Phosphinic Acid

Overview IFRA Request a quote

  • Identifiers

    CAS number
    6303-21-5

    Molecular formula
    H3O2P

    SMILES
    O[PH2]=O

    Safety labels

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Odorless 79.77%
    Sour 37.83%
    Sharp 37.05%
    Pungent 31.25%
    Fruity 28.42%
    Cheesy 23.88%
    Fermented 20.6%
    Ethereal 18.07%
    Sweaty 17.8%
    Burnt 16.57%

     

    Flavor
    Odorless 54.48%
    Pungent 53.71%
    Vinegar 43.19%
    Sour 33.0%
    Formyl 28.19%
    Bitter 26.97%
    Mustard 26.85%
    Sharp 23.07%
    Soy 22.42%
    Mousy 21.58%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.1

    pKa est.
    1.22 (strong acid)

    Molecular weight
    65.996 g/mol

    Melting point expt.

    • 26.5 °C

    Boiling point

    • Decomposes upon heating >133 °C

    Flash point

    • 71.82 ˚C est.

    Solubility expt.

    • Miscible with water
    • Miscible with alcohol

  • Synonyms

    • Acid, Phosphinic
    • RefChem:929168
    • DTXCID401012094
    • 228-601-5
    • 6303-21-5
    • 8B1RL9B4ZJ
    • CHEBI:29031
    • DTXSID90873902
    • Hydroxyphosphine oxide
    • Hypophosphorous acid
    • Hypophosphorus acid
    • NSC-41904
    • Phosphine oxide, hydroxy-
    • Phosphinic Acid
    • 6303-21-5

  • Applications

    Phosphinic Acid (CAS 6303-21-5) is used as a mild reducing agent in organic synthesis and as a precursor to phosphinate/phosphonate esters, which serve as polymer stabilizers (including PVC) and flame-retardant additives; it also acts as a chelating/complexing agent for metal ions in plating baths, water treatment, and cleaning formulations; in catalysis it can function as a ligand or coordinating agent in metal complexes; and it serves as a building block for specialty additives used in coatings and inks.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 275.34
    methanol 679.08
    isopropanol 141.56
    water 910.98
    ethyl acetate 27.47
    n-propanol 152.01
    acetone 140.48
    n-butanol 99.26
    acetonitrile 104.24
    DMF 1227.61
    toluene 3.99
    isobutanol 71.06
    1,4-dioxane 88.18
    methyl acetate 54.01
    THF 112.96
    2-butanone 48.62
    n-pentanol 53.42
    sec-butanol 66.72
    n-hexane 2.95
    ethylene glycol 560.76
    NMP 498.13
    cyclohexane 7.31
    DMSO 1136.6
    n-butyl acetate 20.76
    n-octanol 20.9
    chloroform 28.75
    n-propyl acetate 20.8
    acetic acid 526.08
    dichloromethane 54.29
    cyclohexanone 70.61
    propylene glycol 244.45
    isopropyl acetate 13.52
    DMAc 468.46
    2-ethoxyethanol 183.13
    isopentanol 49.69
    n-heptane 6.14
    ethyl formate 77.64
    1,2-dichloroethane 53.92
    n-hexanol 37.73
    2-methoxyethanol 456.65
    isobutyl acetate 9.42
    tetrachloromethane 9.44
    n-pentyl acetate 17.14
    transcutol 165.58
    n-heptanol 24.0
    ethylbenzene 2.91
    MIBK 13.92
    2-propoxyethanol 106.86
    tert-butanol 110.44
    MTBE 18.25
    2-butoxyethanol 68.74
    propionic acid 196.33
    o-xylene 6.23
    formic acid 990.37
    diethyl ether 26.29
    m-xylene 4.29
    p-xylene 4.3
    chlorobenzene 8.85
    dimethyl carbonate 38.61
    n-octane 2.33
    formamide 998.62
    cyclopentanone 102.27
    2-pentanone 32.88
    anisole 14.17
    cyclopentyl methyl ether 32.61
    gamma-butyrolactone 141.05
    1-methoxy-2-propanol 191.77
    pyridine 60.16
    3-pentanone 25.74
    furfural 190.83
    n-dodecane 1.92
    diethylene glycol 221.76
    diisopropyl ether 5.82
    tert-amyl alcohol 56.07
    acetylacetone 37.09
    n-hexadecane 1.98
    acetophenone 23.16
    methyl propionate 45.56
    isopentyl acetate 14.05
    trichloroethylene 52.83
    n-nonanol 17.98
    cyclohexanol 55.57
    benzyl alcohol 35.37
    2-ethylhexanol 16.49
    isooctanol 16.3
    dipropyl ether 19.95
    1,2-dichlorobenzene 12.29
    ethyl lactate 34.96
    propylene carbonate 52.43
    n-methylformamide 643.15
    2-pentanol 39.41
    n-pentane 5.83
    1-propoxy-2-propanol 64.33
    1-methoxy-2-propyl acetate 26.18
    2-(2-methoxypropoxy) propanol 51.95
    mesitylene 4.35
    ε-caprolactone 61.7
    p-cymene 5.94
    epichlorohydrin 94.27
    1,1,1-trichloroethane 12.8
    2-aminoethanol 455.94
    morpholine-4-carbaldehyde 354.91
    sulfolane 258.27
    2,2,4-trimethylpentane 2.11
    2-methyltetrahydrofuran 49.42
    n-hexyl acetate 19.54
    isooctane 1.5
    2-(2-butoxyethoxy)ethanol 78.38
    sec-butyl acetate 8.5
    tert-butyl acetate 13.35
    decalin 2.09
    glycerin 457.23
    diglyme 141.61
    acrylic acid 263.06
    isopropyl myristate 8.81
    n-butyric acid 121.58
    acetyl acetate 18.87
    di(2-ethylhexyl) phthalate 15.81
    ethyl propionate 17.13
    nitromethane 497.66
    1,2-diethoxyethane 29.53
    benzonitrile 26.84
    trioctyl phosphate 13.57
    1-bromopropane 16.63
    gamma-valerolactone 177.51
    n-decanol 14.22
    triethyl phosphate 15.51
    4-methyl-2-pentanol 15.17
    propionitrile 54.48
    vinylene carbonate 60.37
    1,1,2-trichlorotrifluoroethane 196.4
    DMS 20.03
    cumene 3.6
    2-octanol 13.12
    2-hexanone 18.56
    octyl acetate 13.76
    limonene 9.43
    1,2-dimethoxyethane 156.58
    ethyl orthosilicate 14.07
    tributyl phosphate 14.15
    diacetone alcohol 43.72
    N,N-dimethylaniline 20.81
    acrylonitrile 110.22
    aniline 28.85
    1,3-propanediol 331.01
    bromobenzene 5.57
    dibromomethane 30.15
    1,1,2,2-tetrachloroethane 49.05
    2-methyl-cyclohexyl acetate 14.53
    tetrabutyl urea 30.46
    diisobutyl methanol 11.73
    2-phenylethanol 25.22
    styrene 4.32
    dioctyl adipate 18.06
    dimethyl sulfate 89.86
    ethyl butyrate 19.0
    methyl lactate 83.88
    butyl lactate 32.33
    diethyl carbonate 14.64
    propanediol butyl ether 79.65
    triethyl orthoformate 18.0
    p-tert-butyltoluene 5.99
    methyl 4-tert-butylbenzoate 30.51
    morpholine 150.22
    tert-butylamine 51.17
    n-dodecanol 11.67
    dimethoxymethane 173.38
    ethylene carbonate 46.38
    cyrene 65.37
    2-ethoxyethyl acetate 25.83
    2-ethylhexyl acetate 10.8
    1,2,4-trichlorobenzene 14.63
    4-methylpyridine 38.81
    dibutyl ether 11.65
    2,6-dimethyl-4-heptanol 11.73
    DEF 114.1
    dimethyl isosorbide 61.09
    tetrachloroethylene 47.91
    eugenol 48.68
    triacetin 28.49
    span 80 56.55
    1,4-butanediol 155.3
    1,1-dichloroethane 19.86
    2-methyl-1-pentanol 27.9
    methyl formate 315.16
    2-methyl-1-butanol 47.67
    n-decane 2.49
    butyronitrile 43.76
    3,7-dimethyl-1-octanol 14.37
    1-chlorooctane 6.62
    1-chlorotetradecane 3.77
    n-nonane 2.47
    undecane 2.12
    tert-butylcyclohexane 1.76
    cyclooctane 2.74
    cyclopentanol 95.42
    tetrahydropyran 43.77
    tert-amyl methyl ether 16.09
    2,5,8-trioxanonane 108.1
    1-hexene 5.92
    2-isopropoxyethanol 73.75
    2,2,2-trifluoroethanol 274.75
    methyl butyrate 30.43

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction