Phenoxyethanol

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  • Identifiers

    CAS number
    122-99-6

    Molecular formula
    C8H10O2

    SMILES
    C1=CC=C(C=C1)OCCO

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Floral 77.75%
    Rose 68.87%
    Balsamic 49.46%
    Fresh 44.74%
    Honey 41.89%
    Hyacinth 38.41%
    Sweet 37.5%
    Green 30.73%
    Animal 29.81%
    Phenolic 29.15%

     

    Flavor
    Sweet 72.02%
    Floral 63.94%
    Rose 53.5%
    Bitter 45.81%
    Balsam 45.76%
    Honey 44.66%
    Fruity 44.35%
    Hyacinth 42.87%
    Flower 37.17%
    Vanilla 37.12%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.2

    pKa est.
    6.97 (neutral)

    Molecular weight
    138.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • 57 °F (NTP, 1992)
    • 13 undefined
    • 14 °C
    • 11-13 °C

    Boiling point

    • 473.4 °F at 760 mmHg (NTP, 1992)
    • 245 undefined
    • boiling point equals 473 °F
    • 245.2 °C
    • Liquid; bp: 243 °C /2-Phenoxyethanol acetate/
    • 237.00 to 238.00 °C. @ 760.00 mm Hg
    • 245 °C

    Flash point

    • 117.84 ˚C est.
    • 250 °F (NTP, 1992)
    • Flash point equals 250 °F
    • 260 °F (127 °C) (Closed cup)
    • 127 °C c.c.

    Solubility expt.

    • 10 to 50 mg/mL at 68 °F (NTP, 1992)
    • 24g/L at 20°C
    • Freely soluble in alcohol, ether, and sodium hydroxide
    • Soluble in ethanol, alkali, chloroform
    • 2.67 g/100 mL water
    • In water, 2.6X10+4 mg/L at 20 °C
    • 26700 mg/L @ 20 °C (exp)
    • Solubility in water, g/100ml: 2.7

  • Synonyms

    • 2-PHENOXYETHANOL
    • Phenoxyethanol
    • 122-99-6
    • Ethylene glycol monophenyl ether
    • Phenyl cellosolve
    • Phenoxethol
    • Ethanol, 2-phenoxy-
    • Phenoxytol
    • 2-Phenoxyethan-1-Ol
    • Ethylene glycol phenyl ether
    • 1-Hydroxy-2-phenoxyethane
    • Phenoxetol
    • Phenoxyethyl alcohol
    • Rose ether
    • Phenylmonoglycol ether
    • Arosol
    • Fenyl-cellosolve
    • 2-Fenoxyethanol
    • Dowanol EP
    • 2-Phenoxyethyl alcohol
    • Glycol monophenyl ether
    • 2-Hydroxyethyl phenyl ether
    • Fenylcelosolv
    • Phenylglycol
    • Dowanol EPH
    • 2-Phenoxy-ethanol
    • Emery 6705
    • Emeressence 1160
    • EGMPE
    • beta-Hydroxyethyl phenyl ether
    • MFCD00002857
    • Plastiazan-41
    • NSC 1864
    • PHE-G
    • .beta.-Hydroxyethyl phenyl ether
    • HSDB 5595
    • UNII-HIE492ZZ3T
    • NSC-1864
    • 9004-78-8
    • EINECS 204-589-7
    • HIE492ZZ3T
    • BRN 1364011
    • CCRIS 9481
    • Phenoxyethanol [NF]
    • Ethylene glycol-monophenyl ether
    • AI3-00752()C
    • DTXSID9021976
    • CHEBI:64275
    • PHE-S
    • .beta.-Phenoxyethyl alcohol
    • DTXCID401976
    • 2-Phenoxyethyl--d4 Alcohol
    • FEMA NO. 4620
    • EC 204-589-7
    • 4-06-00-00571 (Beilstein Handbook Reference)
    • Phenoxyethanol (NF)
    • NCGC00090731-01
    • NCGC00090731-05
    • PHENOXYETHANOL (II)
    • PHENOXYETHANOL [II]
    • PHG
    • PHENOXYETHANOL (MART.)
    • PHENOXYETHANOL [MART.]
    • PHENOXYETHANOL (USP-RS)
    • PHENOXYETHANOL [USP-RS]
    • Fenylcelosolv [Czech]
    • 2-Fenoxyethanol [Czech]
    • Fenyl-cellosolve [Czech]
    • PHENOXYETHANOL (EP MONOGRAPH)
    • PHENOXYETHANOL [EP MONOGRAPH]
    • Plastiazan-41 [Russian]
    • beta-Phenoxyethanol
    • CAS-122-99-6
    • .beta.-Phenoxyethanol
    • phenylcellosolve
    • Phenoxyethanolum
    • Dalpad A
    • 2-phenyloxyethanol
    • Newpol EFP
    • 2-phenoxy ethanol
    • 2-(phenoxy)ethanol
    • 2-phenoxy-1-ethanol
    • CPAP WIPES
    • VAXOL PURI
    • beta-phenoxyethylalcohol
    • starbld0047047
    • 2-Phenoxyethanol, 9CI
    • 2-Phenoxyethanol, 99%
    • Phenoxyethanol (Standard)
    • WLN: Q2OR
    • 2-Phenoxyethanol-1,1-d2
    • SCHEMBL15708
    • 2-Phenoxyethanol, >=99%
    • PHENOXYETHANOL [HSDB]
    • MLS002174254
    • ethyleneglycol monophenyl ether
    • Euxyl K 400 (Salt/Mix)
    • ProClin? 8020 preservatives
    • 2-PHENOXYETHANOL [MI]
    • Fungal Terminator (veterinary)
    • PHENOXYETHANOL [WHO-DD]
    • CHEMBL1229846
    • HY-B1729R
    • MSK2538
    • NSC1864
    • HMS2268A20
    • HY-B1729
    • STR04582
    • WAA27338
    • Tox21_111002
    • Tox21_113532
    • Tox21_202111
    • Tox21_300842
    • BBL027410
    • STK802556
    • 2-Phenoxyethanol, analytical standard
    • Fungal Terminator [veterinary] (TN)
    • AKOS000118741
    • Tox21_111002_1
    • DB11304
    • FP31791
    • NCGC00090731-02
    • NCGC00090731-03
    • NCGC00090731-04
    • NCGC00090731-06
    • NCGC00090731-07
    • NCGC00090731-08
    • NCGC00254745-01

  • Applications

    Phenoxyethanol (CAS 122-99-6) is widely used as a preservative and solvent in cosmetics and personal care formulations, helping to stabilize products and inhibit microbial growth; it also serves as a solvent for fragrance materials in perfumery/fragrance and is present in household and cleaning products as a co-solvent or stabilizing component. In coatings, inks and paints, it acts as a solvent or co-solvent for colorants and additives, supporting mixing and formulation stability; additionally, it is used as a solvent/processing aid in polymer and plastics processing to assist mixing and handling. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2903.21
    methanol 3859.04
    isopropanol 1615.36
    water 10.89
    ethyl acetate 1086.07
    n-propanol 1543.82
    acetone 2111.77
    n-butanol 1039.01
    acetonitrile 1906.93
    DMF 1818.5
    toluene 156.21
    isobutanol 861.41
    1,4-dioxane 1914.03
    methyl acetate 1281.68
    THF 1552.4
    2-butanone 1000.37
    n-pentanol 542.78
    sec-butanol 916.69
    n-hexane 45.76
    ethylene glycol 1027.94
    NMP 899.63
    cyclohexane 106.86
    DMSO 5436.96
    n-butyl acetate 551.02
    n-octanol 205.35
    chloroform 1521.02
    n-propyl acetate 589.56
    acetic acid 2085.29
    dichloromethane 2340.21
    cyclohexanone 954.46
    propylene glycol 814.63
    isopropyl acetate 317.28
    DMAc 985.51
    2-ethoxyethanol 1051.77
    isopentanol 557.55
    n-heptane 67.82
    ethyl formate 828.71
    1,2-dichloroethane 1479.88
    n-hexanol 459.43
    2-methoxyethanol 2005.33
    isobutyl acetate 237.2
    tetrachloromethane 169.46
    n-pentyl acetate 199.52
    transcutol 2043.13
    n-heptanol 157.99
    ethylbenzene 89.5
    MIBK 252.56
    2-propoxyethanol 757.12
    tert-butanol 1333.17
    MTBE 584.91
    2-butoxyethanol 336.94
    propionic acid 1320.75
    o-xylene 112.96
    formic acid 855.31
    diethyl ether 914.26
    m-xylene 94.26
    p-xylene 118.03
    chlorobenzene 340.02
    dimethyl carbonate 290.25
    n-octane 21.36
    formamide 1533.42
    cyclopentanone 1148.53
    2-pentanone 651.77
    anisole 325.13
    cyclopentyl methyl ether 525.36
    gamma-butyrolactone 1430.21
    1-methoxy-2-propanol 931.08
    pyridine 971.13
    3-pentanone 444.44
    furfural 1007.63
    n-dodecane 20.38
    diethylene glycol 774.17
    diisopropyl ether 123.34
    tert-amyl alcohol 731.7
    acetylacetone 589.59
    n-hexadecane 22.37
    acetophenone 288.45
    methyl propionate 732.65
    isopentyl acetate 316.82
    trichloroethylene 1895.12
    n-nonanol 165.24
    cyclohexanol 594.8
    benzyl alcohol 286.64
    2-ethylhexanol 223.49
    isooctanol 124.34
    dipropyl ether 397.14
    1,2-dichlorobenzene 275.1
    ethyl lactate 245.47
    propylene carbonate 612.86
    n-methylformamide 1581.55
    2-pentanol 487.34
    n-pentane 61.8
    1-propoxy-2-propanol 504.03
    1-methoxy-2-propyl acetate 337.55
    2-(2-methoxypropoxy) propanol 315.26
    mesitylene 63.77
    ε-caprolactone 730.51
    p-cymene 82.33
    epichlorohydrin 1590.83
    1,1,1-trichloroethane 659.62
    2-aminoethanol 1306.84
    morpholine-4-carbaldehyde 1063.28
    sulfolane 1581.07
    2,2,4-trimethylpentane 28.31
    2-methyltetrahydrofuran 996.06
    n-hexyl acetate 315.81
    isooctane 20.53
    2-(2-butoxyethoxy)ethanol 484.4
    sec-butyl acetate 230.38
    tert-butyl acetate 257.42
    decalin 36.3
    glycerin 867.82
    diglyme 1043.95
    acrylic acid 1016.26
    isopropyl myristate 118.62
    n-butyric acid 1152.26
    acetyl acetate 428.02
    di(2-ethylhexyl) phthalate 103.91
    ethyl propionate 381.2
    nitromethane 3269.19
    1,2-diethoxyethane 587.97
    benzonitrile 381.12
    trioctyl phosphate 91.33
    1-bromopropane 655.33
    gamma-valerolactone 1133.59
    n-decanol 127.08
    triethyl phosphate 142.1
    4-methyl-2-pentanol 171.5
    propionitrile 1009.05
    vinylene carbonate 577.61
    1,1,2-trichlorotrifluoroethane 969.86
    DMS 271.17
    cumene 65.46
    2-octanol 109.59
    2-hexanone 428.29
    octyl acetate 160.24
    limonene 143.15
    1,2-dimethoxyethane 1436.48
    ethyl orthosilicate 136.67
    tributyl phosphate 125.64
    diacetone alcohol 389.29
    N,N-dimethylaniline 178.47
    acrylonitrile 1238.81
    aniline 361.04
    1,3-propanediol 1280.47
    bromobenzene 326.05
    dibromomethane 1333.67
    1,1,2,2-tetrachloroethane 1251.27
    2-methyl-cyclohexyl acetate 196.52
    tetrabutyl urea 166.12
    diisobutyl methanol 122.54
    2-phenylethanol 225.69
    styrene 143.21
    dioctyl adipate 190.76
    dimethyl sulfate 443.18
    ethyl butyrate 383.6
    methyl lactate 348.19
    butyl lactate 201.4
    diethyl carbonate 250.71
    propanediol butyl ether 373.18
    triethyl orthoformate 219.89
    p-tert-butyltoluene 74.24
    methyl 4-tert-butylbenzoate 200.73
    morpholine 2076.8
    tert-butylamine 660.37
    n-dodecanol 102.08
    dimethoxymethane 1003.09
    ethylene carbonate 527.04
    cyrene 258.04
    2-ethoxyethyl acetate 307.34
    2-ethylhexyl acetate 227.95
    1,2,4-trichlorobenzene 316.79
    4-methylpyridine 660.08
    dibutyl ether 280.12
    2,6-dimethyl-4-heptanol 122.54
    DEF 775.63
    dimethyl isosorbide 418.46
    tetrachloroethylene 842.7
    eugenol 228.55
    triacetin 321.15
    span 80 270.7
    1,4-butanediol 543.92
    1,1-dichloroethane 1063.58
    2-methyl-1-pentanol 332.77
    methyl formate 1152.79
    2-methyl-1-butanol 580.63
    n-decane 31.93
    butyronitrile 843.27
    3,7-dimethyl-1-octanol 181.34
    1-chlorooctane 132.02
    1-chlorotetradecane 54.07
    n-nonane 32.45
    undecane 24.67
    tert-butylcyclohexane 32.3
    cyclooctane 30.59
    cyclopentanol 758.05
    tetrahydropyran 1357.48
    tert-amyl methyl ether 333.19
    2,5,8-trioxanonane 639.83
    1-hexene 199.83
    2-isopropoxyethanol 551.44
    2,2,2-trifluoroethanol 495.56
    methyl butyrate 596.88

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction