(+)-Pantothenyl ethyl ether

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  • Identifiers

    CAS number
    667-83-4

    Molecular formula
    C11H23NO4

    SMILES
    CCOCCCNC(=O)[C@@H](C(C)(C)CO)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 40.0%
    Cooling 34.11%
    Mint 31.58%
    Sweet 29.48%
    Savory 24.62%
    Alcoholic 23.77%
    Milky 20.11%
    Fishy 18.29%
    Fruity 18.26%
    Buttery 17.07%

     

    Flavor
    Fruity 39.3%
    Odorless 36.61%
    Sweet 29.01%
    Sweet-like 24.05%
    Mild 23.09%
    Bitter 22.63%
    Very slight 20.63%
    Bland 20.62%
    Grape skin 19.97%
    Pulpy 19.89%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    7.29 (neutral)

    Molecular weight
    233.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    396°C

    Flash point

    • 173.12 ˚C est.

  • Synonyms

    • Panthenyl ethyl ether
    • 667-83-4
    • F4WMF8NX3B
    • ORISTAR PEE
    • RITAPAN EE
    • (+)-PANTOTHENYL ETHYL ETHER
    • Butanamide, N-(3-ethoxypropyl)-2,4-dihydroxy-3,3-dimethyl-, (2R)-
    • RefChem:858491
    • 211-569-1
    • Pantothenyl ethyl ether
    • (2r)-n-(3-ethoxypropyl)-2,4-dihydroxy-3,3-dimethylbutanamide
    • (R)-N-(3-Ethoxypropyl)-2,4-dihydroxy-3,3-dimethylbutanamide
    • ethyl panthenol
    • Pantothenyl ethylether (JAN)
    • PANTOTHENYL ETHYLETHER [JAN]
    • UNII-F4WMF8NX3B
    • (+)-N-(3-Ethoxypropyl)-2,4-dihydroxy-3,3-dimethylbutyramide
    • EINECS 211-569-1
    • panthenol ethyl ether
    • Pantothenyl ethylether
    • PROVITAMIN B3
    • Dexpanthenol Impurity 14
    • Dexpanthenol Impurity 23
    • SCHEMBL27534152
    • DTXSID20904738
    • MRAMPOPITCOOIN-VIFPVBQESA-N
    • Butanamide, N-(3-ethoxypropyl)-2,4-dihydroxy-3,3-dimethyl-, (R)-
    • PANTHENYL ETHYL ETHER [WHO-DD]
    • D01694
    • Q27277638
    • BUTYRAMIDE, N-(3-ETHOXYPROPYL)-2,4-DIHYDROXY-3,3-DIMETHYL-, D-(+)-
    • 667-83-4

  • Applications

    (+)-Pantothenyl ethyl ether, CAS 667-83-4, is primarily used as an intermediate in organic synthesis, especially for preparing pantothenate esters and related derivatives intended for pharmaceutical and cosmetic applications. It also serves as a building block in industrial manufacturing and in specialty polymers, coatings, and inks. In cosmetics and personal care, it may function as a pantothenate-derivative precursor used in formulations. The material is typically handled as a specialty chemical intermediate and is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 639.6
    methanol 1666.95
    isopropanol 270.5
    water 188.63
    ethyl acetate 64.72
    n-propanol 356.84
    acetone 83.43
    n-butanol 230.35
    acetonitrile 50.26
    DMF 581.64
    toluene 9.27
    isobutanol 193.23
    1,4-dioxane 247.37
    methyl acetate 59.88
    THF 222.1
    2-butanone 57.09
    n-pentanol 109.57
    sec-butanol 189.24
    n-hexane 1.63
    ethylene glycol 533.12
    NMP 324.62
    cyclohexane 6.62
    DMSO 810.53
    n-butyl acetate 27.29
    n-octanol 36.6
    chloroform 113.51
    n-propyl acetate 35.24
    acetic acid 1325.96
    dichloromethane 89.38
    cyclohexanone 165.13
    propylene glycol 479.62
    isopropyl acetate 41.26
    DMAc 410.44
    2-ethoxyethanol 406.85
    isopentanol 123.3
    n-heptane 1.78
    ethyl formate 122.18
    1,2-dichloroethane 56.97
    n-hexanol 73.24
    2-methoxyethanol 915.01
    isobutyl acetate 26.66
    tetrachloromethane 19.97
    n-pentyl acetate 27.49
    transcutol 399.48
    n-heptanol 48.83
    ethylbenzene 8.83
    MIBK 40.8
    2-propoxyethanol 195.64
    tert-butanol 309.19
    MTBE 64.12
    2-butoxyethanol 130.29
    propionic acid 328.31
    o-xylene 15.82
    formic acid 1870.69
    diethyl ether 29.36
    m-xylene 12.69
    p-xylene 14.29
    chlorobenzene 20.25
    dimethyl carbonate 38.1
    n-octane 1.55
    formamide 1195.52
    cyclopentanone 162.59
    2-pentanone 46.26
    anisole 28.58
    cyclopentyl methyl ether 65.39
    gamma-butyrolactone 234.69
    1-methoxy-2-propanol 359.66
    pyridine 76.81
    3-pentanone 32.28
    furfural 254.46
    n-dodecane 1.34
    diethylene glycol 329.69
    diisopropyl ether 10.03
    tert-amyl alcohol 235.67
    acetylacetone 89.64
    n-hexadecane 1.45
    acetophenone 54.17
    methyl propionate 59.9
    isopentyl acetate 32.43
    trichloroethylene 125.89
    n-nonanol 31.56
    cyclohexanol 176.71
    benzyl alcohol 78.66
    2-ethylhexanol 29.25
    isooctanol 37.3
    dipropyl ether 13.52
    1,2-dichlorobenzene 27.6
    ethyl lactate 65.9
    propylene carbonate 128.97
    n-methylformamide 439.16
    2-pentanol 84.8
    n-pentane 2.25
    1-propoxy-2-propanol 94.98
    1-methoxy-2-propyl acetate 58.87
    2-(2-methoxypropoxy) propanol 94.28
    mesitylene 10.39
    ε-caprolactone 169.79
    p-cymene 10.1
    epichlorohydrin 180.84
    1,1,1-trichloroethane 40.8
    2-aminoethanol 754.8
    morpholine-4-carbaldehyde 360.16
    sulfolane 366.42
    2,2,4-trimethylpentane 3.47
    2-methyltetrahydrofuran 112.06
    n-hexyl acetate 42.84
    isooctane 1.93
    2-(2-butoxyethoxy)ethanol 139.39
    sec-butyl acetate 24.52
    tert-butyl acetate 56.65
    decalin 3.41
    glycerin 742.04
    diglyme 244.36
    acrylic acid 325.61
    isopropyl myristate 13.94
    n-butyric acid 356.21
    acetyl acetate 60.5
    di(2-ethylhexyl) phthalate 32.5
    ethyl propionate 29.26
    nitromethane 656.75
    1,2-diethoxyethane 40.18
    benzonitrile 42.93
    trioctyl phosphate 25.14
    1-bromopropane 18.25
    gamma-valerolactone 328.21
    n-decanol 21.43
    triethyl phosphate 24.51
    4-methyl-2-pentanol 42.76
    propionitrile 39.92
    vinylene carbonate 120.55
    1,1,2-trichlorotrifluoroethane 399.3
    DMS 41.93
    cumene 9.26
    2-octanol 24.95
    2-hexanone 30.26
    octyl acetate 21.54
    limonene 16.08
    1,2-dimethoxyethane 257.55
    ethyl orthosilicate 23.16
    tributyl phosphate 24.7
    diacetone alcohol 139.73
    N,N-dimethylaniline 30.87
    acrylonitrile 67.48
    aniline 49.46
    1,3-propanediol 806.77
    bromobenzene 14.44
    dibromomethane 47.71
    1,1,2,2-tetrachloroethane 128.74
    2-methyl-cyclohexyl acetate 34.64
    tetrabutyl urea 32.87
    diisobutyl methanol 18.22
    2-phenylethanol 54.13
    styrene 9.27
    dioctyl adipate 31.32
    dimethyl sulfate 100.09
    ethyl butyrate 22.68
    methyl lactate 118.14
    butyl lactate 55.97
    diethyl carbonate 19.28
    propanediol butyl ether 157.14
    triethyl orthoformate 24.97
    p-tert-butyltoluene 10.65
    methyl 4-tert-butylbenzoate 67.26
    morpholine 380.44
    tert-butylamine 94.36
    n-dodecanol 15.19
    dimethoxymethane 134.5
    ethylene carbonate 101.21
    cyrene 140.9
    2-ethoxyethyl acetate 49.0
    2-ethylhexyl acetate 22.23
    1,2,4-trichlorobenzene 39.48
    4-methylpyridine 54.43
    dibutyl ether 13.13
    2,6-dimethyl-4-heptanol 18.22
    DEF 117.74
    dimethyl isosorbide 132.52
    tetrachloroethylene 109.28
    eugenol 74.31
    triacetin 67.2
    span 80 93.59
    1,4-butanediol 302.52
    1,1-dichloroethane 36.55
    2-methyl-1-pentanol 83.5
    methyl formate 282.67
    2-methyl-1-butanol 138.02
    n-decane 2.21
    butyronitrile 45.51
    3,7-dimethyl-1-octanol 31.14
    1-chlorooctane 9.12
    1-chlorotetradecane 3.82
    n-nonane 2.04
    undecane 1.63
    tert-butylcyclohexane 2.98
    cyclooctane 2.45
    cyclopentanol 202.1
    tetrahydropyran 114.09
    tert-amyl methyl ether 53.75
    2,5,8-trioxanonane 155.03
    1-hexene 5.7
    2-isopropoxyethanol 177.21
    2,2,2-trifluoroethanol 485.73
    methyl butyrate 53.28

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction