Phosphorus oxychloride

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  • Identifiers

    CAS number
    10025-87-3

    Molecular formula
    Cl3OP

    SMILES
    O=P(Cl)(Cl)Cl

    Safety labels

    Corrosive
    Corrosive

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 67.8%
    Sweet 25.82%
    Savory 15.57%
    Clean 14.82%
    Bitter 14.39%
    Meaty 13.18%
    Cooked 12.87%
    Fresh 12.58%
    Dry 12.27%
    Fatty 12.09%

     

    Flavor
    Odorless 48.79%
    Bland 19.93%
    Mousy 19.72%
    Formyl 18.77%
    Rotten 18.71%
    Soy 17.99%
    Sulfurous 17.86%
    Urine 17.3%
    Decomposing cabbage 17.23%
    Bouillon 17.22%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.7

    pKa est.
    -2.34 (strong acid)

    Molecular weight
    153.33 g/mol

    Melting point expt.

    • 34.2 °F (EPA, 1998)
    • 1.25 °C
    • 1 - 1.5 °C
    • 34.2 °F
    • 34 °F

    Boiling point

    • 223 °F at 760 mmHg (EPA, 1998)
    • 105.8 °C
    • 223 °F
    • 222 °F

    Flash point

    • 41.85 ˚C est.
    • Not Flammable (EPA, 1998)

    Solubility expt.

    • Decomposes (NIOSH, 2024)
    • Reacts with water
    • Solubility in water: reaction
    • Decomposes

  • Synonyms

    • PHOSPHORUS OXYCHLORIDE
    • Phosphoryl chloride
    • 10025-87-3
    • Phosphoryl trichloride
    • Phosphoric trichloride
    • Phosphorous oxychloride
    • Phosphoroxychloride
    • Trichlorophosphine oxide
    • Phosphorus oxytrichloride
    • Fosforoxychlorid
    • Phosphorylchlorid
    • Phosphoroxychlorid
    • Trichlorophosphorus oxide
    • Oxychlorid fosforecny
    • Phosphorus oxide trichloride
    • POCl3
    • Fosforoxychlorid [Czech]
    • Phosphoroxidchlorid
    • Phosphortrichloridoxid
    • Phosphorus chloride oxide (POCl3)
    • Oxychlorid fosforecny [Czech]
    • HSDB 784
    • trichloridooxidophosphorus
    • trichlorure de phosphoryle
    • Phosphorus(V) oxychloride
    • [PCl3O]
    • Phosphorus (V) oxychloride
    • phosphorus trichloride oxide
    • EINECS 233-046-7
    • MFCD00011443
    • UN1810
    • Phosphorus(V) oxide chloride
    • phosphorusoxychloride
    • phosphorousoxychloride
    • 9XM78OL22K
    • Phosphorus(V) trichloride oxide
    • DTXSID5029710
    • OPCl3
    • CHEBI:30336
    • phosphorus oxy-chloride
    • Phosphorus chloride oxide
    • DTXCID609710
    • EC 233-046-7
    • PHOSPHORUS OXYCHLORIDE [MI]
    • PHOSPHORUS OXYCHLORIDE [HSDB]
    • Fosforoxychlorid (Czech)
    • (PCl3O)
    • Oxychlorid fosforecny (Czech)
    • Phosphorus oxycloride
    • phosphoroyl trichloride
    • Phosphorus(V) oxychloride, ReagentPlus(R), 99%
    • PHOSPHORYL CHLORIDE (PHOSPHORUS OXYCHLORIDE)
    • PHOSPHORYL CHLORIDE {PHOSPHORUS OXYCHLORIDE}
    • UNII-9XM78OL22K
    • phosphoricchloride
    • phosphorylchloride
    • phosphoryl choride
    • phosphor oxychloride
    • phosphoroxy-chloride
    • phosphoryltrichloride
    • phosphorus oxychlorid
    • Phosphorus oxychoride
    • Phosphoryl trichoride
    • phosphorous oxychoride
    • phosphorus oxichloride
    • phosphorus oxychioride
    • phosphorus-oxychloride
    • Oxicloruro de fosforo
    • Phosphorous oxycloride
    • Phosphorusoxy chloride
    • phosphorous oxichloride
    • phosphorous-oxychloride
    • phosphorousoxy chloride
    • Cl3PO
    • phosphor us oxychloride
    • phosphorus oxychloride-
    • phosphorous oxy chloride
    • phosphorous oxy-chloride
    • phosphorous-oxy-chloride
    • Trichlorooxophosphorus(V)
    • Phosphorus oxychloride [UN1810] [Corrosive]
    • P O Cl3
    • P(O)Cl3
    • PHOSPHOROXYTRICHLORIDE
    • PHOSPHONYL TRICHLORIDE
    • Phosphorus oxychloride (ACGIH)
    • CHEMBL3183103
    • Oxicloruro de fosforo (Spanish)
    • BCP24761
    • Tox21_200814
    • PHOSPHORUS MONOXIDE TRICHLORIDE
    • AKOS015903725
    • Phosphorus(V) oxychloride, 99.999%
    • NCGC00248842-01
    • NCGC00258368-01
    • PHOSPHORUS CHLORIDE OXIDE (PCL3O)
    • CAS-10025-87-3
    • DB-058337
    • NS00003748
    • Phosphorus oxychloride [UN1810] [Corrosive]
    • Q898387
    • Phosphorus(V) oxychloride, SAJ first grade, >=98.0%
    • Phosphorus(V) oxychloride, puriss. p.a., >=99.0% (AT)
    • Phosphorus(V) oxychloride, SAJ special grade, 99.0-100.5%
    • 233-046-7

  • Applications

    Phosphorus oxychloride (CAS 10025-87-3) is widely used as a chlorinating and dehydrating agent in organic synthesis and as a key intermediate for the production of phosphate esters. These esters serve as flame retardants and plasticizers for polymers and coatings, and POCl3 is a precursor for phosphorus-containing monomers and additives used in plastics, electronics, and adhesives. It is also employed as an intermediate in the synthesis of a range of organophosphorus compounds via phosphorylation of alcohols and phenols, enabling access to specialty chemicals.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 336.1
    methanol 523.99
    isopropanol 264.82
    water 115.95
    ethyl acetate 147.25
    n-propanol 236.84
    acetone 342.51
    n-butanol 198.11
    acetonitrile 184.16
    DMF 1048.88
    toluene 119.25
    isobutanol 165.45
    1,4-dioxane 329.14
    methyl acetate 173.02
    THF 520.39
    2-butanone 201.27
    n-pentanol 139.45
    sec-butanol 214.36
    n-hexane 65.78
    ethylene glycol 211.07
    NMP 625.92
    cyclohexane 106.18
    DMSO 824.82
    n-butyl acetate 100.62
    n-octanol 124.47
    chloroform 395.5
    n-propyl acetate 116.27
    acetic acid 260.48
    dichloromethane 406.01
    cyclohexanone 237.0
    propylene glycol 151.64
    isopropyl acetate 113.07
    DMAc 665.39
    2-ethoxyethanol 286.83
    isopentanol 144.7
    n-heptane 76.35
    ethyl formate 141.61
    1,2-dichloroethane 275.54
    n-hexanol 132.18
    2-methoxyethanol 521.05
    isobutyl acetate 71.19
    tetrachloromethane 116.88
    n-pentyl acetate 107.25
    transcutol 362.84
    n-heptanol 117.31
    ethylbenzene 68.59
    MIBK 120.8
    2-propoxyethanol 252.8
    tert-butanol 252.38
    MTBE 194.59
    2-butoxyethanol 190.4
    propionic acid 153.96
    o-xylene 113.26
    formic acid 250.99
    diethyl ether 299.74
    m-xylene 100.68
    p-xylene 77.83
    chlorobenzene 102.97
    dimethyl carbonate 138.43
    n-octane 40.58
    formamide 399.82
    cyclopentanone 318.35
    2-pentanone 188.21
    anisole 140.82
    cyclopentyl methyl ether 276.12
    gamma-butyrolactone 295.6
    1-methoxy-2-propanol 375.47
    pyridine 268.72
    3-pentanone 171.07
    furfural 313.71
    n-dodecane 26.54
    diethylene glycol 269.54
    diisopropyl ether 108.45
    tert-amyl alcohol 200.65
    acetylacetone 175.88
    n-hexadecane 28.78
    acetophenone 143.17
    methyl propionate 174.09
    isopentyl acetate 81.51
    trichloroethylene 345.17
    n-nonanol 109.88
    cyclohexanol 199.29
    benzyl alcohol 131.8
    2-ethylhexanol 92.67
    isooctanol 92.13
    dipropyl ether 162.39
    1,2-dichlorobenzene 106.35
    ethyl lactate 92.31
    propylene carbonate 143.16
    n-methylformamide 402.87
    2-pentanol 166.23
    n-pentane 105.83
    1-propoxy-2-propanol 188.46
    1-methoxy-2-propyl acetate 120.55
    2-(2-methoxypropoxy) propanol 140.17
    mesitylene 82.93
    ε-caprolactone 188.27
    p-cymene 67.09
    epichlorohydrin 294.44
    1,1,1-trichloroethane 176.01
    2-aminoethanol 248.39
    morpholine-4-carbaldehyde 510.26
    sulfolane 398.39
    2,2,4-trimethylpentane 38.9
    2-methyltetrahydrofuran 292.47
    n-hexyl acetate 118.18
    isooctane 30.92
    2-(2-butoxyethoxy)ethanol 185.43
    sec-butyl acetate 82.68
    tert-butyl acetate 118.73
    decalin 36.95
    glycerin 228.75
    diglyme 346.31
    acrylic acid 165.47
    isopropyl myristate 71.83
    n-butyric acid 159.56
    acetyl acetate 93.14
    di(2-ethylhexyl) phthalate 62.85
    ethyl propionate 110.26
    nitromethane 353.1
    1,2-diethoxyethane 163.99
    benzonitrile 119.63
    trioctyl phosphate 59.56
    1-bromopropane 189.17
    gamma-valerolactone 332.89
    n-decanol 87.14
    triethyl phosphate 71.01
    4-methyl-2-pentanol 95.49
    propionitrile 139.99
    vinylene carbonate 134.27
    1,1,2-trichlorotrifluoroethane 293.5
    DMS 95.24
    cumene 55.42
    2-octanol 98.3
    2-hexanone 126.05
    octyl acetate 84.62
    limonene 97.36
    1,2-dimethoxyethane 402.73
    ethyl orthosilicate 73.75
    tributyl phosphate 58.56
    diacetone alcohol 156.83
    N,N-dimethylaniline 161.8
    acrylonitrile 178.15
    aniline 155.87
    1,3-propanediol 243.86
    bromobenzene 96.23
    dibromomethane 309.75
    1,1,2,2-tetrachloroethane 316.87
    2-methyl-cyclohexyl acetate 83.98
    tetrabutyl urea 99.03
    diisobutyl methanol 76.45
    2-phenylethanol 114.95
    styrene 83.74
    dioctyl adipate 87.53
    dimethyl sulfate 231.28
    ethyl butyrate 103.28
    methyl lactate 148.64
    butyl lactate 98.1
    diethyl carbonate 72.09
    propanediol butyl ether 164.28
    triethyl orthoformate 94.59
    p-tert-butyltoluene 72.59
    methyl 4-tert-butylbenzoate 149.33
    morpholine 408.57
    tert-butylamine 201.17
    n-dodecanol 72.99
    dimethoxymethane 542.57
    ethylene carbonate 114.82
    cyrene 150.76
    2-ethoxyethyl acetate 117.28
    2-ethylhexyl acetate 72.12
    1,2,4-trichlorobenzene 123.75
    4-methylpyridine 231.68
    dibutyl ether 109.58
    2,6-dimethyl-4-heptanol 76.45
    DEF 343.64
    dimethyl isosorbide 194.73
    tetrachloroethylene 259.63
    eugenol 157.24
    triacetin 121.28
    span 80 140.14
    1,4-butanediol 125.23
    1,1-dichloroethane 227.43
    2-methyl-1-pentanol 103.92
    methyl formate 272.84
    2-methyl-1-butanol 145.11
    n-decane 42.46
    butyronitrile 135.95
    3,7-dimethyl-1-octanol 97.57
    1-chlorooctane 90.03
    1-chlorotetradecane 44.48
    n-nonane 44.89
    undecane 32.13
    tert-butylcyclohexane 33.76
    cyclooctane 53.9
    cyclopentanol 246.95
    tetrahydropyran 283.41
    tert-amyl methyl ether 187.95
    2,5,8-trioxanonane 248.28
    1-hexene 102.74
    2-isopropoxyethanol 190.57
    2,2,2-trifluoroethanol 167.69
    methyl butyrate 137.19

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction