Phenol, 2-methoxy-4-propyl-, acetate

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  • Identifiers

    CAS number
    33943-26-9

    Molecular formula
    C12H16O3

    SMILES
    CCCC1=CC(=C(C=C1)OC(=O)C)OC

    Safety labels

  • Odor profile

    Fragrance
    Spicy 73.85%
    Sweet 71.59%
    Woody 63.92%
    Floral 63.1%
    Fruity 62.36%
    Balsamic 56.81%
    Clove 51.34%
    Vanilla 45.68%
    Phenolic 45.05%
    Powdery 42.3%

     

    Flavor
    Sweet 78.83%
    Woody 71.27%
    Clove 54.7%
    Spicy 53.69%
    Spice 52.49%
    Powdery 41.42%
    Vanilla 40.32%
    Phenolic 39.97%
    Smoky 38.59%
    Floral 38.39%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    2.6

    pKa est.
    8.21 (weak base)

    Molecular weight
    208.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very slow

    Boiling point est.
    274°C

    Flash point

    • 115.44 ˚C est.

  • Synonyms

    • Phenol, 2-methoxy-4-propyl-, acetate
    • 33943-26-9
    • DTXSID80187565
    • RefChem:860857
    • DTXCID40110056
    • 2-methoxy-4-propylphenyl acetate
    • Dihydro-eugenol acetate
    • SCHEMBL357406
    • IXIJPFDYLOLJQN-UHFFFAOYSA-N
    • 33943-26-9

  • Applications

    Phenol, 2-methoxy-4-propyl-, acetate (CAS 33943-26-9) is primarily used as an intermediate in fragrance chemistry, serving as a precursor to aroma compounds and occasionally as a fragrance ingredient or fixative in perfumery and flavor applications. It may also function as a starting material or processing aid in cosmetic and personal-care formulations that rely on fragrance components, and can act as a solvent or intermediate in coatings, inks, and adhesives. In polymer and plastics chemistry, it can serve as a building block for functionalized phenolic polymers or as a protecting-group derivative in synthesis. Depending on formulation strategies and regulatory constraints, it may be evaluated for use in household products and cleaners as part of fragrance profiles, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 622.47
    methanol 1025.36
    isopropanol 370.69
    water 0.33
    ethyl acetate 595.14
    n-propanol 438.48
    acetone 937.27
    n-butanol 411.03
    acetonitrile 574.77
    DMF 1539.34
    toluene 236.84
    isobutanol 298.82
    1,4-dioxane 789.38
    methyl acetate 559.64
    THF 932.24
    2-butanone 538.01
    n-pentanol 262.16
    sec-butanol 300.54
    n-hexane 20.1
    ethylene glycol 214.67
    NMP 898.8
    cyclohexane 44.55
    DMSO 1454.93
    n-butyl acetate 387.25
    n-octanol 97.96
    chloroform 1459.46
    n-propyl acetate 283.24
    acetic acid 651.41
    dichloromethane 1703.92
    cyclohexanone 747.19
    propylene glycol 198.71
    isopropyl acetate 296.14
    DMAc 935.34
    2-ethoxyethanol 445.66
    isopentanol 336.33
    n-heptane 10.08
    ethyl formate 383.57
    1,2-dichloroethane 1233.19
    n-hexanol 261.01
    2-methoxyethanol 855.66
    isobutyl acetate 199.25
    tetrachloromethane 153.06
    n-pentyl acetate 181.04
    transcutol 895.83
    n-heptanol 92.82
    ethylbenzene 130.02
    MIBK 249.56
    2-propoxyethanol 443.26
    tert-butanol 535.08
    MTBE 421.4
    2-butoxyethanol 198.97
    propionic acid 372.74
    o-xylene 154.96
    formic acid 225.05
    diethyl ether 422.28
    m-xylene 168.38
    p-xylene 158.33
    chlorobenzene 410.61
    dimethyl carbonate 260.8
    n-octane 7.06
    formamide 377.05
    cyclopentanone 859.45
    2-pentanone 462.06
    anisole 312.64
    cyclopentyl methyl ether 424.2
    gamma-butyrolactone 960.94
    1-methoxy-2-propanol 526.62
    pyridine 620.5
    3-pentanone 341.71
    furfural 777.47
    n-dodecane 8.72
    diethylene glycol 441.89
    diisopropyl ether 90.3
    tert-amyl alcohol 373.56
    acetylacetone 553.36
    n-hexadecane 10.26
    acetophenone 284.34
    methyl propionate 471.58
    isopentyl acetate 330.43
    trichloroethylene 1819.51
    n-nonanol 85.46
    cyclohexanol 348.1
    benzyl alcohol 285.53
    2-ethylhexanol 139.03
    isooctanol 78.35
    dipropyl ether 125.26
    1,2-dichlorobenzene 364.82
    ethyl lactate 149.01
    propylene carbonate 535.04
    n-methylformamide 576.24
    2-pentanol 216.21
    n-pentane 16.6
    1-propoxy-2-propanol 268.99
    1-methoxy-2-propyl acetate 318.69
    2-(2-methoxypropoxy) propanol 220.88
    mesitylene 98.83
    ε-caprolactone 574.56
    p-cymene 79.17
    epichlorohydrin 1169.73
    1,1,1-trichloroethane 770.07
    2-aminoethanol 304.37
    morpholine-4-carbaldehyde 770.13
    sulfolane 1067.01
    2,2,4-trimethylpentane 18.39
    2-methyltetrahydrofuran 622.82
    n-hexyl acetate 264.09
    isooctane 13.11
    2-(2-butoxyethoxy)ethanol 288.53
    sec-butyl acetate 193.94
    tert-butyl acetate 323.72
    decalin 32.69
    glycerin 302.49
    diglyme 571.09
    acrylic acid 363.06
    isopropyl myristate 95.58
    n-butyric acid 509.47
    acetyl acetate 386.37
    di(2-ethylhexyl) phthalate 109.09
    ethyl propionate 239.16
    nitromethane 1005.9
    1,2-diethoxyethane 322.6
    benzonitrile 329.47
    trioctyl phosphate 77.96
    1-bromopropane 485.52
    gamma-valerolactone 914.91
    n-decanol 65.34
    triethyl phosphate 120.47
    4-methyl-2-pentanol 120.29
    propionitrile 401.76
    vinylene carbonate 499.94
    1,1,2-trichlorotrifluoroethane 688.14
    DMS 294.88
    cumene 89.68
    2-octanol 67.89
    2-hexanone 270.9
    octyl acetate 126.98
    limonene 116.36
    1,2-dimethoxyethane 688.15
    ethyl orthosilicate 112.22
    tributyl phosphate 105.2
    diacetone alcohol 349.54
    N,N-dimethylaniline 188.59
    acrylonitrile 510.07
    aniline 339.25
    1,3-propanediol 411.14
    bromobenzene 454.07
    dibromomethane 1040.53
    1,1,2,2-tetrachloroethane 1374.99
    2-methyl-cyclohexyl acetate 185.75
    tetrabutyl urea 131.51
    diisobutyl methanol 79.24
    2-phenylethanol 256.58
    styrene 180.42
    dioctyl adipate 151.58
    dimethyl sulfate 413.27
    ethyl butyrate 214.69
    methyl lactate 223.61
    butyl lactate 153.48
    diethyl carbonate 172.91
    propanediol butyl ether 199.09
    triethyl orthoformate 142.95
    p-tert-butyltoluene 78.99
    methyl 4-tert-butylbenzoate 200.4
    morpholine 931.8
    tert-butylamine 260.33
    n-dodecanol 52.93
    dimethoxymethane 719.91
    ethylene carbonate 426.42
    cyrene 243.93
    2-ethoxyethyl acetate 278.65
    2-ethylhexyl acetate 247.74
    1,2,4-trichlorobenzene 418.5
    4-methylpyridine 645.69
    dibutyl ether 132.4
    2,6-dimethyl-4-heptanol 79.24
    DEF 543.51
    dimethyl isosorbide 367.43
    tetrachloroethylene 796.29
    eugenol 218.26
    triacetin 239.64
    span 80 175.6
    1,4-butanediol 179.18
    1,1-dichloroethane 914.76
    2-methyl-1-pentanol 250.27
    methyl formate 529.43
    2-methyl-1-butanol 312.11
    n-decane 12.54
    butyronitrile 429.25
    3,7-dimethyl-1-octanol 105.4
    1-chlorooctane 76.18
    1-chlorotetradecane 34.34
    n-nonane 11.72
    undecane 10.16
    tert-butylcyclohexane 28.96
    cyclooctane 11.93
    cyclopentanol 322.38
    tetrahydropyran 677.32
    tert-amyl methyl ether 277.3
    2,5,8-trioxanonane 374.28
    1-hexene 113.64
    2-isopropoxyethanol 289.35
    2,2,2-trifluoroethanol 214.07
    methyl butyrate 336.9

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction