Phendimetrazine

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  • Identifiers

    CAS number
    634-03-7

    Molecular formula
    C12H17NO

    SMILES
    C[C@H]1[C@@H](OCCN1C)C2=CC=CC=C2

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Nutty 33.73%
    Roasted 31.04%
    Sweet 29.67%
    Animal 26.74%
    Fishy 26.5%
    Earthy 25.35%
    Odorless 24.95%
    Popcorn 24.25%
    Almond 24.14%
    Burnt 24.13%

     

    Flavor
    Bitter 51.96%
    Sweet 38.78%
    Earthy 30.01%
    Floral 29.91%
    Fruity 28.4%
    Green 28.2%
    Herbal 24.36%
    Woody 23.68%
    Naphthalic 22.62%
    Metallic 22.3%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.9

    pKa est.
    5.83 (weak acid)

    Molecular weight
    191.27 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • MP: 208 °C; specific optical rotation: +35.7 deg at 20 °C/D /Phendimetrazine hydrochloride/

    Boiling point

    • 134.5 °C at 1.20E+01 mm Hg
    • 122-124 °C at 8 mm Hg; 134-135 °C at 12 mm Hg

    Flash point

    • 99.76 ˚C est.

    Solubility expt.

    • Free sol in water; very slightly sol in alcohol; practically insol in chloroform and ether.

  • Synonyms

    • phendimetrazine
    • Mephenmetrazine
    • Fendimetrazina
    • Adphen (base)
    • Phendimetrazinum
    • 634-03-7
    • Antapentan
    • Sedafamen
    • (2S,3S)-3,4-Dimethyl-2-phenylmorpholine
    • Fendimetrazina [INN-Spanish]
    • Phendimetrazinum [INN-Latin]
    • NSC 169187
    • HSDB 3381
    • EINECS 211-204-6
    • (2R-trans)-3,4-Dimethyl-2-phenylmorpholine
    • UNII-AB2794W8KV
    • 3,4-Dimethyl-2-phenyltetrahydro-1,4-oxazine
    • AB2794W8KV
    • Morpholine, 3,4-dimethyl-2-phenyl-, (2S-trans)-
    • Phendimetrazine (INN)
    • Morpholine, 3,4-dimethyl-2-phenyl-, (+)-
    • NSC-169187
    • Bontril
    • CHEBI:8059
    • DTXSID1023447
    • PHENDIMETRAZINE [INN]
    • Fendimetrazina (INN-Spanish)
    • Phendimetrazinum (INN-Latin)
    • Phendimetrazine [INN:BAN]
    • Phendimetrazine (1.0mg/ml in Methanol)
    • Morpholine, 3,4-dimethyl-2-phenyl-
    • Morpholine, 3,4-dimethyl-2-phenyl-, (2S,3S)-
    • PHENDIMETRAZINE [MI]
    • PHENDIMETRAZINE [HSDB]
    • SCHEMBL598950
    • PHENDIMETRAZINE [VANDF]
    • DTXCID103447
    • CHEMBL1615439
    • PHENDIMETRAZINE [WHO-DD]
    • MFOCDFTXLCYLKU-CMPLNLGQSA-N
    • AKOS006281399
    • DB01579
    • (2S,3S)-3,4-dimethyl-2-phenyl-morpholine
    • NS00006244
    • C07904
    • D08347
    • Morpholine, 3,4-dimethyl-2-phenyl-, (2R-trans)-
    • 211-204-6

  • Applications

    Phendimetrazine (CAS 634-03-7) is primarily used as an active pharmaceutical ingredient in prescription weight-management products for obesity; it is commonly formulated as tartrate salts in oral dosage forms under regulatory oversight; its use is restricted to controlled pharmaceutical applications rather than general consumer chemicals; outside standard clinical formulations, it may also be encountered in medicinal chemistry research as a stimulant-like anorectic analogue in early-stage studies; overall, applications are confined to the pharmaceutical sector and are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 162.63
    methanol 187.7
    isopropanol 74.8
    water 13.72
    ethyl acetate 88.68
    n-propanol 134.93
    acetone 63.68
    n-butanol 122.81
    acetonitrile 101.22
    DMF 105.65
    toluene 66.13
    isobutanol 97.21
    1,4-dioxane 269.88
    methyl acetate 86.63
    THF 129.68
    2-butanone 75.11
    n-pentanol 81.86
    sec-butanol 68.13
    n-hexane 5.99
    ethylene glycol 98.73
    NMP 91.54
    cyclohexane 26.34
    DMSO 178.08
    n-butyl acetate 85.12
    n-octanol 40.8
    chloroform 850.51
    n-propyl acetate 62.68
    acetic acid 275.31
    dichloromethane 729.27
    cyclohexanone 159.86
    propylene glycol 74.57
    isopropyl acetate 40.78
    DMAc 102.11
    2-ethoxyethanol 147.15
    isopentanol 90.72
    n-heptane 9.45
    ethyl formate 135.29
    1,2-dichloroethane 307.2
    n-hexanol 101.54
    2-methoxyethanol 209.51
    isobutyl acetate 46.82
    tetrachloromethane 115.54
    n-pentyl acetate 42.0
    transcutol 365.96
    n-heptanol 52.17
    ethylbenzene 35.93
    MIBK 33.4
    2-propoxyethanol 149.38
    tert-butanol 77.26
    MTBE 41.66
    2-butoxyethanol 93.22
    propionic acid 148.93
    o-xylene 57.12
    formic acid 150.61
    diethyl ether 59.31
    m-xylene 48.99
    p-xylene 48.9
    chlorobenzene 149.68
    dimethyl carbonate 32.21
    n-octane 4.98
    formamide 148.54
    cyclopentanone 121.4
    2-pentanone 44.42
    anisole 68.67
    cyclopentyl methyl ether 68.78
    gamma-butyrolactone 178.29
    1-methoxy-2-propanol 99.16
    pyridine 224.22
    3-pentanone 48.89
    furfural 265.65
    n-dodecane 5.09
    diethylene glycol 162.91
    diisopropyl ether 15.62
    tert-amyl alcohol 63.79
    acetylacetone 59.41
    n-hexadecane 5.68
    acetophenone 76.23
    methyl propionate 61.79
    isopentyl acetate 73.28
    trichloroethylene 552.7
    n-nonanol 38.05
    cyclohexanol 104.16
    benzyl alcohol 94.15
    2-ethylhexanol 62.87
    isooctanol 43.15
    dipropyl ether 46.51
    1,2-dichlorobenzene 144.39
    ethyl lactate 53.43
    propylene carbonate 130.92
    n-methylformamide 113.56
    2-pentanol 50.0
    n-pentane 9.19
    1-propoxy-2-propanol 95.37
    1-methoxy-2-propyl acetate 76.9
    2-(2-methoxypropoxy) propanol 85.75
    mesitylene 32.14
    ε-caprolactone 145.48
    p-cymene 37.53
    epichlorohydrin 242.06
    1,1,1-trichloroethane 213.76
    2-aminoethanol 142.34
    morpholine-4-carbaldehyde 166.11
    sulfolane 173.35
    2,2,4-trimethylpentane 7.87
    2-methyltetrahydrofuran 103.47
    n-hexyl acetate 58.41
    isooctane 5.37
    2-(2-butoxyethoxy)ethanol 121.58
    sec-butyl acetate 37.88
    tert-butyl acetate 38.29
    decalin 12.48
    glycerin 124.92
    diglyme 214.38
    acrylic acid 161.42
    isopropyl myristate 26.7
    n-butyric acid 181.8
    acetyl acetate 73.25
    di(2-ethylhexyl) phthalate 43.19
    ethyl propionate 51.21
    nitromethane 231.62
    1,2-diethoxyethane 94.87
    benzonitrile 117.81
    trioctyl phosphate 27.7
    1-bromopropane 124.55
    gamma-valerolactone 194.77
    n-decanol 31.31
    triethyl phosphate 47.37
    4-methyl-2-pentanol 35.14
    propionitrile 98.53
    vinylene carbonate 177.49
    1,1,2-trichlorotrifluoroethane 238.78
    DMS 60.71
    cumene 33.35
    2-octanol 27.37
    2-hexanone 45.82
    octyl acetate 34.38
    limonene 46.68
    1,2-dimethoxyethane 155.07
    ethyl orthosilicate 46.0
    tributyl phosphate 35.49
    diacetone alcohol 54.9
    N,N-dimethylaniline 51.57
    acrylonitrile 131.82
    aniline 109.49
    1,3-propanediol 165.6
    bromobenzene 150.52
    dibromomethane 425.63
    1,1,2,2-tetrachloroethane 424.86
    2-methyl-cyclohexyl acetate 66.44
    tetrabutyl urea 42.43
    diisobutyl methanol 33.57
    2-phenylethanol 93.87
    styrene 44.82
    dioctyl adipate 47.79
    dimethyl sulfate 51.97
    ethyl butyrate 65.9
    methyl lactate 55.95
    butyl lactate 51.66
    diethyl carbonate 56.55
    propanediol butyl ether 76.89
    triethyl orthoformate 57.82
    p-tert-butyltoluene 32.14
    methyl 4-tert-butylbenzoate 68.33
    morpholine 227.01
    tert-butylamine 54.43
    n-dodecanol 26.02
    dimethoxymethane 73.28
    ethylene carbonate 142.49
    cyrene 89.59
    2-ethoxyethyl acetate 74.34
    2-ethylhexyl acetate 61.12
    1,2,4-trichlorobenzene 157.92
    4-methylpyridine 146.27
    dibutyl ether 39.56
    2,6-dimethyl-4-heptanol 33.57
    DEF 75.05
    dimethyl isosorbide 122.8
    tetrachloroethylene 343.75
    eugenol 78.23
    triacetin 74.12
    span 80 74.53
    1,4-butanediol 78.53
    1,1-dichloroethane 217.55
    2-methyl-1-pentanol 70.24
    methyl formate 100.83
    2-methyl-1-butanol 89.71
    n-decane 7.46
    butyronitrile 105.03
    3,7-dimethyl-1-octanol 42.15
    1-chlorooctane 29.71
    1-chlorotetradecane 13.96
    n-nonane 6.75
    undecane 5.95
    tert-butylcyclohexane 10.56
    cyclooctane 8.86
    cyclopentanol 82.24
    tetrahydropyran 163.17
    tert-amyl methyl ether 35.29
    2,5,8-trioxanonane 153.01
    1-hexene 21.61
    2-isopropoxyethanol 84.45
    2,2,2-trifluoroethanol 127.95
    methyl butyrate 71.46

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction