Palmitoylethanolamide

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  • Identifiers

    CAS number
    544-31-0

    Molecular formula
    C18H37NO2

    SMILES
    CCCCCCCCCCCCCCCC(=O)NCCO

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Waxy 43.13%
    Fatty 37.12%
    Odorless 32.88%
    Savory 32.09%
    Meaty 32.07%
    Fishy 30.66%
    Oily 29.53%
    Animal 25.15%
    Fresh 24.69%
    Citrus 24.5%

     

    Flavor
    Fatty 40.81%
    Mild 35.62%
    Bland 34.55%
    Waxy 34.55%
    Odorless 33.76%
    Faint 28.26%
    Fat 26.39%
    Oily 24.75%
    Slightly waxy 23.98%
    Bay oil 22.72%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.2

    pKa est.
    7.47 (neutral)

    Molecular weight
    299.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    416°C

    Melting point expt.

    • 98.5 °C

    Flash point

    • 196.7 ˚C est.

  • Synonyms

    • Palmitoylethanolamide
    • Palmidrol
    • 544-31-0
    • N-(2-Hydroxyethyl)hexadecanamide
    • Palmitoyl ethanolamide
    • Palmitic acid monoethanolamide
    • Hydroxyethylpalmitamide
    • Loramine P 256
    • palmitylethanolamide
    • Palmidrolum
    • Levagen
    • Palmdrol prodes
    • Anandamide (16:0)
    • Monoethanolamine palmitic acid amide
    • palmitic monoethanolamide
    • Palmitinsaeure-beta-hydroxyethylamid
    • hexadecanoyl ethanolamide
    • N(2-hydroxyethyl)palmitide
    • 6R8T1UDM3V
    • N(2-hydroxyethyl) palmitide
    • NSC-23320
    • N-(2-hydroxyethyl)-palmitide
    • FSD-201
    • n-palmitoyl ethanolamide
    • AM 3112
    • CHEBI:71464
    • NSC23320
    • SCI-110 component palmitoylethanolamide
    • n-palmitoylethanolamide
    • N-(2-hydroxyethyl)palmitate
    • OptiPEA
    • RefChem:858399
    • 208-867-9
    • N-(2-Hydroxyethyl)palmitamide
    • Palmitamide MEA
    • Impulsin
    • N-palmitoylethanolamine
    • Palmitoyl-EA
    • HEXADECANAMIDE, N-(2-HYDROXYETHYL)-
    • Palmidrol [INN]
    • MFCD00020562
    • C18H37NO2
    • N-hexadecanoylethanolamine
    • NSC 23320
    • PEA (Chemical)
    • N-palmitoyl ethanolamine
    • N-hexadecanoyl-ethanolamine
    • DTXSID4042254
    • Palmidrol (INN)
    • Palmitoylethanolamid?e
    • NCGC00015793-03
    • AM 3112;Loramine P 256;Mackpeart DR 14V
    • DTXCID2022254
    • Palmidrolum [INN-Latin]
    • CAS-544-31-0
    • 2-Palmitoylaminoethanol
    • SR-01000076055
    • EINECS 208-867-9
    • UNII-6R8T1UDM3V
    • MimyX
    • Anandamide C16:0
    • Tocris-0879
    • N-hexadecyl-ethanolamine
    • PALMIDROL [MI]
    • Lopac-P-0359
    • PALMIDROL [MART.]
    • Palmityoletanolamide (PEA)
    • 2-PALMITAMIDOETHANOL
    • PALMIDROL [WHO-DD]
    • CBiol_002043
    • Lopac0_000905
    • BSPBio_001454
    • KBioGR_000174
    • KBioSS_000174
    • MLS002153421
    • SCHEMBL120518
    • BML2-B10
    • CHEMBL417675
    • GTPL3622
    • orb1300340
    • Palmidrol|N-palmitoylethanolamine
    • BDBM29083
    • KBio2_000174
    • KBio2_002742
    • KBio2_005310
    • KBio3_000347
    • KBio3_000348
    • Bio1_000329
    • Bio1_000818
    • Bio1_001307
    • Bio2_000174
    • Bio2_000654
    • HMS1361I16
    • HMS1791I16
    • HMS1989I16
    • HMS2234L19
    • HMS3264C10
    • HMS3266N08
    • HMS3374K03
    • HMS3402I16
    • HMS3411B14
    • HMS3649L03
    • HMS3675B14
    • N-(2-hydroxyethyl) hexadecanamide
    • Pharmakon1600-01506156
    • CS-D1253
    • NAE 16:0
    • Tox21_110222
    • ANA(16:0)
    • EBC-47502
    • LMFA08040013
    • NAE(16:0)
    • NSC760371
    • s4708
    • STL454872
    • AKOS002676363
    • Tox21_110222_1
    • CCG-204987
    • DB14043
    • FP76687
    • LP00905
    • NSC-760371
    • SDCCGSBI-0050880.P002
    • IDI1_033924
    • s10398
    • NCGC00015793-01
    • NCGC00015793-02
    • 544-31-0

  • Applications

    Palmitoylethanolamide (CAS 544-31-0) is used as a bioactive lipid in real-world applications across cosmetics/personal care and nutraceuticals/pharmaceuticals. In cosmetics, it is incorporated into topical formulations such as creams, serums, and balms as a skin-conditioning lipid. In nutraceuticals/pharmaceutical-adjacent products, it is used as a dietary supplement ingredient, typically in softgel capsules or powders. It is also used in pet-care nutraceuticals in some markets. In the research sector, PEA serves as a biochemical tool to study lipid signaling and endocannabinoid-like pathways in biological systems. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 29.93
    methanol 55.82
    isopropanol 35.23
    water 0.05
    ethyl acetate 90.03
    n-propanol 37.0
    acetone 68.02
    n-butanol 45.81
    acetonitrile 26.79
    DMF 168.1
    toluene 25.91
    isobutanol 39.49
    1,4-dioxane 100.28
    methyl acetate 58.66
    THF 339.49
    2-butanone 86.44
    n-pentanol 40.39
    sec-butanol 41.29
    n-hexane 8.05
    ethylene glycol 4.13
    NMP 341.74
    cyclohexane 31.96
    DMSO 336.38
    n-butyl acetate 143.19
    n-octanol 42.46
    chloroform 234.26
    n-propyl acetate 161.88
    acetic acid 62.69
    dichloromethane 226.31
    cyclohexanone 330.74
    propylene glycol 13.78
    isopropyl acetate 105.63
    DMAc 281.89
    2-ethoxyethanol 100.62
    isopentanol 64.61
    n-heptane 9.78
    ethyl formate 58.43
    1,2-dichloroethane 172.1
    n-hexanol 40.03
    2-methoxyethanol 110.39
    isobutyl acetate 110.89
    tetrachloromethane 59.06
    n-pentyl acetate 194.65
    transcutol 452.73
    n-heptanol 42.45
    ethylbenzene 26.27
    MIBK 121.69
    2-propoxyethanol 99.67
    tert-butanol 79.25
    MTBE 83.57
    2-butoxyethanol 127.41
    propionic acid 54.16
    o-xylene 32.87
    formic acid 16.49
    diethyl ether 48.69
    m-xylene 27.06
    p-xylene 40.75
    chlorobenzene 61.19
    dimethyl carbonate 27.44
    n-octane 5.19
    formamide 31.92
    cyclopentanone 331.81
    2-pentanone 104.75
    anisole 64.01
    cyclopentyl methyl ether 154.09
    gamma-butyrolactone 305.98
    1-methoxy-2-propanol 115.89
    pyridine 107.82
    3-pentanone 82.39
    furfural 235.02
    n-dodecane 3.32
    diethylene glycol 48.53
    diisopropyl ether 30.89
    tert-amyl alcohol 77.01
    acetylacetone 150.44
    n-hexadecane 4.0
    acetophenone 110.22
    methyl propionate 70.05
    isopentyl acetate 146.36
    trichloroethylene 282.86
    n-nonanol 42.78
    cyclohexanol 95.61
    benzyl alcohol 53.33
    2-ethylhexanol 44.73
    isooctanol 47.54
    dipropyl ether 79.42
    1,2-dichlorobenzene 89.41
    ethyl lactate 67.95
    propylene carbonate 185.41
    n-methylformamide 58.6
    2-pentanol 37.73
    n-pentane 5.09
    1-propoxy-2-propanol 114.99
    1-methoxy-2-propyl acetate 133.05
    2-(2-methoxypropoxy) propanol 105.02
    mesitylene 25.46
    ε-caprolactone 277.53
    p-cymene 29.57
    epichlorohydrin 274.99
    1,1,1-trichloroethane 173.47
    2-aminoethanol 18.17
    morpholine-4-carbaldehyde 232.55
    sulfolane 602.93
    2,2,4-trimethylpentane 8.01
    2-methyltetrahydrofuran 202.78
    n-hexyl acetate 164.23
    isooctane 4.62
    2-(2-butoxyethoxy)ethanol 152.15
    sec-butyl acetate 115.96
    tert-butyl acetate 155.62
    decalin 14.28
    glycerin 29.08
    diglyme 345.05
    acrylic acid 39.81
    isopropyl myristate 49.37
    n-butyric acid 133.09
    acetyl acetate 67.92
    di(2-ethylhexyl) phthalate 49.09
    ethyl propionate 114.97
    nitromethane 127.37
    1,2-diethoxyethane 151.54
    benzonitrile 72.61
    trioctyl phosphate 38.44
    1-bromopropane 88.0
    gamma-valerolactone 427.62
    n-decanol 27.16
    triethyl phosphate 78.01
    4-methyl-2-pentanol 36.28
    propionitrile 36.48
    vinylene carbonate 130.47
    1,1,2-trichlorotrifluoroethane 240.63
    DMS 79.8
    cumene 24.87
    2-octanol 37.32
    2-hexanone 129.62
    octyl acetate 63.69
    limonene 52.9
    1,2-dimethoxyethane 241.73
    ethyl orthosilicate 78.75
    tributyl phosphate 53.53
    diacetone alcohol 161.46
    N,N-dimethylaniline 55.61
    acrylonitrile 41.38
    aniline 39.43
    1,3-propanediol 40.24
    bromobenzene 68.49
    dibromomethane 150.47
    1,1,2,2-tetrachloroethane 313.74
    2-methyl-cyclohexyl acetate 120.87
    tetrabutyl urea 79.56
    diisobutyl methanol 37.61
    2-phenylethanol 52.67
    styrene 31.25
    dioctyl adipate 92.31
    dimethyl sulfate 85.83
    ethyl butyrate 137.16
    methyl lactate 50.01
    butyl lactate 132.28
    diethyl carbonate 75.14
    propanediol butyl ether 100.94
    triethyl orthoformate 114.67
    p-tert-butyltoluene 28.92
    methyl 4-tert-butylbenzoate 130.25
    morpholine 163.13
    tert-butylamine 47.13
    n-dodecanol 19.05
    dimethoxymethane 86.0
    ethylene carbonate 122.65
    cyrene 126.21
    2-ethoxyethyl acetate 188.63
    2-ethylhexyl acetate 120.5
    1,2,4-trichlorobenzene 105.9
    4-methylpyridine 103.04
    dibutyl ether 93.77
    2,6-dimethyl-4-heptanol 37.61
    DEF 170.0
    dimethyl isosorbide 221.07
    tetrachloroethylene 209.76
    eugenol 108.06
    triacetin 179.3
    span 80 101.49
    1,4-butanediol 18.55
    1,1-dichloroethane 122.53
    2-methyl-1-pentanol 52.93
    methyl formate 38.63
    2-methyl-1-butanol 54.55
    n-decane 7.64
    butyronitrile 53.72
    3,7-dimethyl-1-octanol 46.54
    1-chlorooctane 41.28
    1-chlorotetradecane 11.82
    n-nonane 7.27
    undecane 4.63
    tert-butylcyclohexane 11.47
    cyclooctane 7.74
    cyclopentanol 96.8
    tetrahydropyran 164.18
    tert-amyl methyl ether 80.9
    2,5,8-trioxanonane 198.23
    1-hexene 25.61
    2-isopropoxyethanol 88.29
    2,2,2-trifluoroethanol 35.04
    methyl butyrate 189.0

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction