Phenylephrine Hydrochloride

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  • Identifiers

    CAS number
    61-76-7

    Molecular formula
    C9H14ClNO2

    SMILES
    CNC[C@@H](C1=CC(=CC=C1)O)O.Cl

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 47.92%
    Sweet 35.62%
    Fishy 29.65%
    Savory 29.45%
    Bitter 26.98%
    Meaty 24.3%
    Cheesy 23.5%
    Phenolic 22.79%
    Vanilla 22.66%
    Animal 22.13%

     

    Flavor
    Odorless 46.42%
    Mild 41.26%
    Bitter 41.07%
    Bland 23.78%
    Sweet-like 23.73%
    Sweet 21.31%
    Sulfurous 20.18%
    Orange flower 20.15%
    Smoked 19.89%
    Nitrile 19.86%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    8.83 (weak base)

    Molecular weight
    203.66 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    347°C

    Melting point expt.

    • 284 to 293 °F (NTP, 1992)

    Flash point

    • 162.38 ˚C est.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 70 °F (NTP, 1992)

  • Synonyms

    • PHENYLEPHRINE HYDROCHLORIDE
    • 61-76-7
    • Phenylephrine HCl
    • Biomydrin
    • Mydfrin
    • Nostril
    • (R)-Phenylephrine hydrochloride
    • Neo-Synephrine
    • L-PHENYLEPHRINE HYDROCHLORIDE
    • Almefrin
    • Consdrin
    • Fenilfar
    • Histabid
    • Idrianol
    • Neophryn
    • Neosympatol
    • Oftalfrine
    • Phenistan
    • Pyristan
    • Stanephrin
    • Sucraphen
    • Synethenate
    • Vazculep
    • Efricel
    • Emagrin
    • Lexatol
    • Prefrin
    • Rhinall
    • Synasal
    • Fenox
    • meta-Sympatol
    • Alcon-efrin
    • OP-Isophrin
    • Neo-Synesin 1
    • Metaoxedrine chloride
    • Consdrin hydrochloride
    • Isophrin hydrochloride
    • Metaoxedrine hydrochloride
    • (-)-Phenylephrine hydrochloride
    • meta-Synephrine hydrochloride
    • Levophenylephrine hydrochloride
    • D-(-)-Phenylephrine hydrochloride
    • NCI-C55641
    • R-(-)-m-Synephrine hydrochloride
    • Afrin 4 Hour Nasal Spray
    • 04JA59TNSJ
    • m-Methylaminoethanolphenol hydrochloride
    • NSC-757273
    • DTXSID3021142
    • DTXCID301142
    • l-1-(m-Hydroxyphenyl)-2-methyl-aminoethanol hydrochloride
    • (-)-m-Hydroxy-alpha-((methylamino)methyl)benzyl alcohol hydrochloride
    • Benzyl alcohol, m-hydroxy-alpha-((methylamino)methyl)-, hydrochloride, (-)-
    • Derizene
    • OMIDRIA COMPONENT PHENYLEPHRINE HYDROCHLORIDE
    • MYDCOMBI COMPONENT PHENYLEPHRINE HYDROCHLORIDE
    • Pyracort D
    • CHEBI:8094
    • Congestion
    • Nazex
    • heb nasal
    • NSC14029
    • Equaline Nasal
    • Neo Synephrine
    • Better Living
    • Decongestant II
    • Decongestant PE
    • Congestion PE
    • Fresh Clear
    • Nasal Four
    • Sinus Congestion
    • Suphedrine PE
    • basic care nasal
    • Phenylephrine HCI
    • Pseudo Time PE
    • Dover Sudanyl PE
    • Sudo-tab PE
    • Ephrine Nose Drops
    • Topcare Nasal Four
    • Medique Medi-phenyl
    • Neo-Synephrine Mild
    • PhysiciansCare Sinus
    • 4 Way Fast Acting
    • dg health nasal four
    • PE Sinus Congestion
    • Sinus PE Congestion
    • Equaline Fast Acting
    • Extra Strength Nasal
    • IMMPHENTIV
    • OCUSOL
    • Phenylephrine 10 mg
    • Childrens Sudafed PE
    • Equate Suphedrine PE
    • Nasal Decongestant PE
    • Neo-Synephrine Maximum
    • Neo-Synephrine Regular
    • Good Sense Nasal Four
    • PHENYLPHRINE HCL
    • 4 Way
    • Bliss GVS Hemorrhoidal
    • RefChem:6128
    • Sinus Congestion Relief
    • SU PHEDRINE PE
    • Nurofen sinus pain relief
    • Phenylephrine HCl 10 mg
    • Nasal Decongestant Rhinall
    • CareOne Fast Acting Nasal
    • Eb306 Nasal Decongestant
    • McKesson Phenylephrine HCl
    • Uline Sinus and Congestion
    • Decongestant PE Non Drowsy
    • Sudafed PE Sinus Congestion
    • Unishield Sinus Decongestant
    • Help I Have A Stuffy Nose
    • Medi-first Sinus Decongestant
    • PHENYLEPHRINE HCHLORIDE
    • Gencare-Nasal Decongestant PE
    • Green Guard Allergy 2 Relief
    • Suphedrine PE Sinus Congestion
    • Crane Safety Sinus Decongestant
    • Physicianscare Sinus Non-drowsy
    • Nasal Phenylephrine hydrochloride
    • good neighbor pharmacy nasal four
    • Good Sense Nasal Decongestant PE
    • Nasal Decongestant PE Non Drowsy
    • Non-Drowsy Nasal Decongestant PE
    • NASAL DECONGESTANT PE 10mg
    • 61-76-7

  • Applications

    Phenylephrine Hydrochloride (CAS 61-76-7) is primarily used as a pharmaceutical active ingredient and vasoconstrictor; it is applied in common nasal decongestant formulations and in ophthalmic solutions as a mydriatic agent, and it also acts as a vasoconstrictor adjunct when combined with local anesthetics in certain injectable products. It can also serve as an intermediate in the synthesis of other adrenergic compounds, and may be encountered in research and manufacturing settings within the pharmaceuticals and chemical intermediates sectors, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 59.43
    methanol 247.01
    isopropanol 18.59
    water 46.05
    ethyl acetate 9.22
    n-propanol 34.74
    acetone 8.86
    n-butanol 19.68
    acetonitrile 5.18
    DMF 225.52
    toluene 1.89
    isobutanol 20.9
    1,4-dioxane 23.0
    methyl acetate 9.39
    THF 52.98
    2-butanone 7.93
    n-pentanol 15.12
    sec-butanol 14.7
    n-hexane 0.32
    ethylene glycol 235.87
    NMP 184.42
    cyclohexane 0.61
    DMSO 403.7
    n-butyl acetate 11.6
    n-octanol 10.66
    chloroform 4.82
    n-propyl acetate 10.31
    acetic acid 232.2
    dichloromethane 3.85
    cyclohexanone 40.52
    propylene glycol 130.85
    isopropyl acetate 6.3
    DMAc 201.0
    2-ethoxyethanol 96.53
    isopentanol 20.44
    n-heptane 0.84
    ethyl formate 19.61
    1,2-dichloroethane 4.51
    n-hexanol 29.14
    2-methoxyethanol 207.0
    isobutyl acetate 7.32
    tetrachloromethane 3.36
    n-pentyl acetate 7.27
    transcutol 110.3
    n-heptanol 16.77
    ethylbenzene 1.89
    MIBK 9.87
    2-propoxyethanol 82.3
    tert-butanol 45.02
    MTBE 8.02
    2-butoxyethanol 40.9
    propionic acid 87.79
    o-xylene 4.05
    formic acid 468.42
    diethyl ether 2.35
    m-xylene 4.29
    p-xylene 2.56
    chlorobenzene 4.19
    dimethyl carbonate 15.78
    n-octane 0.46
    formamide 355.78
    cyclopentanone 66.08
    2-pentanone 7.74
    anisole 8.87
    cyclopentyl methyl ether 21.34
    gamma-butyrolactone 105.6
    1-methoxy-2-propanol 87.68
    pyridine 14.91
    3-pentanone 5.75
    furfural 101.08
    n-dodecane 0.42
    diethylene glycol 149.26
    diisopropyl ether 1.82
    tert-amyl alcohol 30.95
    acetylacetone 20.26
    n-hexadecane 0.45
    acetophenone 17.45
    methyl propionate 15.67
    isopentyl acetate 12.37
    trichloroethylene 14.58
    n-nonanol 9.73
    cyclohexanol 22.24
    benzyl alcohol 21.33
    2-ethylhexanol 13.59
    isooctanol 13.01
    dipropyl ether 6.31
    1,2-dichlorobenzene 6.5
    ethyl lactate 25.89
    propylene carbonate 50.85
    n-methylformamide 158.05
    2-pentanol 8.44
    n-pentane 0.27
    1-propoxy-2-propanol 41.34
    1-methoxy-2-propyl acetate 24.54
    2-(2-methoxypropoxy) propanol 37.94
    mesitylene 3.79
    ε-caprolactone 43.56
    p-cymene 4.28
    epichlorohydrin 47.43
    1,1,1-trichloroethane 4.7
    2-aminoethanol 222.91
    morpholine-4-carbaldehyde 135.08
    sulfolane 195.89
    2,2,4-trimethylpentane 0.65
    2-methyltetrahydrofuran 25.17
    n-hexyl acetate 11.73
    isooctane 0.53
    2-(2-butoxyethoxy)ethanol 48.52
    sec-butyl acetate 5.76
    tert-butyl acetate 12.44
    decalin 0.75
    glycerin 300.9
    diglyme 80.13
    acrylic acid 111.4
    isopropyl myristate 4.92
    n-butyric acid 71.55
    acetyl acetate 10.03
    di(2-ethylhexyl) phthalate 11.72
    ethyl propionate 8.72
    nitromethane 155.55
    1,2-diethoxyethane 10.3
    benzonitrile 11.94
    trioctyl phosphate 9.59
    1-bromopropane 1.31
    gamma-valerolactone 102.66
    n-decanol 7.42
    triethyl phosphate 11.26
    4-methyl-2-pentanol 9.08
    propionitrile 6.51
    vinylene carbonate 42.94
    1,1,2-trichlorotrifluoroethane 134.58
    DMS 13.63
    cumene 2.77
    2-octanol 7.27
    2-hexanone 8.08
    octyl acetate 7.64
    limonene 5.88
    1,2-dimethoxyethane 63.55
    ethyl orthosilicate 10.21
    tributyl phosphate 9.44
    diacetone alcohol 40.74
    N,N-dimethylaniline 11.39
    acrylonitrile 17.38
    aniline 13.08
    1,3-propanediol 164.85
    bromobenzene 2.55
    dibromomethane 2.28
    1,1,2,2-tetrachloroethane 15.52
    2-methyl-cyclohexyl acetate 14.72
    tetrabutyl urea 13.87
    diisobutyl methanol 7.58
    2-phenylethanol 22.4
    styrene 1.77
    dioctyl adipate 10.28
    dimethyl sulfate 53.65
    ethyl butyrate 10.12
    methyl lactate 51.88
    butyl lactate 18.85
    diethyl carbonate 8.38
    propanediol butyl ether 44.21
    triethyl orthoformate 10.52
    p-tert-butyltoluene 4.52
    methyl 4-tert-butylbenzoate 25.1
    morpholine 46.83
    tert-butylamine 13.59
    n-dodecanol 5.53
    dimethoxymethane 42.24
    ethylene carbonate 32.15
    cyrene 55.34
    2-ethoxyethyl acetate 13.37
    2-ethylhexyl acetate 8.46
    1,2,4-trichlorobenzene 10.48
    4-methylpyridine 11.7
    dibutyl ether 3.56
    2,6-dimethyl-4-heptanol 7.58
    DEF 33.27
    dimethyl isosorbide 55.18
    tetrachloroethylene 17.64
    eugenol 30.63
    triacetin 19.23
    span 80 34.35
    1,4-butanediol 69.94
    1,1-dichloroethane 2.1
    2-methyl-1-pentanol 15.06
    methyl formate 87.89
    2-methyl-1-butanol 20.82
    n-decane 0.6
    butyronitrile 5.98
    3,7-dimethyl-1-octanol 10.25
    1-chlorooctane 2.42
    1-chlorotetradecane 1.23
    n-nonane 0.52
    undecane 0.49
    tert-butylcyclohexane 0.8
    cyclooctane 0.47
    cyclopentanol 37.13
    tetrahydropyran 9.57
    tert-amyl methyl ether 8.4
    2,5,8-trioxanonane 61.11
    1-hexene 0.95
    2-isopropoxyethanol 45.46
    2,2,2-trifluoroethanol 104.95
    methyl butyrate 15.02

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction