

  • Applications

    Piconol, CAS 586-98-1, is used primarily as an intermediate in organic synthesis and as a solvent in chemical manufacturing; in coatings and inks it can function as a processing aid or solvent for formulation components; in polymers/plastics it may serve as a stabilizer, processing additive, or property modifier; in fragrance and cosmetics contexts it may be evaluated as a fragrance ingredient or carrier depending on formulation and regulatory constraints; in cleaning formulations and industrial cleaners it can appear as a solvent or formulation component.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 295.38
    methanol 419.38
    isopropanol 205.99
    water 51.27
    ethyl acetate 128.39
    n-propanol 244.61
    acetone 184.22
    n-butanol 177.49
    acetonitrile 176.27
    DMF 714.35
    toluene 56.37
    isobutanol 157.93
    1,4-dioxane 608.89
    methyl acetate 174.38
    THF 382.65
    2-butanone 176.73
    n-pentanol 116.95
    sec-butanol 137.28
    n-hexane 4.34
    ethylene glycol 158.94
    NMP 545.03
    cyclohexane 7.13
    DMSO 1314.75
    n-butyl acetate 108.51
    n-octanol 42.33
    chloroform 317.18
    n-propyl acetate 104.09
    acetic acid 437.09
    dichloromethane 303.12
    cyclohexanone 287.18
    propylene glycol 83.59
    isopropyl acetate 60.1
    DMAc 393.1
    2-ethoxyethanol 220.77
    isopentanol 112.0
    n-heptane 9.25
    ethyl formate 163.35
    1,2-dichloroethane 217.8
    n-hexanol 115.65
    2-methoxyethanol 378.24
    isobutyl acetate 58.0
    tetrachloromethane 58.11
    n-pentyl acetate 58.44
    transcutol 396.3
    n-heptanol 55.64
    ethylbenzene 18.87
    MIBK 67.46
    2-propoxyethanol 203.44
    tert-butanol 218.06
    MTBE 96.88
    2-butoxyethanol 118.74
    propionic acid 309.11
    o-xylene 39.4
    formic acid 401.24
    diethyl ether 88.84
    m-xylene 40.57
    p-xylene 30.48
    chlorobenzene 111.25
    dimethyl carbonate 61.62
    n-octane 3.58
    formamide 460.65
    cyclopentanone 366.69
    2-pentanone 116.62
    anisole 73.74
    cyclopentyl methyl ether 158.71
    gamma-butyrolactone 520.37
    1-methoxy-2-propanol 204.65
    pyridine 332.72
    3-pentanone 84.36
    furfural 482.66
    n-dodecane 3.25
    diethylene glycol 220.01
    diisopropyl ether 21.1
    tert-amyl alcohol 142.26
    acetylacetone 112.59
    n-hexadecane 3.55
    acetophenone 84.66
    methyl propionate 127.2
    isopentyl acetate 74.62
    trichloroethylene 411.88
    n-nonanol 37.17
    cyclohexanol 137.79
    benzyl alcohol 90.6
    2-ethylhexanol 53.77
    isooctanol 45.52
    dipropyl ether 62.47
    1,2-dichlorobenzene 86.43
    ethyl lactate 62.23
    propylene carbonate 206.54
    n-methylformamide 501.77
    2-pentanol 86.31
    n-pentane 5.45
    1-propoxy-2-propanol 134.62
    1-methoxy-2-propyl acetate 92.08
    2-(2-methoxypropoxy) propanol 92.82
    mesitylene 23.32
    ε-caprolactone 240.52
    p-cymene 22.55
    epichlorohydrin 468.1
    1,1,1-trichloroethane 143.4
    2-aminoethanol 235.71
    morpholine-4-carbaldehyde 494.33
    sulfolane 631.04
    2,2,4-trimethylpentane 5.41
    2-methyltetrahydrofuran 271.71
    n-hexyl acetate 63.28
    isooctane 4.48
    2-(2-butoxyethoxy)ethanol 134.4
    sec-butyl acetate 48.45
    tert-butyl acetate 61.27
    decalin 4.92
    glycerin 199.25
    diglyme 272.59
    acrylic acid 280.23
    isopropyl myristate 23.95
    n-butyric acid 278.51
    acetyl acetate 66.42
    di(2-ethylhexyl) phthalate 30.6
    ethyl propionate 69.84
    nitromethane 669.98
    1,2-diethoxyethane 109.3
    benzonitrile 134.47
    trioctyl phosphate 26.24
    1-bromopropane 91.75
    gamma-valerolactone 503.09
    n-decanol 28.78
    triethyl phosphate 36.54
    4-methyl-2-pentanol 45.75
    propionitrile 167.7
    vinylene carbonate 204.31
    1,1,2-trichlorotrifluoroethane 307.12
    DMS 59.8
    cumene 16.89
    2-octanol 33.31
    2-hexanone 87.77
    octyl acetate 33.07
    limonene 33.03
    1,2-dimethoxyethane 289.59
    ethyl orthosilicate 33.11
    tributyl phosphate 31.53
    diacetone alcohol 115.77
    N,N-dimethylaniline 52.93
    acrylonitrile 267.48
    aniline 135.55
    1,3-propanediol 252.53
    bromobenzene 86.85
    dibromomethane 178.51
    1,1,2,2-tetrachloroethane 292.7
    2-methyl-cyclohexyl acetate 47.72
    tetrabutyl urea 46.57
    diisobutyl methanol 31.95
    2-phenylethanol 85.04
    styrene 26.92
    dioctyl adipate 38.34
    dimethyl sulfate 149.1
    ethyl butyrate 76.95
    methyl lactate 96.95
    butyl lactate 59.38
    diethyl carbonate 45.63
    propanediol butyl ether 91.31
    triethyl orthoformate 48.85
    p-tert-butyltoluene 21.99
    methyl 4-tert-butylbenzoate 69.56
    morpholine 566.32
    tert-butylamine 97.81
    n-dodecanol 22.7
    dimethoxymethane 215.43
    ethylene carbonate 166.22
    cyrene 110.34
    2-ethoxyethyl acetate 84.36
    2-ethylhexyl acetate 53.72
    1,2,4-trichlorobenzene 109.56
    4-methylpyridine 273.93
    dibutyl ether 39.33
    2,6-dimethyl-4-heptanol 31.95
    DEF 220.41
    dimethyl isosorbide 150.27
    tetrachloroethylene 218.24
    eugenol 82.83
    triacetin 67.53
    span 80 75.07
    1,4-butanediol 114.72
    1,1-dichloroethane 184.62
    2-methyl-1-pentanol 82.2
    methyl formate 303.97
    2-methyl-1-butanol 117.26
    n-decane 4.86
    butyronitrile 153.47
    3,7-dimethyl-1-octanol 40.7
    1-chlorooctane 23.31
    1-chlorotetradecane 9.53
    n-nonane 4.46
    undecane 3.87
    tert-butylcyclohexane 5.87
    cyclooctane 3.12
    cyclopentanol 193.47
    tetrahydropyran 286.37
    tert-amyl methyl ether 65.88
    2,5,8-trioxanonane 180.24
    1-hexene 21.07
    2-isopropoxyethanol 127.66
    2,2,2-trifluoroethanol 201.63
    methyl butyrate 111.13

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction