Phloretin

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  • Identifiers

    CAS number
    60-82-2

    Molecular formula
    C15H14O5

    SMILES
    C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 57.33%
    Phenolic 49.6%
    Balsamic 27.91%
    Spicy 27.41%
    Burnt 24.79%
    Bitter 23.95%
    Medicinal 22.63%
    Smoky 22.55%
    Animal 22.26%
    Savory 21.99%

     

    Flavor
    Bitter 84.39%
    Odorless 38.38%
    Mild 28.96%
    Bland 24.94%
    Sweet-like 21.82%
    Cedarleaf 21.63%
    Lovage 21.36%
    Phenolic 21.34%
    Nitrile 21.32%
    Parsley 20.84%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.6

    pKa est.
    10.34 (weak base)

    Molecular weight
    274.27 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    489°C

    Melting point expt.

    • 263.5 °C

    Flash point

    • 236.81 ˚C est.

    Solubility expt.

    • 0.123 mg/mL at 16 °C
    • Slightly soluble in water
    • Sparingly soluble (in ethanol)

  • Synonyms

    • phloretin
    • 60-82-2
    • Dihydronaringenin
    • 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
    • Phloretol
    • 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone
    • 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-
    • NSC 407292
    • MFCD00002288
    • CCRIS 7459
    • beta-(p-Hydroxyphenyl)phloropropiophenone
    • EINECS 200-488-7
    • 2',4',6'-Trihydroxy-3-(p-hydroxyphenyl)propiophenone
    • S5J5OE47MK
    • 2',4',6'-Trihydroxy-3-(4-Hydroxyphenyl)propiophenone
    • DTXSID6022393
    • CHEBI:17276
    • beta-(p-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone
    • PHLORETIN [MI]
    • Propiophenone, 2',4',6'-trihydroxy-3-(p-hydroxyphenyl)-
    • NSC407292
    • NSC-407292
    • 2',4,4',6'-Tetrahydroxydihydrochalcone
    • 4,2',4',6'-Tetrahydroxydihydrochalcone
    • beta-(4-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone
    • CHEMBL45068
    • 2',4',6'-Trihydroxy-3-(4-hydroxyphenyl)-propiophenone
    • 2',4,4',6'-Tetrahydroxy-Dihydrochalcone
    • DTXCID702393
    • FEMA NO. 4390
    • .beta.-(p-Hydroxyphenyl)phloropropiophenone
    • NSC 407292;RJC 02792
    • 3-(4-Hydroxy-phenyl)-1-(2,4,6-trihydroxy-phenyl)-propan-1-one
    • 3-(4-HYDROXYPHENYL)-1-(2,4,6-TRIHYDROXYPHENYL)-PROPAN-1-ONE [FHFI]
    • SMR000326783
    • SR-01000076081
    • UNII-S5J5OE47MK
    • 2uxi
    • G50
    • Phloretin (Standard)
    • Spectrum_001295
    • Phloretin, >=99%
    • SpecPlus_000333
    • Naringenin dihydrochalcone
    • PHLORETIN [INCI]
    • Spectrum2_000681
    • Spectrum3_001036
    • Spectrum4_001172
    • Spectrum5_001698
    • Lopac-P-7912
    • cid_4788
    • Lopac0_001012
    • Oprea1_824722
    • REGID_for_CID_4788
    • SCHEMBL38131
    • BSPBio_002851
    • KBioGR_001803
    • KBioSS_001775
    • SPECTRUM300554
    • MLS000728507
    • MLS000859922
    • MLS006012024
    • BIDD:ER0174
    • DivK1c_006429
    • SPBio_000801
    • GTPL4285
    • BCBcMAP01_000040
    • BDBM23446
    • HY-N0142R
    • KBio1_001373
    • KBio2_001775
    • KBio2_004343
    • KBio2_006911
    • KBio3_002071
    • Phloretin - CAS 60-82-2
    • BP_35
    • HMS2224N17
    • HMS3263K05
    • HMS3332J03
    • HMS3656I07
    • BCP28296
    • HY-N0142
    • TNP00255
    • Tox21_202854
    • Tox21_501012
    • CCG-38573
    • HB0500
    • LMPK12120525
    • s2342
    • STL372996
    • AKOS015856338
    • AC-7995
    • CS-1477
    • DB07810
    • FP06961
    • LP01012
    • SDCCGMLS-0066637.P001
    • SDCCGSBI-0050985.P003
    • CAS-60-82-2
    • Phloretin, analytical reference material
    • SMP1_000238
    • NCGC00015840-01
    • NCGC00015840-02
    • NCGC00015840-03
    • NCGC00015840-04
    • NCGC00015840-05
    • NCGC00015840-06
    • NCGC00015840-07
    • NCGC00015840-08
    • NCGC00015840-09
    • NCGC00015840-18
    • NCGC00094304-01
    • NCGC00094304-02
    • NCGC00094304-03
    • NCGC00094304-04
    • NCGC00260400-01
    • NCGC00261697-01
    • AS-14100
    • SY017103
    • DB-053714
    • EU-0101012
    • NS00006825
    • P1966
    • SW219308-1
    • C00774
    • P 7912
    • 2',6'-Trihydroxy-3-(p-hydroxyphenyl)propiophenone
    • Q2268463

  • Applications

    Phloretin, a natural dihydrochalcone, is primarily used as an antioxidant and stabilizer in cosmetics and personal care formulations, helping improve product shelf life and skin compatibility. It is also regarded as a synthetic intermediate for flavonoid derivatives in pharmaceutical and industrial chemistry research, and it is evaluated for antioxidant and UV-stabilizing roles in polymer materials and coatings to enhance aging resistance. In addition, phloretin is studied in plant science and agriculture as a phytochemical with bioactive properties, supporting research on crop protection and plant defense mechanisms.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 46.69
    methanol 114.04
    isopropanol 62.12
    water 0.09
    ethyl acetate 56.47
    n-propanol 52.1
    acetone 262.9
    n-butanol 49.46
    acetonitrile 51.02
    DMF 509.98
    toluene 0.91
    isobutanol 28.78
    1,4-dioxane 60.36
    methyl acetate 61.44
    THF 1090.57
    2-butanone 108.84
    n-pentanol 31.88
    sec-butanol 30.02
    n-hexane 0.08
    ethylene glycol 94.36
    NMP 189.46
    cyclohexane 0.04
    DMSO 4612.91
    n-butyl acetate 26.81
    n-octanol 9.15
    chloroform 0.41
    n-propyl acetate 31.8
    acetic acid 92.98
    dichloromethane 0.24
    cyclohexanone 61.18
    propylene glycol 183.99
    isopropyl acetate 46.26
    DMAc 390.25
    2-ethoxyethanol 188.37
    isopentanol 43.59
    n-heptane 0.13
    ethyl formate 40.2
    1,2-dichloroethane 1.46
    n-hexanol 20.79
    2-methoxyethanol 588.76
    isobutyl acetate 15.6
    tetrachloromethane 0.23
    n-pentyl acetate 12.66
    transcutol 373.37
    n-heptanol 10.64
    ethylbenzene 0.8
    MIBK 58.98
    2-propoxyethanol 197.27
    tert-butanol 118.89
    MTBE 22.36
    2-butoxyethanol 55.5
    propionic acid 57.22
    o-xylene 1.08
    formic acid 68.24
    diethyl ether 13.34
    m-xylene 1.54
    p-xylene 0.95
    chlorobenzene 0.82
    dimethyl carbonate 65.63
    n-octane 0.06
    formamide 184.91
    cyclopentanone 284.04
    2-pentanone 97.76
    anisole 11.52
    cyclopentyl methyl ether 46.44
    gamma-butyrolactone 298.95
    1-methoxy-2-propanol 496.49
    pyridine 10.61
    3-pentanone 36.97
    furfural 93.81
    n-dodecane 0.17
    diethylene glycol 256.56
    diisopropyl ether 4.44
    tert-amyl alcohol 48.05
    acetylacetone 196.94
    n-hexadecane 0.2
    acetophenone 17.98
    methyl propionate 76.35
    isopentyl acetate 25.17
    trichloroethylene 3.34
    n-nonanol 9.42
    cyclohexanol 16.78
    benzyl alcohol 14.71
    2-ethylhexanol 8.77
    isooctanol 9.22
    dipropyl ether 13.25
    1,2-dichlorobenzene 1.37
    ethyl lactate 56.26
    propylene carbonate 68.59
    n-methylformamide 218.47
    2-pentanol 25.51
    n-pentane 0.06
    1-propoxy-2-propanol 118.9
    1-methoxy-2-propyl acetate 87.31
    2-(2-methoxypropoxy) propanol 82.22
    mesitylene 1.17
    ε-caprolactone 56.82
    p-cymene 1.48
    epichlorohydrin 183.07
    1,1,1-trichloroethane 1.69
    2-aminoethanol 138.09
    morpholine-4-carbaldehyde 175.92
    sulfolane 572.17
    2,2,4-trimethylpentane 0.16
    2-methyltetrahydrofuran 94.95
    n-hexyl acetate 21.32
    isooctane 0.2
    2-(2-butoxyethoxy)ethanol 116.07
    sec-butyl acetate 19.44
    tert-butyl acetate 66.74
    decalin 0.12
    glycerin 351.03
    diglyme 185.81
    acrylic acid 54.69
    isopropyl myristate 10.76
    n-butyric acid 71.74
    acetyl acetate 35.4
    di(2-ethylhexyl) phthalate 12.3
    ethyl propionate 35.62
    nitromethane 386.01
    1,2-diethoxyethane 43.23
    benzonitrile 8.59
    trioctyl phosphate 10.61
    1-bromopropane 0.76
    gamma-valerolactone 269.46
    n-decanol 7.29
    triethyl phosphate 17.34
    4-methyl-2-pentanol 19.67
    propionitrile 30.29
    vinylene carbonate 36.97
    1,1,2-trichlorotrifluoroethane 112.72
    DMS 30.13
    cumene 0.88
    2-octanol 5.84
    2-hexanone 39.21
    octyl acetate 14.18
    limonene 2.37
    1,2-dimethoxyethane 215.17
    ethyl orthosilicate 14.46
    tributyl phosphate 13.74
    diacetone alcohol 194.51
    N,N-dimethylaniline 8.19
    acrylonitrile 47.16
    aniline 5.51
    1,3-propanediol 209.53
    bromobenzene 0.49
    dibromomethane 0.21
    1,1,2,2-tetrachloroethane 4.84
    2-methyl-cyclohexyl acetate 18.66
    tetrabutyl urea 21.77
    diisobutyl methanol 9.69
    2-phenylethanol 16.21
    styrene 0.77
    dioctyl adipate 20.95
    dimethyl sulfate 148.43
    ethyl butyrate 25.64
    methyl lactate 148.76
    butyl lactate 30.66
    diethyl carbonate 17.32
    propanediol butyl ether 69.03
    triethyl orthoformate 22.46
    p-tert-butyltoluene 1.82
    methyl 4-tert-butylbenzoate 30.82
    morpholine 130.3
    tert-butylamine 17.34
    n-dodecanol 5.56
    dimethoxymethane 338.58
    ethylene carbonate 35.03
    cyrene 79.06
    2-ethoxyethyl acetate 30.81
    2-ethylhexyl acetate 14.09
    1,2,4-trichlorobenzene 2.32
    4-methylpyridine 11.71
    dibutyl ether 9.26
    2,6-dimethyl-4-heptanol 9.69
    DEF 73.17
    dimethyl isosorbide 148.23
    tetrachloroethylene 1.94
    eugenol 35.03
    triacetin 37.94
    span 80 47.16
    1,4-butanediol 52.45
    1,1-dichloroethane 1.03
    2-methyl-1-pentanol 21.95
    methyl formate 143.26
    2-methyl-1-butanol 28.24
    n-decane 0.22
    butyronitrile 27.91
    3,7-dimethyl-1-octanol 11.33
    1-chlorooctane 1.59
    1-chlorotetradecane 0.88
    n-nonane 0.15
    undecane 0.2
    tert-butylcyclohexane 0.17
    cyclooctane 0.04
    cyclopentanol 45.96
    tetrahydropyran 26.82
    tert-amyl methyl ether 17.84
    2,5,8-trioxanonane 143.61
    1-hexene 0.54
    2-isopropoxyethanol 90.36
    2,2,2-trifluoroethanol 32.13
    methyl butyrate 45.63

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction