Phenol, 4-[(dimethylamino)methyl]-2,6-bis(1,1-dimethylethyl)-

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  • Identifiers

    CAS number
    88-27-7

    Molecular formula
    C17H29NO

    SMILES
    CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CN(C)C

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Woody 49.35%
    Leathery 36.76%
    Dry 35.59%
    Phenolic 35.17%
    Musk 32.32%
    Animal 31.95%
    Camphoreous 29.89%
    Amber 27.8%
    Vetiver 27.28%
    Mint 25.97%

     

    Flavor
    Mild 35.71%
    Phenolic 33.44%
    Musty 33.35%
    Camphor 32.83%
    Woody 23.83%
    Green pepper 23.09%
    Earthy 22.62%
    Creosote 22.49%
    Thymol 22.03%
    Carrot 21.76%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.7

    pKa est.
    8.09 (weak base)

    Molecular weight
    263.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    305°C

    Flash point

    • 135.79 ˚C est.

  • Synonyms

    • 2,6-Di-tert-butyl-alpha-(dimethylamino)-p-cresol
    • Phenol, 4-((dimethylamino)methyl)-2,6-bis(1,1-dimethylethyl)-
    • Phenol, 4-[(dimethylamino)methyl]-2,6-bis(1,1-dimethylethyl)-
    • RefChem:861181
    • 88-27-7
    • 2,6-di-tert-Butyl-4-(dimethylaminomethyl)phenol
    • N,N-dimethyl-3,5-di-tert-butyl-4-hydroxybenzylamine
    • Ethyl 703
    • 2,6-Di-tert-butyl-4-(dimethylamino)methylphenol
    • Agidol 3
    • F 1 (Antioxidant)
    • 2,6-Di-tert-butyl-4-[(dimethylamino)methyl]phenol
    • Ethyl antioxidant 703
    • 2,6-Di-tert-butyl-4-dimethylaminomethylphenol
    • MFCD00026283
    • NSC 27823
    • 2,6-Di-tert-butyl-alpha-dimethylamino-p-cresol
    • 2,6-ditert-butyl-4-[(dimethylamino)methyl]phenol
    • N-(3,5-Di-tert-butyl-4-hydroxybenzyl)dimethylamine
    • 8TK6VR2KYX
    • 2,6-Di-tert-butyl-.alpha.-(dimethylamino)-p-cresol
    • DTXSID0044997
    • NSC-27823
    • 2,6-bis(tert-butyl)-4-[(dimethylamino)methyl]phenol
    • p-Cresol, 2,6-di-tert-butyl-.alpha.-(dimethylamino)-
    • 2,6-DI-TERT-BUTYL-4-((DIMETHYLAMINO)METHYL)PHENOL
    • 2,6-Di-tert-butyl-.alpha.-dimethylamino-p-cresol
    • p-Cresol,6-di-tert-butyl-.alpha.-(dimethylamino)-
    • EINECS 201-816-1
    • UNII-8TK6VR2KYX
    • BRN 0884076
    • AI3-63215
    • ChemDiv1_023646
    • EC 201-816-1
    • 2,6-ditert-butyl-4-(dimethylaminomethyl)phenol
    • Oprea1_482941
    • SCHEMBL38719
    • 4-13-00-02014 (Beilstein Handbook Reference)
    • IONOL 103
    • MLS000104818
    • BIDD:ER0654
    • 2,6-di-tert-butyl-4-(n,n-dimethylaminomethyl)phenol
    • p-Cresol, 2,6-di-tert-butyl-alpha-(dimethylamino)-
    • CHEMBL1528970
    • DTXCID8024997
    • HMS654C18
    • VMZVBRIIHDRYGK-UHFFFAOYSA-
    • HMS2347D11
    • AAA08827
    • NSC27823
    • NSC58410
    • Tox21_301401
    • MSK161489
    • NSC-58410
    • SBB007983
    • AKOS001659002
    • CCG-109070
    • EBC-267041
    • CAS-88-27-7
    • NCGC00256270-01
    • AS-68762
    • SMR000054751
    • ST029310
    • 4-dimethylaminomethyl-2,6-di-t-butylphenol
    • CS-0204402
    • D2301
    • NS00004279
    • 2,6-di-t-butyl-4-(dimethylaminomethyl)phenol
    • E78869
    • 2,6-Di- t-butyl-4-(dimethylamino-methyl)phenol
    • (4-hydroxy-3,5-di-tert-butylbenzyl)dimethylamine
    • EN300-22956352
    • F222226
    • N,N-dimethyl,2,6-di-t-butyl-4-aminomethylphenol
    • N,N-dimethyl-2,6-di-t-butyl-4-aminomethylphenol
    • N,N-dimethyl-3,5-di-t-butyl-4-hydroxybenzylamine
    • N,N-dimethyl-4-aminomethyl-2,6-di-t-butylphenol
    • N-(3,5-di-tert.butyl-4-hydroxybenzyl)dimethylamine
    • N,N-dimethyl-3,5-di-tert.butyl-4-hydroxybenzylamine
    • N-(3,5-di-tert.butyl-4-hydroxybenzyl) dimethylamine
    • N-(3,5-di-tert.butyl-4-hydroxybenzyl)-dimethylamine
    • Q27270995
    • 2,6-Di-tert-butyl-4-(dimethylaminomethyl)phenol, 96%
    • 2 pound not6-Di-tert-butyl-4-(dimethylaminomethyl)phenol
    • 4-[(Dimethylamino)methyl]-2,6-bis(1,1-dimethylethyl)phenol
    • 201-816-1
    • InChI=1/C17H29NO/c1-16(2,3)13-9-12(11-18(7)8)10-14(15(13)19)17(4,5)6/h9-10,19H,11H2,1-8H3
    • 88-27-7

  • Applications

    Phenol, 4-[(dimethylamino)methyl]-2,6-bis(1,1-dimethylethyl)- (CAS 88-27-7) is a useful synthetic intermediate in the chemical industry, with real-world applications including: serving as a precursor for dyes and pigments used in textiles and printing; acting as a building block for specialty polymers and plastics with tailored properties; acting as a component or precursor for epoxy resins and amino-phenol-containing polymer systems; an intermediate for pharmaceutical or agrochemical synthesis; and a potential source for stabilizers/antioxidants used in coatings and inks. These applications are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 216.24
    methanol 218.98
    isopropanol 223.85
    water 1.73
    ethyl acetate 265.21
    n-propanol 278.19
    acetone 259.29
    n-butanol 270.13
    acetonitrile 163.98
    DMF 556.94
    toluene 260.33
    isobutanol 291.42
    1,4-dioxane 476.54
    methyl acetate 306.25
    THF 807.28
    2-butanone 342.67
    n-pentanol 214.24
    sec-butanol 302.36
    n-hexane 150.92
    ethylene glycol 80.27
    NMP 943.87
    cyclohexane 200.94
    DMSO 246.1
    n-butyl acetate 448.8
    n-octanol 234.4
    chloroform 1162.3
    n-propyl acetate 256.41
    acetic acid 406.15
    dichloromethane 617.11
    cyclohexanone 683.99
    propylene glycol 164.65
    isopropyl acetate 232.58
    DMAc 617.92
    2-ethoxyethanol 206.79
    isopentanol 247.6
    n-heptane 131.24
    ethyl formate 241.89
    1,2-dichloroethane 442.45
    n-hexanol 464.83
    2-methoxyethanol 300.23
    isobutyl acetate 262.66
    tetrachloromethane 262.62
    n-pentyl acetate 290.16
    transcutol 432.95
    n-heptanol 287.82
    ethylbenzene 194.0
    MIBK 223.51
    2-propoxyethanol 477.38
    tert-butanol 306.02
    MTBE 327.66
    2-butoxyethanol 346.96
    propionic acid 384.04
    o-xylene 232.16
    formic acid 148.36
    diethyl ether 246.24
    m-xylene 231.86
    p-xylene 297.04
    chlorobenzene 350.72
    dimethyl carbonate 200.71
    n-octane 57.87
    formamide 134.93
    cyclopentanone 756.95
    2-pentanone 271.46
    anisole 222.87
    cyclopentyl methyl ether 540.22
    gamma-butyrolactone 837.21
    1-methoxy-2-propanol 282.68
    pyridine 440.13
    3-pentanone 285.49
    furfural 655.91
    n-dodecane 32.71
    diethylene glycol 272.92
    diisopropyl ether 144.8
    tert-amyl alcohol 355.89
    acetylacetone 264.62
    n-hexadecane 36.58
    acetophenone 269.57
    methyl propionate 307.01
    isopentyl acetate 463.11
    trichloroethylene 935.57
    n-nonanol 207.55
    cyclohexanol 456.73
    benzyl alcohol 209.32
    2-ethylhexanol 347.43
    isooctanol 239.35
    dipropyl ether 298.46
    1,2-dichlorobenzene 371.09
    ethyl lactate 203.01
    propylene carbonate 649.05
    n-methylformamide 272.67
    2-pentanol 241.02
    n-pentane 120.66
    1-propoxy-2-propanol 410.72
    1-methoxy-2-propyl acetate 433.1
    2-(2-methoxypropoxy) propanol 283.46
    mesitylene 174.32
    ε-caprolactone 661.69
    p-cymene 213.58
    epichlorohydrin 707.18
    1,1,1-trichloroethane 611.44
    2-aminoethanol 172.57
    morpholine-4-carbaldehyde 685.33
    sulfolane 956.06
    2,2,4-trimethylpentane 97.16
    2-methyltetrahydrofuran 649.77
    n-hexyl acetate 400.96
    isooctane 58.7
    2-(2-butoxyethoxy)ethanol 334.72
    sec-butyl acetate 214.56
    tert-butyl acetate 303.57
    decalin 123.27
    glycerin 203.21
    diglyme 532.46
    acrylic acid 349.93
    isopropyl myristate 176.07
    n-butyric acid 425.79
    acetyl acetate 221.31
    di(2-ethylhexyl) phthalate 194.93
    ethyl propionate 242.43
    nitromethane 400.16
    1,2-diethoxyethane 212.84
    benzonitrile 255.79
    trioctyl phosphate 173.66
    1-bromopropane 348.94
    gamma-valerolactone 839.43
    n-decanol 158.18
    triethyl phosphate 223.36
    4-methyl-2-pentanol 172.55
    propionitrile 225.38
    vinylene carbonate 508.93
    1,1,2-trichlorotrifluoroethane 712.42
    DMS 306.45
    cumene 173.85
    2-octanol 207.56
    2-hexanone 254.94
    octyl acetate 238.06
    limonene 308.66
    1,2-dimethoxyethane 371.82
    ethyl orthosilicate 220.93
    tributyl phosphate 187.8
    diacetone alcohol 301.12
    N,N-dimethylaniline 230.06
    acrylonitrile 241.39
    aniline 274.27
    1,3-propanediol 191.81
    bromobenzene 350.29
    dibromomethane 495.49
    1,1,2,2-tetrachloroethane 960.4
    2-methyl-cyclohexyl acetate 397.61
    tetrabutyl urea 223.83
    diisobutyl methanol 182.46
    2-phenylethanol 320.32
    styrene 173.02
    dioctyl adipate 240.73
    dimethyl sulfate 338.93
    ethyl butyrate 319.87
    methyl lactate 255.8
    butyl lactate 291.84
    diethyl carbonate 245.16
    propanediol butyl ether 309.3
    triethyl orthoformate 302.51
    p-tert-butyltoluene 217.38
    methyl 4-tert-butylbenzoate 362.04
    morpholine 579.52
    tert-butylamine 253.96
    n-dodecanol 122.36
    dimethoxymethane 301.37
    ethylene carbonate 445.12
    cyrene 322.68
    2-ethoxyethyl acetate 276.03
    2-ethylhexyl acetate 438.66
    1,2,4-trichlorobenzene 466.37
    4-methylpyridine 449.56
    dibutyl ether 201.17
    2,6-dimethyl-4-heptanol 182.46
    DEF 377.24
    dimethyl isosorbide 502.03
    tetrachloroethylene 627.26
    eugenol 316.05
    triacetin 332.66
    span 80 342.39
    1,4-butanediol 108.84
    1,1-dichloroethane 509.5
    2-methyl-1-pentanol 221.61
    methyl formate 258.41
    2-methyl-1-butanol 299.23
    n-decane 65.93
    butyronitrile 247.23
    3,7-dimethyl-1-octanol 200.25
    1-chlorooctane 209.52
    1-chlorotetradecane 77.42
    n-nonane 68.11
    undecane 44.98
    tert-butylcyclohexane 119.65
    cyclooctane 92.82
    cyclopentanol 479.36
    tetrahydropyran 591.39
    tert-amyl methyl ether 333.53
    2,5,8-trioxanonane 340.78
    1-hexene 263.37
    2-isopropoxyethanol 183.35
    2,2,2-trifluoroethanol 228.93
    methyl butyrate 329.21

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction