Penicillin V Potassium

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  • Identifiers

    CAS number
    132-98-9

    Molecular formula
    C16H17KN2O5S

    SMILES
    CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)COC3=CC=CC=C3)C(=O)[O-])C.[K+]

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 62.2%
    Savory 28.66%
    Meaty 26.41%
    Roasted 23.74%
    Cooked 23.36%
    Cooling 21.66%
    Nutty 18.51%
    Milky 18.09%
    Bitter 17.5%
    Popcorn 17.14%

     

    Flavor
    Bitter 82.36%
    Odorless 34.34%
    Bland 24.93%
    Sweet-like 19.93%
    Very mild 18.9%
    Cedarleaf 18.66%
    Nitrile 18.47%
    Heather 17.9%
    Taco 17.88%
    Bread crust 17.87%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    3.28 (weak acid)

    Molecular weight
    388.5 g/mol

    Melting point expt.

    • 387 to 396 °F (NTP, 1992)

    Flash point

    • 254.21 ˚C est.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 72 °F (NTP, 1992)
    • Very sol in water; 1 g in about 150 ml alcohol

  • Synonyms

    • Penicillin V potassium
    • Penicillin V potassium salt
    • 132-98-9
    • PENICILLIN VK
    • Antibiocin
    • Beepen-VK
    • phenoxymethylpenicillin potassium
    • Primcillin
    • Veetids
    • Potassium penicillin V
    • Ledercillin VK
    • Penapar-Vk
    • Pfizerpen VK
    • Uticillin VK
    • Betapen-VK
    • Suspen
    • Pen-Vee K
    • Penicillin-Vk
    • Calciopen K
    • SK-Penicillin VK
    • V-Cillin K
    • Isocillin
    • Ispenoral
    • Kavepenin
    • Ospeneff
    • Pencompren
    • Penvikal
    • Roscopenin
    • Arcacil
    • Arcasin
    • Cliacil
    • Icipen
    • Orapen
    • Pedipen
    • Penagen
    • Vepen
    • Megacillin oral
    • Compocillin-VK
    • Robicillin VK
    • Rocillin-VK
    • Distaquaine V-K
    • Penapar VK
    • Sumapen VK
    • Distakaps V-K
    • Oracil-VK
    • Penicillin potassium phenoxymethyl
    • Qidpen VK
    • Apsin VK
    • Aspin VK
    • Dov-k
    • Pen-V-K powder
    • Pen-Vee-K powder
    • Dowpen V-K
    • Dqv-K
    • Vamosyn
    • Potassium penicillin V salt
    • V-Cil-K
    • Beromycin (penicillin)
    • Phenoxymethylpenicillin potassium salt
    • Potassium phenoxymethylpenicillin
    • Penicillin V (Potassium)
    • Potassium phenoxymethyl penicillin
    • Beromycin
    • CCRIS 750
    • HSDB 6315
    • EINECS 205-086-5
    • UNII-146T0TU1JB
    • MFCD00051771
    • 146T0TU1JB
    • CHEBI:7967
    • D-alpha-Phenoxymethylpenicillinate K salt
    • DTXSID7021102
    • NSC-757258
    • DTXCID101102
    • Penicillin V potassium [USAN:USP]
    • NSC 757258
    • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(( phenoxyacetyl)amino)-, monopotassium salt, (2S-(2alpha,5alpha,6beta))-
    • Monopotassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate
    • Pen-vee
    • PENICILLIN PHENOXYMETHYL POTASSIUM
    • Veetids '125'
    • Veetids '250'
    • Veetids '500'
    • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenoxyacetyl)amino)-, monopotassium salt, (2S,5R,6R)-
    • Pen VK
    • Penicillin V potassium (USAN:USP)
    • v-cillin-k
    • pen-vee-k
    • potassium 2,2-dimethyl-6beta-(phenoxyacetamido)penam-3alpha-carboxylate
    • Phenoxymethylpenicillin potassium (JAN)
    • PENICILLIN V POTASSIUM (USP-RS)
    • PENICILLIN V POTASSIUM [USP-RS]
    • beromycin 400
    • CAS-132-98-9
    • potassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
    • potassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-{[(phenyloxy)acetyl]amino}-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
    • PENICILLIN V POTASSIUM (USP IMPURITY)
    • PENICILLIN V POTASSIUM [USP IMPURITY]
    • Penicillin V Potassium [USAN]
    • PENICILLIN V POTASSIUM (USP MONOGRAPH)
    • PENICILLIN V POTASSIUM [USP MONOGRAPH]
    • PHENOXYMETHYLPENICILLIN POTASSIUM [JAN]
    • Penicilline V potassium
    • PHENOXYMETHYLPENICILLIN POTASSIUM (MART.)
    • PHENOXYMETHYLPENICILLIN POTASSIUM [MART.]
    • PHENOXYMETHYLPENICILLIN POTASSIUM (EP MONOGRAPH)
    • PHENOXYMETHYLPENICILLIN POTASSIUM [EP MONOGRAPH]
    • Fenocin
    • Compocillin VK
    • Monopotassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
    • Veetids (TN)
    • Penicillin V Potasium
    • MEGACILLIN-ORAL
    • Veetids'125'
    • Veetids'250'
    • Veetids'500'
    • D-alpha-phenoxymethylpencillinate k salt
    • PENICILLIN VK+
    • Potassium, Penicillin V
    • PEN-VEE K POWDER
    • VEETIDS'125
    • VEETIDS'250
    • VEETIDS'500
    • SCHEMBL41271
    • (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Potassium
    • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2 -phenoxyacetamido)-, monopotassium salt
    • Penicilline V potassium 100 microg/mL in Methanol
    • SPECTRUM1500467

  • Applications

    Penicillin V Potassium (CAS 132-98-9) is primarily used as an active pharmaceutical ingredient (API) for the manufacture of oral penicillin V tablets and suspensions intended for human use under prescription. It is also employed in veterinary medicine to treat bacterial infections in animals under regulatory guidance. In laboratory settings, it serves as a reference antibiotic for antimicrobial susceptibility testing and is used in some culture media to evaluate bacterial response to penicillin. The potassium salt form improves aqueous solubility, supporting formulation into aqueous oral solutions and other dosage forms. In pharmaceutical manufacturing, Penicillin V Potassium functions as a core API in penicillin-class antibiotic production and related formulation processes.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 17.45
    methanol 25.63
    isopropanol 6.28
    water 5.5
    ethyl acetate 10.44
    n-propanol 8.5
    acetone 20.92
    n-butanol 7.22
    acetonitrile 20.89
    DMF 117.9
    toluene 0.78
    isobutanol 4.41
    1,4-dioxane 15.15
    methyl acetate 12.33
    THF 33.98
    2-butanone 12.26
    n-pentanol 5.78
    sec-butanol 4.57
    n-hexane 0.08
    ethylene glycol 22.16
    NMP 51.89
    cyclohexane 0.15
    DMSO 85.42
    n-butyl acetate 5.78
    n-octanol 4.2
    chloroform 13.45
    n-propyl acetate 7.07
    acetic acid 42.23
    dichloromethane 14.3
    cyclohexanone 16.28
    propylene glycol 11.74
    isopropyl acetate 5.61
    DMAc 93.16
    2-ethoxyethanol 40.56
    isopentanol 5.81
    n-heptane 0.14
    ethyl formate 14.93
    1,2-dichloroethane 8.73
    n-hexanol 5.02
    2-methoxyethanol 75.88
    isobutyl acetate 4.25
    tetrachloromethane 1.26
    n-pentyl acetate 5.88
    transcutol 45.02
    n-heptanol 4.88
    ethylbenzene 0.75
    MIBK 7.38
    2-propoxyethanol 34.12
    tert-butanol 5.36
    MTBE 2.25
    2-butoxyethanol 20.81
    propionic acid 13.18
    o-xylene 0.83
    formic acid 92.2
    diethyl ether 4.15
    m-xylene 0.89
    p-xylene 1.1
    chlorobenzene 2.18
    dimethyl carbonate 15.3
    n-octane 0.13
    formamide 102.38
    cyclopentanone 26.23
    2-pentanone 11.55
    anisole 3.63
    cyclopentyl methyl ether 5.51
    gamma-butyrolactone 35.3
    1-methoxy-2-propanol 42.5
    pyridine 9.94
    3-pentanone 7.14
    furfural 37.67
    n-dodecane 0.17
    diethylene glycol 51.86
    diisopropyl ether 0.91
    tert-amyl alcohol 4.54
    acetylacetone 17.37
    n-hexadecane 0.19
    acetophenone 7.8
    methyl propionate 13.16
    isopentyl acetate 5.21
    trichloroethylene 19.67
    n-nonanol 4.27
    cyclohexanol 3.71
    benzyl alcohol 7.28
    2-ethylhexanol 2.73
    isooctanol 3.61
    dipropyl ether 2.65
    1,2-dichlorobenzene 3.26
    ethyl lactate 13.32
    propylene carbonate 17.32
    n-methylformamide 53.17
    2-pentanol 3.4
    n-pentane 0.1
    1-propoxy-2-propanol 17.53
    1-methoxy-2-propyl acetate 12.32
    2-(2-methoxypropoxy) propanol 18.02
    mesitylene 0.59
    ε-caprolactone 14.96
    p-cymene 1.09
    epichlorohydrin 36.73
    1,1,1-trichloroethane 4.18
    2-aminoethanol 21.38
    morpholine-4-carbaldehyde 56.45
    sulfolane 43.88
    2,2,4-trimethylpentane 0.08
    2-methyltetrahydrofuran 8.64
    n-hexyl acetate 6.86
    isooctane 0.07
    2-(2-butoxyethoxy)ethanol 23.82
    sec-butyl acetate 3.86
    tert-butyl acetate 5.11
    decalin 0.12
    glycerin 40.94
    diglyme 39.8
    acrylic acid 20.07
    isopropyl myristate 2.94
    n-butyric acid 14.26
    acetyl acetate 8.56
    di(2-ethylhexyl) phthalate 5.71
    ethyl propionate 6.8
    nitromethane 71.87
    1,2-diethoxyethane 8.29
    benzonitrile 8.28
    trioctyl phosphate 4.31
    1-bromopropane 2.54
    gamma-valerolactone 48.09
    n-decanol 3.1
    triethyl phosphate 5.18
    4-methyl-2-pentanol 2.7
    propionitrile 11.24
    vinylene carbonate 20.84
    1,1,2-trichlorotrifluoroethane 40.96
    DMS 8.5
    cumene 0.71
    2-octanol 2.82
    2-hexanone 7.51
    octyl acetate 4.57
    limonene 1.31
    1,2-dimethoxyethane 37.02
    ethyl orthosilicate 4.14
    tributyl phosphate 4.5
    diacetone alcohol 15.53
    N,N-dimethylaniline 3.27
    acrylonitrile 21.72
    aniline 3.18
    1,3-propanediol 28.2
    bromobenzene 1.56
    dibromomethane 6.42
    1,1,2,2-tetrachloroethane 13.61
    2-methyl-cyclohexyl acetate 5.53
    tetrabutyl urea 8.04
    diisobutyl methanol 1.83
    2-phenylethanol 8.15
    styrene 0.86
    dioctyl adipate 5.67
    dimethyl sulfate 26.12
    ethyl butyrate 5.69
    methyl lactate 22.54
    butyl lactate 9.97
    diethyl carbonate 5.15
    propanediol butyl ether 18.24
    triethyl orthoformate 4.99
    p-tert-butyltoluene 0.95
    methyl 4-tert-butylbenzoate 10.63
    morpholine 20.36
    tert-butylamine 1.68
    n-dodecanol 2.23
    dimethoxymethane 47.23
    ethylene carbonate 14.76
    cyrene 27.28
    2-ethoxyethyl acetate 10.95
    2-ethylhexyl acetate 3.69
    1,2,4-trichlorobenzene 4.59
    4-methylpyridine 7.34
    dibutyl ether 2.59
    2,6-dimethyl-4-heptanol 1.83
    DEF 18.33
    dimethyl isosorbide 26.82
    tetrachloroethylene 8.09
    eugenol 15.41
    triacetin 11.86
    span 80 12.31
    1,4-butanediol 14.13
    1,1-dichloroethane 5.19
    2-methyl-1-pentanol 4.69
    methyl formate 42.05
    2-methyl-1-butanol 4.78
    n-decane 0.26
    butyronitrile 9.22
    3,7-dimethyl-1-octanol 3.35
    1-chlorooctane 1.35
    1-chlorotetradecane 0.62
    n-nonane 0.2
    undecane 0.21
    tert-butylcyclohexane 0.1
    cyclooctane 0.08
    cyclopentanol 6.11
    tetrahydropyran 5.99
    tert-amyl methyl ether 2.59
    2,5,8-trioxanonane 30.35
    1-hexene 0.47
    2-isopropoxyethanol 19.06
    2,2,2-trifluoroethanol 29.03
    methyl butyrate 9.39

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction