Palmitoyl Tripeptide-1

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  • Identifiers

    CAS number
    147732-56-7

    Molecular formula
    C30H54N6O5

    SMILES
    CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CCCCN)C(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 52.55%
    Savory 41.14%
    Meaty 33.62%
    Cooling 31.12%
    Fishy 28.04%
    Animal 20.61%
    Oily 19.23%
    Milky 19.06%
    Cooked 18.82%
    Fatty 16.78%

     

    Flavor
    Odorless 47.81%
    Bitter 45.38%
    Bland 40.85%
    Mild 26.73%
    Sweet-like 20.34%
    Faint 20.29%
    Cedarleaf 19.38%
    Nitrile 18.91%
    Slightly waxy 18.9%
    Oriental 18.5%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.2

    pKa est.
    7.9 (neutral)

    Molecular weight
    578.8 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    829°C

    Flash point

    • 326.14 ˚C est.

  • Synonyms

    • 147732-56-7
    • Palmitoyl Tripeptide-1
    • Palmitoyl oligopeptide
    • L-Lysine, N-(1-oxohexadecyl)glycyl-L-histidyl-
    • Pal-val-gly-val-ala-pro-gly-oh
    • DTXSID90163794
    • RV743D216M
    • (2S)-6-amino-2-[(2S)-2-(2-hexadecanamidoacetamido)-3-(1H-imidazol-4-yl)propanamido]hexanoic acid
    • (2S)-6-amino-2-((2S)-2-(2-hexadecanamidoacetamido)-3-(1H-imidazol-4-yl)propanamido)hexanoic acid
    • BIOPEPTIDE CL
    • LIPO-GKH
    • RefChem:858436
    • PALMITOYL-GHK TRIPEPTIDE
    • Palmitoyl Oligopeptide (Retired)
    • DTXCID801476402
    • PALMITOYLGLYCYLHISTIDYLLYSINE
    • PALMITOYL TRIPEPTIDE-1 [INCI]
    • 680-607-0
    • Pal-Gly-His-Lys-OH
    • MFCD18251733
    • C16-GHK
    • (2S)-6-amino-2-[[(2S)-2-[[2-(hexadecanoylamino)acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoic acid
    • N-(1-oxohexadecyl)glycyl-L-histidyl-L-lysine
    • N2-[N-[N-(1-Oxohexadecyl)glycyl]-L-histidyl]-L-lysine
    • (S)-2-((S)-3-(1H-Imidazol-5-yl)-2-(2-palmitamidoacetamido)propanamido)-6-aminohexanoic acid
    • SCHEMBL322731
    • UNII-RV743D216M
    • orb1679192
    • palmitoyl-glycyl-histidyl-lysine
    • SCHEMBL26006164
    • Palmitoyl Tripeptide-1 (Powder)
    • BYUQATUKPXLFLZ-UIOOFZCWSA-N
    • C30H54N6O5
    • Palmitoyl Tripeptide-1 (Liquid)
    • HY-P0047
    • AKOS028109254
    • AKOS030529561
    • DB11297
    • N-Hexadecanoylglycyl-L-histidyl-L-lysine
    • AS-85767
    • DA-76573
    • SY253682
    • CS-0005657
    • Q27288301
    • 147732-56-7

  • Applications

    Palmitoyl Tripeptide-1 (CAS 147732-56-7) is primarily used in cosmetics and personal care as a skin-active peptide delivered in serums, creams, and masks; its palmitoylated structure is associated with improved skin penetration and formulation compatibility, making it a contributor to skin-conditioning claims in anti-aging skincare products. It is commonly evaluated in topical dermatology and cosmeceutical formulations, where developers study its potential effects on skin physiology and peptide signaling pathways. In product development, it is often found as a skin-conditioning ingredient intended to support the overall texture and appearance of the skin in various cosmetic systems.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 10.54
    methanol 31.25
    isopropanol 5.54
    water 4.18
    ethyl acetate 6.3
    n-propanol 8.86
    acetone 17.46
    n-butanol 5.49
    acetonitrile 4.36
    DMF 82.92
    toluene 1.65
    isobutanol 4.71
    1,4-dioxane 11.04
    methyl acetate 9.22
    THF 22.63
    2-butanone 14.18
    n-pentanol 5.64
    sec-butanol 5.93
    n-hexane 0.28
    ethylene glycol 9.27
    NMP 158.01
    cyclohexane 0.3
    DMSO 100.97
    n-butyl acetate 3.43
    n-octanol 1.86
    chloroform 6.58
    n-propyl acetate 5.41
    acetic acid 60.91
    dichloromethane 6.89
    cyclohexanone 24.5
    propylene glycol 14.62
    isopropyl acetate 4.19
    DMAc 177.76
    2-ethoxyethanol 26.37
    isopentanol 3.54
    n-heptane 0.17
    ethyl formate 10.33
    1,2-dichloroethane 5.24
    n-hexanol 2.06
    2-methoxyethanol 39.01
    isobutyl acetate 2.81
    tetrachloromethane 1.93
    n-pentyl acetate 4.75
    transcutol 40.89
    n-heptanol 2.54
    ethylbenzene 1.08
    MIBK 3.67
    2-propoxyethanol 12.87
    tert-butanol 4.03
    MTBE 2.66
    2-butoxyethanol 14.35
    propionic acid 19.36
    o-xylene 1.6
    formic acid 70.83
    diethyl ether 2.58
    m-xylene 1.03
    p-xylene 1.8
    chlorobenzene 1.91
    dimethyl carbonate 10.01
    n-octane 0.15
    formamide 69.49
    cyclopentanone 35.98
    2-pentanone 8.5
    anisole 3.1
    cyclopentyl methyl ether 6.25
    gamma-butyrolactone 45.04
    1-methoxy-2-propanol 22.74
    pyridine 12.12
    3-pentanone 8.0
    furfural 43.14
    n-dodecane 0.08
    diethylene glycol 14.48
    diisopropyl ether 0.59
    tert-amyl alcohol 5.53
    acetylacetone 14.84
    n-hexadecane 0.09
    acetophenone 7.18
    methyl propionate 10.0
    isopentyl acetate 2.94
    trichloroethylene 11.35
    n-nonanol 1.97
    cyclohexanol 5.38
    benzyl alcohol 6.29
    2-ethylhexanol 1.18
    isooctanol 1.79
    dipropyl ether 1.72
    1,2-dichlorobenzene 2.27
    ethyl lactate 8.6
    propylene carbonate 20.37
    n-methylformamide 40.45
    2-pentanol 2.7
    n-pentane 0.2
    1-propoxy-2-propanol 8.34
    1-methoxy-2-propyl acetate 7.19
    2-(2-methoxypropoxy) propanol 11.28
    mesitylene 0.53
    ε-caprolactone 25.05
    p-cymene 0.54
    epichlorohydrin 23.48
    1,1,1-trichloroethane 3.87
    2-aminoethanol 17.13
    morpholine-4-carbaldehyde 73.52
    sulfolane 99.7
    2,2,4-trimethylpentane 0.14
    2-methyltetrahydrofuran 11.2
    n-hexyl acetate 4.29
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 16.05
    sec-butyl acetate 3.75
    tert-butyl acetate 3.77
    decalin 0.19
    glycerin 34.21
    diglyme 29.3
    acrylic acid 25.57
    isopropyl myristate 1.18
    n-butyric acid 17.76
    acetyl acetate 6.46
    di(2-ethylhexyl) phthalate 2.64
    ethyl propionate 5.09
    nitromethane 66.56
    1,2-diethoxyethane 5.89
    benzonitrile 3.59
    trioctyl phosphate 1.84
    1-bromopropane 2.02
    gamma-valerolactone 75.04
    n-decanol 1.29
    triethyl phosphate 3.39
    4-methyl-2-pentanol 1.22
    propionitrile 3.53
    vinylene carbonate 17.51
    1,1,2-trichlorotrifluoroethane 52.54
    DMS 6.35
    cumene 0.8
    2-octanol 1.55
    2-hexanone 7.22
    octyl acetate 2.32
    limonene 0.72
    1,2-dimethoxyethane 22.58
    ethyl orthosilicate 2.94
    tributyl phosphate 2.32
    diacetone alcohol 11.43
    N,N-dimethylaniline 3.35
    acrylonitrile 6.31
    aniline 4.69
    1,3-propanediol 18.84
    bromobenzene 1.46
    dibromomethane 3.32
    1,1,2,2-tetrachloroethane 11.77
    2-methyl-cyclohexyl acetate 3.22
    tetrabutyl urea 4.71
    diisobutyl methanol 0.51
    2-phenylethanol 3.2
    styrene 1.18
    dioctyl adipate 2.95
    dimethyl sulfate 32.99
    ethyl butyrate 3.66
    methyl lactate 18.11
    butyl lactate 9.19
    diethyl carbonate 2.53
    propanediol butyl ether 16.17
    triethyl orthoformate 3.77
    p-tert-butyltoluene 0.48
    methyl 4-tert-butylbenzoate 8.35
    morpholine 20.15
    tert-butylamine 1.38
    n-dodecanol 0.85
    dimethoxymethane 20.83
    ethylene carbonate 12.85
    cyrene 24.12
    2-ethoxyethyl acetate 9.18
    2-ethylhexyl acetate 2.28
    1,2,4-trichlorobenzene 3.78
    4-methylpyridine 9.33
    dibutyl ether 1.63
    2,6-dimethyl-4-heptanol 0.51
    DEF 20.13
    dimethyl isosorbide 13.26
    tetrachloroethylene 9.02
    eugenol 8.76
    triacetin 9.96
    span 80 8.49
    1,4-butanediol 9.8
    1,1-dichloroethane 3.74
    2-methyl-1-pentanol 4.14
    methyl formate 27.26
    2-methyl-1-butanol 4.59
    n-decane 0.17
    butyronitrile 2.87
    3,7-dimethyl-1-octanol 1.07
    1-chlorooctane 0.69
    1-chlorotetradecane 0.25
    n-nonane 0.15
    undecane 0.11
    tert-butylcyclohexane 0.13
    cyclooctane 0.12
    cyclopentanol 9.98
    tetrahydropyran 6.73
    tert-amyl methyl ether 3.03
    2,5,8-trioxanonane 17.44
    1-hexene 0.98
    2-isopropoxyethanol 13.43
    2,2,2-trifluoroethanol 35.33
    methyl butyrate 8.47

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction