Panthenyl hydroxypropyl steardimonium chloride

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  • Identifiers

    CAS number
    132467-76-6

    Molecular formula
    C32H67ClN2O5

    SMILES
    CCCCCCCCCCCCCCCCCC[N+](C)(C)CC(COCC(C)(C)C(C(=O)NCCCO)O)O.[Cl-]

    Safety labels

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Woody 40.3%
    Waxy 39.38%
    Odorless 32.02%
    Amber 27.58%
    Fresh 27.36%
    Mint 27.13%
    Cooling 27.0%
    Oily 26.88%
    Animal 26.28%
    Sandalwood 25.86%

     

    Flavor
    Bland 38.21%
    Mild 36.4%
    Odorless 28.86%
    Waxy 22.21%
    Delicate 21.05%
    Slightly waxy 21.05%
    Faint 20.62%
    Yeasty 20.24%
    Bay oil 20.18%
    Leathery 20.05%

     

    Odor impact est.
    Odorless

  • Properties

    pKa est.
    6.76 (neutral)

    Molecular weight
    595.3 g/mol

    Flash point

    • 119.12 ˚C est.

  • Synonyms

    • Panthequat
    • Panthenyl hydroxypropyl steardimonium chloride
    • 132467-76-6
    • 41Z6CLD12N
    • Panthenyl hydroxypropyl stearyldimonium chloride
    • 1-Octadecanaminium, N-(2-hydroxy-3-(3-hydroxy-4-((3-hydroxypropyl)amino)-2,2-dimethyl-4-oxobutoxy)propyl)-N,N-dimethyl-, chloride
    • 1-Octadecanaminium, N-(2-hydroxy-3-(3-hydroxy-4-((3-hydroxypropyl)amino)-2,2-dimethyl-4-oxobutoxy)propyl)-N,N-dimethyl-, chloride (1:1)
    • DIMETHYL(PANTHENYLHYDROXYPROPYL)STEARYLAMMONIUM CHLORIDE
    • 1-Octadecanaminium, N-[2-hydroxy-3-[3-hydroxy-4-[(3-hydroxypropyl)amino]-2,2-dimethyl-4-oxobutoxy]propyl]-N,N-dimethyl-, chloride
    • 1-Octadecanaminium, N-[2-hydroxy-3-[3-hydroxy-4-[(3-hydroxypropyl)amino]-2,2-dimethyl-4-oxobutoxy]propyl]-N,N-dimethyl-, chloride (1:1)
    • RefChem:858492
    • PANTHENYL HYDROXYPROPYL STEARDIMONIUM CHLORIDE [INCI]
    • 428-640-1
    • 603-599-2
    • UNII-41Z6CLD12N
    • Q27258471
    • N-(2-Hydroxy-3-(3-hydroxy-4-((3-hydroxypropyl)amino)-2,2-dimethyl-4-oxobutoxy)propyl)-N,N-dimethyloctadecan-1-aminium chloride
    • 132467-76-6

  • Applications

    Panthenyl hydroxypropyl steardimonium chloride, CAS 132467-76-6, is used primarily as a cationic surfactant and conditioning agent in cosmetics and personal care. In hair care formulations such as shampoos, conditioners and leave-in treatments, it provides softness, easier detangling, and reduced static; in skin care formulations it can enhance the feel of the product and leave a smooth sensation. As a panthenol-derived ingredient, it typically serves a conditioning function and can help stabilize emulsions or improve product slip. It may also be included in color cosmetics or moisturizing formulations as an additional conditioning component, depending on local regulations and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 23.0
    methanol 55.34
    isopropanol 9.14
    water 3.3
    ethyl acetate 16.99
    n-propanol 20.7
    acetone 23.46
    n-butanol 14.68
    acetonitrile 5.83
    DMF 59.97
    toluene 10.12
    isobutanol 14.54
    1,4-dioxane 35.25
    methyl acetate 14.88
    THF 80.14
    2-butanone 23.61
    n-pentanol 16.54
    sec-butanol 13.54
    n-hexane 1.41
    ethylene glycol 7.83
    NMP 186.92
    cyclohexane 3.49
    DMSO 97.56
    n-butyl acetate 15.0
    n-octanol 15.84
    chloroform 53.95
    n-propyl acetate 19.37
    acetic acid 90.74
    dichloromethane 47.73
    cyclohexanone 78.44
    propylene glycol 15.34
    isopropyl acetate 17.69
    DMAc 120.16
    2-ethoxyethanol 52.27
    isopentanol 12.57
    n-heptane 1.68
    ethyl formate 20.04
    1,2-dichloroethane 27.71
    n-hexanol 12.03
    2-methoxyethanol 57.92
    isobutyl acetate 16.89
    tetrachloromethane 13.12
    n-pentyl acetate 36.73
    transcutol 140.9
    n-heptanol 20.82
    ethylbenzene 6.93
    MIBK 17.59
    2-propoxyethanol 40.17
    tert-butanol 11.28
    MTBE 10.49
    2-butoxyethanol 64.13
    propionic acid 34.99
    o-xylene 10.59
    formic acid 62.37
    diethyl ether 7.94
    m-xylene 9.31
    p-xylene 8.98
    chlorobenzene 13.36
    dimethyl carbonate 17.28
    n-octane 1.16
    formamide 56.32
    cyclopentanone 83.39
    2-pentanone 19.97
    anisole 13.4
    cyclopentyl methyl ether 41.18
    gamma-butyrolactone 98.28
    1-methoxy-2-propanol 42.96
    pyridine 33.35
    3-pentanone 19.03
    furfural 82.77
    n-dodecane 0.64
    diethylene glycol 27.13
    diisopropyl ether 4.09
    tert-amyl alcohol 17.48
    acetylacetone 37.55
    n-hexadecane 0.72
    acetophenone 28.98
    methyl propionate 23.29
    isopentyl acetate 17.95
    trichloroethylene 65.9
    n-nonanol 16.1
    cyclohexanol 27.33
    benzyl alcohol 22.5
    2-ethylhexanol 10.19
    isooctanol 19.19
    dipropyl ether 10.4
    1,2-dichlorobenzene 16.14
    ethyl lactate 25.06
    propylene carbonate 56.88
    n-methylformamide 39.05
    2-pentanol 9.02
    n-pentane 1.11
    1-propoxy-2-propanol 32.86
    1-methoxy-2-propyl acetate 32.7
    2-(2-methoxypropoxy) propanol 38.71
    mesitylene 6.24
    ε-caprolactone 82.39
    p-cymene 6.5
    epichlorohydrin 76.17
    1,1,1-trichloroethane 25.29
    2-aminoethanol 22.33
    morpholine-4-carbaldehyde 109.0
    sulfolane 207.21
    2,2,4-trimethylpentane 1.56
    2-methyltetrahydrofuran 45.23
    n-hexyl acetate 33.49
    isooctane 0.72
    2-(2-butoxyethoxy)ethanol 56.15
    sec-butyl acetate 17.31
    tert-butyl acetate 25.33
    decalin 2.33
    glycerin 30.48
    diglyme 103.74
    acrylic acid 37.32
    isopropyl myristate 8.47
    n-butyric acid 45.85
    acetyl acetate 17.93
    di(2-ethylhexyl) phthalate 18.01
    ethyl propionate 16.68
    nitromethane 69.52
    1,2-diethoxyethane 23.31
    benzonitrile 14.89
    trioctyl phosphate 12.97
    1-bromopropane 11.72
    gamma-valerolactone 148.43
    n-decanol 8.95
    triethyl phosphate 16.15
    4-methyl-2-pentanol 7.32
    propionitrile 6.78
    vinylene carbonate 50.88
    1,1,2-trichlorotrifluoroethane 118.18
    DMS 21.49
    cumene 6.17
    2-octanol 12.97
    2-hexanone 19.78
    octyl acetate 14.46
    limonene 10.03
    1,2-dimethoxyethane 47.73
    ethyl orthosilicate 16.63
    tributyl phosphate 13.38
    diacetone alcohol 42.5
    N,N-dimethylaniline 15.34
    acrylonitrile 10.49
    aniline 16.01
    1,3-propanediol 25.83
    bromobenzene 12.22
    dibromomethane 27.15
    1,1,2,2-tetrachloroethane 64.07
    2-methyl-cyclohexyl acetate 24.05
    tetrabutyl urea 19.09
    diisobutyl methanol 5.99
    2-phenylethanol 18.11
    styrene 6.38
    dioctyl adipate 20.58
    dimethyl sulfate 50.27
    ethyl butyrate 17.3
    methyl lactate 31.33
    butyl lactate 44.02
    diethyl carbonate 10.72
    propanediol butyl ether 55.93
    triethyl orthoformate 21.22
    p-tert-butyltoluene 6.76
    methyl 4-tert-butylbenzoate 49.14
    morpholine 58.33
    tert-butylamine 5.64
    n-dodecanol 5.27
    dimethoxymethane 37.42
    ethylene carbonate 41.59
    cyrene 68.12
    2-ethoxyethyl acetate 48.67
    2-ethylhexyl acetate 16.14
    1,2,4-trichlorobenzene 25.47
    4-methylpyridine 25.88
    dibutyl ether 10.11
    2,6-dimethyl-4-heptanol 5.99
    DEF 39.23
    dimethyl isosorbide 69.55
    tetrachloroethylene 50.43
    eugenol 43.71
    triacetin 57.64
    span 80 42.64
    1,4-butanediol 15.41
    1,1-dichloroethane 17.92
    2-methyl-1-pentanol 16.03
    methyl formate 31.78
    2-methyl-1-butanol 15.58
    n-decane 1.52
    butyronitrile 7.31
    3,7-dimethyl-1-octanol 12.09
    1-chlorooctane 7.8
    1-chlorotetradecane 2.02
    n-nonane 1.4
    undecane 0.92
    tert-butylcyclohexane 1.85
    cyclooctane 1.6
    cyclopentanol 32.07
    tetrahydropyran 35.14
    tert-amyl methyl ether 14.8
    2,5,8-trioxanonane 55.38
    1-hexene 4.09
    2-isopropoxyethanol 37.18
    2,2,2-trifluoroethanol 49.85
    methyl butyrate 25.59

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction