Permethrin

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  • Identifiers

    CAS number
    52645-53-1

    Molecular formula
    C21H20Cl2O3

    SMILES
    CC1(C(C1C(=O)OCC2=CC(=CC=C2)OC3=CC=CC=C3)C=C(Cl)Cl)C

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Floral 51.86%
    Fruity 42.73%
    Balsamic 37.88%
    Fresh 32.38%
    Rose 30.89%
    Sweet 30.46%
    Woody 30.17%
    Odorless 27.87%
    Grape 26.96%
    Herbal 25.58%

     

    Flavor
    Bitter 80.69%
    Odorless 30.03%
    Bland 22.8%
    Heather 19.99%
    Cedarleaf 19.79%
    Broom 19.64%
    Genet 19.45%
    Nitrile 19.29%
    Sweet-like 18.86%
    Parsley 18.71%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.5

    pKa est.
    7.46 (neutral)

    Molecular weight
    391.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 34 °C
    • <20 °C (OECD Method 102)
    • MP: cis-isomers, 63-65 °C; trans-isomers, 44-47 °C
    • 34-39 °C

    Boiling point

    • 220 °C at 5.00E-02 mm Hg
    • >290 °C at 760 mm Hg
    • BP: 200 °C at 0.1 mm Hg

    Flash point

    • 163.84 ˚C est.

    Solubility expt.

    • 0.006 mg/L (at 20 °C)
    • In water, 0.0111 mg/L at 20 °C, pH 7.0-9.3 (OECD Method 105)
    • In water, 6.00X10-3 mg/L (pH 7, 20 °C); cis-isomers 0.20 mg/L (25 °C); trans-isomers 0.13 mg/L (25 °C)
    • In xylene and hexane >1000, methanol 258 (all in g/kg at 25 °C)
    • Soluble in most organic solvents except ethylene glycol. Soluble in acetone, ethanol, ether, and xylene
    • In water, 6.00X10-3 mg/ml @ 20 °C.
    • 6.91e-05 g/L
    • Solubility in water: none

  • Synonyms

    • Permethrin
    • 52645-53-1
    • Pounce
    • Permethrine
    • Permetrina
    • Elimite
    • Kudos
    • Permethrinum
    • Acticin
    • Ambushfog
    • Chinetrin
    • Corsair
    • Dragnet
    • Ecsumin
    • Ectiban
    • Efmethrin
    • Imperator
    • Kaleait
    • Kestrel
    • Lyclear
    • Outflank
    • Perigen
    • Permasect
    • Perthrine
    • Quamlin
    • Stomoxi
    • Stomoxin
    • Stomozan
    • Coopex
    • Cosair
    • Eksmin
    • Exsmin
    • Ipitox
    • Picket
    • Pramex
    • Exmin
    • Expar
    • Kafil
    • Kavil
    • (3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate
    • Anomethrin N
    • Ridect pour-on
    • Diffusil H
    • Insorbcid MP
    • Stomoxin P
    • Perigen W
    • Dragnet FT
    • Picket G
    • Permethrin,racemic
    • Mitin BC
    • Permanone 80
    • Kestrel (pesticide)
    • Antiborer 3768
    • Bematin 987
    • Activyl tick plus
    • ICI-PP 557
    • MP79
    • NRDC 143
    • SBP 15131TEC
    • DTXSID8022292
    • OMS 1821
    • FMC 33297
    • FMC 41655
    • NIA 33297
    • PP 557
    • NSC-760105
    • JF 7065
    • WL 43479
    • 3-(2,2-Dichloroethenyl)-2,2-dimethylcyclopropanecarboxylic acid (3-phenoxyphenyl)methyl ester
    • DTXCID102292
    • CHEBI:34911
    • S 3151
    • 509F88P9SZ
    • 3-(2,2-Dichloroethenyl)-2,2-dimethylcyclopropane carboxylic acid, (3-phenoxyphenyl) methyl ester
    • (+-)-3-Phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
    • m-Phenoxybenzyl (+-)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
    • permetrin
    • Cyclopropanecarboxylic acid, 3-(2,2-dichloroethenyl)-2,2-dimethyl-, (3-phenoxyphenyl)methyl ester
    • Cyclopropanecarboxylic acid, 3-(2,2-dichlorovinyl)-2,2-dimethyl-, 3-phenoxybenzyl ester, (+-)-, (cis,trans)-
    • Permitrene
    • Lythrin
    • cis permethrin
    • Lice Treatment
    • trans permethrin
    • Permethrin 5% w/w
    • Leader Lice Treatment
    • Airline Pesticide Detox
    • cis-(1RS)-permethrin
    • RefChem:6115
    • trans-(1RS)-Permethrin
    • Permethrin Cream 5% w/w
    • permethrin, cis-(1RS)-
    • Nix Complete Lice Treatment
    • Permethrin, trans-(1RS)-
    • NRDC143
    • NRDC147
    • Nix Lice Killing Creme Rinse
    • Airline Pesticide Detox 6030
    • Topcare lice killing creme rinse
    • P03AC04
    • PP557
    • FMC33297
    • good sense lice killing creme rinse
    • NIA33297
    • Good Neighbor Pharmacy Lice Treatment
    • VECTRA 3D COMPONENT PERMETHRIN
    • 3-Phenoxybenzyl-cis,trans-(1RS)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
    • 258-067-9
    • S3151
    • Ambush
    • 52341-32-9
    • MFCD00041809
    • C21H20Cl2O3
    • (+-)-cis-Permethrin
    • Cyclopropanecarboxylicacid, 3-(2,2-dichloroethenyl)-2,2-dimethyl-, (3-phenoxyphenyl)methyl ester,(1R,3S)-rel-
    • 1RS cis-Permethrin
    • NCGC00159390-02
    • 3-phenoxybenzyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate
    • trans-(+-)-Permethrin
    • 93389-07-2
    • NRDC-143
    • Indothrin
    • NRDC 148
    • SBP-1513
    • (+-)-trans-Permethrin
    • Permethrine,c&t
    • (+-)-cis-Fmc 33297
    • 52645-53-1

  • Applications

    Permethrin, CAS 52645-53-1, is a pyrethroid widely used as an insecticide across sectors, including agriculture for crop protection against pests; in public health vector control such as mosquito and other insect control; in household and consumer pest control products such as sprays and treated articles; in textiles and clothing applications through fabric and garment treatment to deter insects; and in veterinary/animal care for fleas, ticks, and other pests on pets and livestock.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 26.33
    methanol 10.78
    isopropanol 22.5
    water 0.0
    ethyl acetate 101.11
    n-propanol 32.35
    acetone 112.04
    n-butanol 36.12
    acetonitrile 40.78
    DMF 87.27
    toluene 64.92
    isobutanol 25.31
    1,4-dioxane 118.54
    methyl acetate 90.47
    THF 378.78
    2-butanone 166.21
    n-pentanol 44.29
    sec-butanol 44.57
    n-hexane 1.69
    ethylene glycol 2.38
    NMP 92.96
    cyclohexane 2.38
    DMSO 58.94
    n-butyl acetate 97.17
    n-octanol 24.04
    chloroform 473.06
    n-propyl acetate 101.19
    acetic acid 51.26
    dichloromethane 345.92
    cyclohexanone 186.94
    propylene glycol 10.04
    isopropyl acetate 83.25
    DMAc 229.6
    2-ethoxyethanol 90.85
    isopentanol 40.47
    n-heptane 2.06
    ethyl formate 45.16
    1,2-dichloroethane 143.11
    n-hexanol 43.1
    2-methoxyethanol 76.54
    isobutyl acetate 77.72
    tetrachloromethane 15.74
    n-pentyl acetate 72.6
    transcutol 275.16
    n-heptanol 28.08
    ethylbenzene 40.18
    MIBK 87.45
    2-propoxyethanol 124.88
    tert-butanol 31.32
    MTBE 65.98
    2-butoxyethanol 83.05
    propionic acid 35.87
    o-xylene 27.71
    formic acid 8.68
    diethyl ether 53.87
    m-xylene 29.75
    p-xylene 51.54
    chlorobenzene 92.29
    dimethyl carbonate 40.76
    n-octane 1.12
    formamide 19.48
    cyclopentanone 193.7
    2-pentanone 125.02
    anisole 107.09
    cyclopentyl methyl ether 89.39
    gamma-butyrolactone 157.81
    1-methoxy-2-propanol 88.43
    pyridine 163.41
    3-pentanone 93.69
    furfural 149.84
    n-dodecane 1.61
    diethylene glycol 53.45
    diisopropyl ether 15.33
    tert-amyl alcohol 48.35
    acetylacetone 144.35
    n-hexadecane 1.9
    acetophenone 109.79
    methyl propionate 80.58
    isopentyl acetate 102.44
    trichloroethylene 446.28
    n-nonanol 26.5
    cyclohexanol 41.42
    benzyl alcohol 79.33
    2-ethylhexanol 33.4
    isooctanol 28.78
    dipropyl ether 41.29
    1,2-dichlorobenzene 83.98
    ethyl lactate 53.75
    propylene carbonate 99.17
    n-methylformamide 28.56
    2-pentanol 30.02
    n-pentane 1.08
    1-propoxy-2-propanol 92.63
    1-methoxy-2-propyl acetate 135.53
    2-(2-methoxypropoxy) propanol 98.05
    mesitylene 13.66
    ε-caprolactone 157.37
    p-cymene 21.0
    epichlorohydrin 322.7
    1,1,1-trichloroethane 137.24
    2-aminoethanol 11.17
    morpholine-4-carbaldehyde 134.77
    sulfolane 140.86
    2,2,4-trimethylpentane 2.55
    2-methyltetrahydrofuran 181.86
    n-hexyl acetate 85.42
    isooctane 1.41
    2-(2-butoxyethoxy)ethanol 118.21
    sec-butyl acetate 80.42
    tert-butyl acetate 90.93
    decalin 3.52
    glycerin 15.54
    diglyme 216.16
    acrylic acid 31.82
    isopropyl myristate 35.28
    n-butyric acid 70.07
    acetyl acetate 64.36
    di(2-ethylhexyl) phthalate 41.04
    ethyl propionate 86.29
    nitromethane 103.66
    1,2-diethoxyethane 99.56
    benzonitrile 80.59
    trioctyl phosphate 25.99
    1-bromopropane 86.69
    gamma-valerolactone 252.95
    n-decanol 19.1
    triethyl phosphate 42.57
    4-methyl-2-pentanol 23.89
    propionitrile 46.01
    vinylene carbonate 88.44
    1,1,2-trichlorotrifluoroethane 170.42
    DMS 73.89
    cumene 23.62
    2-octanol 20.35
    2-hexanone 121.93
    octyl acetate 44.2
    limonene 29.0
    1,2-dimethoxyethane 170.6
    ethyl orthosilicate 41.64
    tributyl phosphate 33.35
    diacetone alcohol 100.85
    N,N-dimethylaniline 57.86
    acrylonitrile 56.7
    aniline 60.45
    1,3-propanediol 24.48
    bromobenzene 110.17
    dibromomethane 199.13
    1,1,2,2-tetrachloroethane 295.75
    2-methyl-cyclohexyl acetate 76.67
    tetrabutyl urea 46.8
    diisobutyl methanol 21.31
    2-phenylethanol 80.57
    styrene 50.35
    dioctyl adipate 58.78
    dimethyl sulfate 61.13
    ethyl butyrate 78.86
    methyl lactate 45.08
    butyl lactate 62.14
    diethyl carbonate 55.11
    propanediol butyl ether 62.92
    triethyl orthoformate 61.98
    p-tert-butyltoluene 19.46
    methyl 4-tert-butylbenzoate 85.64
    morpholine 156.07
    tert-butylamine 15.22
    n-dodecanol 14.12
    dimethoxymethane 91.89
    ethylene carbonate 67.98
    cyrene 100.93
    2-ethoxyethyl acetate 118.89
    2-ethylhexyl acetate 83.97
    1,2,4-trichlorobenzene 104.92
    4-methylpyridine 157.42
    dibutyl ether 39.2
    2,6-dimethyl-4-heptanol 21.31
    DEF 96.08
    dimethyl isosorbide 171.09
    tetrachloroethylene 132.48
    eugenol 88.33
    triacetin 109.97
    span 80 73.37
    1,4-butanediol 14.44
    1,1-dichloroethane 152.83
    2-methyl-1-pentanol 53.05
    methyl formate 26.64
    2-methyl-1-butanol 43.22
    n-decane 2.68
    butyronitrile 61.03
    3,7-dimethyl-1-octanol 31.54
    1-chlorooctane 19.25
    1-chlorotetradecane 7.6
    n-nonane 2.02
    undecane 1.98
    tert-butylcyclohexane 3.49
    cyclooctane 0.83
    cyclopentanol 38.95
    tetrahydropyran 134.2
    tert-amyl methyl ether 64.29
    2,5,8-trioxanonane 143.69
    1-hexene 18.11
    2-isopropoxyethanol 80.37
    2,2,2-trifluoroethanol 18.93
    methyl butyrate 108.87

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction