Perfluoro(1,3-dimethylcyclohexane)

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  • Identifiers

    CAS number
    335-27-3

    Molecular formula
    C8F16

    SMILES
    C1(C(C(C(C(C1(F)F)(F)F)(F)F)(C(F)(F)F)F)(F)F)(C(F)(F)F)F

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 59.65%
    Woody 24.54%
    Cooling 20.97%
    Sweet 20.77%
    Fishy 20.75%
    Balsamic 17.01%
    Animal 15.4%
    Savory 15.31%
    Dry 15.15%
    Clean 14.57%

     

    Flavor
    Odorless 32.77%
    Bitter 29.43%
    Bland 20.35%
    Sweet-like 19.18%
    Bouillon 18.0%
    Bloody 17.97%
    Mild 17.77%
    Rotten 17.72%
    Nitrile 17.68%
    Glue 17.65%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    5.4

    pKa est.
    5.5 (weak acid)

    Molecular weight
    400.06 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    97°C

    Flash point

    • 8.4 ˚C est.

  • Synonyms

    • 335-27-3
    • Perfluoro(1,3-dimethylcyclohexane)
    • 1,1,2,2,3,3,4,5,5,6-Decafluoro-4,6-bis(trifluoromethyl)cyclohexane
    • Perfluorodimethylcyclohexane
    • Decafluoro-1,3-bis(trifluoromethyl)cyclohexane
    • Cyclohexane, decafluoro-1,3-bis(trifluoromethyl)-
    • Q1Y54IOL0P
    • Cyclohexane, perfluoro-1,3-dimethyl-
    • Cyclohexane, 1,1,2,2,3,3,4,5,5,6-decafluoro-4,6-bis(trifluoromethyl)-
    • FLUTEC PC3
    • NSC 4782
    • NSC-4782
    • EINECS 206-386-9
    • FLUTEC PC-3
    • FIFLOW 100
    • RefChem:860198
    • Perfluoro1,3dimethylcyclohexane
    • Cyclohexane, perfluoro1,3dimethyl
    • Hexadecafluoro1,3dimethylcyclohexane
    • PERFLUORODIMETHYLCYCLOHEXANE [INCI]
    • Decafluoro1,3bis(trifluoromethyl)cyclohexane
    • Cyclohexane, decafluoro1,3bis(trifluoromethyl)
    • 1,1,2,2,3,3,4,5,5,6Decafluoro4,6bis(trifluoromethyl)cyclohexane
    • Cyclohexane, 1,1,2,2,3,3,4,5,5,6decafluoro4,6bis(trifluoromethyl)
    • Perfluoro-1,3-dimethylcyclohexane
    • Hexadecafluoro(1,3-dimethylcyclohexane)
    • MFCD00001469
    • Perfluoro-1,3-dimethylcyclohexane,
    • Hexadecafluoro-1,3-dimethylcyclohexane
    • UNII-Q1Y54IOL0P
    • NSC4782
    • Flutec PP3
    • Cyclohexane,3-dimethyl-
    • FLUTEC PP3102
    • SCHEMBL33642
    • orb1987307
    • DTXSID0036926
    • Cyclohexane,3-bis(trifluoromethyl)-
    • MSK168547
    • AKOS015853371
    • FH60442
    • FS-4494
    • Perfluoro-1,3-dimethylcyclohexane, tech
    • Perfluoro-1,3-dimethylcyclohexane, tech.
    • Perfluoro-1 pound not3-dimethylcyclohexane
    • NS00013971
    • P1420
    • D92127
    • A821818
    • F003287
    • Q17074532
    • Perfluoro-1,3-dimethylcyclohexane, technical grade, 80%
    • 1,1,2,2,3,3,4,5,5,6-Decafluoro-4,6-bis(trifluoromethyl)cyclohexane #
    • Cyclohexane,1,2,2,3,3,4,5,5,6-decafluoro-4,6-bis(trifluoromethyl)-
    • 1,1,2,2,3,3,4,5,5,6-decakis(fluoranyl)-4,6-bis(trifluoromethyl)cyclohexane
    • 335-27-3

  • Applications

    Perfluoro(1,3-dimethylcyclohexane) (CAS 335-27-3) is a highly inert, fully fluorinated cycloalkane used as a specialty solvent and processing aid across several industries. In electronics and electrical applications, it serves as a dielectric fluid and a cooling medium. In coatings, inks and polymers, it can act as a solvent or processing aid for fluorinated polymers and high-performance coatings. It also finds use as a heat-transfer fluid in industrial equipment. As an inert cleaning solvent, it is employed for precision components in electronics and semiconductor manufacturing. In polymer processing, it may serve as an inert diluent or solvent in formulation and processing workflows.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 167.68
    methanol 441.63
    isopropanol 79.45
    water 31.53
    ethyl acetate 289.53
    n-propanol 123.98
    acetone 359.69
    n-butanol 69.68
    acetonitrile 257.04
    DMF 990.73
    toluene 110.73
    isobutanol 68.54
    1,4-dioxane 289.34
    methyl acetate 243.22
    THF 552.54
    2-butanone 264.62
    n-pentanol 63.14
    sec-butanol 78.6
    n-hexane 14.57
    ethylene glycol 129.65
    NMP 878.68
    cyclohexane 25.61
    DMSO 1374.22
    n-butyl acetate 145.21
    n-octanol 46.8
    chloroform 120.11
    n-propyl acetate 190.04
    acetic acid 175.31
    dichloromethane 202.84
    cyclohexanone 234.22
    propylene glycol 91.2
    isopropyl acetate 174.41
    DMAc 845.93
    2-ethoxyethanol 267.62
    isopentanol 47.76
    n-heptane 21.36
    ethyl formate 191.91
    1,2-dichloroethane 170.09
    n-hexanol 59.57
    2-methoxyethanol 387.34
    isobutyl acetate 76.65
    tetrachloromethane 23.87
    n-pentyl acetate 86.89
    transcutol 300.46
    n-heptanol 41.79
    ethylbenzene 60.18
    MIBK 129.62
    2-propoxyethanol 274.61
    tert-butanol 77.17
    MTBE 106.4
    2-butoxyethanol 114.67
    propionic acid 160.42
    o-xylene 87.96
    formic acid 253.86
    diethyl ether 214.22
    m-xylene 83.14
    p-xylene 56.71
    chlorobenzene 55.12
    dimethyl carbonate 282.86
    n-octane 10.79
    formamide 466.72
    cyclopentanone 371.62
    2-pentanone 220.12
    anisole 152.6
    cyclopentyl methyl ether 257.68
    gamma-butyrolactone 563.09
    1-methoxy-2-propanol 290.58
    pyridine 263.65
    3-pentanone 252.71
    furfural 388.72
    n-dodecane 8.37
    diethylene glycol 253.96
    diisopropyl ether 70.0
    tert-amyl alcohol 75.21
    acetylacetone 312.91
    n-hexadecane 9.2
    acetophenone 181.86
    methyl propionate 340.28
    isopentyl acetate 87.14
    trichloroethylene 205.24
    n-nonanol 48.57
    cyclohexanol 69.69
    benzyl alcohol 104.52
    2-ethylhexanol 42.96
    isooctanol 30.42
    dipropyl ether 146.7
    1,2-dichlorobenzene 51.5
    ethyl lactate 150.46
    propylene carbonate 238.84
    n-methylformamide 556.86
    2-pentanol 57.44
    n-pentane 22.55
    1-propoxy-2-propanol 177.92
    1-methoxy-2-propyl acetate 251.24
    2-(2-methoxypropoxy) propanol 142.38
    mesitylene 54.19
    ε-caprolactone 246.97
    p-cymene 47.76
    epichlorohydrin 355.88
    1,1,1-trichloroethane 62.59
    2-aminoethanol 151.69
    morpholine-4-carbaldehyde 636.82
    sulfolane 661.12
    2,2,4-trimethylpentane 9.19
    2-methyltetrahydrofuran 242.82
    n-hexyl acetate 97.37
    isooctane 6.6
    2-(2-butoxyethoxy)ethanol 150.43
    sec-butyl acetate 112.83
    tert-butyl acetate 151.99
    decalin 10.7
    glycerin 164.73
    diglyme 295.69
    acrylic acid 178.99
    isopropyl myristate 55.87
    n-butyric acid 127.54
    acetyl acetate 181.02
    di(2-ethylhexyl) phthalate 42.12
    ethyl propionate 243.8
    nitromethane 616.33
    1,2-diethoxyethane 175.37
    benzonitrile 89.52
    trioctyl phosphate 37.88
    1-bromopropane 93.83
    gamma-valerolactone 521.74
    n-decanol 38.44
    triethyl phosphate 95.45
    4-methyl-2-pentanol 35.9
    propionitrile 168.29
    vinylene carbonate 237.87
    1,1,2-trichlorotrifluoroethane 227.6
    DMS 163.8
    cumene 37.12
    2-octanol 31.4
    2-hexanone 138.91
    octyl acetate 66.36
    limonene 61.78
    1,2-dimethoxyethane 426.08
    ethyl orthosilicate 80.92
    tributyl phosphate 45.9
    diacetone alcohol 154.16
    N,N-dimethylaniline 138.76
    acrylonitrile 248.04
    aniline 106.05
    1,3-propanediol 122.54
    bromobenzene 51.12
    dibromomethane 127.42
    1,1,2,2-tetrachloroethane 136.49
    2-methyl-cyclohexyl acetate 93.46
    tetrabutyl urea 86.91
    diisobutyl methanol 33.58
    2-phenylethanol 92.91
    styrene 66.58
    dioctyl adipate 81.74
    dimethyl sulfate 434.87
    ethyl butyrate 175.85
    methyl lactate 249.63
    butyl lactate 81.44
    diethyl carbonate 124.85
    propanediol butyl ether 89.31
    triethyl orthoformate 124.21
    p-tert-butyltoluene 45.82
    methyl 4-tert-butylbenzoate 127.58
    morpholine 314.9
    tert-butylamine 51.05
    n-dodecanol 30.22
    dimethoxymethane 655.07
    ethylene carbonate 195.9
    cyrene 208.59
    2-ethoxyethyl acetate 149.37
    2-ethylhexyl acetate 79.36
    1,2,4-trichlorobenzene 64.77
    4-methylpyridine 211.81
    dibutyl ether 67.47
    2,6-dimethyl-4-heptanol 33.58
    DEF 362.65
    dimethyl isosorbide 296.31
    tetrachloroethylene 105.94
    eugenol 117.51
    triacetin 155.55
    span 80 88.72
    1,4-butanediol 70.34
    1,1-dichloroethane 90.16
    2-methyl-1-pentanol 44.74
    methyl formate 401.88
    2-methyl-1-butanol 56.58
    n-decane 14.3
    butyronitrile 101.03
    3,7-dimethyl-1-octanol 38.77
    1-chlorooctane 31.18
    1-chlorotetradecane 15.95
    n-nonane 13.39
    undecane 10.82
    tert-butylcyclohexane 8.45
    cyclooctane 15.17
    cyclopentanol 100.95
    tetrahydropyran 179.17
    tert-amyl methyl ether 115.47
    2,5,8-trioxanonane 232.72
    1-hexene 36.69
    2-isopropoxyethanol 159.83
    2,2,2-trifluoroethanol 131.0
    methyl butyrate 235.57

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction